SDCB2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SDCB2_HUMAN
• UniProt AC: Q9H190
• Protein Name: Syntenin-2
• Gene Name: SDCBP2 {ECO:0000312|HGNC:HGNC:15756}
• Organism: Homo sapiens (Human).
• Sequence Length: 292
• Subcellular Localization: Cytoplasm . Nucleus, nucleolus . Nucleus, nucleoplasm . Cell membrane . Nucleus speckle . Associates with intracellular membranes and enriched in the apical region of the cell and in intracellular compartments (PubMed:11102519). Colocalizes with TM4S
• Protein Description: Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival. [PubMed: 15961997]
• Protein Sequence: MSSLYPSLEDLKVDQAIQAQVRASPKMPALPVQATAISPPPVLYPNLAELENYMGLSLSSQEVQESLLQIPEGDSTAVSGPGPGQMVAPVTGYSLGVRRAEIKPGVREIHLCKDERGKTGLRLRKVDQGLFVQLVQANTPASLVGLRFGDQLLQIDGRDCAGWSSHKAHQVVKKASGDKIVVVVRDRPFQRTVTMHKDSMGHVGFVIKKGKIVSLVKGSSAARNGLLTNHYVCEVDGQNVIGLKDKKIMEILATAGNVVTLTIIPSVIYEHMVKKLPPVLLHHTMDHSIPDA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSLYPSLE ------CCCCCCCHH	29.11	24043423
3	Phosphorylation	-----MSSLYPSLED -----CCCCCCCHHH	30.53	20068231
5	Phosphorylation	---MSSLYPSLEDLK ---CCCCCCCHHHCC	7.85	29255136
7	Phosphorylation	-MSSLYPSLEDLKVD -CCCCCCCHHHCCHH	30.73	29255136
24	Phosphorylation	IQAQVRASPKMPALP HHHHHHCCCCCCCCC	17.94	25159151
93	Phosphorylation	MVAPVTGYSLGVRRA EEEECCEEEECEEHH	7.43	21253578
94	Ubiquitination	VAPVTGYSLGVRRAE EEECCEEEECEEHHE	21.71	29901268
176	Phosphorylation	HQVVKKASGDKIVVV HHHHHHHCCCEEEEE	57.30	27134283
179	Ubiquitination	VKKASGDKIVVVVRD HHHHCCCEEEEEECC	40.71	29901268
288	Phosphorylation	LHHTMDHSIPDA--- HHHCCCCCCCCC---	31.39	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SDCB2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SDCB2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SDCB2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MMTA2_HUMAN	C1orf35	physical	16189514
TIFA_HUMAN	TIFA	physical	16189514
NO40_HUMAN	ZCCHC17	physical	16189514
BEND7_HUMAN	BEND7	physical	16189514
DPPA2_HUMAN	DPPA2	physical	16189514
PRR13_HUMAN	PRR13	physical	16189514
SC23A_HUMAN	SEC23A	physical	21988832
THAP6_HUMAN	THAP6	physical	21988832
SDCB2_HUMAN	SDCBP2	physical	25416956
NO40_HUMAN	ZCCHC17	physical	25416956
ZN581_HUMAN	ZNF581	physical	25416956
PRR13_HUMAN	PRR13	physical	25416956
ZCH10_HUMAN	ZCCHC10	physical	25416956
CK057_HUMAN	C11orf57	physical	25416956
LYAR_HUMAN	LYAR	physical	25416956
PR40A_HUMAN	PRPF40A	physical	25416956
PPL13_HUMAN	LGALS14	physical	25416956
EIF1A_HUMAN	EIF1AD	physical	25416956
PR38A_HUMAN	PRPF38A	physical	25416956
YTDC1_HUMAN	YTHDC1	physical	25416956
TIFA_HUMAN	TIFA	physical	25416956
FAM9B_HUMAN	FAM9B	physical	25416956
FA13C_HUMAN	FAM13C	physical	25416956
SR1IP_HUMAN	SREK1IP1	physical	25416956
F133A_HUMAN	FAM133A	physical	25416956
CT453_HUMAN	CT45A3	physical	25416956
CT453_HUMAN	CT45A3	physical	21516116
NO40_HUMAN	ZCCHC17	physical	21516116
PR40A_HUMAN	PRPF40A	physical	21516116
EIF1A_HUMAN	EIF1AD	physical	21516116

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.