MYOM3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYOM3_HUMAN
• UniProt AC: Q5VTT5
• Protein Name: Myomesin-3
• Gene Name: MYOM3
• Organism: Homo sapiens (Human).
• Sequence Length: 1437
• Subcellular Localization: Cytoplasm, myofibril, sarcomere, M line.
• Protein Description: May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle..
• Protein Sequence: MTLPHSLGGAGDPRPPQAMEVHRLEHRQEEEQKEERQHSLRMGSSVRRRTFRSSEEEHEFSAADYALAAALALTASSELSWEAQLRRQTSAVELEERGQKRVGFGNDWERTEIAFLQTHRLLRQRRDWKTLRRRTEEKVQEAKELRELCYGRGPWFWIPLRSHAVWEHTTVLLTCTVQASPPPQVTWYKNDTRIDPRLFRAGKYRITNNYGLLSLEIRRCAIEDSATYTVRVKNAHGQASSFAKVLVRTYLGKDAGFDSEIFKRSTFGPSVEFTSVLKPVFAREKEPFSLSCLFSEDVLDAESIQWFRDGSLLRSSRRRKILYTDRQASLKVSCTYKEDEGLYMVRVPSPFGPREQSTYVLVRDAEAENPGAPGSPLNVRCLDVNRDCLILTWAPPSDTRGNPITAYTIERCQGESGEWIACHEAPGGTCRCPIQGLVEGQSYRFRVRAISRVGSSVPSKASELVVMGDHDAARRKTEIPFDLGNKITISTDAFEDTVTIPSPPTNVHASEIREAYVVLAWEEPSPRDRAPLTYSLEKSVIGSGTWEAISSESPVRSPRFAVLDLEKKKSYVFRVRAMNQYGLSDPSEPSEPIALRGPPATLPPPAQVQAFRDTQTSVSLTWDPVKDPELLGYYIYSRKVGTSEWQTVNNKPIQGTRFTVPGLRTGKEYEFCVRSVSEAGVGESSAATEPIRVKQALATPSAPYGFALLNCGKNEMVIGWKPPKRRGGGKILGYFLDQHDSEELDWHAVNQQPIPTRVCKVSDLHEGHFYEFRARAANWAGVGELSAPSSLFECKEWTMPQPGPPYDVRASEVRATSLVLQWEPPLYMGAGPVTGYHVSFQEEGSEQWKPVTPGPISGTHLRVSDLQPGKSYVFQVQAMNSAGLGQPSMPTDPVLLEDKPGAHEIEVGVDEEGFIYLAFEAPEAPDSSEFQWSKDYKGPLDPQRVKIEDKVNKSKVILKEPGLEDLGTYSVIVTDADEDISASHTLTEEELEKLKKLSHEIRNPVIKLISGWNIDILERGEVRLWLEVEKLSPAAELHLIFNNKEIFSSPNRKINFDREKGLVEVIIQNLSEEDKGSYTAQLQDGKAKNQITLTLVDDDFDKLLRKADAKRRDWKRKQGPYFERPLQWKVTEDCQVQLTCKVTNTKKETRFQWFFQRAEMPDGQYDPETGTGLLCIEELSKKDKGIYRAMVSDDRGEDDTILDLTGDALDAIFTELGRIGALSATPLKIQGTEEGIRIFSKVKYYNVEYMKTTWFHKDKRLESGDRIRTGTTLDEIWLHILDPKDSDKGKYTLEIAAGKEVRQLSTDLSGQAFEDAMAEHQRLKTLAIIEKNRAKVVRGLPDVATIMEDKTLCLTCIVSGDPTPEISWLKNDQPVTFLDRYRMEVRGTEVTITIEKVNSEDSGRYGVFVKNKYGSETGQVTISVFKHGDEPKELKSM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Phosphorylation	HSLRMGSSVRRRTFR HHHHHCHHHHHHCCC	17.57	26437602
50	Phosphorylation	GSSVRRRTFRSSEEE CHHHHHHCCCCCHHH	22.91	-
89	Phosphorylation	EAQLRRQTSAVELEE HHHHHHCCCCEEHHH	19.49	19764811
90	Phosphorylation	AQLRRQTSAVELEER HHHHHCCCCEEHHHH	23.21	19764811
188	Phosphorylation	PPPQVTWYKNDTRID CCCCEEEEECCCCCC	7.19	-
