ZN462_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN462_HUMAN
• UniProt AC: Q96JM2
• Protein Name: Zinc finger protein 462
• Gene Name: ZNF462
• Organism: Homo sapiens (Human).
• Sequence Length: 2506
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MEVLQCDGCDFRAPSYEDLKAHIQDVHTAFLQPTDVAEDNVNELRCGSVNASNQTEVEFSSIKDEFAIAEDLSGQNATSLGTGGYYGHSPGYYGQHIAANPKPTNKFFQCKFCVRYFRSKNLLIEHTRKVHGAQAEGSSSGPPVPGSLNYNIMMHEGFGKVFSCQFCTYKSPRRARIIKHQKMYHKNNLKETTAPPPAPAPMPDPVVPPVSLQDPCKELPAEVVERSILESMVKPLTKSRGNFCCEWCSYQTPRRERWCDHMMKKHRSMVKILSSLRQQQEGTNLPDVPNKSAPSPTSNSTYLTMNAASREIPNTTVSNFRGSMGNSIMRPNSSASKFSPMSYPQMKPKSPHNSGLVNLTERSRYGMTDMTNSSADLETNSMLNDSSSDEELNEIDSENGLSAMDHQTSGLSAEQLMGSDGNKLLETKGIPFRRFMNRFQCPFCPFLTMHRRSISRHIENIHLSGKTAVYKCDECPFTCKSSLKLGAHKQCHTGTTSDWDAVNSQSESISSSLNEGVVSYESSSINGRKSGVMLDPLQQQQPPQPPPPPPPPPPSQPQPLQQPQPPQLQPPHQVPPQPQTQPPPTQQPQPPTQAAPLHPYKCTMCNYSTTTLKGLRVHQQHKHSFCDNLPKFEGQPSSLPLENETDSHPSSSNTVKKSQTSILGLSSKNNFVAKASRKLANDFPLDLSPVKKRTRIDEIASNLQSKINQTKQQEDAVINVEDDEEEEEDNEVEIEVELDREEEPTEPIIEVPTSFSAQQIWVRDTSEPQKEPNFRNITHDYNATNGAEIELTLSEDEEDYYGSSTNLKDHQVSNTALLNTQTPIYGTEHNSENTDFGDSGRLYYCKHCDFNNKSARSVSTHYQRMHPYIKFSFRYILDPNDHSAVYRCLECYIDYTNFEDLQQHYGEHHPEAMNVLNFDHSDLIYRCRFCSYTSPNVRSLMPHYQRMHPTVKINNAMIFSSYVVEQQEGLNTESQTLREILNSAPKNMATSTPVARGGGLPATFNKNTPKTFTPECENQKDPLVNTVVVYDCDVCSFASPNMHSVLVHYQKKHPEEKASYFRIQKTMRMVSVDRGSALSQLSFEVGAPMSPKMSNMGSPPPPQPPPPDLSTELYYCKHCSYSNRSVVGVLVHYQKRHPEIKVTAKYIRQAPPTAAMMRGVEGPQGSPRPPAPIQQLNRSSSERDGPPVENEMFFCQHCDYGNRTVKGVLIHYQKKHRDFKANADVIRQHTATIRSLCDRNQKKPASCVLVSPSNLERDKTKLRALKCRQCSYTSPYFYALRKHIKKDHPALKATVTSIMRWAFLDGLIEAGYHCEWCIYSHTEPNGLLLHYQRRHPEHYVDYTYMATKLWAGPDPSPPSLTMPAEAKTYRCRDCVFEAVSIWDITNHYQAFHPWAMNGDESVLLDIIKEKDAVEKPILSSEELAGPVNCENSIPTPFPEQEAECPEDARLSPEKSLQLASANPAISSTPYQCTVCQSEYNNLHGLLTHYGKKHPGMKVKAADFAQDIDINPGAVYKCRHCPYINTRIHGVLTHYQKRHPSIKVTAEDFVHDVEQSADISQNDVEETSRIFKQGYGAYRCKLCPYTHGTLEKLKIHYEKYHNQPEFDVFSQSPPKLPVPLEPEMTTEVSPSQVSITEEEVGEEPVSTSHFSTSHLVSHTVFRCQLCKYFCSTRKGIARHYRIKHNNVRAQPEGKNNLFKCALCAYTNPIRKGLAAHYQKRHDIDAYYTHCLAASRTISDKPNKVIIPSPPKDDSPQLSEELRRAVEKKKCSLCSFQSFSKKGIVSHYMKRHPGVFPKKQHASKLGGYFTAVYADEHEKPTLMEEEERGNFEKAEVEGEAQEIEWLPFRCIKCFKLSFSTAELLCMHYTDHHSRDLKRDFIILGNGPRLQNSTYQCKHCDSKLQSTAELTSHLNIHNEEFQKRAKRQERRKQLLSKQKYADGAFADFKQERPFGHLEEVPKIKERKVVGYKCKFCVEVHPTLRAICNHLRKHVQYGNVPAVSAAVKGLRSHERSHLALAMFTREDKYSCQYCSFVSAFRHNLDRHMQTHHGHHKPFRCKLCSFKSSYNSRLKTHILKAHAGEHAYKCSWCSFSTMTISQLKEHSLKVHGKALTLPRPRIVSLLSSHSHHSSQKATPAEEVEDSNDSSYSEPPDVQQQLNHYQSAALARNNSRVSPVPLSGAAAGTEQKTEAVLHCEFCEFSSGYIQSIRRHYRDKHGGKKLFKCKDCSFYTGFKSAFTMHVEAGHSAVPEEGPKDLRCPLCLYHTKYKRNMIDHIVLHREERVVPIEVCRSKLSKYLQGVVFRCDKCTFTCSSDESLQQHIEKHNELKPYKCQLCYYETKHTEELDSHLRDEHKVSRNFELVGRVNLDQLEQMKEKMESSSSDDEDKEEEMNSKAEDRELMRFSDHGAALNTEKRFPCEFCGRAFSQGSEWERHVLRHGMALNDTKQVSREEIHPKEIMENSVKMPSIEEKEDDEAIGIDFSLKNETVAICVVTADKSLLENAEAKKE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	GCDFRAPSYEDLKAH CCCCCCCCHHHHHHH	39.92	23312004
16	Phosphorylation	CDFRAPSYEDLKAHI CCCCCCCHHHHHHHH	16.65	23312004
20	Sumoylation	APSYEDLKAHIQDVH CCCHHHHHHHHHHHH	50.68	-
20	Sumoylation	APSYEDLKAHIQDVH CCCHHHHHHHHHHHH	50.68	25114211
171	Phosphorylation	CQFCTYKSPRRARII EEECCCCCCCHHHHH	17.15	29214152
234	Sumoylation	SILESMVKPLTKSRG HHHHHHHHHCCCCCC	26.18	-
234	Sumoylation	SILESMVKPLTKSRG HHHHHHHHHCCCCCC	26.18	28112733
252	Phosphorylation	CEWCSYQTPRRERWC CHHHCCCCCCHHHHH	15.55	28555341
268	O-linked_Glycosylation	HMMKKHRSMVKILSS HHHHHHHHHHHHHHH	27.87	30379171
271	Sumoylation	KKHRSMVKILSSLRQ HHHHHHHHHHHHHHH	29.32	28112733
274	Phosphorylation	RSMVKILSSLRQQQE HHHHHHHHHHHHHHC	30.69	17081983
275	Phosphorylation	SMVKILSSLRQQQEG HHHHHHHHHHHHHCC	24.91	25954137
292	O-linked_Glycosylation	LPDVPNKSAPSPTSN CCCCCCCCCCCCCCC	52.64	22826440
295	Phosphorylation	VPNKSAPSPTSNSTY CCCCCCCCCCCCCCE	40.29	28985074
297	Phosphorylation	NKSAPSPTSNSTYLT CCCCCCCCCCCCEEE	44.90	28555341
301	Phosphorylation	PSPTSNSTYLTMNAA CCCCCCCCEEEECCC	27.14	28555341
309	O-linked_Glycosylation	YLTMNAASREIPNTT EEEECCCCCCCCCCC	28.21	22826440
323	Phosphorylation	TVSNFRGSMGNSIMR CEECCCCCCCCCCCC	21.18	-
327	Phosphorylation	FRGSMGNSIMRPNSS CCCCCCCCCCCCCCC	16.42	30576142
333	Phosphorylation	NSIMRPNSSASKFSP CCCCCCCCCCCCCCC	29.93	27251275
334	Phosphorylation	SIMRPNSSASKFSPM CCCCCCCCCCCCCCC	43.11	30576142
336	Phosphorylation	MRPNSSASKFSPMSY CCCCCCCCCCCCCCC	35.86	-
337	Sumoylation	RPNSSASKFSPMSYP CCCCCCCCCCCCCCC	49.96	28112733
339	Phosphorylation	NSSASKFSPMSYPQM CCCCCCCCCCCCCCC	24.35	27732954
343	Phosphorylation	SKFSPMSYPQMKPKS CCCCCCCCCCCCCCC	7.39	30576142
347	Sumoylation	PMSYPQMKPKSPHNS CCCCCCCCCCCCCCC	44.01	28112733
349	Sumoylation	SYPQMKPKSPHNSGL CCCCCCCCCCCCCCC	71.72	28112733
350	Phosphorylation	YPQMKPKSPHNSGLV CCCCCCCCCCCCCCC	39.66	30266825
