CPNE7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CPNE7_HUMAN
• UniProt AC: Q9UBL6
• Protein Name: Copine-7 {ECO:0000305}
• Gene Name: CPNE7 {ECO:0000312|HGNC:HGNC:2320}
• Organism: Homo sapiens (Human).
• Sequence Length: 633
• Subcellular Localization: Cytoplasm . Nucleus . Cell membrane . Translocates to the cell membrane in a calcium-dependent manner (PubMed:21087455).
• Protein Description: Calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes..
• Protein Sequence: MSAGSERGAAATPGGLPAPCASKVELRLSCRHLLDRDPLTKSDPSVALLQQAQGQWVQVGRTEVVRSSLHPVFSKVFTVDYYFEEVQRLRFEVYDTHGPSGFSCQEDDFLGGMECTLGQPAQKWLLQVVMRVSVDVLGPAGHCAKHFLCCTESSHLARTGPSFLLRYDDLCLPWATAGAVRWWTCRGGHTQGWQIVAQKKVTRPLLLKFGRNAGKSTITVIAEDISGNNGYVELSFRARKLDDKDLFSKSDPFLELYRVNDDQGLQLVYRTEVVKNNLNPVWEAFKVSLSSLCSCEETRPLKCLVWDYDSRGKHDFIGEFSTTFEEMQKAFEEGQAQWDCVNPKYKQKRRSYKNSGVVVLADLKFHRVYSFLDYIMGGCQIHFTVAIDFTASNGDPRNSCSLHYINPYQPNEYLKALVSVGEICQDYDSDKRFSALGFGARIPPKYEVSHDFAINFNPEDDECEGIQGVVEAYQNCLPRVQLYGPTNVAPIISKVARVAAAEESTGKASQYYILLILTDGVVTDMADTREAIVRASRLPMSIIIVGVGNADFTDMQVLDGDDGVLRSPRGEPALRDIVQFVPFRELKNASPAALAKCVLAEVPKQVVEYYSHRGLPPRSLGVPAGEASPGCTP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSAGSERGA ------CCCCCCCCC	41.14	24719451
5	Phosphorylation	---MSAGSERGAAAT ---CCCCCCCCCCCC	24.68	24719451
12	Phosphorylation	SERGAAATPGGLPAP CCCCCCCCCCCCCCC	20.10	23312004
22	Phosphorylation	GLPAPCASKVELRLS CCCCCCCCCCHHHHH	43.90	24719451
23	Ubiquitination	LPAPCASKVELRLSC CCCCCCCCCHHHHHH	22.62	-
29	Phosphorylation	SKVELRLSCRHLLDR CCCHHHHHHHHHCCC	11.59	20068231
41 (in isoform 2)	Ubiquitination	-	61.62	21906983
41 (in isoform 1)	Ubiquitination	-	61.62	21906983
41	Ubiquitination	LDRDPLTKSDPSVAL CCCCCCCCCCHHHHH	61.62	22817900
101	Ubiquitination	YDTHGPSGFSCQEDD ECCCCCCCCCCCCCC	22.94	22817900
106	Ubiquitination	PSGFSCQEDDFLGGM CCCCCCCCCCCCCCC	64.97	22817900
132	Ubiquitination	LLQVVMRVSVDVLGP HHHHHHHHCCHHHCC	3.36	22817900
162	Phosphorylation	HLARTGPSFLLRYDD HHHHHCCCEEEEECC	29.85	24719451
168	Ubiquitination	PSFLLRYDDLCLPWA CCEEEEECCCCCCCC	35.65	27667366
169	Ubiquitination	SFLLRYDDLCLPWAT CEEEEECCCCCCCCC	30.28	22817900
173	Ubiquitination	RYDDLCLPWATAGAV EECCCCCCCCCCCCE	20.05	22817900
174 (in isoform 2)	Ubiquitination	-	8.03	21906983
174	Ubiquitination	YDDLCLPWATAGAVR ECCCCCCCCCCCCEE	8.03	22817900
178	Ubiquitination	CLPWATAGAVRWWTC CCCCCCCCCEEEEEE	21.90	22817900
200	Ubiquitination	WQIVAQKKVTRPLLL EEEEEEEECCCHHHH	36.44	22817900
204	Ubiquitination	AQKKVTRPLLLKFGR EEEECCCHHHHHHCC	20.28	22817900
231	Phosphorylation	DISGNNGYVELSFRA ECCCCCCEEEEEEEE	7.90	24719451
