dbPTM

CE290_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CE290_HUMAN
UniProt AC	O15078
Protein Name	Centrosomal protein of 290 kDa
Gene Name	CEP290
Organism	Homo sapiens (Human).
Sequence Length	2479
Subcellular Localization	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite . Nucleus . Cell projection, cilium . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cyt
Protein Description	Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110. [PubMed: 18694559 May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1]
Protein Sequence	MPPNINWKEIMKVDPDDLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEFEDEEESPVNFPIY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	LADNLLISLSKVEVN HHHHHHHHHHHHCHH	26.93	26074081
78 (in isoform 2)	Ubiquitination	-	52.36	-
93 (in isoform 2)	Ubiquitination	-	56.49	21890473
102 (in isoform 2)	Ubiquitination	-	36.13	21890473
105 (in isoform 2)	Ubiquitination	-	21.81	21890473
140	Acetylation	DMEKELEKEKKVNEQ HHHHHHHHHHHHHHH	83.74	18528975
185	Ubiquitination	QDIIDYQKQIDSQKE HHHHHHHHHHHHHHH	42.88	-
191	Ubiquitination	QKQIDSQKETLLSRR HHHHHHHHHHHHHHC	57.53	-
213	Phosphorylation	SQLSKKNYELIQYLD HHHHHHHHHHHHHHH	22.46	-
348	Phosphorylation	AQLDADKSNVMALQQ CCCCCHHHHHHHHHH	34.89	20860994
368	Phosphorylation	DSQIKMLTEQVEQYT HHHHHHHHHHHHHHH	22.37	29978859
374	Phosphorylation	LTEQVEQYTKEMEKN HHHHHHHHHHHHHHC	13.28	23663014
375	Phosphorylation	TEQVEQYTKEMEKNT HHHHHHHHHHHHHCC	21.88	23663014
382	Phosphorylation	TKEMEKNTCIIEDLK HHHHHHCCCCHHHHH	19.02	-
451	Phosphorylation	ALKRLKDYESGVYGL HHHHHCHHHCCCCCH	15.48	21712546
456	Phosphorylation	KDYESGVYGLEDAVV CHHHCCCCCHHHHEE	21.37	21712546
484	Ubiquitination	REIEILTKEINKLEL HHHHHHHHHHHHHHC	53.83	-
512	Ubiquitination	ERVGLEPKTMIDLTE HHHCCCCCCCEEHHH	41.15	-
527	Ubiquitination	FRNSKHLKQQQYRAE HCCCHHHHHHHHHHH	45.86	-
567	Phosphorylation	AQERGKRSATSGLTT HHHHCCCCCCCCCCH	39.11	21406692
569	Phosphorylation	ERGKRSATSGLTTED HHCCCCCCCCCCHHH	25.27	20068231
570	Phosphorylation	RGKRSATSGLTTEDL HCCCCCCCCCCHHHH	31.36	21406692
573	Phosphorylation	RSATSGLTTEDLNLT CCCCCCCCHHHHCCC	31.50	21406692
574	Phosphorylation	SATSGLTTEDLNLTE CCCCCCCHHHHCCCC	32.32	21406692
580	Phosphorylation	TTEDLNLTENISQGD CHHHHCCCCCCCCCC	26.39	20068231
584	Phosphorylation	LNLTENISQGDRISE HCCCCCCCCCCCCCH	39.43	21406692
593	Ubiquitination	GDRISERKLDLLSLK CCCCCHHHHHHHHHC	42.15	-
598	Phosphorylation	ERKLDLLSLKNMSEA HHHHHHHHHCCCCHH	44.59	24719451
600	Ubiquitination	KLDLLSLKNMSEAQS HHHHHHHCCCCHHHH	47.42	-
608	Ubiquitination	NMSEAQSKNEFLSRE CCCHHHHHHHHHCHH	48.71	-
672	Phosphorylation	PDVKGGETSLIIPSL CCCCCCCCEEHHHCH	31.91	27251275
673	Phosphorylation	DVKGGETSLIIPSLE CCCCCCCEEHHHCHH	17.17	27251275
688	Phosphorylation	RLVNAIESKNAEGIF HHHHHHHCCCCCCCC	25.70	24719451
