dbPTM

SETD2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SETD2_HUMAN
UniProt AC	Q9BYW2
Protein Name	Histone-lysine N-methyltransferase SETD2 {ECO:0000305}
Gene Name	SETD2
Organism	Homo sapiens (Human).
Sequence Length	2564
Subcellular Localization	Nucleus . Chromosome .
Protein Description	Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate. [PubMed: 16118227]
Protein Sequence	MKQLQPQPPPKMGDFYDPEHPTPEEEENEAKIENVQKTGFIKGPMFKGVASSRFLPKGTKTKVNLEEQGRQKVSFSFSLTKKTLQNRFLTALGNEKQSDTPNPPAVPLQVDSTPKMKMEIGDTLSTAEESSPPKSRVELGKIHFKKHLLHVTSRPLLATTTAVASPPTHAAPLPAVIAESTTVDSPPSSPPPPPPPAQATTLSSPAPVTEPVALPHTPITVLMAAPVPLPVDVAVRSLKEPPIIIVPESLEADTKQDTISNSLEEHVTQILNEQADISSKKEDSHIGKDEEIPDSSKISLSCKKTGSKKKSSQSEGIFLGSESDEDSVRTSSSQRSHDLKFSASIEKERDFKKSSAPLKSEDLGKPSRSKTDRDDKYFSYSKLERDTRYVSSRCRSERERRRSRSHSRSERGSRTNLSYSRSERSHYYDSDRRYHRSSPYRERTRYSRPYTDNRARESSDSEEEYKKTYSRRTSSHSSSYRDLRTSSYSKSDRDCKTETSYLEMERRGKYSSKLERESKRTSENEAIKRCCSPPNELGFRRGSSYSKHDSSASRYKSTLSKPIPKSDKFKNSFCCTELNEEIKQSHSFSLQTPCSKGSELRMINKNPEREKAGSPAPSNRLNDSPTLKKLDELPIFKSEFITHDSHDSIKELDSLSKVKNDQLRSFCPIELNINGSPGAESDLATFCTSKTDAVLMTSDDSVTGSELSPLVKACMLSSNGFQNISRCKEKDLDDTCMLHKKSESPFRETEPLVSPHQDKLMSMPVMTVDYSKTVVKEPVDTRVSCCKTKDSDIYCTLNDSNPSLCNSEAENIEPSVMKISSNSFMNVHLESKPVICDSRNLTDHSKFACEEYKQSIGSTSSASVNHFDDLYQPIGSSGIASSLQSLPPGIKVDSLTLLKCGENTSPVLDAVLKSKKSSEFLKHAGKETIVEVGSDLPDSGKGFASRENRRNNGLSGKCLQEAQEEGNSILPERRGRPEISLDERGEGGHVHTSDDSEVVFSSCDLNLTMEDSDGVTYALKCDSSGHAPEIVSTVHEDYSGSSESSNDESDSEDTDSDDSSIPRNRLQSVVVVPKNSTLPMEETSPCSSRSSQSYRHYSDHWEDERLESRRHLYEEKFESIASKACPQTDKFFLHKGTEKNPEISFTQSSRKQIDNRLPELSHPQSDGVDSTSHTDVKSDPLGHPNSEETVKAKIPSRQQEELPIYSSDFEDVPNKSWQQTTFQNRPDSRLGKTELSFSSSCEIPHVDGLHSSEELRNLGWDFSQEKPSTTYQQPDSSYGACGGHKYQQNAEQYGGTRDYWQGNGYWDPRSGRPPGTGVVYDRTQGQVPDSLTDDREEEENWDQQDGSHFSDQSDKFLLSLQKDKGSVQAPEISSNSIKDTLAVNEKKDFSKNLEKNDIKDRGPLKKRRQEIESDSESDGELQDRKKVRVEVEQGETSVPPGSALVGPSCVMDDFRDPQRWKECAKQGKMPCYFDLIEENVYLTERKKNKSHRDIKRMQCECTPLSKDERAQGEIACGEDCLNRLLMIECSSRCPNGDYCSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQKCFCGSANCRGYLGGENRVSIRAAGGKMKKERSRKKDSVDGELEALMENGEGLSDKNQVLSLSRLMVRIETLEQKLTCLELIQNTHSQSCLKSFLERHGLSLLWIWMAELGDGRESNQKLQEEIIKTLEHLPIPTKNMLEESKVLPIIQRWSQTKTAVPPLSEGDGYSSENTSRAHTPLNTPDPSTKLSTEADTDTPKKLMFRRLKIISENSMDSAISDATSELEGKDGKEDLDQLENVPVEEEEELQSQQLLPQQLPECKVDSETNIEASKLPTSEPEADAEIEPKESNGTKLEEPINEETPSQDEEEGVSDVESERSQEQPDKTVDISDLATKLLDSWKDLKEVYRIPKKSQTEKENTTTERGRDAVGFRDQTPAPKTPNRSRERDPDKQTQNKEKRKRRSSLSPPSSAYERGTKRPDDRYDTPTSKKKVRIKDRNKLSTEERRKLFEQEVAQREAQKQQQQMQNLGMTSPLPYDSLGYNAPHHPFAGYPPGYPMQAYVDPSNPNAGKVLLPTPSMDPVCSPAPYDHAQPLVGHSTEPLSAPPPVPVVPHVAAPVEVSSSQYVAQSDGVVHQDSSVAVLPVPAPGPVQGQNYSVWDSNQQSVSVQQQYSPAQSQATIYYQGQTCPTVYGVTSPYSQTTPPIVQSYAQPSLQYIQGQQIFTAHPQGVVVQPAAAVTTIVAPGQPQPLQPSEMVVTNNLLDLPPPSPPKPKTIVLPPNWKTARDPEGKIYYYHVITRQTQWDPPTWESPGDDASLEHEAEMDLGTPTYDENPMKASKKPKTAEADTSSELAKKSKEVFRKEMSQFIVQCLNPYRKPDCKVGRITTTEDFKHLARKLTHGVMNKELKYCKNPEDLECNENVKHKTKEYIKKYMQKFGAVYKPKEDTELE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Phosphorylation	KIENVQKTGFIKGPM HHCHHHHHCCCCCCC	21.89	-
42	Ubiquitination	VQKTGFIKGPMFKGV HHHHCCCCCCCCCCC	55.49	-
47	Methylation	FIKGPMFKGVASSRF CCCCCCCCCCCCCCC	46.34	115981433
51	Phosphorylation	PMFKGVASSRFLPKG CCCCCCCCCCCCCCC	21.46	-
52	Phosphorylation	MFKGVASSRFLPKGT CCCCCCCCCCCCCCC	19.81	21964256
