HD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HD_HUMAN
• UniProt AC: P42858
• Protein Name: Huntingtin
• Gene Name: HTT
• Organism: Homo sapiens (Human).
• Sequence Length: 3142
• Subcellular Localization: Cytoplasm . Nucleus . The mutant Huntingtin protein colocalizes with AKAP8L in the nuclear matrix of Huntington disease neurons. Shuttles between cytoplasm and nucleus in a Ran GTPase-independent manner.
• Protein Description: May play a role in microtubule-mediated transport or vesicle function..
• Protein Sequence: MATLEKLMKAFESLKSFQQQQQQQQQQQQQQQQQQQQQPPPPPPPPPPPQLPQPPPQAQPLLPQPQPPPPPPPPPPGPAVAEEPLHRPKKELSATKKDRVNHCLTICENIVAQSVRNSPEFQKLLGIAMELFLLCSDDAESDVRMVADECLNKVIKALMDSNLPRLQLELYKEIKKNGAPRSLRAALWRFAELAHLVRPQKCRPYLVNLLPCLTRTSKRPEESVQETLAAAVPKIMASFGNFANDNEIKVLLKAFIANLKSSSPTIRRTAAGSAVSICQHSRRTQYFYSWLLNVLLGLLVPVEDEHSTLLILGVLLTLRYLVPLLQQQVKDTSLKGSFGVTRKEMEVSPSAEQLVQVYELTLHHTQHQDHNVVTGALELLQQLFRTPPPELLQTLTAVGGIGQLTAAKEESGGRSRSGSIVELIAGGGSSCSPVLSRKQKGKVLLGEEEALEDDSESRSDVSSSALTASVKDEISGELAASSGVSTPGSAGHDIITEQPRSQHTLQADSVDLASCDLTSSATDGDEEDILSHSSSQVSAVPSDPAMDLNDGTQASSPISDSSQTTTEGPDSAVTPSDSSEIVLDGTDNQYLGLQIGQPQDEDEEATGILPDEASEAFRNSSMALQQAHLLKNMSHCRQPSDSSVDKFVLRDEATEPGDQENKPCRIKGDIGQSTDDDSAPLVHCVRLLSASFLLTGGKNVLVPDRDVRVSVKALALSCVGAAVALHPESFFSKLYKVPLDTTEYPEEQYVSDILNYIDHGDPQVRGATAILCGTLICSILSRSRFHVGDWMGTIRTLTGNTFSLADCIPLLRKTLKDESSVTCKLACTAVRNCVMSLCSSSYSELGLQLIIDVLTLRNSSYWLVRTELLETLAEIDFRLVSFLEAKAENLHRGAHHYTGLLKLQERVLNNVVIHLLGDEDPRVRHVAAASLIRLVPKLFYKCDQGQADPVVAVARDQSSVYLKLLMHETQPPSHFSVSTITRIYRGYNLLPSITDVTMENNLSRVIAAVSHELITSTTRALTFGCCEALCLLSTAFPVCIWSLGWHCGVPPLSASDESRKSCTVGMATMILTLLSSAWFPLDLSAHQDALILAGNLLAASAPKSLRSSWASEEEANPAATKQEEVWPALGDRALVPMVEQLFSHLLKVINICAHVLDDVAPGPAIKAALPSLTNPPSLSPIRRKGKEKEPGEQASVPLSPKKGSEASAASRQSDTSGPVTTSKSSSLGSFYHLPSYLKLHDVLKATHANYKVTLDLQNSTEKFGGFLRSALDVLSQILELATLQDIGKCVEEILGYLKSCFSREPMMATVCVQQLLKTLFGTNLASQFDGLSSNPSKSQGRAQRLGSSSVRPGLYHYCFMAPYTHFTQALADASLRNMVQAEQENDTSGWFDVLQKVSTQLKTNLTSVTKNRADKNAIHNHIRLFEPLVIKALKQYTTTTCVQLQKQVLDLLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYIEVGQFRESEAIIPNIFFFLVLLSYERYHSKQIIGIPKIIQLCDGIMASGRKAVTHAIPALQPIVHDLFVLRGTNKADAGKELETQKEVVVSMLLRLIQYHQVLEMFILVLQQCHKENEDKWKRLSRQIADIILPMLAKQQMHIDSHEALGVLNTLFEILAPSSLRPVDMLLRSMFVTPNTMASVSTVQLWISGILAILRVLISQSTEDIVLSRIQELSFSPYLISCTVINRLRDGDSTSTLEEHSEGKQIKNLPEETFSRFLLQLVGILLEDIVTKQLKVEMSEQQHTFYCQELGTLLMCLIHIFKSGMFRRITAAATRLFRSDGCGGSFYTLDSLNLRARSMITTHPALVLLWCQILLLVNHTDYRWWAEVQQTPKRHSLSSTKLLSPQMSGEEEDSDLAAKLGMCNREIVRRGALILFCDYVCQNLHDSEHLTWLIVNHIQDLISLSHEPPVQDFISAVHRNSAASGLFIQAIQSRCENLSTPTMLKKTLQCLEGIHLSQSGAVLTLYVDRLLCTPFRVLARMVDILACRRVEMLLAANLQSSMAQLPMEELNRIQEYLQSSGLAQRHQRLYSLLDRFRLSTMQDSLSPSPPVSSHPLDGDGHVSLETVSPDKDWYVHLVKSQCWTRSDSALLEGAELVNRIPAEDMNAFMMNSEFNLSLLAPCLSLGMSEISGGQKSALFEAAREVTLARVSGTVQQLPAVHHVFQPELPAEPAAYWSKLNDLFGDAALYQSLPTLARALAQYLVVVSKLPSHLHLPPEKEKDIVKFVVATLEALSWHLIHEQIPLSLDLQAGLDCCCLALQLPGLWSVVSSTEFVTHACSLIYCVHFILEAVAVQPGEQLLSPERRTNTPKAISEEEEEVDPNTQNPKYITAACEMVAEMVESLQSVLALGHKRNSGVPAFLTPLLRNIIISLARLPLVNSYTRVPPLVWKLGWSPKPGGDFGTAFPEIPVEFLQEKEVFKEFIYRINTLGWTSRTQFEETWATLLGVLVTQPLVMEQEESPPEEDTERTQINVLAVQAITSLVLSAMTVPVAGNPAVSCLEQQPRNKPLKALDTRFGRKLSIIRGIVEQEIQAMVSKRENIATHHLYQAWDPVPSLSPATTGALISHEKLLLQINPERELGSMSYKLGQVSIHSVWLGNSITPLREEEWDEEEEEEADAPAPSSPPTSPVNSRKHRAGVDIHSCSQFLLELYSRWILPSSSARRTPAILISEVVRSLLVVSDLFTERNQFELMYVTLTELRRVHPSEDEILAQYLVPATCKAAAVLGMDKAVAEPVSRLLESTLRSSHLPSRVGALHGVLYVLECDLLDDTAKQLIPVISDYLLSNLKGIAHCVNIHSQQHVLVMCATAFYLIENYPLDVGPEFSASIIQMCGVMLSGSEESTPSIIYHCALRGLERLLLSEQLSRLDAESLVKLSVDRVNVHSPHRAMAALGLMLTCMYTGKEKVSPGRTSDPNPAAPDSESVIVAMERVSVLFDRIRKGFPCEARVVARILPQFLDDFFPPQDIMNKVIGEFLSNQQPYPQFMATVVYKVFQTLHSTGQSSMVRDWVMLSLSNFTQRAPVAMATWSLSCFFVSASTSPWVAAILPHVISRMGKLEQVDVNLFCLVATDFYRHQIEEELDRRAFQSVLEVVAAPGSPYHRLLTCLRNVHKVTTC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MATLEKLMKA -----CHHHHHHHHH	47.51	19710014
6	Sumoylation	--MATLEKLMKAFES --CHHHHHHHHHHHH	57.92	-