724	Ubiquitination	QELRESRKEAINYSQ HHHHHHHHHHHHHHH	61.86	-
729	Phosphorylation	SRKEAINYSQQLAKA HHHHHHHHHHHHHHC	11.18	25003641
730	Phosphorylation	RKEAINYSQQLAKAN HHHHHHHHHHHHHCC	13.63	25003641
735	Ubiquitination	NYSQQLAKANLKIDH HHHHHHHHCCCCCHH	46.53	21890473
737 (in isoform 1)	Ubiquitination	-	40.95	21890473
745	Ubiquitination	LKIDHLEKETSLLRQ CCCHHHHHHHHHHHH	73.06	-
748	Phosphorylation	DHLEKETSLLRQSEG HHHHHHHHHHHHCCC	26.88	24719451
820	Phosphorylation	AVIRHQQSLLYKEYL HHHHHHHHHHHHHHH	17.48	29083192
823	Phosphorylation	RHQQSLLYKEYLSEK HHHHHHHHHHHHCCC	13.68	29083192
826	Phosphorylation	QSLLYKEYLSEKETW HHHHHHHHHCCCCCH	16.04	29083192
828	Phosphorylation	LLYKEYLSEKETWKT HHHHHHHCCCCCHHC	45.80	29083192
830	Ubiquitination	YKEYLSEKETWKTES HHHHHCCCCCHHCCC	58.00	21890473
832	Phosphorylation	EYLSEKETWKTESKT HHHCCCCCHHCCCHH	43.24	-
832 (in isoform 1)	Ubiquitination	-	43.24	21890473
846	Acetylation	TIKEEKRKLEDQVQQ HHHHHHHHHHHHHHH	68.26	18584311
859	Acetylation	QQDAIKVKEYNNLLN HHHHHHHHHHHHHHH	49.86	18584321
883	Phosphorylation	KKILAENSRKITVLQ HHHHHHCCCCEEEEE	26.84	-
895	Phosphorylation	VLQVNEKSLIRQYTT EEEECHHHHHHHHHH	23.89	19664995
902	Phosphorylation	SLIRQYTTLVELERQ HHHHHHHHHHHHHHH	24.71	-
951	Ubiquitination	FKIAALQKVVDNSVS HHHHHHHHHHHCCCC	45.11	-
1002	Phosphorylation	HLECENISLKEQVES HHHEECCCHHHHHHH	44.99	24719451
1017	Phosphorylation	INKELEITKEKLHTI HHHHHHHHHHHHHHH	24.63	24670416
1023	Phosphorylation	ITKEKLHTIEQAWEQ HHHHHHHHHHHHHHH	36.32	29083192
1032	Phosphorylation	EQAWEQETKLGNESS HHHHHHHHHCCCCCH	31.12	25599653
1033	Ubiquitination	QAWEQETKLGNESSM HHHHHHHHCCCCCHH	54.36	21890473
1035 (in isoform 1)	Ubiquitination	-	37.10	21890473
1042	Ubiquitination	GNESSMDKAKKSITN CCCCHHHHHHHHCCH	54.16	21890473
1044	Ubiquitination	ESSMDKAKKSITNSD CCHHHHHHHHCCHHH	53.44	-
1044 (in isoform 1)	Ubiquitination	-	53.44	21890473
1045	Ubiquitination	SSMDKAKKSITNSDI CHHHHHHHHCCHHHH	52.53	21890473
1046	Phosphorylation	SMDKAKKSITNSDIV HHHHHHHHCCHHHHH	33.66	28555341
1047 (in isoform 1)	Ubiquitination	-	6.08	21890473
1060	Phosphorylation	VSISKKITMLEMKEL HHHHHHHHHHHHHHH	25.28	20071362
1125	Phosphorylation	LRDELADSVSKAVSD HHHHHHHHHHHHCCH	23.76	28060719
1127	Phosphorylation	DELADSVSKAVSDAD HHHHHHHHHHCCHHH	20.89	28060719
1131	Phosphorylation	DSVSKAVSDADRQRI HHHHHHCCHHHHHHH	31.76	28060719
1159	Phosphorylation	VSKLREISDIARRQV HHHHHHHHHHHHHHH	20.43	21815630
1178	Ubiquitination	AQQQSRDKEVESLRM HHHHHCHHHHHHHHH	63.65	-
1209	Phosphorylation	KLHQHNVSLQLSEAT HHHHCCCEEEEHHHH	18.73	18187866
1251	Phosphorylation	EKEQALYYARLEGRN HHHHHHHHHHHHCCH	6.01	18083107
1287	Phosphorylation	LAQQEKFSKTMIQLQ HHHHHHHHHHHHHHH	37.98	27174698
1289	Phosphorylation	QQEKFSKTMIQLQND HHHHHHHHHHHHHHH	20.50	27174698
