ISOC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ISOC1_HUMAN
• UniProt AC: Q96CN7
• Protein Name: Isochorismatase domain-containing protein 1
• Gene Name: ISOC1
• Organism: Homo sapiens (Human).
• Sequence Length: 298
• Protein Sequence: MAAAEPAVLALPNSGAGGAGAPSGTVPVLFCFSVFARPSSVPHGAGYELLIQKFLSLYGDQIDMHRKFVVQLFAEEWGQYVDLPKGFAVSERCKVRLVPLQIQLTTLGNLTPSSTVFFCCDMQERFRPAIKYFGDIISVGQRLLQGARILGIPVIVTEQYPKGLGSTVQEIDLTGVKLVLPKTKFSMVLPEVEAALAEIPGVRSVVLFGVETHVCIQQTALELVGRGVEVHIVADATSSRSMMDRMFALERLARTGIIVTTSEAVLLQLVADKDHPKFKEIQNLIKASAPESGLLSKV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	AGGAGAPSGTVPVLF CCCCCCCCCCCCEEE	46.71	24719451
25	Phosphorylation	GAGAPSGTVPVLFCF CCCCCCCCCCEEEEE	26.44	24719451
131	Acetylation	ERFRPAIKYFGDIIS HHHHHHHHHHHHHHH	36.31	25953088
132	Phosphorylation	RFRPAIKYFGDIISV HHHHHHHHHHHHHHH	13.49	28152594
157	Phosphorylation	LGIPVIVTEQYPKGL CCCCEEEECCCCCCC	13.27	28857561
160	Phosphorylation	PVIVTEQYPKGLGST CEEEECCCCCCCCCC	10.73	24927040
162	Ubiquitination	IVTEQYPKGLGSTVQ EEECCCCCCCCCCCE	62.93	-
166	Phosphorylation	QYPKGLGSTVQEIDL CCCCCCCCCCEEEEC	30.37	21406692
167	Phosphorylation	YPKGLGSTVQEIDLT CCCCCCCCCEEEECC	25.14	21406692
174	Phosphorylation	TVQEIDLTGVKLVLP CCEEEECCCCEEECC	35.86	21406692
245	Methylation	SSRSMMDRMFALERL CCCHHHHHHHHHHHH	12.29	115480637
261	Phosphorylation	RTGIIVTTSEAVLLQ HCCEEEECCHHHHHH	17.42	24275569
279	Ubiquitination	DKDHPKFKEIQNLIK CCCCHHHHHHHHHHH	61.09	29967540
279	Succinylation	DKDHPKFKEIQNLIK CCCCHHHHHHHHHHH	61.09	-
279	Acetylation	DKDHPKFKEIQNLIK CCCCHHHHHHHHHHH	61.09	23954790
279	Malonylation	DKDHPKFKEIQNLIK CCCCHHHHHHHHHHH	61.09	26320211
279	Succinylation	DKDHPKFKEIQNLIK CCCCHHHHHHHHHHH	61.09	-
286	Acetylation	KEIQNLIKASAPESG HHHHHHHHHHCCCCC	39.18	25953088
286	Ubiquitination	KEIQNLIKASAPESG HHHHHHHHHHCCCCC	39.18	29967540
286	Malonylation	KEIQNLIKASAPESG HHHHHHHHHHCCCCC	39.18	26320211
288	Phosphorylation	IQNLIKASAPESGLL HHHHHHHHCCCCCCC	39.08	21406692
292	Phosphorylation	IKASAPESGLLSKV- HHHHCCCCCCCCCC-	33.41	21406692
296	Phosphorylation	APESGLLSKV----- CCCCCCCCCC-----	36.09	21406692

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ISOC1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ISOC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ISOC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ASNS_HUMAN	ASNS	physical	22863883
LIS1_HUMAN	PAFAH1B1	physical	22863883
PAK2_HUMAN	PAK2	physical	22863883
PDIA4_HUMAN	PDIA4	physical	22863883
PUR4_HUMAN	PFAS	physical	22863883
PLPHP_HUMAN	PROSC	physical	22863883
UBFD1_HUMAN	UBFD1	physical	22863883
VINC_HUMAN	VCL	physical	22863883
1433E_HUMAN	YWHAE	physical	22863883
1433F_HUMAN	YWHAH	physical	22863883
1433Z_HUMAN	YWHAZ	physical	22863883
CACO1_HUMAN	CALCOCO1	physical	25416956
LACB2_HUMAN	LACTB2	physical	26344197
C1TM_HUMAN	MTHFD1L	physical	26344197
UMPS_HUMAN	UMPS	physical	26344197
RHG08_HUMAN	ARHGAP8	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.