PRR13_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRR13_HUMAN
• UniProt AC: Q9NZ81
• Protein Name: Proline-rich protein 13
• Gene Name: PRR13
• Organism: Homo sapiens (Human).
• Sequence Length: 148
• Subcellular Localization: Nucleus .
• Protein Description: Negatively regulates TSP1 expression at the level of transcription. This down-regulation was shown to reduce taxane-induced apoptosis..
• Protein Sequence: MWNPNAGQPGPNPYPPNIGCPGGSNPAHPPPINPPFPPGPCPPPPGAPHGNPAFPPGGPPHPVPQPGYPGCQPLGPYPPPYPPPAPGIPPVNPLAPGMVGPAVIVDKKMQKKMKKAHKKMHKHQKHHKYHKHGKHSSSSSSSSSSDSD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
111	Acetylation	IVDKKMQKKMKKAHK CCCHHHHHHHHHHHH	51.87	30591579
112	Acetylation	VDKKMQKKMKKAHKK CCHHHHHHHHHHHHH	38.77	30591585
137	Phosphorylation	HKHGKHSSSSSSSSS CCCCCCCCCCCCCCC	33.68	-
138	Phosphorylation	KHGKHSSSSSSSSSS CCCCCCCCCCCCCCC	36.94	-
139	Phosphorylation	HGKHSSSSSSSSSSD CCCCCCCCCCCCCCC	35.87	-
140	Phosphorylation	GKHSSSSSSSSSSDS CCCCCCCCCCCCCCC	35.87	-
141	Phosphorylation	KHSSSSSSSSSSDSD CCCCCCCCCCCCCCC	35.87	-
142	Phosphorylation	HSSSSSSSSSSDSD- CCCCCCCCCCCCCC-	35.87	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRR13_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRR13_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRR13_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KLH12_HUMAN	KLHL12	physical	16189514
KR412_HUMAN	KRTAP4-12	physical	16189514
PRR13_HUMAN	PRR13	physical	25416956
ZCH10_HUMAN	ZCCHC10	physical	25416956
VAC14_HUMAN	VAC14	physical	25416956
KLH12_HUMAN	KLHL12	physical	25416956
LNX1_HUMAN	LNX1	physical	25416956
F133A_HUMAN	FAM133A	physical	25416956
KR107_HUMAN	KRTAP10-7	physical	25416956
KR108_HUMAN	KRTAP10-8	physical	25416956
LNX1_HUMAN	LNX1	physical	21516116

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.