DSG1_HUMAN - dbPTM
DSG1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DSG1_HUMAN
UniProt AC Q02413
Protein Name Desmoglein-1
Gene Name DSG1
Organism Homo sapiens (Human).
Sequence Length 1049
Subcellular Localization Cell membrane
Single-pass type I membrane protein. Cell junction, desmosome.
Protein Description Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion..
Protein Sequence MDWSFFRVVAMLFIFLVVVEVNSEFRIQVRDYNTKNGTIKWHSIRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFVINQKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQENTLNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQSLQLSIGVRNKAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGSNDKVGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQGTILSIDDNLQRTCTGTININIQSFGNDDRTNTEPNTKITTNTGRQESTSSTNYDTSTTSTDSSQVYSSEPGNGAKDLLSDNVHFGPAGIGLLIMGFLVLGLVPFLMICCDCGGAPRSAAGFEPVPECSDGAIHSWAVEGPQPEPRDITTVIPQIPPDNANIIECIDNSGVYTNEYGGREMQDLGGGERMTGFELTEGVKTSGMPEICQEYSGTLRRNSMRECREGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIGEDLDDSFLDTLGPKFKKLADISLGKESYPDLDPSWPPQSTEPVCLPQETEPVVSGHPPISPHFGTTTVISESTYPSGPGVLHPKPILDPLGYGNVTVTESYTTSDTLKPSVHVHDNRPASNVVVTERVVGPISGADLHGMLEMPDLRDGSNVIVTERVIAPSSSLPTSLTIHHPRESSNVVVTERVIQPTSGMIGSLSMHPELANAHNVIVTERVVSGAGVTGISGTTGISGGIGSSGLVGTSMGAGSGALSGAGISGGGIGLSSLGGTASIGHMRSSSDHHFNQTIGSASPSTARSRITKYSTVQYSK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MDWSFFRVVAM
----CCHHHHHHHHH		27.1724719451
23PhosphorylationLVVVEVNSEFRIQVR
HHHHCCCCCEEEEEE		43.20-
32PhosphorylationFRIQVRDYNTKNGTI
EEEEEEECCCCCCEE		17.7322461510
36N-linked_GlycosylationVRDYNTKNGTIKWHS
EEECCCCCCEEEEEE		51.29UniProtKB CARBOHYD
38PhosphorylationDYNTKNGTIKWHSIR
ECCCCCCEEEEEEEC		28.8622461510
43PhosphorylationNGTIKWHSIRRQKRE
CCEEEEEEECHHHHH		19.37-
65PhosphorylationCREGEDNSKRNPIAK
HHCCCCCCCCCCCEE		45.3630301811
77S-nitrosylationIAKIHSDCAANQQVT
CEEECCCHHCCCEEE		4.2824105792
110N-linked_GlycosylationNQKTGEINITSIVDR
ECCCCEEEEEEEECC		27.4716740002
180N-linked_GlycosylationNTLVMILNATDADEP
CEEEEEEECCCCCCC		29.84UniProtKB CARBOHYD
204PhosphorylationKIIRQEPSDSPMFII
EEECCCCCCCCEEEE		50.3921406692
206PhosphorylationIRQEPSDSPMFIINR
ECCCCCCCCEEEEEC		23.7021406692
215PhosphorylationMFIINRNTGEIRTMN
EEEEECCCCCEEECC		32.71-
220PhosphorylationRNTGEIRTMNNFLDR
CCCCCEEECCCCCCH		29.8820068231
437PhosphorylationADLLAVDSRTGKLTL
HHEEEEECCCCCEEE		25.7428450419
443PhosphorylationDSRTGKLTLKNKVTK
ECCCCCEEEECCCCH		38.8924719451
450AcetylationTLKNKVTKEQYNMLG
EEECCCCHHHHHHCC		45.8987839
509PhosphorylationTNTGRQESTSSTNYD
CCCCCCEECCCCCCC		25.8330576142
512PhosphorylationGRQESTSSTNYDTST
CCCEECCCCCCCCCC		22.2922468782
513PhosphorylationRQESTSSTNYDTSTT
CCEECCCCCCCCCCC		37.2522468782
515PhosphorylationESTSSTNYDTSTTST
EECCCCCCCCCCCCC		22.2330576142
519PhosphorylationSTNYDTSTTSTDSSQ
CCCCCCCCCCCCCCC		27.19-