6	Acetylation	--MATLEKLMKAFES --CHHHHHHHHHHHH	57.92	20413433
6	Sumoylation	--MATLEKLMKAFES --CHHHHHHHHHHHH	57.92	-
9	Sumoylation	ATLEKLMKAFESLKS HHHHHHHHHHHHHHH	61.43	-
9	Acetylation	ATLEKLMKAFESLKS HHHHHHHHHHHHHHH	61.43	21685499
9	Sumoylation	ATLEKLMKAFESLKS HHHHHHHHHHHHHHH	61.43	21685499
13	Phosphorylation	KLMKAFESLKSFQQQ HHHHHHHHHHHHHHH	34.34	19710014
15	Sumoylation	MKAFESLKSFQQQQQ HHHHHHHHHHHHHHH	59.51	-
15	Acetylation	MKAFESLKSFQQQQQ HHHHHHHHHHHHHHH	59.51	274491399
15	Sumoylation	MKAFESLKSFQQQQQ HHHHHHHHHHHHHHH	59.51	-
16	Phosphorylation	KAFESLKSFQQQQQQ HHHHHHHHHHHHHHH	33.31	21623356
89	Sumoylation	EEPLHRPKKELSATK CCCCCCCHHHCCCCC	59.86	-
93	Phosphorylation	HRPKKELSATKKDRV CCCHHHCCCCCHHHH	34.68	26657352
96	Acetylation	KKELSATKKDRVNHC HHHCCCCCHHHHHHH	53.01	19825621
105	Phosphorylation	DRVNHCLTICENIVA HHHHHHHHHHHHHHH	29.04	23663014
114	Phosphorylation	CENIVAQSVRNSPEF HHHHHHHHHHCCHHH	17.20	23663014
118	Phosphorylation	VAQSVRNSPEFQKLL HHHHHHCCHHHHHHH	18.42	-
176	Acetylation	ELYKEIKKNGAPRSL HHHHHHHHCCCCHHH	67.29	21685499
212	S-palmitoylation	YLVNLLPCLTRTSKR HHHHHHHHHHCCCCC	6.46	16699508
234	Acetylation	TLAAAVPKIMASFGN HHHHHHHHHHHHHCC	38.22	21685499
253	Acetylation	NEIKVLLKAFIANLK HHHHHHHHHHHHHHH	36.77	25953088
253	Ubiquitination	NEIKVLLKAFIANLK HHHHHHHHHHHHHHH	36.77	-
261	Phosphorylation	AFIANLKSSSPTIRR HHHHHHHCCCCCCCH	38.93	23403867
262	Phosphorylation	FIANLKSSSPTIRRT HHHHHHCCCCCCCHH	38.46	23403867
263	Phosphorylation	IANLKSSSPTIRRTA HHHHHCCCCCCCHHC	32.90	24719451
265	Phosphorylation	NLKSSSPTIRRTAAG HHHCCCCCCCHHCCC	29.12	23403867
269	Phosphorylation	SSPTIRRTAAGSAVS CCCCCCHHCCCCHHH	15.83	30387612
276	Phosphorylation	TAAGSAVSICQHSRR HCCCCHHHHCCCCCC	19.84	-
332	Phosphorylation	LQQQVKDTSLKGSFG HHHHHCCCCCCCCCC	30.18	20068231
333	Phosphorylation	QQQVKDTSLKGSFGV HHHHCCCCCCCCCCC	37.91	20068231
335	Ubiquitination	QVKDTSLKGSFGVTR HHCCCCCCCCCCCCH	52.88	-
337	Phosphorylation	KDTSLKGSFGVTRKE CCCCCCCCCCCCHHH	19.76	20068231
337	Ubiquitination	KDTSLKGSFGVTRKE CCCCCCCCCCCCHHH	19.76	29967540
339	Phosphorylation	TSLKGSFGVTRKEME CCCCCCCCCCHHHEE	22.91	27251275
341	Phosphorylation	LKGSFGVTRKEMEVS CCCCCCCCHHHEEEC	36.08	20068231
343	Acetylation	GSFGVTRKEMEVSPS CCCCCCHHHEEECCC	52.64	21685499
394	Phosphorylation	PPPELLQTLTAVGGI CCHHHHHHHHHHCCH	26.50	23312004
396	Phosphorylation	PELLQTLTAVGGIGQ HHHHHHHHHHCCHHH	23.76	23312004
405	Phosphorylation	VGGIGQLTAAKEESG HCCHHHHHHHHHHCC	19.38	22617229
407	Phosphorylation	GIGQLTAAKEESGGR CHHHHHHHHHHCCCC	17.98	24719451
410	Ubiquitination	QLTAAKEESGGRSRS HHHHHHHHCCCCCCC	54.71	30230243
411	Phosphorylation	LTAAKEESGGRSRSG HHHHHHHCCCCCCCC	47.87	22617229
413	Phosphorylation	AAKEESGGRSRSGSI HHHHHCCCCCCCCCE	33.40	18669648
415	Phosphorylation	KEESGGRSRSGSIVE HHHCCCCCCCCCEEE	33.79	25159151
417	Phosphorylation	ESGGRSRSGSIVELI HCCCCCCCCCEEEEE	37.83	23927012
419	Phosphorylation	GGRSRSGSIVELIAG CCCCCCCCEEEEECC	25.38	23927012
421	Phosphorylation	RSRSGSIVELIAGGG CCCCCCEEEEECCCC	5.40	24719451
429	Phosphorylation	ELIAGGGSSCSPVLS EEECCCCCCCHHHHC	31.29	29255136
430	Phosphorylation	LIAGGGSSCSPVLSR EECCCCCCCHHHHCC	23.14	29255136
431	Phosphorylation	IAGGGSSCSPVLSRK ECCCCCCCHHHHCCC	5.96	24719451
432	Phosphorylation	AGGGSSCSPVLSRKQ CCCCCCCHHHHCCCC	21.71	29255136
434	Phosphorylation	GGSSCSPVLSRKQKG CCCCCHHHHCCCCCC	4.33	33259812
436	Phosphorylation	SSCSPVLSRKQKGKV CCCHHHHCCCCCCCE	37.35	30266825
438	Acetylation	CSPVLSRKQKGKVLL CHHHHCCCCCCCEEE	53.65	19345187
442	Acetylation	LSRKQKGKVLLGEEE HCCCCCCCEEECCHH	36.42	21685499
442	Ubiquitination	LSRKQKGKVLLGEEE HCCCCCCCEEECCHH	36.42	22623107
455	Phosphorylation	EEALEDDSESRSDVS HHHCCCCCCCCCCCC	50.20	27251275
457	Phosphorylation	ALEDDSESRSDVSSS HCCCCCCCCCCCCHH	40.82	24173317
459	Phosphorylation	EDDSESRSDVSSSAL CCCCCCCCCCCHHHH	52.20	27251275
462	Phosphorylation	SESRSDVSSSALTAS CCCCCCCCHHHHHHH	24.46	21815630
463	Phosphorylation	ESRSDVSSSALTASV CCCCCCCHHHHHHHH	21.34	-