354	Phosphorylation	KPKSPHNSGLVNLTE CCCCCCCCCCCCCCC	30.39	30266825
428	Sumoylation	GNKLLETKGIPFRRF CCHHHHCCCCCHHHH	45.53	28112733
453	Phosphorylation	FLTMHRRSISRHIEN HHHHCHHHHHHHHHE	25.52	21406692
455	Phosphorylation	TMHRRSISRHIENIH HHCHHHHHHHHHEEE	21.03	21406692
464	Phosphorylation	HIENIHLSGKTAVYK HHHEEECCCCEEEEE	24.87	21406692
467	Phosphorylation	NIHLSGKTAVYKCDE EEECCCCEEEEECCC	25.53	25219547
470	Phosphorylation	LSGKTAVYKCDECPF CCCCEEEEECCCCCC	11.93	25219547
484	Sumoylation	FTCKSSLKLGAHKQC CCCCCCCCCCCCCCC	46.99	28112733
607	Phosphorylation	YKCTMCNYSTTTLKG CCCCCCCCCCCCCCC	11.49	21712546
609	Phosphorylation	CTMCNYSTTTLKGLR CCCCCCCCCCCCCCC	17.28	21712546
624	Phosphorylation	VHQQHKHSFCDNLPK HHHHCCCCCCCCCCC	32.16	27732954
631	Sumoylation	SFCDNLPKFEGQPSS CCCCCCCCCCCCCCC	60.25	28112733
637	Phosphorylation	PKFEGQPSSLPLENE CCCCCCCCCCCCCCC	36.30	23312004
638	Phosphorylation	KFEGQPSSLPLENET CCCCCCCCCCCCCCC	40.46	23312004
645	Phosphorylation	SLPLENETDSHPSSS CCCCCCCCCCCCCCC	55.15	23312004
647	Phosphorylation	PLENETDSHPSSSNT CCCCCCCCCCCCCCC	44.72	23312004
650	Phosphorylation	NETDSHPSSSNTVKK CCCCCCCCCCCCCCH	40.76	23312004
651	Phosphorylation	ETDSHPSSSNTVKKS CCCCCCCCCCCCCHH	31.87	23312004
652	Phosphorylation	TDSHPSSSNTVKKSQ CCCCCCCCCCCCHHH	40.64	23312004
654	Phosphorylation	SHPSSSNTVKKSQTS CCCCCCCCCCHHHCC	35.33	23312004
657	Sumoylation	SSSNTVKKSQTSILG CCCCCCCHHHCCCCC	43.38	28112733
658	Phosphorylation	SSNTVKKSQTSILGL CCCCCCHHHCCCCCC	32.73	21406692
660	Phosphorylation	NTVKKSQTSILGLSS CCCCHHHCCCCCCCC	25.48	21406692
661	Phosphorylation	TVKKSQTSILGLSSK CCCHHHCCCCCCCCC	14.26	24173317
668	Sumoylation	SILGLSSKNNFVAKA CCCCCCCCCCHHHHH	53.16	28112733
674	Methylation	SKNNFVAKASRKLAN CCCCHHHHHHHHHHH	41.41	-
688	Phosphorylation	NDFPLDLSPVKKRTR HCCCCCCCCCCHHHC	27.58	19664994
694	Phosphorylation	LSPVKKRTRIDEIAS CCCCCHHHCHHHHHH	40.64	27174698
701	Phosphorylation	TRIDEIASNLQSKIN HCHHHHHHHHHHHHH	43.67	25159151
705	Phosphorylation	EIASNLQSKINQTKQ HHHHHHHHHHHHCCC	38.37	27174698
706	Sumoylation	IASNLQSKINQTKQQ HHHHHHHHHHHCCCC	32.49	28112733
778	Phosphorylation	EPNFRNITHDYNATN CCCCCCCCCCCCCCC	16.55	-
834	Phosphorylation	TEHNSENTDFGDSGR CCCCCCCCCCCCCCC	28.75	-
870 (in isoform 2)	Phosphorylation	-	29.16	21406692
872	Phosphorylation	MHPYIKFSFRYILDP HCCCEEEEEEEEECC	12.10	24719451
931	Phosphorylation	IYRCRFCSYTSPNVR HHCCCCCCCCCCCHH	28.83	24719451
