PTMS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTMS_HUMAN
• UniProt AC: P20962
• Protein Name: Parathymosin
• Gene Name: PTMS
• Organism: Homo sapiens (Human).
• Sequence Length: 102
• Protein Description: Parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistance to certain opportunistic infections..
• Protein Sequence: MSEKSVEAAAELSAKDLKEKKEKVEEKASRKERKKEVVEEEENGAEEEEEETAEDGEEEDEGEEEDEEEEEEDDEGPALKRAAEEEDEADPKRQKTENGASA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSEKSVEAA ------CCHHHHHHH	54.45	22814378
2	Phosphorylation	------MSEKSVEAA ------CCHHHHHHH	54.45	29255136
4	Acetylation	----MSEKSVEAAAE ----CCHHHHHHHHH	53.12	19608861
4	Ubiquitination	----MSEKSVEAAAE ----CCHHHHHHHHH	53.12	21890473
5	Phosphorylation	---MSEKSVEAAAEL ---CCHHHHHHHHHH	22.57	29255136
13	Phosphorylation	VEAAAELSAKDLKEK HHHHHHHCHHHHHHH	25.44	29255136
15	Acetylation	AAAELSAKDLKEKKE HHHHHCHHHHHHHHH	61.28	19608861
15	Ubiquitination	AAAELSAKDLKEKKE HHHHHCHHHHHHHHH	61.28	21890473
15	Succinylation	AAAELSAKDLKEKKE HHHHHCHHHHHHHHH	61.28	23954790
27	Acetylation	KKEKVEEKASRKERK HHHHHHHHHHHHHHH	37.85	26051181
29	Phosphorylation	EKVEEKASRKERKKE HHHHHHHHHHHHHHH	55.76	21601212
52	Phosphorylation	AEEEEEETAEDGEEE CHHHHHHHCCCCCCC	38.33	30576142
80	Acetylation	DDEGPALKRAAEEED CCCCHHHHHHHHHCC	41.94	26051181
92	Acetylation	EEDEADPKRQKTENG HCCCCCHHHHCCCCC	68.92	19608861
92	Ubiquitination	EEDEADPKRQKTENG HCCCCCHHHHCCCCC	68.92	21906983
96	Phosphorylation	ADPKRQKTENGASA- CCHHHHCCCCCCCC-	26.75	20736484

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PTMS_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTMS_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTMS_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GCR_HUMAN	NR3C1	physical	16150697
EP300_HUMAN	EP300	physical	16150697
CBP_HUMAN	CREBBP	physical	16150697
A4_HUMAN	APP	physical	21832049
CH60_HUMAN	HSPD1	physical	22863883
CH10_HUMAN	HSPE1	physical	22863883
RBBP7_HUMAN	RBBP7	physical	22863883
TALDO_HUMAN	TALDO1	physical	22863883
WDR1_HUMAN	WDR1	physical	22863883
SDCB2_HUMAN	SDCBP2	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-4; LYS-15 AND LYS-92, ANDMASS SPECTROMETRY.
PubMed: 19608861