dbPTM

SR1IP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SR1IP_HUMAN
UniProt AC	Q8N9Q2
Protein Name	Protein SREK1IP1
Gene Name	SREK1IP1
Organism	Homo sapiens (Human).
Sequence Length	155
Subcellular Localization
Protein Description	Possible splicing regulator involved in the control of cellular survival..
Protein Sequence	MAVPGCNKDSVRAGCKKCGYPGHLTFECRNFLRVDPKRDIVLDVSSTSSEDSDEENEELNKLQALQEKRINEEEEKKKEKSKEKIKLKKKRKRSYSSSSTEEDTSKQKKQKYQKKEKKKEKKSKSKKGKHHKKEKKKRKKEKHSSTPNSSEFSRK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	VPGCNKDSVRAGCKK CCCCCHHHHCCCHHH	18.34	23401153
45	Phosphorylation	RDIVLDVSSTSSEDS CCEEEECCCCCCCCC	27.80	20873877
46	Phosphorylation	DIVLDVSSTSSEDSD CEEEECCCCCCCCCH	31.96	20873877
47	Phosphorylation	IVLDVSSTSSEDSDE EEEECCCCCCCCCHH	28.85	20873877
48	Phosphorylation	VLDVSSTSSEDSDEE EEECCCCCCCCCHHH	33.41	20873877
49	Phosphorylation	LDVSSTSSEDSDEEN EECCCCCCCCCHHHH	45.57	20873877
52	Phosphorylation	SSTSSEDSDEENEEL CCCCCCCCHHHHHHH	42.76	20068231
68	Ubiquitination	KLQALQEKRINEEEE HHHHHHHHCCCHHHH	45.69	29967540
94	Phosphorylation	LKKKRKRSYSSSSTE HHHHHHCCCCCCCCC	32.19	20873877
95	Phosphorylation	KKKRKRSYSSSSTEE HHHHHCCCCCCCCCC	19.32	29759185
96	Phosphorylation	KKRKRSYSSSSTEED HHHHCCCCCCCCCCH	25.62	25627689
97	Phosphorylation	KRKRSYSSSSTEEDT HHHCCCCCCCCCCHH	21.78	29759185
98	Phosphorylation	RKRSYSSSSTEEDTS HHCCCCCCCCCCHHH	35.03	25627689
99	Phosphorylation	KRSYSSSSTEEDTSK HCCCCCCCCCCHHHH	41.61	25159151
100	Phosphorylation	RSYSSSSTEEDTSKQ CCCCCCCCCCHHHHH	45.39	20873877
144	Phosphorylation	KRKKEKHSSTPNSSE HHHHHHCCCCCCCHH	47.15	30266825
145	Phosphorylation	RKKEKHSSTPNSSEF HHHHHCCCCCCCHHH	47.83	30266825
146	Phosphorylation	KKEKHSSTPNSSEFS HHHHCCCCCCCHHHC	29.51	29255136
149	Phosphorylation	KHSSTPNSSEFSRK- HCCCCCCCHHHCCC-	32.23	25159151
150	Phosphorylation	HSSTPNSSEFSRK-- CCCCCCCHHHCCC--	49.66	23927012
153	Phosphorylation	TPNSSEFSRK----- CCCCHHHCCC-----	34.80	23927012

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SR1IP_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SR1IP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SR1IP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MAP1A_HUMAN	MAP1A	physical	28514442
CSK22_HUMAN	CSNK2A2	physical	28514442
CSK21_HUMAN	CSNK2A1	physical	28514442
RABL6_HUMAN	RABL6	physical	28514442
CA131_HUMAN	C1orf131	physical	28514442
FRIL_HUMAN	FTL	physical	28514442
CAPON_HUMAN	NOS1AP	physical	28514442
NU153_HUMAN	NUP153	physical	28514442
IMA6_HUMAN	KPNA5	physical	28514442
IMA7_HUMAN	KPNA6	physical	28514442
EF1A2_HUMAN	EEF1A2	physical	28514442
TCAF1_HUMAN	FAM115A	physical	28514442
SRRM2_HUMAN	SRRM2	physical	28514442
IMA5_HUMAN	KPNA1	physical	28514442
NKAP_HUMAN	NKAP	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SR1IP_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-146 AND SER-149, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45; SER-46; THR-47;SER-48; SER-49 AND SER-52, AND MASS SPECTROMETRY.	17081983 [Abstract]