934	Phosphorylation	CRFCSYTSPNVRSLM CCCCCCCCCCHHHHC	13.27	28555341
983	Phosphorylation	TLREILNSAPKNMAT HHHHHHHHCCCCCCC	42.37	-
986	Sumoylation	EILNSAPKNMATSTP HHHHHCCCCCCCCCC	60.10	28112733
986	Ubiquitination	EILNSAPKNMATSTP HHHHHCCCCCCCCCC	60.10	-
990	Phosphorylation	SAPKNMATSTPVARG HCCCCCCCCCCCCCC	23.51	29396449
991	Phosphorylation	APKNMATSTPVARGG CCCCCCCCCCCCCCC	22.60	29396449
992	Phosphorylation	PKNMATSTPVARGGG CCCCCCCCCCCCCCC	19.89	29396449
996	Methylation	ATSTPVARGGGLPAT CCCCCCCCCCCCCCC	44.52	115920493
1008	Phosphorylation	PATFNKNTPKTFTPE CCCCCCCCCCCCCHH	27.98	28348404
1013	Phosphorylation	KNTPKTFTPECENQK CCCCCCCCHHHCCCC	24.33	21815630
1026	Phosphorylation	QKDPLVNTVVVYDCD CCCCCCCEEEEEECC	13.75	28270605
1030	Phosphorylation	LVNTVVVYDCDVCSF CCCEEEEEECCCCCC	10.15	28270605
1036	Phosphorylation	VYDCDVCSFASPNMH EEECCCCCCCCCCCH	24.56	28270605
1039	Phosphorylation	CDVCSFASPNMHSVL CCCCCCCCCCCHHHH	18.13	28270605
1044	Phosphorylation	FASPNMHSVLVHYQK CCCCCCHHHHHHHHH	13.33	28270605
1052	Ubiquitination	VLVHYQKKHPEEKAS HHHHHHHHCHHHHHH	49.19	-
1076	Phosphorylation	MVSVDRGSALSQLSF EEEECCCCHHHHHCE	27.25	26074081
1079	Phosphorylation	VDRGSALSQLSFEVG ECCCCHHHHHCEECC	28.88	26074081
1082	Phosphorylation	GSALSQLSFEVGAPM CCHHHHHCEECCCCC	16.24	22199227
1090	Phosphorylation	FEVGAPMSPKMSNMG EECCCCCCCCCCCCC	21.95	30266825
1135	Sumoylation	GVLVHYQKRHPEIKV EEEEEEHHHCCCCEE	45.57	28112733
1145	Ubiquitination	PEIKVTAKYIRQAPP CCCEEEHHHHHHCCC	31.67	-
1166	Phosphorylation	GVEGPQGSPRPPAPI CCCCCCCCCCCCCCH	16.70	30266825
1179	Phosphorylation	PIQQLNRSSSERDGP CHHHCCCCCCCCCCC	36.82	28348404
1180	Phosphorylation	IQQLNRSSSERDGPP HHHCCCCCCCCCCCC	32.74	28348404
1181	Phosphorylation	QQLNRSSSERDGPPV HHCCCCCCCCCCCCC	37.59	28348404
1206	Sumoylation	DYGNRTVKGVLIHYQ CCCCCEEEEEEEEEH	42.56	28112733
1214	Sumoylation	GVLIHYQKKHRDFKA EEEEEEHHHCCCHHH	43.30	28112733
1220	Sumoylation	QKKHRDFKANADVIR HHHCCCHHHCHHHHH	45.05	28112733
1243	Sumoylation	LCDRNQKKPASCVLV HHHCCCCCCCCEEEE	35.73	28112733
1251	Phosphorylation	PASCVLVSPSNLERD CCCEEEECHHHHCCC	20.60	28985074
1253	Phosphorylation	SCVLVSPSNLERDKT CEEEECHHHHCCCHH	46.68	29396449
1271	Phosphorylation	ALKCRQCSYTSPYFY HHHCCCCCCCCHHHH	24.09	26074081
1272	Phosphorylation	LKCRQCSYTSPYFYA HHCCCCCCCCHHHHH	20.90	26074081
1273	Phosphorylation	KCRQCSYTSPYFYAL HCCCCCCCCHHHHHH	13.61	26074081