464	Phosphorylation	SRSDVSSSALTASVK CCCCCCHHHHHHHHH	21.57	-
485	Phosphorylation	LAASSGVSTPGSAGH HHHHCCCCCCCCCCC	32.20	25159151
486	Phosphorylation	AASSGVSTPGSAGHD HHHCCCCCCCCCCCC	29.30	25159151
489	Phosphorylation	SGVSTPGSAGHDIIT CCCCCCCCCCCCCCC	32.08	-
496	Phosphorylation	SAGHDIITEQPRSQH CCCCCCCCCCCCCCC	28.97	-
534	Phosphorylation	EDILSHSSSQVSAVP HHHHHCCCCCEECCC	21.26	16782707
551	Myristoylation	PAMDLNDGTQASSPI CCCCCCCCCCCCCCC	20.75	29802276
620	Phosphorylation	ASEAFRNSSMALQQA HHHHHHCHHHHHHHH	19.75	21712546
621	Phosphorylation	SEAFRNSSMALQQAH HHHHHCHHHHHHHHH	16.18	28857561
623	Phosphorylation	AFRNSSMALQQAHLL HHHCHHHHHHHHHHH	12.27	27251275
634	Phosphorylation	AHLLKNMSHCRQPSD HHHHHCCCCCCCCCC	28.91	29514088
640	Phosphorylation	MSHCRQPSDSSVDKF CCCCCCCCCCCCCEE	41.61	30266825
642	Phosphorylation	HCRQPSDSSVDKFVL CCCCCCCCCCCEEEE	36.28	30266825
643	Phosphorylation	CRQPSDSSVDKFVLR CCCCCCCCCCEEEEC	39.05	30266825
654	Phosphorylation	FVLRDEATEPGDQEN EEECCCCCCCCCCCC	40.44	29496963
656	Phosphorylation	LRDEATEPGDQENKP ECCCCCCCCCCCCCC	47.51	24719451
662	Ubiquitination	EPGDQENKPCRIKGD CCCCCCCCCCCEECC	44.75	-
664	Ubiquitination	GDQENKPCRIKGDIG CCCCCCCCCEECCCC	8.19	29967540
667	Ubiquitination	ENKPCRIKGDIGQST CCCCCCEECCCCCCC	31.04	-
673	Phosphorylation	IKGDIGQSTDDDSAP EECCCCCCCCCCCCC	28.70	27174698
674	Phosphorylation	KGDIGQSTDDDSAPL ECCCCCCCCCCCCCH	35.24	27174698
678	Phosphorylation	GQSTDDDSAPLVHCV CCCCCCCCCCHHHHH	38.49	27174698
689	Phosphorylation	VHCVRLLSASFLLTG HHHHHHHHHHHHHCC	26.85	27174698
698	Ubiquitination	SFLLTGGKNVLVPDR HHHHCCCCCEECCCC	45.27	-
778	Phosphorylation	LCGTLICSILSRSRF HHHHHHHHHHHCCCC	21.41	24719451
781	Phosphorylation	TLICSILSRSRFHVG HHHHHHHHCCCCCCC	26.92	24719451
796	Phosphorylation	DWMGTIRTLTGNTFS CCCCHHHHHHCCCCC	25.48	-
813	Ubiquitination	DCIPLLRKTLKDESS HHHHHHHHHCCCCCC	59.17	-
888	Ubiquitination	SFLEAKAENLHRGAH HHHHHHHHHCCCCHH	60.67	30230243
897	Phosphorylation	LHRGAHHYTGLLKLQ CCCCHHHHHHHHHHH	7.82	22985185
898	Phosphorylation	HRGAHHYTGLLKLQE CCCHHHHHHHHHHHH	19.59	28509920
902	Ubiquitination	HHYTGLLKLQERVLN HHHHHHHHHHHHHHC	53.84	-
930	Phosphorylation	VRHVAAASLIRLVPK HHHHHHHHHHHHHHH	21.43	-
937	Ubiquitination	SLIRLVPKLFYKCDQ HHHHHHHHHHHCCCC	43.69	-
941	Ubiquitination	LVPKLFYKCDQGQAD HHHHHHHCCCCCCCC	24.81	-
943	Ubiquitination	PKLFYKCDQGQADPV HHHHHCCCCCCCCCE	52.04	32015554
978	Phosphorylation	PPSHFSVSTITRIYR CCCCCCHHHHHHHHC	16.94	24719451
1104	Phosphorylation	LAASAPKSLRSSWAS HHHHCCHHHHHCCCC	28.14	-
1111	Phosphorylation	SLRSSWASEEEANPA HHHHCCCCHHHCCCC	39.00	-
1120	Phosphorylation	EEANPAATKQEEVWP HHCCCCCCCHHHHHH	35.05	-
1121	Ubiquitination	EANPAATKQEEVWPA HCCCCCCCHHHHHHH	51.49	-
1123	Ubiquitination	NPAATKQEEVWPALG CCCCCCHHHHHHHHC	56.95	29967540
1171	Phosphorylation	AIKAALPSLTNPPSL HHHHHCHHCCCCCCC	48.99	23403867
1173	Phosphorylation	KAALPSLTNPPSLSP HHHCHHCCCCCCCCC	50.44	23403867
1175	Phosphorylation	ALPSLTNPPSLSPIR HCHHCCCCCCCCCCC	18.02	24719451
1177	O-linked_Glycosylation	PSLTNPPSLSPIRRK HHCCCCCCCCCCCCC	42.61	30379171
1177	Phosphorylation	PSLTNPPSLSPIRRK HHCCCCCCCCCCCCC	42.61	29255136
1179	Phosphorylation	LTNPPSLSPIRRKGK CCCCCCCCCCCCCCC	23.71	29255136
1181	Phosphorylation	NPPSLSPIRRKGKEK CCCCCCCCCCCCCCC	6.30	32142685
1190	Ubiquitination	RKGKEKEPGEQASVP CCCCCCCCCCCCCCC	63.79	24816145
1195	Phosphorylation	KEPGEQASVPLSPKK CCCCCCCCCCCCCCC	24.78	23927012
1199	Phosphorylation	EQASVPLSPKKGSEA CCCCCCCCCCCCCHH	28.71	19664994
1201	Phosphorylation	ASVPLSPKKGSEASA CCCCCCCCCCCHHHH	67.40	24719451
1204	Phosphorylation	PLSPKKGSEASAASR CCCCCCCCHHHHHCC	38.58	28111955
1207	Phosphorylation	PKKGSEASAASRQSD CCCCCHHHHHCCCCC	21.95	28111955
1210	Phosphorylation	GSEASAASRQSDTSG CCHHHHHCCCCCCCC	30.48	28111955
1213	Phosphorylation	ASAASRQSDTSGPVT HHHHCCCCCCCCCCC	41.57	24043423
1215	Phosphorylation	AASRQSDTSGPVTTS HHCCCCCCCCCCCCC	40.61	24043423
1216	Phosphorylation	ASRQSDTSGPVTTSK HCCCCCCCCCCCCCC	46.20	24043423