520PhosphorylationTNYDTSTTSTDSSQV
CCCCCCCCCCCCCCE		29.42-
525PhosphorylationSTTSTDSSQVYSSEP
CCCCCCCCCEEECCC		26.8622468782
579PhosphorylationDCGGAPRSAAGFEPV
CCCCCCCCCCCCCCC		22.7816740002
590PhosphorylationFEPVPECSDGAIHSW
CCCCCCCCCCCEEEE		37.1025072903
596PhosphorylationCSDGAIHSWAVEGPQ
CCCCCEEEEEECCCC		15.6025072903
630PhosphorylationIIECIDNSGVYTNEY
EEEEECCCCCEECCC		26.36-
633PhosphorylationCIDNSGVYTNEYGGR
EECCCCCEECCCCCE		13.84-
634PhosphorylationIDNSGVYTNEYGGRE
ECCCCCEECCCCCEE		21.11-
637PhosphorylationSGVYTNEYGGREMQD
CCCEECCCCCEECEE		27.2723879269
652PhosphorylationLGGGERMTGFELTEG
CCCCCCCCCEEECCC		44.9622817900
672PhosphorylationMPEICQEYSGTLRRN
CHHHHHHHCCCCCHH		6.1122817900
903PhosphorylationERVIAPSSSLPTSLT
EEEECCCCCCCCEEE		34.5324719451
904PhosphorylationRVIAPSSSLPTSLTI
EEECCCCCCCCEEEE		42.5828348404
977PhosphorylationISGGIGSSGLVGTSM
CCCCCCCCCCCCCCC		30.8225332170
988PhosphorylationGTSMGAGSGALSGAG
CCCCCCCCCCCCCCC		21.9925332170
1017PhosphorylationASIGHMRSSSDHHFN
CEECCCCCCCCCCCC		26.9824719451
1018PhosphorylationSIGHMRSSSDHHFNQ
EECCCCCCCCCCCCC		29.4424719451
1019PhosphorylationIGHMRSSSDHHFNQT
ECCCCCCCCCCCCCC		42.0628348404
1026PhosphorylationSDHHFNQTIGSASPS
CCCCCCCCCCCCCCH		28.5428348404
1029PhosphorylationHFNQTIGSASPSTAR
CCCCCCCCCCCHHHH		23.0218691976
1031PhosphorylationNQTIGSASPSTARSR
CCCCCCCCCHHHHHH		22.5324719451
1033PhosphorylationTIGSASPSTARSRIT
CCCCCCCHHHHHHHE		32.0025072903
1034PhosphorylationIGSASPSTARSRITK
CCCCCCHHHHHHHEE		29.4925072903
1042PhosphorylationARSRITKYSTVQYSK
HHHHHEECEEEECCC		10.83-
1043PhosphorylationRSRITKYSTVQYSK-
HHHHEECEEEECCC-		24.53-
1044PhosphorylationSRITKYSTVQYSK--
HHHEECEEEECCC--		14.45-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DSG1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DSG1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DSG1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PLAK_HUMANJUPphysical
9606214
PKP1_HUMANPKP1physical
9606214
DSC1_HUMANDSC1physical
9606214
Drug and Disease Associations
Kegg Disease
H00717 Striate palmoplantar keratoderma
OMIM Disease
148700Palmoplantar keratoderma 1, striate, focal, or diffuse (PPKS1)
615508Erythroderma, congenital, with palmoplantar keratoderma, hypotrichosis, and hyper IgE (EPKHE)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DSG1_HUMAN

loading...

Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Identification of N-linked glycoproteins in human saliva byglycoprotein capture and mass spectrometry.";
Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T.,Loo J.A.;
J. Proteome Res. 5:1493-1503(2006).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-110, AND MASSSPECTROMETRY.
Phosphorylation
ReferencePubMed
"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-579, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory