| UniProt ID | CAD11_HUMAN | |
|---|---|---|
| UniProt AC | P55287 | |
| Protein Name | Cadherin-11 | |
| Gene Name | CDH11 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 796 | |
| Subcellular Localization |
Cell membrane Single-pass type I membrane protein. |
|
| Protein Description | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.. | |
| Protein Sequence | MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFISNGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPNFTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPMSSTNTLTIKVCGCDVNGALLSCNAEAYILNAGLSTGALIAILACIVILLVIVVLFVTLRRQKKEPLIVFEEEDVRENIITYDDEGGGEEDTEAFDIATLQNPDGINGFIPRKDIKPEYQYMPRPGLRPAPNSVDVDDFINTRIQEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESATTDSDLDYDYLQNWGPRFKKLADLYGSKDTFDDDS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 43 | Acetylation | HGHHEKGKEGQVLQR CCCCCCCCCCCEEEH | 70.51 | 7669905 | |
| 93 | Phosphorylation | GNIKYILSGEGAGTI CCEEEEEECCCCCEE | 25.82 | - | |
| 99 | Phosphorylation | LSGEGAGTIFVIDDK EECCCCCEEEEEECC | 15.65 | - | |
| 107 | Phosphorylation | IFVIDDKSGNIHATK EEEEECCCCCEEEEE | 44.03 | 22210691 | |
| 124 | Phosphorylation | DREERAQYTLMAQAV CHHHHHHHHHHHHHH | 10.80 | 24260401 | |
| 125 | Phosphorylation | REERAQYTLMAQAVD HHHHHHHHHHHHHHC | 9.66 | 24260401 | |
| 200 | Phosphorylation | NSAKLVYSILEGQPY CCCHHHHHHHCCCCE | 17.14 | 24275569 | |
| 219 | Phosphorylation | AQTGIIRTALPNMDR ECCCCEEECCCCCCH | 23.34 | 20886841 | |
| 343 | Phosphorylation | DFETKRAYSLKVEAA CCCCCCEEEEEEEEE | 20.69 | 22210691 | |
| 344 | Phosphorylation | FETKRAYSLKVEAAN CCCCCEEEEEEEEEE | 22.26 | 24719451 | |
| 365 | Ubiquitination | FISNGPFKDTVTVKI HHCCCCCCCEEEEEE | 56.47 | - | |
| 420 | Phosphorylation | ANSPIRYSIDRHTDL CCCCCEEEEECCCCC | 14.25 | 22912867 | |
| 455 | N-linked_Glycosylation | REETAWLNITVFAAE HHHHHHEEEEEEEHH | 19.72 | UniProtKB CARBOHYD | |
| 540 | N-linked_Glycosylation | PEIIHNPNFTVRDNR HHHHCCCCCEEECCC | 51.00 | UniProtKB CARBOHYD | |
| 568 | Phosphorylation | SRQKQDLYLLPIVIS CCCCCEEEEEEEEEE | 17.93 | 24043423 | |
| 575 | Phosphorylation | YLLPIVISDGGIPPM EEEEEEEECCCCCCC | 21.22 | 24043423 | |
| 583 | Phosphorylation | DGGIPPMSSTNTLTI CCCCCCCCCCCEEEE | 39.52 | 24043423 | |
| 584 | Phosphorylation | GGIPPMSSTNTLTIK CCCCCCCCCCEEEEE | 21.30 | 24043423 | |
| 585 | Phosphorylation | GIPPMSSTNTLTIKV CCCCCCCCCEEEEEE | 25.56 | 24043423 | |
| 587 | Phosphorylation | PPMSSTNTLTIKVCG CCCCCCCEEEEEECC | 25.93 | 24043423 | |
| 589 | Phosphorylation | MSSTNTLTIKVCGCD CCCCCEEEEEECCCC | 19.40 | 24043423 | |
| 694 | Ubiquitination | INGFIPRKDIKPEYQ CCCCCCHHHCCCHHC | 59.45 | - | |
| 697 | Ubiquitination | FIPRKDIKPEYQYMP CCCHHHCCCHHCCCC | 41.76 | - | |
| 700 | Phosphorylation | RKDIKPEYQYMPRPG HHHCCCHHCCCCCCC | 17.30 | 27259358 | |
| 702 | Phosphorylation | DIKPEYQYMPRPGLR HCCCHHCCCCCCCCC | 14.26 | 22817900 | |
| 714 | Phosphorylation | GLRPAPNSVDVDDFI CCCCCCCCCCHHHHH | 20.73 | 30266825 | |
| 723 | Phosphorylation | DVDDFINTRIQEADN CHHHHHHHHHHHCCC | 25.08 | 30266825 | |
| 786 | Phosphorylation | FKKLADLYGSKDTFD HHHHHHHHCCCCCCC | 21.65 | 23403867 | |
| 788 | Phosphorylation | KLADLYGSKDTFDDD HHHHHHCCCCCCCCC | 17.50 | 28355574 | |
| 791 | Phosphorylation | DLYGSKDTFDDDS-- HHHCCCCCCCCCC-- | 32.47 | 23403867 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CAD11_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CAD11_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CAD11_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CADH2_HUMAN | CDH2 | physical | 14625392 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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