1220	Phosphorylation	SDTSGPVTTSKSSSL CCCCCCCCCCCCCCC	28.61	24043423
1221	Phosphorylation	DTSGPVTTSKSSSLG CCCCCCCCCCCCCCC	34.10	24043423
1222	Phosphorylation	TSGPVTTSKSSSLGS CCCCCCCCCCCCCCC	22.60	24043423
1223	Ubiquitination	SGPVTTSKSSSLGSF CCCCCCCCCCCCCCC	52.87	-
1225	Ubiquitination	PVTTSKSSSLGSFYH CCCCCCCCCCCCCCC	33.06	29967540
1229	Phosphorylation	SKSSSLGSFYHLPSY CCCCCCCCCCCCCHH	28.11	28857561
1240	Ubiquitination	LPSYLKLHDVLKATH CCHHHHHHHHHHHHC	22.88	32015554
1244	Ubiquitination	LKLHDVLKATHANYK HHHHHHHHHHCCCEE	51.60	-
1246	Ubiquitination	LHDVLKATHANYKVT HHHHHHHHCCCEEEE	21.67	29967540
1253	Phosphorylation	THANYKVTLDLQNST HCCCEEEEEECCCCH	15.48	26552605
1259	Phosphorylation	VTLDLQNSTEKFGGF EEEECCCCHHHHHHH	25.61	26552605
1260	Phosphorylation	TLDLQNSTEKFGGFL EEECCCCHHHHHHHH	51.23	26552605
1262	Ubiquitination	DLQNSTEKFGGFLRS ECCCCHHHHHHHHHH	49.77	21890473
1264	Ubiquitination	QNSTEKFGGFLRSAL CCCHHHHHHHHHHHH	36.69	21890473
1282	Phosphorylation	SQILELATLQDIGKC HHHHHHHHHHHHHHH	37.26	-
1322	Phosphorylation	LLKTLFGTNLASQFD HHHHHHCCCHHHHCC	21.52	-
1337	Ubiquitination	GLSSNPSKSQGRAQR CCCCCCCCCCCCHHH	48.32	-
1339	Ubiquitination	SSNPSKSQGRAQRLG CCCCCCCCCCHHHHC	49.48	30230243
1347	O-linked_Glycosylation	GRAQRLGSSSVRPGL CCHHHHCCCCCCCCH	24.83	30379171
1348	O-linked_Glycosylation	RAQRLGSSSVRPGLY CHHHHCCCCCCCCHH	30.93	30379171
1348	Phosphorylation	RAQRLGSSSVRPGLY CHHHHCCCCCCCCHH	30.93	-
1349	Phosphorylation	AQRLGSSSVRPGLYH HHHHCCCCCCCCHHH	24.68	-
1355	Phosphorylation	SSVRPGLYHYCFMAP CCCCCCHHHHHCCCC	9.17	-
1402	Ubiquitination	QKVSTQLKTNLTSVT HHHHHHHHHCCHHHC	26.08	21890473
1404	Ubiquitination	VSTQLKTNLTSVTKN HHHHHHHCCHHHCCC	39.47	21890473
1410	Ubiquitination	TNLTSVTKNRADKNA HCCHHHCCCHHCCCH	42.13	-
1412	Ubiquitination	LTSVTKNRADKNAIH CHHHCCCHHCCCHHC	45.80	32015554
1415	Ubiquitination	VTKNRADKNAIHNHI HCCCHHCCCHHCHHH	47.49	-
1417	Ubiquitination	KNRADKNAIHNHIRL CCHHCCCHHCHHHHH	15.34	29967540
1431	Ubiquitination	LFEPLVIKALKQYTT HHHHHHHHHHHHCCH	39.94	21890473
1433	Ubiquitination	EPLVIKALKQYTTTT HHHHHHHHHHCCHHH	2.78	23000965
1436	Phosphorylation	VIKALKQYTTTTCVQ HHHHHHHCCHHHHHH	12.41	28258704
1436	Ubiquitination	VIKALKQYTTTTCVQ HHHHHHHCCHHHHHH	12.41	23000965
1440	Phosphorylation	LKQYTTTTCVQLQKQ HHHCCHHHHHHHHHH	14.48	28258704
1535	Ubiquitination	MASGRKAVTHAIPAL HHCCHHHHHHHHHHH	4.52	30230243
1730	Ubiquitination	LEEHSEGKQIKNLPE HHHCCCCCCCCCCCH	44.81	-
1732	Ubiquitination	EHSEGKQIKNLPEET HCCCCCCCCCCCHHH	3.49	30230243
1733	Ubiquitination	HSEGKQIKNLPEETF CCCCCCCCCCCHHHH	50.35	-
1772	Phosphorylation	SEQQHTFYCQELGTL CCCCCCHHHHHHHHH	8.38	22210691
1778	Phosphorylation	FYCQELGTLLMCLIH HHHHHHHHHHHHHHH	29.37	22210691
1789	O-linked_Glycosylation	CLIHIFKSGMFRRIT HHHHHHHHCHHHHHH	25.41	30379171
1796	O-linked_Glycosylation	SGMFRRITAAATRLF HCHHHHHHHHHHHHH	14.39	30379171
1805	Phosphorylation	AATRLFRSDGCGGSF HHHHHHCCCCCCCCC	30.90	-
1811	Phosphorylation	RSDGCGGSFYTLDSL CCCCCCCCCEEHHHC	10.60	-
1813	Phosphorylation	DGCGGSFYTLDSLNL CCCCCCCEEHHHCCC	14.21	-
1814	Phosphorylation	GCGGSFYTLDSLNLR CCCCCCEEHHHCCCC	23.29	-
1862	Phosphorylation	QQTPKRHSLSSTKLL HCCCCCCCCCCCCCC	33.70	26657352
1864	Phosphorylation	TPKRHSLSSTKLLSP CCCCCCCCCCCCCCC	38.69	22496350
1865	Phosphorylation	PKRHSLSSTKLLSPQ CCCCCCCCCCCCCCC	34.55	22496350
1866	Phosphorylation	KRHSLSSTKLLSPQM CCCCCCCCCCCCCCC	23.49	28176443
1867	Ubiquitination	RHSLSSTKLLSPQMS CCCCCCCCCCCCCCC	49.75	-
1870	Phosphorylation	LSSTKLLSPQMSGEE CCCCCCCCCCCCCCC	24.42	30266825
1872	Phosphorylation	STKLLSPQMSGEEED CCCCCCCCCCCCCCC	34.99	18669648
1873	Sulfoxidation	TKLLSPQMSGEEEDS CCCCCCCCCCCCCCH	6.71	21406390
1874	Phosphorylation	KLLSPQMSGEEEDSD CCCCCCCCCCCCCHH	37.49	29255136
1876	Phosphorylation	LSPQMSGEEEDSDLA CCCCCCCCCCCHHHH	51.40	24719451
1880	Phosphorylation	MSGEEEDSDLAAKLG CCCCCCCHHHHHHHC	37.49	29255136
1885	Ubiquitination	EDSDLAAKLGMCNRE CCHHHHHHHCCCCHH	39.71	-
