| UniProt ID | HYPK_HUMAN | |
|---|---|---|
| UniProt AC | Q9NX55 | |
| Protein Name | Huntingtin-interacting protein K | |
| Gene Name | HYPK | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 129 | |
| Subcellular Localization | Nucleus. Cytoplasm. | |
| Protein Description | Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10-NAA15 complex-mediated N-terminal acetylation.. | |
| Protein Sequence | MRRRGEIDMATEGDVELELETETSGPERPPEKPRKHDSGAADLERVTDYAEEKEIQSSNLETAMSVIGDRRSREQKAKQEREKELAKVTIKKEDLELIMTEMEISRAAAERSLREHMGNVVEALIALTN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 35 | Acetylation | RPPEKPRKHDSGAAD CCCCCCCCCCCCCCC | 61.36 | 21466224 | |
| 38 | Phosphorylation | EKPRKHDSGAADLER CCCCCCCCCCCCHHH | 30.01 | 29255136 | |
| 47 | Phosphorylation | AADLERVTDYAEEKE CCCHHHHHCHHHHHH | 29.52 | 23186163 | |
| 49 | Phosphorylation | DLERVTDYAEEKEIQ CHHHHHCHHHHHHHH | 13.42 | 28796482 | |
| 58 | Phosphorylation | EEKEIQSSNLETAMS HHHHHHCCCHHHHHH | 29.11 | 28555341 | |
| 65 | Phosphorylation | SNLETAMSVIGDRRS CCHHHHHHHHCCHHH | 14.23 | 25849741 | |
| 69 (in isoform 3) | Phosphorylation | - | 31.53 | 28796482 | |
| 71 (in isoform 3) | Phosphorylation | - | 44.82 | 28796482 | |
| 87 | Ubiquitination | EREKELAKVTIKKED HHHHHHHHHEECHHH | 53.16 | - | |
| 105 | Phosphorylation | IMTEMEISRAAAERS HHHHHHHHHHHHHHH | 11.54 | 28555341 | |
| 112 | Phosphorylation | SRAAAERSLREHMGN HHHHHHHHHHHHHHH | 24.23 | - | |
| 117 | Sulfoxidation | ERSLREHMGNVVEAL HHHHHHHHHHHHHHH | 3.42 | 21406390 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HYPK_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HYPK_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HYPK_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Acetylation | |
| Reference | PubMed |
| "Substrate and functional diversity of lysine acetylation revealed bya proteomics survey."; Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.; Mol. Cell 23:607-618(2006). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-35, AND MASS SPECTROMETRY. | |