192	Phosphorylation	VTWYKNDTRIDPRLF EEEEECCCCCCHHHH	38.63	26437602
210	Phosphorylation	KYRITNNYGLLSLEI CEEEECCCCEEEEEE	15.95	-
214	Phosphorylation	TNNYGLLSLEIRRCA ECCCCEEEEEEEEEE	29.06	24719451
227	Phosphorylation	CAIEDSATYTVRVKN EECCCCEEEEEEEEC	24.55	26437602
229	Phosphorylation	IEDSATYTVRVKNAH CCCCEEEEEEEECCC	9.47	-
240	Phosphorylation	KNAHGQASSFAKVLV ECCCCCHHHHHHHHH	20.35	26437602
241	Phosphorylation	NAHGQASSFAKVLVR CCCCCHHHHHHHHHH	32.04	22673903
263	Acetylation	GFDSEIFKRSTFGPS CCCHHHHHCCCCCCC	51.61	30590645
270	Phosphorylation	KRSTFGPSVEFTSVL HCCCCCCCCEEEECC	34.36	30631047
275	Phosphorylation	GPSVEFTSVLKPVFA CCCCEEEECCCCHHC	30.67	30631047
311	Phosphorylation	IQWFRDGSLLRSSRR CHHHCCCCCCCCCCC	28.64	22673903
316	Phosphorylation	DGSLLRSSRRRKILY CCCCCCCCCCCEEEE	24.31	26437602
323	Phosphorylation	SRRRKILYTDRQASL CCCCEEEEECCCCEE	15.29	-
335	Phosphorylation	ASLKVSCTYKEDEGL CEEEEEEEEECCCCE	30.07	26437602
336	Phosphorylation	SLKVSCTYKEDEGLY EEEEEEEEECCCCEE	19.39	-
343	Phosphorylation	YKEDEGLYMVRVPSP EECCCCEEEEEECCC	12.38	24719451
349	Phosphorylation	LYMVRVPSPFGPREQ EEEEEECCCCCCCCC	29.97	29396449
375	Phosphorylation	ENPGAPGSPLNVRCL CCCCCCCCCCEEEEE	25.75	26437602
442	Phosphorylation	QGLVEGQSYRFRVRA CCCCCCCEEEEEEEE	29.18	26437602
451	Phosphorylation	RFRVRAISRVGSSVP EEEEEEEEECCCCCC	21.67	24719451
455	Phosphorylation	RAISRVGSSVPSKAS EEEEECCCCCCCCCC	25.88	26699800
456	Phosphorylation	AISRVGSSVPSKASE EEEECCCCCCCCCCE	31.92	24719451
459	Phosphorylation	RVGSSVPSKASELVV ECCCCCCCCCCEEEE	38.40	24719451
477	Phosphorylation	HDAARRKTEIPFDLG HHHHHCCCCCCCCCC	37.02	26437602
539	Phosphorylation	LTYSLEKSVIGSGTW CEEEECEEEECCCCC	15.02	26437602
543	Phosphorylation	LEKSVIGSGTWEAIS ECEEEECCCCCEEEC	23.17	22673903
545	Phosphorylation	KSVIGSGTWEAISSE EEEECCCCCEEECCC	23.10	22673903
550	Phosphorylation	SGTWEAISSESPVRS CCCCEEECCCCCCCC	34.79	22673903
551	Phosphorylation	GTWEAISSESPVRSP CCCEEECCCCCCCCC	35.66	22673903
553	Phosphorylation	WEAISSESPVRSPRF CEEECCCCCCCCCEE	30.55	26437602
557	Phosphorylation	SSESPVRSPRFAVLD CCCCCCCCCEEEEEE	22.21	22673903
568	Acetylation	AVLDLEKKKSYVFRV EEEECCCCCEEEEEE	37.26	30590639
571	Phosphorylation	DLEKKKSYVFRVRAM ECCCCCEEEEEEEEE	16.70	24719451
637	Phosphorylation	LLGYYIYSRKVGTSE HHEEEEEECCCCCCC	18.96	24719451
