| UniProt ID | D2HDH_HUMAN | |
|---|---|---|
| UniProt AC | Q8N465 | |
| Protein Name | D-2-hydroxyglutarate dehydrogenase, mitochondrial | |
| Gene Name | D2HGDH | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 521 | |
| Subcellular Localization | Mitochondrion . | |
| Protein Description | Catalyzes the oxidation of D-2-hydroxyglutarate to alpha-ketoglutarate.. | |
| Protein Sequence | MLPRRPLAWPAWLLRGAPGAAGSWGRPVGPLARRGCCSAPGTPEVPLTRERYPVRRLPFSTVSKQDLAAFERIVPGGVVTDPEALQAPNVDWLRTLRGCSKVLLRPRTSEEVSHILRHCHERNLAVNPQGGNTGMVGGSVPVFDEIILSTARMNRVLSFHSVSGILVCQAGCVLEELSRYVEERDFIMPLDLGAKGSCHIGGNVATNAGGLRFLRYGSLHGTVLGLEVVLADGTVLDCLTSLRKDNTGYDLKQLFIGSEGTLGIITTVSILCPPKPRAVNVAFLGCPGFAEVLQTFSTCKGMLGEILSAFEFMDAVCMQLVGRHLHLASPVQESPFYVLIETSGSNAGHDAEKLGHFLEHALGSGLVTDGTMATDQRKVKMLWALRERITEALSRDGYVYKYDLSLPVERLYDIVTDLRARLGPHAKHVVGYGHLGDGNLHLNVTAEAFSPSLLAALEPHVYEWTAGQQGSVSAEHGVGFRKRDVLGYSKPPGALQLMQQLKALLDPKGILNPYKTLPSQA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 64 | Ubiquitination | LPFSTVSKQDLAAFE CCCCCCCHHHHHHHH | 43.42 | 21890473 | |
| 64 | Malonylation | LPFSTVSKQDLAAFE CCCCCCCHHHHHHHH | 43.42 | 30639696 | |
| 64 | Ubiquitination | LPFSTVSKQDLAAFE CCCCCCCHHHHHHHH | 43.42 | 21890473 | |
| 64 (in isoform 1) | Ubiquitination | - | 43.42 | 21890473 | |
| 64 (in isoform 2) | Ubiquitination | - | 43.42 | 21890473 | |
| 101 | Malonylation | RTLRGCSKVLLRPRT HHHCCCCEEEECCCC | 40.76 | 26320211 | |
| 101 | Succinylation | RTLRGCSKVLLRPRT HHHCCCCEEEECCCC | 40.76 | - | |
| 101 | Succinylation | RTLRGCSKVLLRPRT HHHCCCCEEEECCCC | 40.76 | 27452117 | |
| 222 | Phosphorylation | RYGSLHGTVLGLEVV EECCCCCEEEEEEEE | 11.21 | 22210691 | |
| 240 | Phosphorylation | GTVLDCLTSLRKDNT CCHHHHHHHHCCCCC | 31.85 | 22210691 | |
| 241 | Phosphorylation | TVLDCLTSLRKDNTG CHHHHHHHHCCCCCC | 17.15 | 22210691 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of D2HDH_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of D2HDH_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of D2HDH_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SDHB_HUMAN | SDHB | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 600721 | D-2-hydroxyglutaric aciduria 1 (D2HGA1) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