1336	Ubiquitination	EELISTLKDTKGAQK HHHHHHHHCCCCHHH	64.54	-
1360	Ubiquitination	ELRLQELKLNRELVK HHHHHHHCCCHHHHC	42.85	-
1382 (in isoform 2)	Ubiquitination	-	12.15	21890473
1385	Phosphorylation	IISEYERTISSLEEE HHHHHHHHHHHHHHH	17.17	27050516
1517	Ubiquitination	PATAEREKLIAELGR CCHHHHHHHHHHHCC	51.95	-
1552	Ubiquitination	MQARLNQKEEVLKKY HHHHHHHHHHHHHHH	55.56	-
1594	Phosphorylation	RLELQADSSLNKFKQ HHHHHCCCCHHHHHH	39.48	20873877
1595	Phosphorylation	LELQADSSLNKFKQT HHHHCCCCHHHHHHH	36.19	20873877
1598	Ubiquitination	QADSSLNKFKQTAWD HCCCCHHHHHHHHHH	60.27	-
1600	Ubiquitination	DSSLNKFKQTAWDLM CCCHHHHHHHHHHHH	48.63	-
1608	Ubiquitination	QTAWDLMKQSPTPVP HHHHHHHHCCCCCCC	55.72	-
1610	Phosphorylation	AWDLMKQSPTPVPTN HHHHHHCCCCCCCCC	25.81	28985074
1618	Ubiquitination	PTPVPTNKHFIRLAE CCCCCCCHHHHHHHH	42.23	-
1636	Phosphorylation	TVAEQDDSLSSLLVK HHHHCCCCHHHHHHH	38.14	22210691
1638	Phosphorylation	AEQDDSLSSLLVKLK HHCCCCHHHHHHHHH	23.92	22210691
1639	Phosphorylation	EQDDSLSSLLVKLKK HCCCCHHHHHHHHHH	30.89	22210691
1658	Phosphorylation	LERQREITELKVKEF HHHHHHHHHHHHHHH	30.43	23403867
1684	Acetylation	EDEVKKVKAEVEDLK HHHHHHHHHHHHHHH	47.94	7677519
1691	Acetylation	KAEVEDLKYLLDQSQ HHHHHHHHHHHHHHH	46.29	7677529
1692	Phosphorylation	AEVEDLKYLLDQSQK HHHHHHHHHHHHHHH	21.57	28122231
1697	Phosphorylation	LKYLLDQSQKESQCL HHHHHHHHHHHHHHH	42.77	25599653
1731	Acetylation	RNLVERLKSQLALKE HHHHHHHHHHHHHHH	42.23	12655493
1737	Acetylation	LKSQLALKEKQQKAL HHHHHHHHHHHHHHH	58.20	12655503
1788	Ubiquitination	DRHTRELKTQVEDLN HHHHHHHHHHHHHHH	31.96	-
1814	Phosphorylation	TSKNRENSLTDNLND HCCCHHHHHHHCHHH	28.08	25072903
1816	Phosphorylation	KNRENSLTDNLNDLN CCHHHHHHHCHHHHH	23.74	25072903
1828	Acetylation	DLNNELQKKQKAYNK HHHHHHHHHHHHHHH	70.56	20167786
1833	Phosphorylation	LQKKQKAYNKILREK HHHHHHHHHHHHHHH	24.83	29457462
1840	Acetylation	YNKILREKEEIDQEN HHHHHHHHHHHHHHC	54.97	20167786
1864	Ubiquitination	LTSGLQGKPLTDNKQ HHHCCCCCCCCCCHH	24.72	-
1906	Ubiquitination	PMKEKNAKEELIRWE HCCCCCHHHHHHHHH	62.20	-
1916	Methylation	LIRWEEGKKWQAKIE HHHHHHHHHHHHHHH	54.86	23644510
1921	Methylation	EGKKWQAKIEGIRNK HHHHHHHHHHHHHHH	26.62	23644510
1959	Phosphorylation	KADKEKLTLQRKLKT HHCHHHCHHHHHHHH	31.73	-
1966	Phosphorylation	TLQRKLKTTGMTVDQ HHHHHHHHCCCCHHH	38.73	-
1982	Phosphorylation	LGIRALESEKELEEL HHHHHHHCHHHHHHH	55.61	26471730
2002	Phosphorylation	DLENDILYMRAHQAL CCHHCHHHHHHHHCC	5.72	-
2013	Phosphorylation	HQALPRDSVVEDLHL HHCCCCCCHHHHHHH	29.37	28348404
2034	Ubiquitination	EKLHALEKQFSKDTY HHHHHHHHHHCCCCC	58.45	-
2043	Ubiquitination	FSKDTYSKPSISGIE HCCCCCCCCCCCCCC	32.16	-
2045	Phosphorylation	KDTYSKPSISGIESD CCCCCCCCCCCCCCC	32.87	27251275
2069	Phosphorylation	QKENLKLSSENIELK HHHHHCCCHHHHHHH	33.74	20068231
2070	Phosphorylation	KENLKLSSENIELKF HHHHCCCHHHHHHHH	45.13	20068231