1274	Phosphorylation	CRQCSYTSPYFYALR CCCCCCCCHHHHHHH	14.90	26074081
1276	Phosphorylation	QCSYTSPYFYALRKH CCCCCCHHHHHHHHH	14.69	26074081
1278	Phosphorylation	SYTSPYFYALRKHIK CCCCHHHHHHHHHHH	10.01	26074081
1285	Sumoylation	YALRKHIKKDHPALK HHHHHHHHCCCHHHH	52.44	-
1330	Phosphorylation	EPNGLLLHYQRRHPE CCCCEEEEEHHCCHH	19.35	17525332
1356	Phosphorylation	LWAGPDPSPPSLTMP CCCCCCCCCCCCCCC	57.74	19664995
1359	Phosphorylation	GPDPSPPSLTMPAEA CCCCCCCCCCCCCCC	39.60	27732954
1361	Phosphorylation	DPSPPSLTMPAEAKT CCCCCCCCCCCCCCC	25.99	27732954
1435	Phosphorylation	NCENSIPTPFPEQEA CCCCCCCCCCCHHHC	35.57	27251275
1451	Phosphorylation	CPEDARLSPEKSLQL CCCCCCCCHHHHHHH	26.01	28176443
1499	Sumoylation	KHPGMKVKAADFAQD CCCCCEEEHHHHHHC	32.13	28112733
1515	Phosphorylation	DINPGAVYKCRHCPY CCCCCCEEEEECCCC	12.11	25954137
1525	O-linked_Glycosylation	RHCPYINTRIHGVLT ECCCCCCHHHHHHHH	22.80	30379171
1555	Phosphorylation	FVHDVEQSADISQND HHHCHHHCCCCCCCC	17.88	27732954
1559	Phosphorylation	VEQSADISQNDVEET HHHCCCCCCCCHHHH	24.39	28387310
1566	Phosphorylation	SQNDVEETSRIFKQG CCCCHHHHHHHHHHC	15.14	27732954
1567	Phosphorylation	QNDVEETSRIFKQGY CCCHHHHHHHHHHCC	27.02	27732954
1571	Sumoylation	EETSRIFKQGYGAYR HHHHHHHHHCCCEEE	40.20	-
1571	Sumoylation	EETSRIFKQGYGAYR HHHHHHHHHCCCEEE	40.20	28112733
1584	Phosphorylation	YRCKLCPYTHGTLEK EECEECCCCCCHHHH	15.46	25072903
1585	Phosphorylation	RCKLCPYTHGTLEKL ECEECCCCCCHHHHH	10.04	25072903
1588	Phosphorylation	LCPYTHGTLEKLKIH ECCCCCCHHHHHHHH	24.92	25072903
1591	Sumoylation	YTHGTLEKLKIHYEK CCCCHHHHHHHHHHH	59.18	28112733
1609	Phosphorylation	QPEFDVFSQSPPKLP CCCCCCCCCCCCCCC	29.60	25850435
1611	Phosphorylation	EFDVFSQSPPKLPVP CCCCCCCCCCCCCCC	41.81	25850435
1698	Methylation	EGKNNLFKCALCAYT CCCCCHHHHHHHHHC	23.05	115978191
1698	Sumoylation	EGKNNLFKCALCAYT CCCCCHHHHHHHHHC	23.05	28112733
1718	Ubiquitination	GLAAHYQKRHDIDAY HHHHHHHHHHCCHHH	44.53	-
1725	Phosphorylation	KRHDIDAYYTHCLAA HHHCCHHHHHHHHHH	12.73	-
1726	Phosphorylation	RHDIDAYYTHCLAAS HHCCHHHHHHHHHHC	7.54	-
1727	Phosphorylation	HDIDAYYTHCLAASR HCCHHHHHHHHHHCC	8.08	-
1733	Phosphorylation	YTHCLAASRTISDKP HHHHHHHCCCCCCCC	25.09	-
1747	Phosphorylation	PNKVIIPSPPKDDSP CCCEEECCCCCCCCH	43.35	30266825
1753	Phosphorylation	PSPPKDDSPQLSEEL CCCCCCCCHHHHHHH	25.36	30266825
1757	Phosphorylation	KDDSPQLSEELRRAV CCCCHHHHHHHHHHH	24.63	23927012
