VPP4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VPP4_HUMAN
• UniProt AC: Q9HBG4
• Protein Name: V-type proton ATPase 116 kDa subunit a isoform 4
• Gene Name: ATP6V0A4
• Organism: Homo sapiens (Human).
• Sequence Length: 840
• Subcellular Localization: Apical cell membrane; Multi-pass membrane protein. Present at high density almost exclusively on the apical surface of alpha-intercalated cells in the cortical collecting ducts of the distal nephron.
• Protein Description: Part of the proton channel of the V-ATPase that is involved in normal vectorial acid transport into the urine by the kidney..
• Protein Sequence: MVSVFRSEEMCLSQLFLQVEAAYCCVAELGELGLVQFKDLNMNVNSFQRKFVNEVRRCESLERILRFLEDEMQNEIVVQLLEKSPLTPLPREMITLETVLEKLEGELQEANQNQQALKQSFLELTELKYLLKKTQDFFETETNLADDFFTEDTSGLLELKAVPAYMTGKLGFIAGVINRERMASFERLLWRICRGNVYLKFSEMDAPLEDPVTKEEIQKNIFIIFYQGEQLRQKIKKICDGFRATVYPCPEPAVERREMLESVNVRLEDLITVITQTESHRQRLLQEAAANWHSWLIKVQKMKAVYHILNMCNIDVTQQCVIAEIWFPVADATRIKRALEQGMELSGSSMAPIMTTVQSKTAPPTFNRTNKFTAGFQNIVDAYGVGSYREINPAPYTIITFPFLFAVMFGDCGHGTVMLLAALWMILNERRLLSQKTDNEIWNTFFHGRYLILLMGIFSIYTGLIYNDCFSKSLNIFGSSWSVQPMFRNGTWNTHVMEESLYLQLDPAIPGVYFGNPYPFGIDPIWNLASNKLTFLNSYKMKMSVILGIVQMVFGVILSLFNHIYFRRTLNIILQFIPEMIFILCLFGYLVFMIIFKWCCFDVHVSQHAPSILIHFINMFLFNYSDSSNAPLYKHQQEVQSFFVVMALISVPWMLLIKPFILRASHRKSQLQASRIQEDATENIEGDSSSPSSRSGQRTSADTHGALDDHGEEFNFGDVFVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVMNSGLQTRGWGGIVGVFIIFAVFAVLTVAILLIMEGLSAFLHALRLHWVEFQNKFYVGDGYKFSPFSFKHILDGTAEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
50	Ubiquitination	NVNSFQRKFVNEVRR CHHHHHHHHHHHHHH	42.77	-
87	Phosphorylation	LLEKSPLTPLPREMI HHHCCCCCCCCHHHH	26.60	-
95	Phosphorylation	PLPREMITLETVLEK CCCHHHHHHHHHHHH	19.75	20068231
98	Phosphorylation	REMITLETVLEKLEG HHHHHHHHHHHHHHH	33.24	20068231
118	Ubiquitination	NQNQQALKQSFLELT HHHHHHHHHHHHHHH	47.08	-
125	Phosphorylation	KQSFLELTELKYLLK HHHHHHHHHHHHHHH	29.87	-
306	Phosphorylation	VQKMKAVYHILNMCN HHHHHHHHHHHHHCC	6.49	-
333	Phosphorylation	WFPVADATRIKRALE ECCHHCHHHHHHHHH	33.21	-
346	Phosphorylation	LEQGMELSGSSMAPI HHHCCCCCCCCCCCC	24.27	26434776
348	Phosphorylation	QGMELSGSSMAPIMT HCCCCCCCCCCCCCC	17.36	26434776
349	Phosphorylation	GMELSGSSMAPIMTT CCCCCCCCCCCCCCE	23.61	26434776
355	Phosphorylation	SSMAPIMTTVQSKTA CCCCCCCCEECCCCC	25.24	26434776
356	Phosphorylation	SMAPIMTTVQSKTAP CCCCCCCEECCCCCC	10.12	26434776
359	Phosphorylation	PIMTTVQSKTAPPTF CCCCEECCCCCCCCC	27.86	26434776
361	Phosphorylation	MTTVQSKTAPPTFNR CCEECCCCCCCCCCC	50.04	30242111
365	Phosphorylation	QSKTAPPTFNRTNKF CCCCCCCCCCCCCCC	32.27	30242111
369	Phosphorylation	APPTFNRTNKFTAGF CCCCCCCCCCCCCCC	43.81	30242111
373	Phosphorylation	FNRTNKFTAGFQNIV CCCCCCCCCCCHHHH	27.72	24719451
387	Phosphorylation	VDAYGVGSYREINPA HHHHCCCCCCCCCCC	20.71	24719451
388	Phosphorylation	DAYGVGSYREINPAP HHHCCCCCCCCCCCC	13.31	24719451
544	Phosphorylation	NSYKMKMSVILGIVQ HHHHHHHHHHHHHHH	10.65	-
681	Phosphorylation	SRIQEDATENIEGDS HHHCCCCCCCCCCCC	41.72	20068231
688	Phosphorylation	TENIEGDSSSPSSRS CCCCCCCCCCCCCCC	43.50	20068231
689	Phosphorylation	ENIEGDSSSPSSRSG CCCCCCCCCCCCCCC	51.51	30576142
690	Phosphorylation	NIEGDSSSPSSRSGQ CCCCCCCCCCCCCCC	32.52	30576142
692	Phosphorylation	EGDSSSPSSRSGQRT CCCCCCCCCCCCCCC	40.09	18669648
693	Phosphorylation	GDSSSPSSRSGQRTS CCCCCCCCCCCCCCC	33.57	20068231
829	Phosphorylation	GYKFSPFSFKHILDG CCCCCCCCHHHHCCC	36.45	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VPP4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VPP4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VPP4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PFKAM_HUMAN	PFKM	physical	12649290
VATB1_HUMAN	ATP6V1B1	physical	27127844

Drug and Disease Associations

• Kegg Disease
• H00428: Distal renal tubular acidosis (RTA type 1)
• OMIM Disease
• 602722: Renal tubular acidosis, distal, autosomal recessive (RTADR)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.