2126	Phosphorylation	GSGRSGKTIPELEKT CCCCCCCCHHHHHHH	45.34	-
2133	Phosphorylation	TIPELEKTIGLMKKV CHHHHHHHHHHHHHH	15.76	27155012
2155	Phosphorylation	NEQLKKASGILTSEK HHHHHHHHCCCCHHH	34.93	20860994
2172	Ubiquitination	NIEQENEKLKAELEK CHHHHHHHHHHHHHH	67.86	-
2189	Phosphorylation	AHLGHQLSMHYESKT HHHHHHHHHHHHCCC	9.28	27251275
2238	Phosphorylation	EILNEKMTVQLEETG HHHCHHCEEEHHHHH	19.03	27174698
2244	Phosphorylation	MTVQLEETGKRLQFA CEEEHHHHHCCHHHH	38.33	27174698
2284	Phosphorylation	TKLKELETDIAKKNQ HHHHHHHHHHHHHCC	45.38	-
2292	Phosphorylation	DIAKKNQSITDLKQL HHHHHCCCHHHHHHH	36.53	26471730
2294	Phosphorylation	AKKNQSITDLKQLVK HHHCCCHHHHHHHHH	40.29	26471730
2304	Phosphorylation	KQLVKEATEREQKVN HHHHHHHHHHHHHHH	36.35	16674116
2322	Ubiquitination	EDLEQQIKILKHVPE HHHHHHHHHHHCCCC	37.33	21890473
2324 (in isoform 1)	Ubiquitination	-	2.39	21890473
2338	Ubiquitination	AETEQGLKRELQVLR CCCHHHHHHHHHHHH	51.13	-
2369	Phosphorylation	IEANKDQSGAESTIP HHHCCCCCCCCCCCC	50.53	26471730
2373	Phosphorylation	KDQSGAESTIPDADQ CCCCCCCCCCCCHHH	30.97	29083192
2374	Phosphorylation	DQSGAESTIPDADQL CCCCCCCCCCCHHHH	28.21	28985074
2395	Phosphorylation	LETQLKMSDLEKQHL HHHHHHHHHHHHHHH	37.14	19413330
2437	Acetylation	NYKEEVKKNILLEEK CCHHHHHHHHHHHHH	55.16	20167786

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	MIB1	Q86YT6	PMID:24121310

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CE290_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CE290_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CEP97_HUMAN	CEP97	physical	22441691
CEP76_HUMAN	CEP76	physical	22441691
CP110_HUMAN	CCP110	physical	22441691
ZN423_HUMAN	ZNF423	physical	22863007
CE170_HUMAN	CEP170	physical	26638075
FR1OP_HUMAN	FGFR1OP	physical	26638075
OFD1_HUMAN	OFD1	physical	26638075
CP131_HUMAN	CEP131	physical	26638075
CC138_HUMAN	CCDC138	physical	26638075
CP110_HUMAN	CCP110	physical	26638075
CEP72_HUMAN	CEP72	physical	26638075
CEP76_HUMAN	CEP76	physical	26638075
CEP97_HUMAN	CEP97	physical	26638075
FKBP4_HUMAN	FKBP4	physical	26638075
HERC2_HUMAN	HERC2	physical	26638075
IQCB1_HUMAN	IQCB1	physical	26638075
CE162_HUMAN	CEP162	physical	26638075
MED4_HUMAN	MED4	physical	26638075
MIB1_HUMAN	MIB1	physical	26638075
NEUL4_HUMAN	NEURL4	physical	26638075
PTPRR_HUMAN	PTPRR	physical	26638075
PCNT_HUMAN	PCNT	physical	26638075
PIBF1_HUMAN	PIBF1	physical	26638075
ADIP_HUMAN	SSX2IP	physical	26638075
CCD77_HUMAN	CCDC77	physical	26638075
KC1E_HUMAN	CSNK1E	physical	26638075
ECH1_HUMAN	ECH1	physical	26638075
SREK1_HUMAN	SREK1	physical	26638075
SPT5H_HUMAN	SUPT5H	physical	26638075
LDHA_HUMAN	LDHA	physical	26638075
TADBP_HUMAN	TARDBP	physical	26638075
MARE1_HUMAN	MAPRE1	physical	26638075
AKA12_HUMAN	AKAP12	physical	26638075