1972	Ubiquitination	STPTMLKKTLQCLEG CCHHHHHHHHHHHHC	50.97	-
2042	Phosphorylation	ELNRIQEYLQSSGLA HHHHHHHHHHHCCHH	8.15	25690035
2065	Phosphorylation	LLDRFRLSTMQDSLS HHHHHCHHHCCCCCC	19.99	30377224
2066	Phosphorylation	LDRFRLSTMQDSLSP HHHHCHHHCCCCCCC	24.36	30377224
2070	Phosphorylation	RLSTMQDSLSPSPPV CHHHCCCCCCCCCCC	17.54	30377224
2072	Phosphorylation	STMQDSLSPSPPVSS HHCCCCCCCCCCCCC	27.55	22210691
2074	Phosphorylation	MQDSLSPSPPVSSHP CCCCCCCCCCCCCCC	38.16	22210691
2078	Phosphorylation	LSPSPPVSSHPLDGD CCCCCCCCCCCCCCC	28.80	28348404
2079	Phosphorylation	SPSPPVSSHPLDGDG CCCCCCCCCCCCCCC	29.38	28348404
2089	Phosphorylation	LDGDGHVSLETVSPD CCCCCCEEEEEECCC	18.14	30377224
2092	Phosphorylation	DGHVSLETVSPDKDW CCCEEEEEECCCCCC	31.41	22210691
2094	Phosphorylation	HVSLETVSPDKDWYV CEEEEEECCCCCCEE	34.50	30377224
2112	Phosphorylation	KSQCWTRSDSALLEG HHHCCCCCHHHHHHH	28.66	27732954
2114	Phosphorylation	QCWTRSDSALLEGAE HCCCCCHHHHHHHHH	23.28	27732954
2138	Phosphorylation	MNAFMMNSEFNLSLL HCHHHHCCCCCHHHH	26.18	24043423
2143	Phosphorylation	MNSEFNLSLLAPCLS HCCCCCHHHHHHHHH	23.57	24043423
2150	Phosphorylation	SLLAPCLSLGMSEIS HHHHHHHHHCCCCCC	29.60	24043423
2154	Phosphorylation	PCLSLGMSEISGGQK HHHHHCCCCCCCCHH	29.94	24043423
2157	Phosphorylation	SLGMSEISGGQKSAL HHCCCCCCCCHHHHH	32.59	24043423
2228	Phosphorylation	LARALAQYLVVVSKL HHHHHHHHHHHHCCC	8.89	21406692
2233	Phosphorylation	AQYLVVVSKLPSHLH HHHHHHHCCCCCCCC	19.50	21406692
2328	Phosphorylation	QPGEQLLSPERRTNT CCCCCCCCCCCCCCC	33.05	24719451
2335	Phosphorylation	SPERRTNTPKAISEE CCCCCCCCCCCCCCC	26.08	-
2337	Acetylation	ERRTNTPKAISEEEE CCCCCCCCCCCCCHH	57.21	7294519
2337	Ubiquitination	ERRTNTPKAISEEEE CCCCCCCCCCCCCHH	57.21	-
2340	Phosphorylation	TNTPKAISEEEEEVD CCCCCCCCCCHHCCC	43.76	25159151
2342	Phosphorylation	TPKAISEEEEEVDPN CCCCCCCCHHCCCCC	65.01	24719451
2382	O-linked_Glycosylation	ALGHKRNSGVPAFLT HHCCCCCCCCCCHHH	45.24	30379171
2382	Phosphorylation	ALGHKRNSGVPAFLT HHCCCCCCCCCCHHH	45.24	30108239
2389	O-linked_Glycosylation	SGVPAFLTPLLRNII CCCCCHHHHHHHHHH	12.87	30379171
2417	Ubiquitination	RVPPLVWKLGWSPKP CCCCCCHHCCCCCCC	29.64	21890473
2419	Ubiquitination	PPLVWKLGWSPKPGG CCCCHHCCCCCCCCC	21.06	21890473
2421	Phosphorylation	LVWKLGWSPKPGGDF CCHHCCCCCCCCCCC	22.65	24719451
2423	Ubiquitination	WKLGWSPKPGGDFGT HHCCCCCCCCCCCCC	51.26	-
2425	Ubiquitination	LGWSPKPGGDFGTAF CCCCCCCCCCCCCCC	55.20	29967540
2443	Ubiquitination	PVEFLQEKEVFKEFI CHHHHHCHHHHHHHH	46.33	-
2445	Ubiquitination	EFLQEKEVFKEFIYR HHHHCHHHHHHHHHH	14.22	29967540
2451	Phosphorylation	EVFKEFIYRINTLGW HHHHHHHHHHHCCCC	15.68	29978859
2455	Phosphorylation	EFIYRINTLGWTSRT HHHHHHHCCCCCCCH	25.03	29978859
2459	Phosphorylation	RINTLGWTSRTQFEE HHHCCCCCCCHHHHH	13.41	22210691
2460	Phosphorylation	INTLGWTSRTQFEET HHCCCCCCCHHHHHH	27.16	22210691
2477	Phosphorylation	TLLGVLVTQPLVMEQ HHHHHHHHCCCCCCC	21.95	22210691
2536	Ubiquitination	QQPRNKPLKALDTRF CCCCCCCCCHHHHHH	5.60	24816145
2537	Ubiquitination	QPRNKPLKALDTRFG CCCCCCCCHHHHHHH	56.27	-
2548	Phosphorylation	TRFGRKLSIIRGIVE HHHHHHHHHHHHHHH	21.00	-
2564	Acetylation	EIQAMVSKRENIATH HHHHHHHCCCHHCHH	52.93	25953088
2564	Ubiquitination	EIQAMVSKRENIATH HHHHHHHCCCHHCHH	52.93	-
2566	Ubiquitination	QAMVSKRENIATHHL HHHHHCCCHHCHHHH	57.64	30230243
2570	Phosphorylation	SKRENIATHHLYQAW HCCCHHCHHHHHHCC	13.16	28634298
2574	Phosphorylation	NIATHHLYQAWDPVP HHCHHHHHHCCCCCC	7.57	28634298
2582	Phosphorylation	QAWDPVPSLSPATTG HCCCCCCCCCCCCCC	41.53	28634298
2584	Phosphorylation	WDPVPSLSPATTGAL CCCCCCCCCCCCCCE	19.47	28634298
2587	Phosphorylation	VPSLSPATTGALISH CCCCCCCCCCCEECC	29.19	28634298
2588	Phosphorylation	PSLSPATTGALISHE CCCCCCCCCCEECCH	23.67	28634298
2593	Phosphorylation	ATTGALISHEKLLLQ CCCCCEECCHHHHHH	26.83	28634298
2650	Phosphorylation	EADAPAPSSPPTSPV HCCCCCCCCCCCCCC	58.55	26471730
2651	Phosphorylation	ADAPAPSSPPTSPVN CCCCCCCCCCCCCCC	33.56	16782707
2654	Phosphorylation	PAPSSPPTSPVNSRK CCCCCCCCCCCCCCC	49.39	26471730
