ARGI2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARGI2_HUMAN
• UniProt AC: P78540
• Protein Name: Arginase-2, mitochondrial
• Gene Name: ARG2
• Organism: Homo sapiens (Human).
• Sequence Length: 354
• Subcellular Localization: Mitochondrion .
• Protein Description: May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells. [PubMed: 27745970 May suppress inflammation-related signaling in asthmatic airway epithelium]
• Protein Sequence: MSLRGSLSRLLQTRVHSILKKSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLRGSLSR ------CCHHHHHHH	27.12	30001349
6	Phosphorylation	--MSLRGSLSRLLQT --CCHHHHHHHHHHH	19.41	30001349
8	Phosphorylation	MSLRGSLSRLLQTRV CCHHHHHHHHHHHHH	23.68	22496350
17	Phosphorylation	LLQTRVHSILKKSVH HHHHHHHHHHHHCCC	27.10	24719451
34	Phosphorylation	AVIGAPFSQGQKRKG EEECCCCCCCCCCCC	32.13	21659604
56	Acetylation	IREAGLMKRLSSLGC HHHHHHHHHHHHCCC	56.05	20167786
59	Phosphorylation	AGLMKRLSSLGCHLK HHHHHHHHHCCCCCC	27.79	29449344
74	Phosphorylation	DFGDLSFTPVPKDDL CCCCCCCEECCHHHC	21.72	-
78	Ubiquitination	LSFTPVPKDDLYNNL CCCEECCHHHCCCCC	65.20	-
165	Phosphorylation	NLHGQPVSFLLRELQ CCCCCCHHHHHHHHH	19.50	24719451
212	Phosphorylation	EHFILKNYDIQYFSM CCEEECCCCEEEEEH	16.91	24043423
216	Phosphorylation	LKNYDIQYFSMRDID ECCCCEEEEEHHHHH	9.65	24043423
218	Phosphorylation	NYDIQYFSMRDIDRL CCCEEEEEHHHHHHH	14.15	24043423
234	Phosphorylation	IQKVMERTFDLLIGK HHHHHHHHHHHHCCC	14.27	21406692
241	Ubiquitination	TFDLLIGKRQRPIHL HHHHHCCCCCCCEEE	38.06	-
310	Phosphorylation	TSEEEAKTTANLAVD CCHHHHHHHHHHHHH	37.88	21406692
311	Phosphorylation	SEEEAKTTANLAVDV CHHHHHHHHHHHHHH	16.91	21406692
321	Phosphorylation	LAVDVIASSFGQTRE HHHHHHHHHCCCCCC	18.31	21406692
322	Phosphorylation	AVDVIASSFGQTREG HHHHHHHHCCCCCCC	25.11	21406692
326	Phosphorylation	IASSFGQTREGGHIV HHHHCCCCCCCCEEE	30.94	21406692
342	Phosphorylation	DQLPTPSSPDESENQ ECCCCCCCCCCCCCC	37.26	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARGI2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARGI2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARGI2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CPT2_HUMAN	CPT2	physical	26186194

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00125: L-Arginine
• DB00129: L-Ornithine