642	Phosphorylation	IYSRKVGTSEWQTVN EEECCCCCCCCEEEC	26.85	26437602
643	Phosphorylation	YSRKVGTSEWQTVNN EECCCCCCCCEEECC	30.80	26437602
669	Phosphorylation	GLRTGKEYEFCVRSV CCCCCCEEEEEEEEH	20.14	30624053
675	Phosphorylation	EYEFCVRSVSEAGVG EEEEEEEEHHHCCCC	15.03	26437602
677	Phosphorylation	EFCVRSVSEAGVGES EEEEEEHHHCCCCCC	23.99	26437602
684	Phosphorylation	SEAGVGESSAATEPI HHCCCCCCCCCCCCC	21.24	30624053
685	Phosphorylation	EAGVGESSAATEPIR HCCCCCCCCCCCCCC	20.02	30624053
688	Phosphorylation	VGESSAATEPIRVKQ CCCCCCCCCCCCCEE	41.85	24719451
864	Phosphorylation	SGTHLRVSDLQPGKS CCCEEEECCCCCCCE	26.60	26437602
1048	Phosphorylation	FNNKEIFSSPNRKIN ECCCCCCCCCCCEEC	51.01	26437602
1049	Phosphorylation	NNKEIFSSPNRKINF CCCCCCCCCCCEECC	18.55	26437602
1139	Phosphorylation	EDCQVQLTCKVTNTK CCCEEEEEEEECCCC	8.00	26437602
1143	Phosphorylation	VQLTCKVTNTKKETR EEEEEEECCCCCEEE	23.75	26437602
1169	Phosphorylation	DGQYDPETGTGLLCI CCCCCCCCCCEEEEH	45.49	22210691
1171	Phosphorylation	QYDPETGTGLLCIEE CCCCCCCCEEEEHHH	31.88	22210691
1180	Phosphorylation	LLCIEELSKKDKGIY EEEHHHHHHCCCCEE	40.72	22210691
1184	Acetylation	EELSKKDKGIYRAMV HHHHHCCCCEEEEEE	56.97	45919633
1240	Phosphorylation	EEGIRIFSKVKYYNV HHHEEEEEEEEEEEE	33.88	24719451
1244	Phosphorylation	RIFSKVKYYNVEYMK EEEEEEEEEEEEEEE	11.85	25907765
1245	Phosphorylation	IFSKVKYYNVEYMKT EEEEEEEEEEEEEEC	13.65	25907765
1249	Phosphorylation	VKYYNVEYMKTTWFH EEEEEEEEEECEEEE	10.30	24719451
1252	Phosphorylation	YNVEYMKTTWFHKDK EEEEEEECEEEECCC	16.84	24719451
1253	Phosphorylation	NVEYMKTTWFHKDKR EEEEEECEEEECCCC	22.18	26437602
1263	Phosphorylation	HKDKRLESGDRIRTG ECCCCCCCCCCCCCC	51.06	24719451
1291	Phosphorylation	KDSDKGKYTLEIAAG CCCCCCCEEEEEECC	25.81	-
1305	Phosphorylation	GKEVRQLSTDLSGQA CHHHEEECCCCCCHH	16.13	26437602
1306	Phosphorylation	KEVRQLSTDLSGQAF HHHEEECCCCCCHHH	49.94	22673903
1309	Phosphorylation	RQLSTDLSGQAFEDA EEECCCCCCHHHHHH	31.50	26437602

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYOM3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYOM3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYOM3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MYOM3_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.