78	Phosphorylation	QKVSFSFSLTKKTLQ EEEEEEEECCHHHHH	33.65	28555341
87	Phosphorylation	TKKTLQNRFLTALGN CHHHHHHHHHHHHCC	18.26	32142685
112	Phosphorylation	AVPLQVDSTPKMKME CCCCCCCCCCCEEEE	47.99	21815630
113	Phosphorylation	VPLQVDSTPKMKMEI CCCCCCCCCCEEEEC	23.59	21815630
123	Phosphorylation	MKMEIGDTLSTAEES EEEECCCHHCCCCCC	19.86	30175587
125	Phosphorylation	MEIGDTLSTAEESSP EECCCHHCCCCCCCC	27.88	27794612
126	Phosphorylation	EIGDTLSTAEESSPP ECCCHHCCCCCCCCC	41.00	25159151
130	Phosphorylation	TLSTAEESSPPKSRV HHCCCCCCCCCCCHH	39.38	23401153
131	Phosphorylation	LSTAEESSPPKSRVE HCCCCCCCCCCCHHE	48.80	29255136
135	Phosphorylation	EESSPPKSRVELGKI CCCCCCCCHHEEECC	47.54	29978859
153	Phosphorylation	KHLLHVTSRPLLATT HHHHHCCCCCCEEEC	30.71	18767875
188	Phosphorylation	TTVDSPPSSPPPPPP CCCCCCCCCCCCCCC	59.88	25137130
189	Phosphorylation	TVDSPPSSPPPPPPP CCCCCCCCCCCCCCC	47.39	25137130
258	Phosphorylation	EADTKQDTISNSLEE CCCCCCCHHHHHHHH	24.66	23879269
260	Phosphorylation	DTKQDTISNSLEEHV CCCCCHHHHHHHHHH	23.58	27080861
262	Phosphorylation	KQDTISNSLEEHVTQ CCCHHHHHHHHHHHH	30.30	25159151
268	Phosphorylation	NSLEEHVTQILNEQA HHHHHHHHHHHHHHH	16.29	23879269
284	Phosphorylation	ISSKKEDSHIGKDEE CCCCCCCCCCCCCCC	20.35	28985074
299	Phosphorylation	IPDSSKISLSCKKTG CCCCCCEEEEEECCC	20.26	23312004
301	Phosphorylation	DSSKISLSCKKTGSK CCCCEEEEEECCCCC	19.66	23898821
303	Acetylation	SKISLSCKKTGSKKK CCEEEEEECCCCCCC	50.42	25953088
311	Phosphorylation	KTGSKKKSSQSEGIF CCCCCCCCCCCCCEE	42.35	23403867
312	Phosphorylation	TGSKKKSSQSEGIFL CCCCCCCCCCCCEEC	46.75	23403867
314	Phosphorylation	SKKKSSQSEGIFLGS CCCCCCCCCCEECCC	39.47	23403867
321	Phosphorylation	SEGIFLGSESDEDSV CCCEECCCCCCCCCC	35.75	25159151
323	Phosphorylation	GIFLGSESDEDSVRT CEECCCCCCCCCCCC	48.25	25159151
327	Phosphorylation	GSESDEDSVRTSSSQ CCCCCCCCCCCCCCC	16.08	23927012
331	Phosphorylation	DEDSVRTSSSQRSHD CCCCCCCCCCCCCCC	19.89	22210691
332	Phosphorylation	EDSVRTSSSQRSHDL CCCCCCCCCCCCCCC	29.85	22210691
333	Phosphorylation	DSVRTSSSQRSHDLK CCCCCCCCCCCCCCC	29.40	22210691
342	Phosphorylation	RSHDLKFSASIEKER CCCCCCCCCCHHHHH	21.37	30266825
344	Phosphorylation	HDLKFSASIEKERDF CCCCCCCCHHHHHCC	30.04	30266825
359	Sumoylation	KKSSAPLKSEDLGKP CCCCCCCCHHHCCCC	51.22	-
359	Sumoylation	KKSSAPLKSEDLGKP CCCCCCCCHHHCCCC	51.22	28112733
365	Acetylation	LKSEDLGKPSRSKTD CCHHHCCCCCCCCCC	47.30	26051181
367	Phosphorylation	SEDLGKPSRSKTDRD HHHCCCCCCCCCCCC	53.31	20068231
371	Phosphorylation	GKPSRSKTDRDDKYF CCCCCCCCCCCCCCC	37.20	29116813
377	Phosphorylation	KTDRDDKYFSYSKLE CCCCCCCCCCHHHHH	12.54	29116813
380	Phosphorylation	RDDKYFSYSKLERDT CCCCCCCHHHHHHHH	10.42	29116813
411	Methylation	RSHSRSERGSRTNLS HCCCCCCCCCCCCCC	50.03	18963455
415	Phosphorylation	RSERGSRTNLSYSRS CCCCCCCCCCCCCHH	42.06	22798277
418	Phosphorylation	RGSRTNLSYSRSERS CCCCCCCCCCHHHCC	24.11	24719451
422	Phosphorylation	TNLSYSRSERSHYYD CCCCCCHHHCCCCCC	31.27	23917254
427	Phosphorylation	SRSERSHYYDSDRRY CHHHCCCCCCCCCCC	15.37	27642862
428	Phosphorylation	RSERSHYYDSDRRYH HHHCCCCCCCCCCCC	11.98	-
430	Phosphorylation	ERSHYYDSDRRYHRS HCCCCCCCCCCCCCC	19.52	27642862
437	Phosphorylation	SDRRYHRSSPYRERT CCCCCCCCCCHHHCC	23.50	30576142
438	Phosphorylation	DRRYHRSSPYRERTR CCCCCCCCCHHHCCC	26.38	27422710
440	Phosphorylation	RYHRSSPYRERTRYS CCCCCCCHHHCCCCC	27.36	24719451
444	Phosphorylation	SSPYRERTRYSRPYT CCCHHHCCCCCCCCC	29.25	24719451
446	Phosphorylation	PYRERTRYSRPYTDN CHHHCCCCCCCCCCC	14.39	22798277
447	Phosphorylation	YRERTRYSRPYTDNR HHHCCCCCCCCCCCC	24.40	28555341
458	Phosphorylation	TDNRARESSDSEEEY CCCCCCCCCCCHHHH	33.61	27362937
459	Phosphorylation	DNRARESSDSEEEYK CCCCCCCCCCHHHHH	40.16	27362937
461	Phosphorylation	RARESSDSEEEYKKT CCCCCCCCHHHHHHH	49.18	27362937
465	Phosphorylation	SSDSEEEYKKTYSRR CCCCHHHHHHHHCCC	22.51	28111955
468	Phosphorylation	SEEEYKKTYSRRTSS CHHHHHHHHCCCCCC	23.68	23882029
470	Phosphorylation	EEYKKTYSRRTSSHS HHHHHHHCCCCCCCC	22.10	23882029
473	Phosphorylation	KKTYSRRTSSHSSSY HHHHCCCCCCCCCCH	33.21	23882029
474	Phosphorylation	KTYSRRTSSHSSSYR HHHCCCCCCCCCCHH	25.00	20860994
475	Phosphorylation	TYSRRTSSHSSSYRD HHCCCCCCCCCCHHH	27.12	23882029
477	Phosphorylation	SRRTSSHSSSYRDLR CCCCCCCCCCHHHHC	23.95	23882029
478	Phosphorylation	RRTSSHSSSYRDLRT CCCCCCCCCHHHHCC	26.43	23882029
479	Phosphorylation	RTSSHSSSYRDLRTS CCCCCCCCHHHHCCC	27.48	23186163
480	Phosphorylation	TSSHSSSYRDLRTSS CCCCCCCHHHHCCCC	15.30	23186163
485	Phosphorylation	SSYRDLRTSSYSKSD CCHHHHCCCCCCCCC	29.35	-
488	Phosphorylation	RDLRTSSYSKSDRDC HHHCCCCCCCCCCCC	21.64	32645325
500	Phosphorylation	RDCKTETSYLEMERR CCCCCCHHHHHHHHH	22.84	28555341
521	Phosphorylation	LERESKRTSENEAIK HHHHHCCCCHHHHHH	44.09	28348404
522	Phosphorylation	ERESKRTSENEAIKR HHHHCCCCHHHHHHH	42.32	28102081
532	Phosphorylation	EAIKRCCSPPNELGF HHHHHHCCCCCCCCC	47.20	19664994
543	Phosphorylation	ELGFRRGSSYSKHDS CCCCCCCCCCCCCCC	25.04	23882029
544	Phosphorylation	LGFRRGSSYSKHDSS CCCCCCCCCCCCCCC	35.93	23882029
546	O-linked_Glycosylation	FRRGSSYSKHDSSAS CCCCCCCCCCCCCHH	26.01	30379171
546	Phosphorylation	FRRGSSYSKHDSSAS CCCCCCCCCCCCCHH	26.01	23882029
555	Phosphorylation	HDSSASRYKSTLSKP CCCCHHHHHHCCCCC	13.54	25884760
556	Methylation	DSSASRYKSTLSKPI CCCHHHHHHCCCCCC	35.54	115981437
561	Acetylation	RYKSTLSKPIPKSDK HHHHCCCCCCCCCHH	50.51	25953088
572	Phosphorylation	KSDKFKNSFCCTELN CCHHHCCCCCCHHHC	21.91	25159151
580	Phosphorylation	FCCTELNEEIKQSHS CCCHHHCHHHHHHHC	73.96	32142685
585	Phosphorylation	LNEEIKQSHSFSLQT HCHHHHHHHCEECCC	18.98	27251275
587	Phosphorylation	EEIKQSHSFSLQTPC HHHHHHHCEECCCCC	23.06	27251275
589	Phosphorylation	IKQSHSFSLQTPCSK HHHHHCEECCCCCCC	23.68	27251275
592	Phosphorylation	SHSFSLQTPCSKGSE HHCEECCCCCCCCHH	31.40	25159151
614	Phosphorylation	PEREKAGSPAPSNRL HHHHCCCCCCCCCCC	23.81	26503892
618	Phosphorylation	KAGSPAPSNRLNDSP CCCCCCCCCCCCCCC	36.37	25159151
624	Phosphorylation	PSNRLNDSPTLKKLD CCCCCCCCCCCCCHH	20.79	29255136
626	Phosphorylation	NRLNDSPTLKKLDEL CCCCCCCCCCCHHCC	55.98	29255136
629	Ubiquitination	NDSPTLKKLDELPIF CCCCCCCCHHCCCCC	65.37	29967540
632	Phosphorylation	PTLKKLDELPIFKSE CCCCCHHCCCCCEEE	67.87	32142685
637	Sumoylation	LDELPIFKSEFITHD HHCCCCCEEECCCCC	50.20	-
637	Sumoylation	LDELPIFKSEFITHD HHCCCCCEEECCCCC	50.20	28112733
637	Ubiquitination	LDELPIFKSEFITHD HHCCCCCEEECCCCC	50.20	29967540
638	Phosphorylation	DELPIFKSEFITHDS HCCCCCEEECCCCCC	27.30	27251275
642	Phosphorylation	IFKSEFITHDSHDSI CCEEECCCCCCCHHH	25.58	21712546
645	Phosphorylation	SEFITHDSHDSIKEL EECCCCCCCHHHHHH	22.91	27251275
648	Phosphorylation	ITHDSHDSIKELDSL CCCCCCHHHHHHHHH	30.09	25159151
650	Ubiquitination	HDSHDSIKELDSLSK CCCCHHHHHHHHHHH	57.06	29967540
654	Phosphorylation	DSIKELDSLSKVKND HHHHHHHHHHHCCHH	47.36	21815630
656	Phosphorylation	IKELDSLSKVKNDQL HHHHHHHHHCCHHHH	39.08	29396449
657	Ubiquitination	KELDSLSKVKNDQLR HHHHHHHHCCHHHHH	63.62	29967540
659	Ubiquitination	LDSLSKVKNDQLRSF HHHHHHCCHHHHHHC	59.55	29967540
665	Phosphorylation	VKNDQLRSFCPIELN CCHHHHHHCCCEEEE	39.53	26074081
676	Phosphorylation	IELNINGSPGAESDL EEEEECCCCCCCCHH	18.70	23401153
681	Phosphorylation	NGSPGAESDLATFCT CCCCCCCCHHHHHHC	37.07	23663014
685	Phosphorylation	GAESDLATFCTSKTD CCCCHHHHHHCCCCC	26.92	23663014
688	Phosphorylation	SDLATFCTSKTDAVL CHHHHHHCCCCCEEE	29.12	26074081
689	Phosphorylation	DLATFCTSKTDAVLM HHHHHHCCCCCEEEE	34.44	26074081
691	Phosphorylation	ATFCTSKTDAVLMTS HHHHCCCCCEEEECC	29.02	26074081
697	Phosphorylation	KTDAVLMTSDDSVTG CCCEEEECCCCCCCH	25.50	20068231
698	Phosphorylation	TDAVLMTSDDSVTGS CCEEEECCCCCCCHH	26.00	20068231
700	Phosphorylation	AVLMTSDDSVTGSEL EEEECCCCCCCHHHH	44.78	32142685
701	Phosphorylation	VLMTSDDSVTGSELS EEECCCCCCCHHHHH	26.94	20068231
703	Phosphorylation	MTSDDSVTGSELSPL ECCCCCCCHHHHHHH	38.65	20068231
705	Phosphorylation	SDDSVTGSELSPLVK CCCCCCHHHHHHHHH	26.46	29978859
708	Phosphorylation	SVTGSELSPLVKACM CCCHHHHHHHHHHHH	16.49	25159151
710	Phosphorylation	TGSELSPLVKACMLS CHHHHHHHHHHHHHC	5.76	33259812
717	Phosphorylation	LVKACMLSSNGFQNI HHHHHHHCCCCCCCH	8.55	28555341
725	Phosphorylation	SNGFQNISRCKEKDL CCCCCCHHHHCCCCC	38.89	18669648
735	Phosphorylation	KEKDLDDTCMLHKKS CCCCCCCCCCCCCCC	10.24	28555341
742	Phosphorylation	TCMLHKKSESPFRET CCCCCCCCCCCCCCC	48.38	29255136
744	Phosphorylation	MLHKKSESPFRETEP CCCCCCCCCCCCCCC	36.11	29255136
749	Phosphorylation	SESPFRETEPLVSPH CCCCCCCCCCCCCCC	38.35	30266825
754	Phosphorylation	RETEPLVSPHQDKLM CCCCCCCCCCHHHCC	25.09	29255136
762	Phosphorylation	PHQDKLMSMPVMTVD CCHHHCCCCCEEEEE	30.30	28555341
776	Sumoylation	DYSKTVVKEPVDTRV ECCCEEECCCCCCCE	52.55	28112733
776	Ubiquitination	DYSKTVVKEPVDTRV ECCCEEECCCCCCCE	52.55	29967540
788	Phosphorylation	TRVSCCKTKDSDIYC CCEEEECCCCCCEEE	26.60	29978859
791	Phosphorylation	SCCKTKDSDIYCTLN EEECCCCCCEEEEEC	27.71	29978859
794	Phosphorylation	KTKDSDIYCTLNDSN CCCCCCEEEEECCCC	5.60	27642862
796	Phosphorylation	KDSDIYCTLNDSNPS CCCCEEEEECCCCHH	16.18	29978859
800	Phosphorylation	IYCTLNDSNPSLCNS EEEEECCCCHHHCCC	49.95	30576142
803	Phosphorylation	TLNDSNPSLCNSEAE EECCCCHHHCCCCCC	50.21	30576142
807	Phosphorylation	SNPSLCNSEAENIEP CCHHHCCCCCCCCCC	36.87	29978859
823	Phosphorylation	VMKISSNSFMNVHLE EEEECCCCCEEEEEC	28.02	28555341
832	Acetylation	MNVHLESKPVICDSR EEEEECCCCEEECCC	33.65	25953088
894	Phosphorylation	PPGIKVDSLTLLKCG CCCCEEEEEEEEECC	26.66	28555341
899	Ubiquitination	VDSLTLLKCGENTSP EEEEEEEECCCCCHH	43.22	29967540
904	Phosphorylation	LLKCGENTSPVLDAV EEECCCCCHHHHHHH	30.06	30266825
905	Phosphorylation	LKCGENTSPVLDAVL EECCCCCHHHHHHHH	25.29	23401153
914	Phosphorylation	VLDAVLKSKKSSEFL HHHHHHHCCCCHHHH	40.95	18669648
917	Phosphorylation	AVLKSKKSSEFLKHA HHHHCCCCHHHHHHC	38.55	30266825
918	Phosphorylation	VLKSKKSSEFLKHAG HHHCCCCHHHHHHCC	41.05	30266825
922	Ubiquitination	KKSSEFLKHAGKETI CCCHHHHHHCCCCEE	36.41	29967540
928	Phosphorylation	LKHAGKETIVEVGSD HHHCCCCEEEEECCC	33.53	-
934	Phosphorylation	ETIVEVGSDLPDSGK CEEEEECCCCCCCCC	40.94	24245541
939	Phosphorylation	VGSDLPDSGKGFASR ECCCCCCCCCCCCCH	40.23	21815630
941	Acetylation	SDLPDSGKGFASREN CCCCCCCCCCCCHHH	55.60	26051181
941	Ubiquitination	SDLPDSGKGFASREN CCCCCCCCCCCCHHH	55.60	29967540
957	Acetylation	RNNGLSGKCLQEAQE HCCCCCHHHHHHHHH	28.53	26051181
980	Phosphorylation	RRGRPEISLDERGEG CCCCCCCCCCCCCCC	28.27	23312004
1001	Phosphorylation	DDSEVVFSSCDLNLT CCCEEEEEECCEEEE	20.60	27251275
1002	Phosphorylation	DSEVVFSSCDLNLTM CCEEEEEECCEEEEE	10.53	27251275
1008	Phosphorylation	SSCDLNLTMEDSDGV EECCEEEEEECCCCC	19.90	27251275
1032	Phosphorylation	GHAPEIVSTVHEDYS CCCCCEEEEEECCCC	30.30	-
1033	Phosphorylation	HAPEIVSTVHEDYSG CCCCEEEEEECCCCC	18.26	-
1068	Phosphorylation	IPRNRLQSVVVVPKN CCHHCEEEEEEEECC	22.82	29116813
1076	Phosphorylation	VVVVPKNSTLPMEET EEEEECCCCCCCCCC	37.13	21406692
1077	Phosphorylation	VVVPKNSTLPMEETS EEEECCCCCCCCCCC	44.25	30108239
1083	Phosphorylation	STLPMEETSPCSSRS CCCCCCCCCCCCCCC	25.35	23401153
1084	Phosphorylation	TLPMEETSPCSSRSS CCCCCCCCCCCCCCC	27.47	25159151
1087	Phosphorylation	MEETSPCSSRSSQSY CCCCCCCCCCCCCCC	31.97	25159151
1088	Phosphorylation	EETSPCSSRSSQSYR CCCCCCCCCCCCCCC	42.79	30108239
1090	Phosphorylation	TSPCSSRSSQSYRHY CCCCCCCCCCCCCCC	34.38	26074081
1091	Phosphorylation	SPCSSRSSQSYRHYS CCCCCCCCCCCCCCC	23.26	26074081
1093	Phosphorylation	CSSRSSQSYRHYSDH CCCCCCCCCCCCCCC	26.53	26074081
1094	Phosphorylation	SSRSSQSYRHYSDHW CCCCCCCCCCCCCCC	8.18	26074081
1097	Phosphorylation	SSQSYRHYSDHWEDE CCCCCCCCCCCCHHH	13.54	29978859
1098	Phosphorylation	SQSYRHYSDHWEDER CCCCCCCCCCCHHHH	19.51	23401153
1113	Phosphorylation	LESRRHLYEEKFESI HHHHHHHHHHHHHHH	18.86	27642862
1116	Ubiquitination	RRHLYEEKFESIASK HHHHHHHHHHHHHHH	42.35	29967540
1119	Phosphorylation	LYEEKFESIASKACP HHHHHHHHHHHHHCC	26.96	-
1123	Acetylation	KFESIASKACPQTDK HHHHHHHHHCCCCCC	45.01	25953088
1130	Acetylation	KACPQTDKFFLHKGT HHCCCCCCEEECCCC	41.21	25953088
1137	Phosphorylation	KFFLHKGTEKNPEIS CEEECCCCCCCCCCC	48.90	-
1144	Phosphorylation	TEKNPEISFTQSSRK CCCCCCCCCCHHHHH	22.15	25159151
1146	Phosphorylation	KNPEISFTQSSRKQI CCCCCCCCHHHHHHH	22.28	20068231
1148	Phosphorylation	PEISFTQSSRKQIDN CCCCCCHHHHHHHHC	29.11	23186163
1149	Phosphorylation	EISFTQSSRKQIDNR CCCCCHHHHHHHHCC	33.41	23917254
1161	Phosphorylation	DNRLPELSHPQSDGV HCCCCCCCCCCCCCC	31.31	28985074
1165	Phosphorylation	PELSHPQSDGVDSTS CCCCCCCCCCCCCCC	40.56	23186163
1170	Phosphorylation	PQSDGVDSTSHTDVK CCCCCCCCCCCCCCC	29.42	28985074
1172	Phosphorylation	SDGVDSTSHTDVKSD CCCCCCCCCCCCCCC	28.48	28555341
1174	Phosphorylation	GVDSTSHTDVKSDPL CCCCCCCCCCCCCCC	42.10	28985074
1178	Phosphorylation	TSHTDVKSDPLGHPN CCCCCCCCCCCCCCC	44.29	25159151
1184	Phosphorylation	KSDPLGHPNSEETVK CCCCCCCCCCHHHHH	44.22	32142685
1186	Phosphorylation	DPLGHPNSEETVKAK CCCCCCCCHHHHHHC	41.06	25159151
1189	Phosphorylation	GHPNSEETVKAKIPS CCCCCHHHHHHCCCC	24.21	-
1196	Phosphorylation	TVKAKIPSRQQEELP HHHHCCCCCCHHCCC	46.31	-
1205	Phosphorylation	QQEELPIYSSDFEDV CHHCCCCCCCCCCCC	10.53	28796482
1206	Phosphorylation	QEELPIYSSDFEDVP HHCCCCCCCCCCCCC	24.93	25159151
1207	Phosphorylation	EELPIYSSDFEDVPN HCCCCCCCCCCCCCC	29.37	25159151
1215	Ubiquitination	DFEDVPNKSWQQTTF CCCCCCCCCCCCCCC	47.18	29967540
1216	Phosphorylation	FEDVPNKSWQQTTFQ CCCCCCCCCCCCCCC	36.44	25159151
1220	Phosphorylation	PNKSWQQTTFQNRPD CCCCCCCCCCCCCCC	17.93	23403867
1221	Phosphorylation	NKSWQQTTFQNRPDS CCCCCCCCCCCCCCC	20.91	23403867
1228	Phosphorylation	TFQNRPDSRLGKTEL CCCCCCCCCCCCCEE	31.89	23401153
1233	Phosphorylation	PDSRLGKTELSFSSS CCCCCCCCEEEECCC	40.12	27080861
1236	Phosphorylation	RLGKTELSFSSSCEI CCCCCEEEECCCCCC	19.49	25159151
1238	Phosphorylation	GKTELSFSSSCEIPH CCCEEEECCCCCCCC	20.26	27080861
1239	Phosphorylation	KTELSFSSSCEIPHV CCEEEECCCCCCCCC	36.68	29978859
1240	Phosphorylation	TELSFSSSCEIPHVD CEEEECCCCCCCCCC	17.99	29978859
1251	Phosphorylation	PHVDGLHSSEELRNL CCCCCCCCHHHHHHC	44.48	27080861
1252	Phosphorylation	HVDGLHSSEELRNLG CCCCCCCHHHHHHCC	25.09	27080861
1263	Phosphorylation	RNLGWDFSQEKPSTT HHCCCCCCCCCCCCC	34.65	25159151
1266	Ubiquitination	GWDFSQEKPSTTYQQ CCCCCCCCCCCCCCC	36.31	29967540
1285	Ubiquitination	YGACGGHKYQQNAEQ CCCCCCCCCCCCHHH	48.29	29967540
1293	Phosphorylation	YQQNAEQYGGTRDYW CCCCHHHHCCCCCCC	14.72	27642862
1316	Phosphorylation	RSGRPPGTGVVYDRT CCCCCCCCCEEEECC	32.36	28555341
1330	Phosphorylation	TQGQVPDSLTDDREE CCCCCCCCCCCCHHH	27.39	23403867
1332	Phosphorylation	GQVPDSLTDDREEEE CCCCCCCCCCHHHHH	39.54	23403867
1350	Phosphorylation	QQDGSHFSDQSDKFL CCCCCCCCCCHHHHH	29.35	28985074
1359	Phosphorylation	QSDKFLLSLQKDKGS CHHHHHHHHHCCCCC	30.79	24719451
1366	Phosphorylation	SLQKDKGSVQAPEIS HHHCCCCCCCCCCCC	19.45	28555341
1376	Phosphorylation	APEISSNSIKDTLAV CCCCCCCHHHHHHHH	32.72	28290473
1399	Acetylation	NLEKNDIKDRGPLKK HHHHCCCCCCCCHHH	44.21	19824359
1413	Phosphorylation	KRRQEIESDSESDGE HHHHHHHCCCCCCCC	52.69	22167270
1415	Phosphorylation	RQEIESDSESDGELQ HHHHHCCCCCCCCCC	48.56	22167270
1417	Phosphorylation	EIESDSESDGELQDR HHHCCCCCCCCCCCC	55.67	22167270
1461	"N6,N6-dimethyllysine"	FRDPQRWKECAKQGK CCCHHHHHHHHHCCC	45.14	-
1461	Methylation	FRDPQRWKECAKQGK CCCHHHHHHHHHCCC	45.14	-
1465	"N6,N6-dimethyllysine"	QRWKECAKQGKMPCY HHHHHHHHCCCCCCC	71.84	-
1465	Methylation	QRWKECAKQGKMPCY HHHHHHHHCCCCCCC	71.84	-
1468	"N6,N6-dimethyllysine"	KECAKQGKMPCYFDL HHHHHCCCCCCCHHH	36.86	-
1468	Methylation	KECAKQGKMPCYFDL HHHHHCCCCCCCHHH	36.86	-
1472	Phosphorylation	KQGKMPCYFDLIEEN HCCCCCCCHHHHHHH	8.34	22817900
1481	Phosphorylation	DLIEENVYLTERKKN HHHHHHCHHCCCCCC	21.35	22817900
1483	Phosphorylation	IEENVYLTERKKNKS HHHHCHHCCCCCCCC	18.96	-
1489	Methylation	LTERKKNKSHRDIKR HCCCCCCCCHHHHHH	57.42	116253705
1604	Phosphorylation	ARNKNIHYYFMALKN HHCCCCCEEEEEECC	8.46	24719451
1620	Ubiquitination	EIIDATQKGNCSRFM CEEEHHHCCCHHHHC	47.97	29967540
1686	Methylation	FCGSANCRGYLGGEN CCCCCCCCCCCCCCC	36.28	115388487
1696	Phosphorylation	LGGENRVSIRAAGGK CCCCCCEEEEECCCC	11.79	30576142
1737	Phosphorylation	SDKNQVLSLSRLMVR CCHHHHHHHHHHHHH	25.99	24719451
1739	Phosphorylation	KNQVLSLSRLMVRIE HHHHHHHHHHHHHHH	21.71	17081983
1792	Phosphorylation	ELGDGRESNQKLQEE HHCCCHHHHHHHHHH	43.11	-
1802	Acetylation	KLQEEIIKTLEHLPI HHHHHHHHHHHCCCC	53.36	7826151
1812	Acetylation	EHLPIPTKNMLEESK HCCCCCCHHHHHHHC	34.70	7826163
1818	Phosphorylation	TKNMLEESKVLPIIQ CHHHHHHHCCHHHHH	20.77	20068231
1832	Phosphorylation	QRWSQTKTAVPPLSE HHHCCCCCCCCCCCC	35.95	28450419
1838	Phosphorylation	KTAVPPLSEGDGYSS CCCCCCCCCCCCCCC	45.36	28450419
1843	Phosphorylation	PLSEGDGYSSENTSR CCCCCCCCCCCCCCC	17.48	23927012