1768	Sumoylation	RRAVEKKKCSLCSFQ HHHHHHHCCCCCCCC	39.87	-
1768	Sumoylation	RRAVEKKKCSLCSFQ HHHHHHHCCCCCCCC	39.87	-
1776	Phosphorylation	CSLCSFQSFSKKGIV CCCCCCCCCCCCCHH	29.49	24719451
1780	Methylation	SFQSFSKKGIVSHYM CCCCCCCCCHHHHHH	53.31	115978199
1780	Sumoylation	SFQSFSKKGIVSHYM CCCCCCCCCHHHHHH	53.31	28112733
1784	O-linked_Glycosylation	FSKKGIVSHYMKRHP CCCCCHHHHHHHHCC	13.64	30379171
1786	Phosphorylation	KKGIVSHYMKRHPGV CCCHHHHHHHHCCCC	9.23	24719451
1875	Sumoylation	DHHSRDLKRDFIILG CCCCCCCCCCEEEEC	54.96	-
1933	Phosphorylation	ERRKQLLSKQKYADG HHHHHHHHHHHHCCC	41.45	24719451
1946	Sumoylation	DGAFADFKQERPFGH CCCCCCHHCCCCCCC	52.36	-
1946	Sumoylation	DGAFADFKQERPFGH CCCCCCHHCCCCCCC	52.36	28112733
1979	Phosphorylation	FCVEVHPTLRAICNH EEEECCHHHHHHHHH	17.63	26699800
2000	Phosphorylation	YGNVPAVSAAVKGLR HCCHHHHHHHHHHHH	16.77	25954137
2004	Methylation	PAVSAAVKGLRSHER HHHHHHHHHHHHHCH	47.72	24129315
2008	Phosphorylation	AAVKGLRSHERSHLA HHHHHHHHHCHHHHH	34.44	24719451
2012	Phosphorylation	GLRSHERSHLALAMF HHHHHCHHHHHHHHH	21.62	24719451
2020	Phosphorylation	HLALAMFTREDKYSC HHHHHHHCCCCCCHH	21.77	24719451
2024 (in isoform 3)	Phosphorylation	-	34.02	21406692
2025	Phosphorylation	MFTREDKYSCQYCSF HHCCCCCCHHHHHHH	27.31	-
2062	Methylation	RCKLCSFKSSYNSRL CCEECCCCCCHHHHH	23.38	115978207
2083	Phosphorylation	AHAGEHAYKCSWCSF HCCCCCEECCCCCCC	17.90	22817900
2096	Phosphorylation	SFSTMTISQLKEHSL CCEECCHHHHHHHCC	21.94	24719451
2104	Sumoylation	QLKEHSLKVHGKALT HHHHHCCEECCEEEC	34.89	28112733
2111	Phosphorylation	KVHGKALTLPRPRIV EECCEEECCCCHHHH	39.31	24719451
2119	Phosphorylation	LPRPRIVSLLSSHSH CCCHHHHHHHHCCCC	22.63	23312004
2122	Phosphorylation	PRIVSLLSSHSHHSS HHHHHHHHCCCCCCC	31.16	23312004
2123	Phosphorylation	RIVSLLSSHSHHSSQ HHHHHHHCCCCCCCC	29.04	23312004
2125	Phosphorylation	VSLLSSHSHHSSQKA HHHHHCCCCCCCCCC	25.50	23312004
2128	Phosphorylation	LSSHSHHSSQKATPA HHCCCCCCCCCCCCH	29.10	23312004
2129	Phosphorylation	SSHSHHSSQKATPAE HCCCCCCCCCCCCHH	31.20	23312004
2131	Methylation	HSHHSSQKATPAEEV CCCCCCCCCCCHHHC	57.06	115978215
2133	Phosphorylation	HHSSQKATPAEEVED CCCCCCCCCHHHCCC	30.02	27251275
2141	Phosphorylation	PAEEVEDSNDSSYSE CHHHCCCCCCCCCCC	29.09	25921289
2144	Phosphorylation	EVEDSNDSSYSEPPD HCCCCCCCCCCCCCH	35.11	30177828
2145	Phosphorylation	VEDSNDSSYSEPPDV CCCCCCCCCCCCCHH	35.23	30177828
