CASPE_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CASPE_HUMAN
• UniProt AC: P31944
• Protein Name: Caspase-14
• Gene Name: CASP14
• Organism: Homo sapiens (Human).
• Sequence Length: 242
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum. [PubMed: 15556625 Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF]
• Protein Sequence: MSNPRSLEEEKYDMSGARLALILCVTKAREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLMAHGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPGETVGGDEIVMVIKDSPQTIPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTKRKGHILELLTEVTRRMAEAELVQEGKARKTNPEIQSTLRKRLYLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Dimethylation	---MSNPRSLEEEKY ---CCCCCCHHHHHC	59.11	-
5	Methylation	---MSNPRSLEEEKY ---CCCCCCHHHHHC	59.11	-
6	Phosphorylation	--MSNPRSLEEEKYD --CCCCCCHHHHHCC	41.19	27251275
12	Phosphorylation	RSLEEEKYDMSGARL CCHHHHHCCCCHHHH	21.84	28270605
15	Phosphorylation	EEEKYDMSGARLALI HHHHCCCCHHHHHHH	26.80	28270605
155	Phosphorylation	IVMVIKDSPQTIPTY EEEEEECCCCCCCCC	17.57	24043423
158	Phosphorylation	VIKDSPQTIPTYTDA EEECCCCCCCCCCCC	32.10	24043423
161	Phosphorylation	DSPQTIPTYTDALHV CCCCCCCCCCCCCHH	34.89	24043423
162	Phosphorylation	SPQTIPTYTDALHVY CCCCCCCCCCCCHHE	9.40	24043423
163	Phosphorylation	PQTIPTYTDALHVYS CCCCCCCCCCCHHEE	19.78	24043423
169	Phosphorylation	YTDALHVYSTVEGYI CCCCCHHEEEECEEE	6.46	24043423
170	Phosphorylation	TDALHVYSTVEGYIA CCCCHHEEEECEEEC	25.53	24043423
171	Phosphorylation	DALHVYSTVEGYIAY CCCHHEEEECEEECE	12.61	24043423
175	Phosphorylation	VYSTVEGYIAYRHDQ HEEEECEEECEECCC	2.94	24043423
178	Phosphorylation	TVEGYIAYRHDQKGS EECEEECEECCCCCC	10.02	24043423
185	Phosphorylation	YRHDQKGSCFIQTLV EECCCCCCEEEHHHH	16.94	20068231
190	Phosphorylation	KGSCFIQTLVDVFTK CCCEEEHHHHHHHHC	24.75	20068231
196	Phosphorylation	QTLVDVFTKRKGHIL HHHHHHHHCCCCHHH	29.77	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CASPE_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CASPE_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CASPE_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CASP1_HUMAN	CASP1	physical	9792675
CASP2_HUMAN	CASP2	physical	9792675
CASP4_HUMAN	CASP4	physical	9792675
CASP8_HUMAN	CASP8	physical	9792675
CASPA_HUMAN	CASP10	physical	9792675

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.