1844	Phosphorylation	LSEGDGYSSENTSRA CCCCCCCCCCCCCCC	36.38	25159151
1845	Phosphorylation	SEGDGYSSENTSRAH CCCCCCCCCCCCCCC	26.78	23927012
1848	Phosphorylation	DGYSSENTSRAHTPL CCCCCCCCCCCCCCC	18.62	23927012
1849	Phosphorylation	GYSSENTSRAHTPLN CCCCCCCCCCCCCCC	38.77	23927012
1853	Phosphorylation	ENTSRAHTPLNTPDP CCCCCCCCCCCCCCC	28.61	30266825
1857	Phosphorylation	RAHTPLNTPDPSTKL CCCCCCCCCCCCCCC	36.43	30266825
1861	Phosphorylation	PLNTPDPSTKLSTEA CCCCCCCCCCCCCCC	45.62	23403867
1862	Phosphorylation	LNTPDPSTKLSTEAD CCCCCCCCCCCCCCC	41.20	23403867
1865	Phosphorylation	PDPSTKLSTEADTDT CCCCCCCCCCCCCCC	26.25	23312004
1866	Phosphorylation	DPSTKLSTEADTDTP CCCCCCCCCCCCCCC	45.70	25850435
1870	Phosphorylation	KLSTEADTDTPKKLM CCCCCCCCCCCHHHH	49.15	23401153
1872	Phosphorylation	STEADTDTPKKLMFR CCCCCCCCCHHHHHH	38.82	23401153
1874	Acetylation	EADTDTPKKLMFRRL CCCCCCCHHHHHHHH	61.71	26051181
1885	Phosphorylation	FRRLKIISENSMDSA HHHHHHHCCCCHHHH	33.91	30278072
1888	Phosphorylation	LKIISENSMDSAISD HHHHCCCCHHHHHHH	21.66	30278072
1891	Phosphorylation	ISENSMDSAISDATS HCCCCHHHHHHHHHH	20.89	30278072
1894	Phosphorylation	NSMDSAISDATSELE CCHHHHHHHHHHHHC	22.40	28102081
1897	Phosphorylation	DSAISDATSELEGKD HHHHHHHHHHHCCCC	27.94	23663014
1898	Phosphorylation	SAISDATSELEGKDG HHHHHHHHHHCCCCC	41.74	25159151
1907	Phosphorylation	LEGKDGKEDLDQLEN HCCCCCCCCHHHHHC	70.14	32142685
1925	Phosphorylation	EEEEELQSQQLLPQQ HHHHHHHHCCCCCCC	32.30	-
1940	Phosphorylation	LPECKVDSETNIEAS CCCCCCCCCCCCCHH	49.67	26074081
1942	Phosphorylation	ECKVDSETNIEASKL CCCCCCCCCCCHHCC	45.51	26074081
1947	Phosphorylation	SETNIEASKLPTSEP CCCCCCHHCCCCCCC	23.18	26074081
1951	Phosphorylation	IEASKLPTSEPEADA CCHHCCCCCCCCCCC	57.04	25159151
1952	Phosphorylation	EASKLPTSEPEADAE CHHCCCCCCCCCCCC	49.57	25159151
1978	Phosphorylation	EEPINEETPSQDEEE CCCCCCCCCCCCHHC	23.28	23090842
1980	Phosphorylation	PINEETPSQDEEEGV CCCCCCCCCCHHCCC	58.65	21955146
1988	Phosphorylation	QDEEEGVSDVESERS CCHHCCCCHHHHHHH	46.96	25159151
1992	Phosphorylation	EGVSDVESERSQEQP CCCCHHHHHHHHCCC	37.85	21955146
1995	Phosphorylation	SDVESERSQEQPDKT CHHHHHHHHCCCCCE	33.74	30266825
2002	Phosphorylation	SQEQPDKTVDISDLA HHCCCCCEECHHHHH	30.69	30266825
2006	Phosphorylation	PDKTVDISDLATKLL CCCEECHHHHHHHHH	23.31	21815630
2010	Phosphorylation	VDISDLATKLLDSWK ECHHHHHHHHHHHHH	29.53	-
2036	Phosphorylation	SQTEKENTTTERGRD CCCCCCCCCCCCCHH	35.87	-
2051	Phosphorylation	AVGFRDQTPAPKTPN CCCCCCCCCCCCCCC	26.21	25159151
2056	Phosphorylation	DQTPAPKTPNRSRER CCCCCCCCCCCCCCC	25.41	26055452
2060	Phosphorylation	APKTPNRSRERDPDK CCCCCCCCCCCCCCH	45.17	20873877
2069	Phosphorylation	ERDPDKQTQNKEKRK CCCCCHHHHCHHHHH	39.59	28060719
2079	Phosphorylation	KEKRKRRSSLSPPSS HHHHHHHHCCCCCCH	39.40	23401153
2080	Phosphorylation	EKRKRRSSLSPPSSA HHHHHHHCCCCCCHH	30.93	22167270
2082	Phosphorylation	RKRRSSLSPPSSAYE HHHHHCCCCCCHHHH	36.39	22167270
2085	Phosphorylation	RSSLSPPSSAYERGT HHCCCCCCHHHHCCC	30.86	22167270
2086	Phosphorylation	SSLSPPSSAYERGTK HCCCCCCHHHHCCCC	40.41	22167270
2088	Phosphorylation	LSPPSSAYERGTKRP CCCCCHHHHCCCCCC	14.22	23927012
2092	Phosphorylation	SSAYERGTKRPDDRY CHHHHCCCCCCCCCC	30.05	30576142
2099	Phosphorylation	TKRPDDRYDTPTSKK CCCCCCCCCCCCCCC	31.03	28985074