2146	Phosphorylation	EDSNDSSYSEPPDVQ CCCCCCCCCCCCHHH	22.47	26852163
2147	Phosphorylation	DSNDSSYSEPPDVQQ CCCCCCCCCCCHHHH	45.64	25921289
2169	Phosphorylation	AALARNNSRVSPVPL HHHHHCCCCCCCCCC	37.29	22167270
2172	Phosphorylation	ARNNSRVSPVPLSGA HHCCCCCCCCCCCCC	21.04	19664994
2177	Phosphorylation	RVSPVPLSGAAAGTE CCCCCCCCCCCCCCC	21.95	22167270
2183	Phosphorylation	LSGAAAGTEQKTEAV CCCCCCCCCCCCCEE	30.43	29396449
2226	Phosphorylation	LFKCKDCSFYTGFKS EEECCCCCEECCCCE	31.27	28555341
2244	Phosphorylation	MHVEAGHSAVPEEGP EEECCCCCCCCCCCC	30.00	28555341
2293	Sumoylation	VCRSKLSKYLQGVVF HHHHHHHHHHCCCEE	61.49	28112733
2310	Phosphorylation	DKCTFTCSSDESLQQ CCCEEECCCCHHHHH	37.45	27251275
2311	Phosphorylation	KCTFTCSSDESLQQH CCEEECCCCHHHHHH	47.76	27251275
2377	Phosphorylation	QMKEKMESSSSDDED HHHHHHHHCCCCHHH	31.83	21406692
2378	Phosphorylation	MKEKMESSSSDDEDK HHHHHHHCCCCHHHH	22.13	21406692
2379	Phosphorylation	KEKMESSSSDDEDKE HHHHHHCCCCHHHHH	47.25	21406692
2380	Phosphorylation	EKMESSSSDDEDKEE HHHHHCCCCHHHHHH	51.53	21406692
2402	Phosphorylation	DRELMRFSDHGAALN HHHHHHHHCCCCCCC	20.52	29255136
2424	Phosphorylation	EFCGRAFSQGSEWER CCCCCCCCCCCHHHH	32.42	17525332
2427	Phosphorylation	GRAFSQGSEWERHVL CCCCCCCCHHHHHHH	31.72	28787133
2444	Sumoylation	GMALNDTKQVSREEI CCCCCCCCCCCHHHC	52.12	28112733
2460	Phosphorylation	PKEIMENSVKMPSIE HHHHHHCCCCCCCCC	15.14	27135362
2465	Phosphorylation	ENSVKMPSIEEKEDD HCCCCCCCCCCCCCC	38.85	28348404
2482	Sumoylation	IGIDFSLKNETVAIC CCCCEECCCCEEEEE	52.09	-
2496	Phosphorylation	CVVTADKSLLENAEA EEEECCHHHHHHHHH	38.44	21815630
2504	Sumoylation	LLENAEAKKE----- HHHHHHHHCC-----	49.27	28112733

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN462_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN462_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN462_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WIZ_HUMAN	WIZ	physical	28514442
EHMT1_HUMAN	EHMT1	physical	28514442
EHMT2_HUMAN	EHMT2	physical	28514442
D2HDH_HUMAN	D2HGDH	physical	28514442
ZN644_HUMAN	ZNF644	physical	28514442
CBX5_HUMAN	CBX5	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1076; SER-1079 ANDSER-1082, AND MASS SPECTROMETRY.
PubMed: 19690332

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2424, AND MASSSPECTROMETRY.
PubMed: 17525332

"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-2083, AND MASSSPECTROMETRY.
PubMed: 18187866