| UniProt ID | PLPHP_HUMAN | |
|---|---|---|
| UniProt AC | O94903 | |
| Protein Name | Pyridoxal phosphate homeostasis protein {ECO:0000255|HAMAP-Rule:MF_03225} | |
| Gene Name | PLPBP {ECO:0000255|HAMAP-Rule:MF_03225, ECO:0000312|HGNC:HGNC:9457} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 275 | |
| Subcellular Localization | ||
| Protein Description | Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.. | |
| Protein Sequence | MWRAGSMSAELGVGCALRAVNERVQQAVARRPRDLPAIQPRLVAVSKTKPADMVIEAYGHGQRTFGENYVQELLEKASNPKILSLCPEIKWHFIGHLQKQNVNKLMAVPNLFMLETVDSVKLADKVNSSWQRKGSPERLKVMVQINTSGEESKHGLPPSETIAIVEHINAKCPNLEFVGLMTIGSFGHDLSQGPNPDFQLLLSLREELCKKLNIPADQVELSMGMSADFQHAVEVGSTNVRIGSTIFGERDYSKKPTPDKCAADVKAPLEVAQEH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Phosphorylation | --MWRAGSMSAELGV --CCCCCCCHHHHCH | 25690035 | ||
| 8 | Phosphorylation | MWRAGSMSAELGVGC CCCCCCCHHHHCHHH | 26074081 | ||
| 47 | N6-(pyridoxal phosphate)lysine | PRLVAVSKTKPADMV CEEEEEECCCCCCEE | - | ||
| 47 | Acetylation | PRLVAVSKTKPADMV CEEEEEECCCCCCEE | 25953088 | ||
| 47 | Other | PRLVAVSKTKPADMV CEEEEEECCCCCCEE | - | ||
| 47 | Ubiquitination | PRLVAVSKTKPADMV CEEEEEECCCCCCEE | 33845483 | ||
| 53 | Sulfoxidation | SKTKPADMVIEAYGH ECCCCCCEEEEECCC | 30846556 | ||
| 69 | Phosphorylation | QRTFGENYVQELLEK CCCCCHHHHHHHHHH | 22115753 | ||
| 69 | Nitration | QRTFGENYVQELLEK CCCCCHHHHHHHHHH | - | ||
| 73 | Ubiquitination | GENYVQELLEKASNP CHHHHHHHHHHHCCH | 30230243 | ||
| 76 | Ubiquitination | YVQELLEKASNPKIL HHHHHHHHHCCHHHH | 29967540 | ||
| 81 | Ubiquitination | LEKASNPKILSLCPE HHHHCCHHHHHHCHH | 29967540 | ||
| 82 | Ubiquitination | EKASNPKILSLCPEI HHHCCHHHHHHCHHH | 24816145 | ||
| 99 | Acetylation | HFIGHLQKQNVNKLM HHHHHHHHCCHHHHH | 25953088 | ||
| 99 | Ubiquitination | HFIGHLQKQNVNKLM HHHHHHHHCCHHHHH | 29967540 | ||
| 123 | Ubiquitination | TVDSVKLADKVNSSW ECCHHHHHHHHCCHH | 30230243 | ||
| 125 | Succinylation | DSVKLADKVNSSWQR CHHHHHHHHCCHHHC | 27452117 | ||
| 125 | Malonylation | DSVKLADKVNSSWQR CHHHHHHHHCCHHHC | 26320211 | ||
| 125 | Acetylation | DSVKLADKVNSSWQR CHHHHHHHHCCHHHC | 23954790 | ||
| 125 | Ubiquitination | DSVKLADKVNSSWQR CHHHHHHHHCCHHHC | 30230243 | ||
| 125 | Succinylation | DSVKLADKVNSSWQR CHHHHHHHHCCHHHC | - | ||
| 128 | Phosphorylation | KLADKVNSSWQRKGS HHHHHHCCHHHCCCC | 28857561 | ||
| 129 | Phosphorylation | LADKVNSSWQRKGSP HHHHHCCHHHCCCCH | - | ||
| 135 | Phosphorylation | SSWQRKGSPERLKVM CHHHCCCCHHHEEEE | 26074081 | ||
| 142 | Sulfoxidation | SPERLKVMVQINTSG CHHHEEEEEEEECCC | 21406390 | ||
| 148 | Phosphorylation | VMVQINTSGEESKHG EEEEEECCCCHHCCC | - | ||
| 152 | Phosphorylation | INTSGEESKHGLPPS EECCCCHHCCCCCCH | - | ||
| 226 | Phosphorylation | VELSMGMSADFQHAV HHHHHCCCCCCCCCH | 24275569 | ||
| 244 | Phosphorylation | STNVRIGSTIFGERD CCCEEEECEECCCCC | 23401153 | ||
| 245 | Phosphorylation | TNVRIGSTIFGERDY CCEEEECEECCCCCC | 30266825 | ||
| 252 | Phosphorylation | TIFGERDYSKKPTPD EECCCCCCCCCCCCC | 23312004 | ||
| 253 | Phosphorylation | IFGERDYSKKPTPDK ECCCCCCCCCCCCCC | 23312004 | ||
| 255 | Ubiquitination | GERDYSKKPTPDKCA CCCCCCCCCCCCCCC | 24816145 | ||
| 257 | Phosphorylation | RDYSKKPTPDKCAAD CCCCCCCCCCCCCCC | 28857561 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PLPHP_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PLPHP_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PLPHP_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| AHSA1_HUMAN | AHSA1 | physical | 22863883 | |
| GSHR_HUMAN | GSR | physical | 22863883 | |
| HXK1_HUMAN | HK1 | physical | 22863883 | |
| ULA1_HUMAN | NAE1 | physical | 22863883 | |
| PA1B2_HUMAN | PAFAH1B2 | physical | 22863883 | |
| IPP2_HUMAN | PPP1R2 | physical | 22863883 | |
| SPSY_HUMAN | SMS | physical | 22863883 | |
| MTND_HUMAN | ADI1 | physical | 26344197 | |
| ARBK1_HUMAN | ADRBK1 | physical | 26344197 | |
| ARFP1_HUMAN | ARFIP1 | physical | 26344197 | |
| ENSA_HUMAN | ENSA | physical | 26344197 | |
| ROA1_HUMAN | HNRNPA1 | physical | 26344197 | |
| ROA3_HUMAN | HNRNPA3 | physical | 26344197 | |
| MYEF2_HUMAN | MYEF2 | physical | 26344197 | |
| PAPOA_HUMAN | PAPOLA | physical | 26344197 | |
| PHP14_HUMAN | PHPT1 | physical | 26344197 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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