NEP1_HUMAN	EMG1	physical	26638075
KIF7_HUMAN	KIF7	physical	26638075
PNMA2_HUMAN	PNMA2	physical	26638075
SSBP_HUMAN	SSBP1	physical	26638075
CAND1_HUMAN	CAND1	physical	26638075
UBA1_HUMAN	UBA1	physical	26638075
6PGD_HUMAN	PGD	physical	26638075
USO1_HUMAN	USO1	physical	26638075
SAHH_HUMAN	AHCY	physical	26638075
KAD2_HUMAN	AK2	physical	26638075
AN32A_HUMAN	ANP32A	physical	26638075
ARPC3_HUMAN	ARPC3	physical	26638075
BAP31_HUMAN	BCAP31	physical	26638075
CK049_HUMAN	C11orf49	physical	26638075
CU002_HUMAN	C21orf2	physical	26638075
CSPP1_HUMAN	CSPP1	physical	26638075
NB5R3_HUMAN	CYB5R3	physical	26638075
GYS1_HUMAN	GYS1	physical	26638075
HAUS7_HUMAN	HAUS7	physical	26638075
HAUS8_HUMAN	HAUS8	physical	26638075
ISOC1_HUMAN	ISOC1	physical	26638075
ERD22_HUMAN	KDELR2	physical	26638075
LRC49_HUMAN	LRRC49	physical	26638075
LUZP1_HUMAN	LUZP1	physical	26638075
MIF_HUMAN	MIF	physical	26638075
MPP9_HUMAN	MPHOSPH9	physical	26638075
MTPN_HUMAN	MTPN	physical	26638075
NEK1_HUMAN	NEK1	physical	26638075
PAWR_HUMAN	PAWR	physical	26638075
PCM1_HUMAN	PCM1	physical	26638075
PLP2_HUMAN	PLP2	physical	26638075
MPPB_HUMAN	PMPCB	physical	26638075
TEBP_HUMAN	PTGES3	physical	26638075
RAB2A_HUMAN	RAB2A	physical	26638075
TPGS1_HUMAN	TPGS1	physical	26638075
WRP73_HUMAN	WRAP73	physical	26638075
1433F_HUMAN	YWHAH	physical	26638075
CCD61_HUMAN	CCDC61	physical	26638075
CE104_HUMAN	CEP104	physical	26638075
CE350_HUMAN	CEP350	physical	26638075
CHTOP_HUMAN	CHTOP	physical	26638075
DDX47_HUMAN	DDX47	physical	26638075
FOPNL_HUMAN	FOPNL	physical	26638075
GPTC1_HUMAN	GPATCH1	physical	26638075
HAUS1_HUMAN	HAUS1	physical	26638075
HAUS3_HUMAN	HAUS3	physical	26638075
HAUS4_HUMAN	HAUS4	physical	26638075
HAUS6_HUMAN	HAUS6	physical	26638075
HMGN1_HUMAN	HMGN1	physical	26638075
MOONR_HUMAN	KIAA0753	physical	26638075
KIF14_HUMAN	KIF14	physical	26638075
NEDD1_HUMAN	NEDD1	physical	26638075
NDK7_HUMAN	NME7	physical	26638075
TCHP_HUMAN	TCHP	physical	26638075
TBC31_HUMAN	TBC1D31	physical	26638075
WDR83_HUMAN	WDR83	physical	26638075

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
610188	Joubert syndrome 5 (JBTS5)
610189	Senior-Loken syndrome 6 (SLSN6)
611755	Leber congenital amaurosis 10 (LCA10)
611134	Meckel syndrome 4 (MKS4)
0000269\|PubMed	Note=Antibodies against CEP290 are present in sera from patients with cutaneous T-cell lymphomas, but not in the healthy control population. {ECO
615991
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CE290_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2395, AND MASSSPECTROMETRY.	19413330 [Abstract]
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1209, AND MASSSPECTROMETRY.	18187866 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1697, AND MASSSPECTROMETRY.	17081983 [Abstract]