PHP14_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PHP14_HUMAN
• UniProt AC: Q9NRX4
• Protein Name: 14 kDa phosphohistidine phosphatase {ECO:0000303|PubMed:12383260}
• Gene Name: PHPT1
• Organism: Homo sapiens (Human).
• Sequence Length: 125
• Subcellular Localization: Cytoplasm.
• Protein Description: Exhibits phosphohistidine phosphatase activity..
• Protein Sequence: MAVADLALIPDVDIDSDGVFKYVLIRVHSAPRSGAPAAESKEIVRGYKWAEYHADIYDKVSGDMQKQGCDCECLGGGRISHQSQDKKIHVYGYSMAYGPAQHAISTEKIKAKYPDYEVTWANDGY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAVADLALI ------CCCCCEEEC	12.76	19413330
16	Phosphorylation	IPDVDIDSDGVFKYV CCCCEECCCCEEEEE	36.28	20068231
22	Phosphorylation	DSDGVFKYVLIRVHS CCCCEEEEEEEEEEC	6.77	29514088
29	Phosphorylation	YVLIRVHSAPRSGAP EEEEEEECCCCCCCC	36.79	29514088
33	Phosphorylation	RVHSAPRSGAPAAES EEECCCCCCCCCHHH	37.94	28985074
40	Phosphorylation	SGAPAAESKEIVRGY CCCCCHHHHHHHHCC	30.75	28857561
41	2-Hydroxyisobutyrylation	GAPAAESKEIVRGYK CCCCHHHHHHHHCCC	42.86	-
41	Acetylation	GAPAAESKEIVRGYK CCCCHHHHHHHHCCC	42.86	26822725
41	Ubiquitination	GAPAAESKEIVRGYK CCCCHHHHHHHHCCC	42.86	-
48	2-Hydroxyisobutyrylation	KEIVRGYKWAEYHAD HHHHHCCCHHHHHHH	42.63	-
57	Phosphorylation	AEYHADIYDKVSGDM HHHHHHHHHHHCCCH	15.40	27642862
59	Ubiquitination	YHADIYDKVSGDMQK HHHHHHHHHCCCHHH	22.71	21890473
59	Ubiquitination	YHADIYDKVSGDMQK HHHHHHHHHCCCHHH	22.71	21890473
66	Ubiquitination	KVSGDMQKQGCDCEC HHCCCHHHCCCCCEE	41.86	-
86	2-Hydroxyisobutyrylation	ISHQSQDKKIHVYGY CCCCCCCCCEEEEEE	46.09	-
91	Phosphorylation	QDKKIHVYGYSMAYG CCCCEEEEEEEECCC	9.00	28152594
93	Phosphorylation	KKIHVYGYSMAYGPA CCEEEEEEEECCCCH	4.24	21082442
94	Phosphorylation	KIHVYGYSMAYGPAQ CEEEEEEEECCCCHH	7.80	28152594
95	Sulfoxidation	IHVYGYSMAYGPAQH EEEEEEEECCCCHHH	2.22	28465586
97	Phosphorylation	VYGYSMAYGPAQHAI EEEEEECCCCHHHCC	18.26	28152594
105	Phosphorylation	GPAQHAISTEKIKAK CCHHHCCCHHHHHHH	31.15	24719451
106	Phosphorylation	PAQHAISTEKIKAKY CHHHCCCHHHHHHHC	34.87	24719451
112	Ubiquitination	STEKIKAKYPDYEVT CHHHHHHHCCCCEEE	52.92	-
113	Phosphorylation	TEKIKAKYPDYEVTW HHHHHHHCCCCEEEE	13.24	28152594
116	Phosphorylation	IKAKYPDYEVTWAND HHHHCCCCEEEECCC	14.06	28152594
119	Phosphorylation	KYPDYEVTWANDGY- HCCCCEEEECCCCC-	13.61	28152594
125	Phosphorylation	VTWANDGY------- EEECCCCC-------	20.46	28152594

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PHP14_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PHP14_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PHP14_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DNM3L_HUMAN	DNMT3L	physical	16189514
PTMS_HUMAN	PTMS	physical	22939629
PSME1_HUMAN	PSME1	physical	22939629
RANB3_HUMAN	RANBP3	physical	22939629
ZPR1_HUMAN	ZPR1	physical	22939629
GDPP1_HUMAN	GDPGP1	physical	26344197
PTPA_HUMAN	PPP2R4	physical	26344197
TPPC4_HUMAN	TRAPPC4	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells.";
Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.;
J. Proteome Res. 8:3852-3861(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-116 AND TYR-125, ANDMASS SPECTROMETRY.
PubMed: 19534553