IMA6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IMA6_HUMAN
• UniProt AC: O15131
• Protein Name: Importin subunit alpha-6
• Gene Name: KPNA5
• Organism: Homo sapiens (Human).
• Sequence Length: 536
• Subcellular Localization: Cytoplasm.
• Protein Description: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS..
• Protein Sequence: MASPGKDNYRMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVYLPRNDESMLESPIQDPDISSTVPIPEEEVVTTDMVQMIFSNNADQQLTATQKFRKLLSKEPNPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVALGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQESKQNGIGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEEDDPSIVPQVDENQQQFIFQQQEAPMDGFQL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASPGKDNY ------CCCCCCCCC		-
3	Phosphorylation	-----MASPGKDNYR -----CCCCCCCCCC		23401153
6	Phosphorylation	--MASPGKDNYRMKS --CCCCCCCCCCCHH		24719451
6	Ubiquitination	--MASPGKDNYRMKS --CCCCCCCCCCCHH		24816145
9	Phosphorylation	ASPGKDNYRMKSYKN CCCCCCCCCCHHHHC		22673903
9	Ubiquitination	ASPGKDNYRMKSYKN CCCCCCCCCCHHHHC		24816145
14	Phosphorylation	DNYRMKSYKNKALNP CCCCCHHHHCCCCCH		-
26	Phosphorylation	LNPQEMRRRREEEGI CCHHHHHHHHHHHHH		33259812
29	Ubiquitination	QEMRRRREEEGIQLR HHHHHHHHHHHHHHH		24816145
32	Ubiquitination	RRRREEEGIQLRKQK HHHHHHHHHHHHHHH		27667366
37	Ubiquitination	EEGIQLRKQKREEQL HHHHHHHHHHHHHHH		27667366
46	Ubiquitination	KREEQLFKRRNVYLP HHHHHHHHHCCCCCC		21890473
49	Ubiquitination	EQLFKRRNVYLPRND HHHHHHCCCCCCCCC		21890473
69	Ubiquitination	SPIQDPDISSTVPIP CCCCCCCCCCCCCCC		21890473
110	Methylation	KFRKLLSKEPNPPID HHHHHHCCCCCCCHH		23644510
110	Ubiquitination	KFRKLLSKEPNPPID HHHHHHCCCCCCCHH		-
110	"N6,N6-dimethyllysine"	KFRKLLSKEPNPPID HHHHHHCCCCCCCHH		-
113	Methylation	KLLSKEPNPPIDQVI HHHCCCCCCCHHHHH		-
113	Ubiquitination	KLLSKEPNPPIDQVI HHHCCCCCCCHHHHH		-
122	Ubiquitination	PIDQVIQKPGVVQRF CHHHHHCCHHHHHHH		-
125	Ubiquitination	QVIQKPGVVQRFVKF HHHCCHHHHHHHHHH		29967540
131	Ubiquitination	GVVQRFVKFLERNEN HHHHHHHHHHHHCCC		21890473
134	Ubiquitination	QRFVKFLERNENCTL HHHHHHHHHCCCCEE		21890473
154	Phosphorylation	WALTNIASGTFLHTK HHHHHHCCCCCEEEE		-
154	Ubiquitination	WALTNIASGTFLHTK HHHHHHCCCCCEEEE		21890473
187	Ubiquitination	HEDVQEQAVWALGNI CHHHHHHHHHHHHHH		22817900
192	Ubiquitination	EQAVWALGNIAGDNA HHHHHHHHHHCCCCH		22817900
219	Phosphorylation	PPLLELLTNSNRLTT HHHHHHHHCCCCCCC		-
235	Phosphorylation	RNAVWALSNLCRGKN HHHHHHHHHHHCCCC		21712546
238	Phosphorylation	VWALSNLCRGKNPPP HHHHHHHHCCCCCCC		-
241	Ubiquitination	LSNLCRGKNPPPNFS HHHHHCCCCCCCCHH		27667366
244	Ubiquitination	LCRGKNPPPNFSKVS HHCCCCCCCCHHHHH		27667366
264	Ubiquitination	LSRLLFSSDPDVLAD HHHHHHCCCHHHHHH		27667366
293	Phosphorylation	KIQAVIDSGVCRRLV HHHHHHHHHHHHHHH		32142685
296	Phosphorylation	AVIDSGVCRRLVELL HHHHHHHHHHHHHHH		32142685
308	Phosphorylation	ELLMHNDYKVVSPAL HHHHCCCHHHHCHHH		-
309	Ubiquitination	LLMHNDYKVVSPALR HHHCCCHHHHCHHHH		-
312	Ubiquitination	HNDYKVVSPALRAVG CCCHHHHCHHHHHHC		-
316	Phosphorylation	KVVSPALRAVGNIVT HHHCHHHHHHCCEEC		32142685
396	Ubiquitination	KAEFRTRKEAAWAIT HCCCCCHHHHHHHHH		22817900
399	Ubiquitination	FRTRKEAAWAITNAT CCCHHHHHHHHHCCC		21906983
416	Phosphorylation	GTPEQIRYLVALGCI CCHHHHHHHHHHCCH		21406692
419	Ubiquitination	EQIRYLVALGCIKPL HHHHHHHHHCCHHHH		22817900
419	Phosphorylation	EQIRYLVALGCIKPL HHHHHHHHHCCHHHH		-
474	Phosphorylation	CALIEEAYGLDKIEF HHHHHHHHCCCHHHH		25884760
477	Phosphorylation	IEEAYGLDKIEFLQS HHHHHCCCHHHHHHC		-
491	Phosphorylation	SHENQEIYQKAFDLI CCCCHHHHHHHHHHH		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IMA6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IMA6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IMA6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IMB1_HUMAN	KPNB1	physical	22939629
AN32B_HUMAN	ANP32B	physical	25416956
NUP50_HUMAN	NUP50	physical	25416956
SPOPL_HUMAN	SPOPL	physical	25416956
RBBP4_HUMAN	RBBP4	physical	26491019
PHB2_HUMAN	PHB2	physical	26052702

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.