2655	Phosphorylation	APSSPPTSPVNSRKH CCCCCCCCCCCCCCC	32.40	26471730
2659	Phosphorylation	PPTSPVNSRKHRAGV CCCCCCCCCCCCCCC	42.83	26471730
2680	Phosphorylation	QFLLELYSRWILPSS HHHHHHHHHHHCCCC	33.49	24719451
2686	Phosphorylation	YSRWILPSSSARRTP HHHHHCCCCCCCCCH	33.22	29449344
2687	Phosphorylation	SRWILPSSSARRTPA HHHHCCCCCCCCCHH	26.52	29449344
2688	Phosphorylation	RWILPSSSARRTPAI HHHCCCCCCCCCHHH	30.08	29449344
2708	Phosphorylation	VRSLLVVSDLFTERN HHHHHHHHHHHCCCC	22.55	-
2712	Phosphorylation	LVVSDLFTERNQFEL HHHHHHHCCCCCCEE	41.13	-
2757	Ubiquitination	AAVLGMDKAVAEPVS HHHHCCCHHHHHHHH	35.55	-
2759	Ubiquitination	VLGMDKAVAEPVSRL HHCCCHHHHHHHHHH	8.36	30230243
2764	Phosphorylation	KAVAEPVSRLLESTL HHHHHHHHHHHHHHH	28.11	20068231
2807	Phosphorylation	KQLIPVISDYLLSNL HHHHHHHHHHHHHHC	22.04	20068231
2809	Phosphorylation	LIPVISDYLLSNLKG HHHHHHHHHHHHCCC	11.62	20068231
2812	Phosphorylation	VISDYLLSNLKGIAH HHHHHHHHHCCCHHH	37.21	20068231
2888	Phosphorylation	GLERLLLSEQLSRLD HHHHHHHHHHHHCCC	24.22	21406692
2892	Phosphorylation	LLLSEQLSRLDAESL HHHHHHHHCCCHHHH	30.41	21406692
2901	Ubiquitination	LDAESLVKLSVDRVN CCHHHHHHHCCCCCC	40.10	-
2934	Phosphorylation	YTGKEKVSPGRTSDP HHCCCCCCCCCCCCC	32.48	30576142
2936	Phosphorylation	GKEKVSPGRTSDPNP CCCCCCCCCCCCCCC	37.68	24719451
2938	Phosphorylation	EKVSPGRTSDPNPAA CCCCCCCCCCCCCCC	43.31	21712546
2939	Phosphorylation	KVSPGRTSDPNPAAP CCCCCCCCCCCCCCC	50.11	30576142
2940	Phosphorylation	VSPGRTSDPNPAAPD CCCCCCCCCCCCCCC	46.51	18669648
2948	Phosphorylation	PNPAAPDSESVIVAM CCCCCCCCHHHEEEH	30.61	29396449
2950	Phosphorylation	PAAPDSESVIVAMER CCCCCCHHHEEEHHH	22.54	29396449
2967	Ubiquitination	VLFDRIRKGFPCEAR HHHHHHHCCCCHHHH	63.63	-
3026	Phosphorylation	VFQTLHSTGQSSMVR HHHHHHHCCCCHHHH	28.61	22210691
3030	Phosphorylation	LHSTGQSSMVRDWVM HHHCCCCHHHHHHHH	17.26	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
3	T	Phosphorylation	Kinase	IKKB	O14920	PSP
13	S	Phosphorylation	Kinase	CK2A1	P68400	PSP
13	S	Phosphorylation	Kinase	IKKB	O14920	PSP
16	S	Phosphorylation	Kinase	CK2A1	P68400	PSP
16	S	Phosphorylation	Kinase	IKKB	O14920	PSP
419	S	Phosphorylation	Kinase	AKT1	P31749	PSP
419	S	Phosphorylation	Kinase	SGK1	O00141	PSP
419	S	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
419	S	Phosphorylation	Kinase	SGK-FAMILY	-	GPS
421	S	Phosphorylation	Kinase	PKB_GROUP	-	PhosphoELM
421	S	Phosphorylation	Kinase	SGK_GROUP	-	PhosphoELM
432	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
1179	S	Phosphorylation	Kinase	CDK5	Q00535	Uniprot
1199	S	Phosphorylation	Kinase	CDK5	Q00535	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	SYVN1	Q86TM6	PMID:17141218
-	K	Ubiquitination	E3 ubiquitin ligase	TRIM11	Q96F44	PMID:18248090

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
550	D	Myristoylation	[Huntingtin, myristoylated N-terminal fragment]: Myristoylated at Gly-551, following proteolytic cleavage at Asp-550.	24459296
551	G	Myristoylation	[Huntingtin, myristoylated N-terminal fragment]: Myristoylated at Gly-551, following proteolytic cleavage at Asp-550.	24459296
1179	S	Phosphorylation	[Huntingtin]: Phosphorylation at Ser-1179 and Ser-1199 by CDK5 in response to DNA damage in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity.	17611284
1199	S	Phosphorylation	[Huntingtin]: Phosphorylation at Ser-1179 and Ser-1199 by CDK5 in response to DNA damage in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity.	17611284

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SETD2_HUMAN	SETD2	physical	9700202
ZDH17_HUMAN	ZDHHC17	physical	9700202
PR40A_HUMAN	PRPF40A	physical	9700202
PR40B_HUMAN	PRPF40B	physical	9700202
MAGA3_HUMAN	MAGEA3	physical	9700202
FICD_HUMAN	FICD	physical	9700202
UBE2K_HUMAN	UBE2K	physical	9700202
AP2A2_HUMAN	AP2A2	physical	9700202
HYPK_HUMAN	HYPK	physical	9700202
OPTN_HUMAN	OPTN	physical	9700202
HYPM_HUMAN	HYPM	physical	9700202
CBP_HUMAN	CREBBP	physical	11264541