2101	Phosphorylation	RPDDRYDTPTSKKKV CCCCCCCCCCCCCCC	21.38	25159151
2103	Phosphorylation	DDRYDTPTSKKKVRI CCCCCCCCCCCCCCC	56.10	29449344
2104	Phosphorylation	DRYDTPTSKKKVRIK CCCCCCCCCCCCCCC	43.62	25159151
2115	Acetylation	VRIKDRNKLSTEERR CCCCCCCCCCHHHHH	44.71	25953088
2118	Phosphorylation	KDRNKLSTEERRKLF CCCCCCCHHHHHHHH	52.91	21815630
2147	Phosphorylation	QMQNLGMTSPLPYDS HHHHCCCCCCCCCHH	25.95	26074081
2148	Phosphorylation	MQNLGMTSPLPYDSL HHHCCCCCCCCCHHC	18.62	26074081
2152	Phosphorylation	GMTSPLPYDSLGYNA CCCCCCCCHHCCCCC	26.33	26074081
2154	Phosphorylation	TSPLPYDSLGYNAPH CCCCCCHHCCCCCCC	20.18	28348404
2157	Phosphorylation	LPYDSLGYNAPHHPF CCCHHCCCCCCCCCC	17.28	28348404
2191	Phosphorylation	AGKVLLPTPSMDPVC CCCCCCCCCCCCCCC	28.15	26853621
2388	O-linked_Glycosylation	PSPPKPKTIVLPPNW CCCCCCCEEECCCCC	25.50	30379171
2421	Phosphorylation	QTQWDPPTWESPGDD CCCCCCCCCCCCCCC	47.45	27251275
2424	Phosphorylation	WDPPTWESPGDDASL CCCCCCCCCCCCCCH	26.24	22210691
2430	Phosphorylation	ESPGDDASLEHEAEM CCCCCCCCHHHHHHC	41.08	22210691
2441	Phosphorylation	EAEMDLGTPTYDENP HHHCCCCCCCCCCCC	21.54	26074081
2443	Phosphorylation	EMDLGTPTYDENPMK HCCCCCCCCCCCCCC	43.36	26074081
2444	Phosphorylation	MDLGTPTYDENPMKA CCCCCCCCCCCCCCC	23.59	22210691
2452	Phosphorylation	DENPMKASKKPKTAE CCCCCCCCCCCCCCC	35.38	26074081
2457	Phosphorylation	KASKKPKTAEADTSS CCCCCCCCCCCCCHH	37.95	26074081
2462	Phosphorylation	PKTAEADTSSELAKK CCCCCCCCHHHHHHH	41.00	26074081
2463	Phosphorylation	KTAEADTSSELAKKS CCCCCCCHHHHHHHH	23.51	21815630
2464	Phosphorylation	TAEADTSSELAKKSK CCCCCCHHHHHHHHH	38.43	29396449
2506	Acetylation	ITTTEDFKHLARKLT EECCHHHHHHHHHHH	50.45	25953088
2546	Acetylation	KTKEYIKKYMQKFGA HHHHHHHHHHHHHCC	36.07	7707215
2558	Acetylation	FGAVYKPKEDTELE- HCCCCCCCCCCCCC-	65.16	7707227
2561	Phosphorylation	VYKPKEDTELE---- CCCCCCCCCCC----	43.49	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	SPOP	O43791	PMID:27614073

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SETD2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SETD2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HD_HUMAN	HTT	physical	9700202
P53_HUMAN	TP53	physical	18585004
H31_HUMAN	HIST1H3A	physical	16118227
SETD2_HUMAN	SETD2	physical	16118227
RPB1_HUMAN	POLR2A	physical	16118227
SMAD3_HUMAN	SMAD3	physical	21988832
SIAH2_HUMAN	SIAH2	physical	21988832
H31T_HUMAN	HIST3H3	physical	24412544
EIF3I_HUMAN	EIF3I	physical	26344197
H31_HUMAN	HIST1H3A	physical	27528607

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
144700	Renal cell carcinoma (RCC)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SETD2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-131; SER-321; SER-323;SER-708; SER-744; SER-754; SER-2080 AND SER-2082, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-131; SER-321; SER-323;SER-532; SER-614; SER-624; THR-626; SER-708; SER-905; SER-2080 ANDSER-2082, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321; SER-323; SER-624;SER-742; SER-754; SER-1413; SER-1415; SER-1417; THR-1872; SER-2080 ANDSER-2082, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1228, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321; SER-323 ANDSER-532, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1413, AND MASSSPECTROMETRY.	15302935 [Abstract]