244	Ubiquitination	RARKLDDKDLFSKSD EEEECCCHHHCCCCC	56.87	22817900
248	Ubiquitination	LDDKDLFSKSDPFLE CCCHHHCCCCCCCEE	38.25	22817900
248	Phosphorylation	LDDKDLFSKSDPFLE CCCHHHCCCCCCCEE	38.25	24719451
249 (in isoform 1)	Ubiquitination	-	52.09	21906983
249	Ubiquitination	DDKDLFSKSDPFLEL CCHHHCCCCCCCEEE	52.09	22817900
253	Ubiquitination	LFSKSDPFLELYRVN HCCCCCCCEEEEEEC	11.26	22817900
275	Ubiquitination	VYRTEVVKNNLNPVW EEEEEHHHCCCCHHH	45.34	22817900
279	Ubiquitination	EVVKNNLNPVWEAFK EHHHCCCCHHHHHHH	31.07	22817900
351	Ubiquitination	KYKQKRRSYKNSGVV HHHHHHHHHCCCCEE	44.48	27667366
352	Phosphorylation	YKQKRRSYKNSGVVV HHHHHHHHCCCCEEE	16.63	18452278
374	Phosphorylation	RVYSFLDYIMGGCQI HHHHHHHHHHCCCEE	8.58	29507054
384	Phosphorylation	GGCQIHFTVAIDFTA CCCEEEEEEEEEEEC	8.55	29507054
419	Ubiquitination	EYLKALVSVGEICQD HHHHHHHHHHHHHCC	25.84	27667366
419 (in isoform 2)	Ubiquitination	-	25.84	-
423	Ubiquitination	ALVSVGEICQDYDSD HHHHHHHHHCCCCCC	1.79	27667366
427	Phosphorylation	VGEICQDYDSDKRFS HHHHHCCCCCCCCEE	7.46	18452278
429	Phosphorylation	EICQDYDSDKRFSAL HHHCCCCCCCCEECC	38.51	18452278
483	Phosphorylation	CLPRVQLYGPTNVAP HCCCEEEECCCCHHH	12.17	28152594
486	Phosphorylation	RVQLYGPTNVAPIIS CEEEECCCCHHHHHH	37.65	28152594
493	Phosphorylation	TNVAPIISKVARVAA CCHHHHHHHHHHHHH	23.07	28152594
494	Ubiquitination	NVAPIISKVARVAAA CHHHHHHHHHHHHHH	29.52	27667366
498	Ubiquitination	IISKVARVAAAEEST HHHHHHHHHHHHHHC	2.83	27667366
509	Phosphorylation	EESTGKASQYYILLI HHHCCCCCCEEEEEE	23.38	-
518	Phosphorylation	YYILLILTDGVVTDM EEEEEEEECCCCCCC	24.58	22210691
523	Phosphorylation	ILTDGVVTDMADTRE EEECCCCCCCCCHHH	20.04	22210691
528	Phosphorylation	VVTDMADTREAIVRA CCCCCCCHHHHHHHH	22.37	22210691
536	Phosphorylation	REAIVRASRLPMSII HHHHHHHHHCCCEEE	24.64	18669648
541	Phosphorylation	RASRLPMSIIIVGVG HHHHCCCEEEEEEEC	14.54	18669648
553	Phosphorylation	GVGNADFTDMQVLDG EECCCCCCCCEEEEC	30.98	18669648
567	Phosphorylation	GDDGVLRSPRGEPAL CCCCCCCCCCCCHHH	18.13	18669648
628	Phosphorylation	GVPAGEASPGCTP-- CCCCCCCCCCCCC--	19.95	25159151
632	Phosphorylation	GEASPGCTP------ CCCCCCCCC------	37.64	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CPNE7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CPNE7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CPNE7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATL4_HUMAN	ADAMTSL4	physical	25416956
BAHC1_HUMAN	BAHCC1	physical	28514442
UBF1_HUMAN	UBTF	physical	28514442
COE3_HUMAN	EBF3	physical	28514442
RS27A_HUMAN	RPS27A	physical	28514442
SETD2_HUMAN	SETD2	physical	28514442
SPT5H_HUMAN	SUPT5H	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.