SH3G3_HUMAN	SH3GL3	physical	9809064
M3K10_HUMAN	MAP3K10	physical	10801775
EGFR_HUMAN	EGFR	physical	9079622
GRB2_HUMAN	GRB2	physical	9079622
RASA1_HUMAN	RASA1	physical	9079622
P53_HUMAN	TP53	physical	10823891
SIN3A_MOUSE	Sin3a	physical	10823891
F8I2_HUMAN	F8A1	physical	11035034
HIP1_HUMAN	HIP1	physical	9147654
NCOR1_HUMAN	NCOR1	physical	10441327
ZDH17_HUMAN	ZDHHC17	physical	12393793
UBE2K_HUMAN	UBE2K	physical	8702625
CTBP1_HUMAN	CTBP1	physical	11739372
STP2_YEAST	STP2	genetic	14657499
PHM8_YEAST	PHM8	genetic	14657499
FHP_YEAST	YHB1	genetic	14657499
RIM4_YEAST	RIM4	genetic	14657499
OAF3_YEAST	OAF3	genetic	14657499
PSP1_YEAST	PSP1	genetic	14657499
HLJ1_YEAST	HLJ1	genetic	14657499
YO292_YEAST	YOR292C	genetic	14657499
GDA1_YEAST	GDA1	genetic	14657499
APJ1_YEAST	APJ1	genetic	14657499
APM2_YEAST	APM2	genetic	14657499
AYR1_YEAST	AYR1	genetic	14657499
CISY2_YEAST	CIT2	genetic	14657499
KCC1_YEAST	CMK1	genetic	14657499
CS111_YEAST	COS111	genetic	14657499
CBPS_YEAST	CPS1	genetic	14657499
DCG1_YEAST	DCG1	genetic	14657499
RRF1_YEAST	RRF1	genetic	14657499
FKBP2_YEAST	FPR2	genetic	14657499
GLO2_YEAST	GLO2	genetic	14657499
GSHB_YEAST	GSH2	genetic	14657499
HLR1_YEAST	HLR1	genetic	14657499
HMS1_YEAST	HMS1	genetic	14657499
IPK1_YEAST	IPK1	genetic	14657499
ODO1_YEAST	KGD1	genetic	14657499
MSB1_YEAST	MSB1	genetic	14657499
MUP1_YEAST	MUP1	genetic	14657499
PRM5_YEAST	PRM5	genetic	14657499
METK2_YEAST	SAM2	genetic	14657499
SAS3_YEAST	SAS3	genetic	14657499
SDT1_YEAST	SDT1	genetic	14657499
SIP18_YEAST	SIP18	genetic	14657499
SNG1_YEAST	SNG1	genetic	14657499
TEA1_YEAST	TEA1	genetic	14657499
TVP15_YEAST	TVP15	genetic	14657499
UBP13_YEAST	UBP13	genetic	14657499
VPS70_YEAST	VPS70	genetic	14657499
YRB30_YEAST	YRB30	genetic	14657499
MMS4_YEAST	MMS4	genetic	14657499
MTC4_YEAST	MTC4	genetic	14657499
YG19_YEAST	YGR015C	genetic	14657499
YJ77_YEAST	YJR107W	genetic	14657499
YM35_YEAST	YMR160W	genetic	14657499
YP067_YEAST	YPL067C	genetic	14657499
AGO2_HUMAN	AGO2	physical	18669659
CBP_HUMAN	CREBBP	physical	16456924
CBP_HUMAN	CREBBP	physical	15994095
CBP_HUMAN	CREBBP	physical	11607033
KAT2B_HUMAN	KAT2B	physical	11607033
RNQ1_YEAST	RNQ1	genetic	19656852
SYVN1_MOUSE	Syvn1	genetic	17141218
AMFR_HUMAN	AMFR	physical	20126661
TERA_HUMAN	VCP	physical	20126661
TRAF6_HUMAN	TRAF6	physical	21454471
RNQ1_YEAST	RNQ1	genetic	22536159
ERF3_YEAST	SUP35	genetic	22536159
GRE2_YEAST	GRE2	genetic	14657499
RM11_YEAST	MRPL11	genetic	14657499
PCL6_YEAST	PCL6	genetic	14657499
HEL1_YEAST	HEL1	genetic	14657499
DCN1_YEAST	DCN1	genetic	14657499
UBQL1_HUMAN	UBQLN1	physical	17603015
NEMO_HUMAN	IKBKG	physical	15371500
CTNB1_HUMAN	CTNNB1	physical	20531388
G3P_HUMAN	GAPDH	physical	16492755
SIAH1_HUMAN	SIAH1	physical	16492755
GIT1_HUMAN	GIT1	physical	15383276
PR40A_HUMAN	PRPF40A	physical	15383276
HIP1_HUMAN	HIP1	physical	15383276
SH3G3_HUMAN	SH3GL3	physical	15383276
GASP2_HUMAN	GPRASP2	physical	15383276
PIAS4_HUMAN	PIAS4	physical	15383276
MED31_HUMAN	MED31	physical	15383276
HAP1_HUMAN	HAP1	physical	15383276
UT14A_HUMAN	UTP14A	physical	15383276
FICD_HUMAN	FICD	physical	15383276
FEZ1_HUMAN	FEZ1	physical	15383276
ELP1_HUMAN	IKBKAP	physical	15383276
IDLC_HUMAN	DNALI1	physical	15383276
PROF2_HUMAN	PFN2	physical	15383276
TCRG1_HUMAN	TCERG1	physical	15383276
HS90B_HUMAN	HSP90AB1	physical	12417652
HSP7C_HUMAN	HSPA8	physical	12417652
DNJB1_HUMAN	DNAJB1	physical	12417652
DNJA1_HUMAN	DNAJA1	physical	12417652
HBS1L_HUMAN	HBS1L	physical	12417652
TBA1A_HUMAN	TUBA1A	physical	12417652
TBB5_HUMAN	TUBB	physical	12417652
PRS8_HUMAN	PSMC5	physical	18986984
ATG5_HUMAN	ATG5	physical	20417604
SQSTM_HUMAN	SQSTM1	physical	20417604
NBR1_HUMAN	NBR1	physical	20417604
MLP3A_HUMAN	MAP1LC3A	physical	20417604
HD_HUMAN	HTT	physical	15225551
SP1_HUMAN	SP1	physical	11988536
TAF4_HUMAN	TAF4	physical	11988536
OPTN_HUMAN	OPTN	physical	23275563
PIAS1_HUMAN	PIAS1	physical	23275563
ZDH17_HUMAN	ZDHHC17	physical	23275563
