ARGI1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARGI1_HUMAN
• UniProt AC: P05089
• Protein Name: Arginase-1
• Gene Name: ARG1
• Organism: Homo sapiens (Human).
• Sequence Length: 322
• Subcellular Localization: Cytoplasm . Cytoplasmic granule . Localized in azurophil granules of neutrophils (PubMed:15546957).
• Protein Description: Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys.; Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available intracellular substrate arginine. Arginine metabolism is a critical regulator of innate and adaptive immune responses. Involved in an antimicrobial effector pathway in polymorphonuclear granulocytes (PMN). Upon PMN cell death is liberated from the phagolysosome and depletes arginine in the microenvironment leading to suppressed T cell and natural killer (NK) cell proliferation and cytokine secretion. [PubMed: 15546957]
• Protein Sequence: MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MSAKSRTIGIIGAP -CCCCCCEEEEECCC	30.55	21406692
16 (in isoform 2)	Phosphorylation	-	34.51	21406692
16	Phosphorylation	GIIGAPFSKGQPRGG EEECCCCCCCCCCCC	34.51	21406692
17	Succinylation	IIGAPFSKGQPRGGV EECCCCCCCCCCCCC	63.04	-
17	Succinylation	IIGAPFSKGQPRGGV EECCCCCCCCCCCCC	63.04	-
29	Phosphorylation	GGVEEGPTVLRKAGL CCCCCCHHHHHHHCH	42.92	-
33	2-Hydroxyisobutyrylation	EGPTVLRKAGLLEKL CCHHHHHHHCHHHHH	42.52	-
33	Ubiquitination	EGPTVLRKAGLLEKL CCHHHHHHHCHHHHH	42.52	29967540
33	Malonylation	EGPTVLRKAGLLEKL CCHHHHHHHCHHHHH	42.52	26320211
50	Phosphorylation	QECDVKDYGDLPFAD CCCCCCCCCCCCCCC	13.56	28192239
62	Phosphorylation	FADIPNDSPFQIVKN CCCCCCCCCCEEECC	33.96	28192239
72	Phosphorylation	QIVKNPRSVGKASEQ EEECCHHHHHHHHHH	36.16	-
75	Succinylation	KNPRSVGKASEQLAG CCHHHHHHHHHHHCC	46.73	-
75	Succinylation	KNPRSVGKASEQLAG CCHHHHHHHHHHHCC	46.73	-
94	Phosphorylation	VKKNGRISLVLGGDH EEECCEEEEEECCCC	15.86	-
102	Phosphorylation	LVLGGDHSLAIGSIS EEECCCCEEEEEEEC	25.00	-
107	Phosphorylation	DHSLAIGSISGHARV CCEEEEEEECCCCEE	13.89	-
109	Phosphorylation	SLAIGSISGHARVHP EEEEEEECCCCEECC	26.65	-
163	Phosphorylation	IPDVPGFSWVTPCIS CCCCCCCCCCCCCCC	26.93	20166139
166	Phosphorylation	VPGFSWVTPCISAKD CCCCCCCCCCCCHHH	13.24	20166139
168	S-nitrosocysteine	GFSWVTPCISAKDIV CCCCCCCCCCHHHEE	2.54	-
168	S-nitrosylation	GFSWVTPCISAKDIV CCCCCCCCCCHHHEE	2.54	22178444
170	Phosphorylation	SWVTPCISAKDIVYI CCCCCCCCHHHEEEE	35.66	26270265
176	Phosphorylation	ISAKDIVYIGLRDVD CCHHHEEEEEECCCC	6.93	26270265
191	Acetylation	PGEHYILKTLGIKYF CCCCEEEEECCCCEE	31.95	20167786
217	Phosphorylation	KVMEETLSYLLGRKK HHHHHHHHHHHCCCC	22.58	1598908
265	Phosphorylation	LYITEEIYKTGLLSG EEEEHHHHHCCCCCC	13.04	-
267	Phosphorylation	ITEEIYKTGLLSGLD EEHHHHHCCCCCCCC	18.98	21406692
271	Phosphorylation	IYKTGLLSGLDIMEV HHHCCCCCCCCEEEC	42.21	21406692
281	Phosphorylation	DIMEVNPSLGKTPEE CEEECCCHHCCCHHH	44.54	22210691
303	S-nitrosocysteine	AVAITLACFGLAREG HHHHHHHHHHHHHCC	2.90	-
303	S-nitrosylation	AVAITLACFGLAREG HHHHHHHHHHHHHCC	2.90	22178444

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARGI1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARGI1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARGI1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARGI2_HUMAN	ARG2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 207800: Argininemia (ARGIN)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00129: L-Ornithine