ZN451_HUMAN	ZNF451	physical	23275563
HXC4_HUMAN	HOXC4	physical	23275563
EVL_HUMAN	EVL	physical	23275563
UBAC1_HUMAN	UBAC1	physical	23275563
HM20A_HUMAN	HMG20A	physical	23275563
ERC6L_HUMAN	ERCC6L	physical	23275563
FRIL_HUMAN	FTL	physical	23275563
TTC23_HUMAN	TTC23	physical	23275563
BRE1A_HUMAN	RNF20	physical	23275563
HEY2_HUMAN	HEY2	physical	23275563
ZN655_HUMAN	ZNF655	physical	23275563
P85A_HUMAN	PIK3R1	physical	23275563
ANCHR_HUMAN	ZFYVE19	physical	23275563
GLP3L_HUMAN	GOLPH3L	physical	23275563
UBE2K_HUMAN	UBE2K	physical	23275563
MAGBI_HUMAN	MAGEB18	physical	23275563
MOFA1_HUMAN	MRFAP1	physical	23275563
HYPM_HUMAN	HYPM	physical	23275563
UB2E3_HUMAN	UBE2E3	physical	23275563
ZMAT2_HUMAN	ZMAT2	physical	23275563
DUS10_HUMAN	DUSP10	physical	23275563
MR1L1_HUMAN	MRFAP1L1	physical	23275563
GGA2_HUMAN	GGA2	physical	23275563
ING5_HUMAN	ING5	physical	23275563
IFT20_HUMAN	IFT20	physical	23275563
HEYL_HUMAN	HEYL	physical	23275563
TACC1_HUMAN	TACC1	physical	23275563
MBD4_HUMAN	MBD4	physical	23275563
DPPA4_HUMAN	DPPA4	physical	23275563
ETV4_HUMAN	ETV4	physical	23275563
MAGB6_HUMAN	MAGEB6	physical	23275563
MED21_HUMAN	MED21	physical	23275563
PX11B_HUMAN	PEX11B	physical	23275563
MBD1_HUMAN	MBD1	physical	23275563
TRAD1_HUMAN	TRAFD1	physical	23275563
HXC11_HUMAN	HOXC11	physical	23275563
OSTF1_HUMAN	OSTF1	physical	23275563
NUP58_HUMAN	NUPL1	physical	23275563
XAGE3_HUMAN	XAGE3	physical	23275563
TBB5_HUMAN	TUBB	physical	11870213
PGES2_HUMAN	PTGES2	physical	23275563
MIPEP_HUMAN	MIPEP	physical	23275563
PSB7_HUMAN	PSMB7	physical	23275563
NDKM_HUMAN	NME4	physical	23275563
RL4_HUMAN	RPL4	physical	23275563
ZC3H1_HUMAN	ZFC3H1	physical	23275563
HS104_YEAST	HSP104	physical	24412307
TPS1_YEAST	TPS1	physical	24412307
PML_HUMAN	PML	physical	24882209
ITCH_HUMAN	ITCH	physical	24865853
UBP14_HUMAN	USP14	physical	24951540
TRI18_HUMAN	MID1	physical	23443539
KS6B1_HUMAN	RPS6KB1	physical	23443539
PP2AA_HUMAN	PPP2CA	physical	23443539
SQSTM_HUMAN	SQSTM1	physical	25311206
HD_HUMAN	HTT	physical	25311206
SQSTM_HUMAN	SQSTM1	physical	25686248
ULK1_HUMAN	ULK1	physical	25686248
UBQL2_HUMAN	UBQLN2	physical	26141599
HAP1_MOUSE	Hap1	physical	25686248
MTOR_HUMAN	MTOR	physical	25351248
RHEB_HUMAN	RHEB	physical	25351248
STI1_YEAST	STI1	genetic	24828240
POP2_YEAST	POP2	genetic	24828240
CBK1_YEAST	CBK1	genetic	24828240
NAB3_YEAST	NAB3	genetic	24828240
YHS7_YEAST	YHR127W	genetic	24828240

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 143100: Huntington disease (HD)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Mass spectrometric identification of novel lysine acetylation sitesin huntingtin.";
Cong X., Held J.M., Degiacomo F., Bonner A., Chen J.M., Schilling B.,Czerwieniec G.A., Gibson B.W., Ellerby L.M.;
Mol. Cell. Proteomics 0:0-0(2011).
Cited for: ACETYLATION AT LYS-9; LYS-176; LYS-234; LYS-343 AND LYS-442.
PubMed: 21685499

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-432 AND SER-1874, ANDMASS SPECTROMETRY.
PubMed: 19690332

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-419; SER-432; SER-1199;SER-1870 AND SER-1874, AND MASS SPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-411; SER-1870 ANDSER-1874, AND MASS SPECTROMETRY.
PubMed: 18669648

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1179; SER-1199 ANDSER-1870, AND MASS SPECTROMETRY.
PubMed: 18691976

"Phosphoproteome of resting human platelets.";
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.;
J. Proteome Res. 7:526-534(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-419 AND SER-432, ANDMASS SPECTROMETRY.
PubMed: 18088087

"Phosphorylation of huntingtin by cyclin-dependent kinase 5 is inducedby DNA damage and regulates wild-type and mutant huntingtin toxicityin neurons.";
Anne S.L., Saudou F., Humbert S.;
J. Neurosci. 27:7318-7328(2007).
Cited for: PHOSPHORYLATION AT SER-1179 AND SER-1199.
PubMed: 17611284