CA131_HUMAN - dbPTM
CA131_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CA131_HUMAN
UniProt AC Q8NDD1
Protein Name Uncharacterized protein C1orf131
Gene Name C1orf131
Organism Homo sapiens (Human).
Sequence Length 293
Subcellular Localization Chromosome .
Protein Description
Protein Sequence MRVDSSADPTMSQEQGPGSSTPPSSPTLLDALLQNLYDFGGTEGETEQKKIIKKRENKKRDVMASAALAAEPSPLPGSLIRGQRKSASSFFKELREERHCAPSGTPTGPEILAAAVPPSSLKNNREQVEVVEFHSNKKRKLTPDHNKNTKQANPSVLERDVDTQEFNLEKARLEVHRFGITGYGKGKERILEQERAIMLGAKPPKKSYVNYKVLQEQIKEKKAAKEEEKRLAQETDIFKKKKRKGQEDRKSKKKSAPSILSNGRIGQVGKFKNGTLILSPVDIKKINSSRVAK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MRVDSSADPTMS
---CCCCCCCCCCCC		25.2720873877
6Phosphorylation--MRVDSSADPTMSQ
--CCCCCCCCCCCCC		32.0220873877
10PhosphorylationVDSSADPTMSQEQGP
CCCCCCCCCCCCCCC		29.9620873877
12PhosphorylationSSADPTMSQEQGPGS
CCCCCCCCCCCCCCC		32.8024144214
19PhosphorylationSQEQGPGSSTPPSSP
CCCCCCCCCCCCCCH		33.8820873877
20PhosphorylationQEQGPGSSTPPSSPT
CCCCCCCCCCCCCHH		51.3420873877
21PhosphorylationEQGPGSSTPPSSPTL
CCCCCCCCCCCCHHH		40.7020873877
24PhosphorylationPGSSTPPSSPTLLDA
CCCCCCCCCHHHHHH		50.5920873877
25PhosphorylationGSSTPPSSPTLLDAL
CCCCCCCCHHHHHHH		27.9020873877
27PhosphorylationSTPPSSPTLLDALLQ
CCCCCCHHHHHHHHH		41.7320873877
37PhosphorylationDALLQNLYDFGGTEG
HHHHHHHHHCCCCCC		19.4420873877
42O-linked_GlycosylationNLYDFGGTEGETEQK
HHHHCCCCCCHHHHH		40.9929351928
42PhosphorylationNLYDFGGTEGETEQK
HHHHCCCCCCHHHHH		40.9924144214
46O-linked_GlycosylationFGGTEGETEQKKIIK
CCCCCCHHHHHHHHH		55.3529351928
46PhosphorylationFGGTEGETEQKKIIK
CCCCCCHHHHHHHHH		55.3524144214
65PhosphorylationKKRDVMASAALAAEP
HHHHHHHHHHHHCCC		8.93-
73PhosphorylationAALAAEPSPLPGSLI
HHHHCCCCCCCCCHH		30.4925159151
78PhosphorylationEPSPLPGSLIRGQRK
CCCCCCCCHHHCCHH		20.7725159151
85MethylationSLIRGQRKSASSFFK
CHHHCCHHHHHHHHH		42.35-
86PhosphorylationLIRGQRKSASSFFKE
HHHCCHHHHHHHHHH		35.2623401153
88PhosphorylationRGQRKSASSFFKELR
HCCHHHHHHHHHHHH		34.4730266825
89PhosphorylationGQRKSASSFFKELRE
CCHHHHHHHHHHHHH		34.1230266825
103PhosphorylationEERHCAPSGTPTGPE
HHCCCCCCCCCCCHH		36.4524732914
105PhosphorylationRHCAPSGTPTGPEIL
CCCCCCCCCCCHHHH		23.2424732914
107PhosphorylationCAPSGTPTGPEILAA
CCCCCCCCCHHHHHH		66.2724732914
119PhosphorylationLAAAVPPSSLKNNRE
HHHCCCHHHHCCCHH		42.0825159151
120PhosphorylationAAAVPPSSLKNNREQ
HHCCCHHHHCCCHHH		49.4921712546
135PhosphorylationVEVVEFHSNKKRKLT
EEEEEECCCCCCCCC		56.5225159151
142PhosphorylationSNKKRKLTPDHNKNT
CCCCCCCCCCCCCCC		29.7026657352
155PhosphorylationNTKQANPSVLERDVD
CCCCCCHHHHHCCCC		38.86-
163PhosphorylationVLERDVDTQEFNLEK
HHHCCCCCCCCCHHH		29.8217525332
169UbiquitinationDTQEFNLEKARLEVH
CCCCCCHHHHHHEEH		45.8624816145
170UbiquitinationTQEFNLEKARLEVHR
CCCCCHHHHHHEEHH		41.8124816145
185AcetylationFGITGYGKGKERILE
HCCCCCCCCHHHHHH		59.3219608861
207PhosphorylationGAKPPKKSYVNYKVL
CCCCCCHHHCCHHHH		40.2020860994
208PhosphorylationAKPPKKSYVNYKVLQ
CCCCCHHHCCHHHHH		11.1229083192
211PhosphorylationPKKSYVNYKVLQEQI
CCHHHCCHHHHHHHH		7.7629083192
219AcetylationKVLQEQIKEKKAAKE
HHHHHHHHHHHHHHH		64.2726051181
240UbiquitinationQETDIFKKKKRKGQE
HHHHHHHHHHHCCHH		53.4224816145
241UbiquitinationETDIFKKKKRKGQED
HHHHHHHHHHCCHHH		59.4024816145
254 (in isoform 3)Phosphorylation-60.08-
255PhosphorylationDRKSKKKSAPSILSN
HHHHHCCCCCHHHHC		56.43-
255 (in isoform 2)Phosphorylation-56.43-
256PhosphorylationRKSKKKSAPSILSNG
HHHHCCCCCHHHHCC		55.0520860994
258PhosphorylationSKKKSAPSILSNGRI
HHCCCCCHHHHCCCC		29.06-
259PhosphorylationKKKSAPSILSNGRIG
HCCCCCHHHHCCCCC		35.5623312004
262PhosphorylationSAPSILSNGRIGQVG
CCCHHHHCCCCCCCC		35.25-
270AcetylationGRIGQVGKFKNGTLI
CCCCCCCCCCCCEEE		23.07-
270MethylationGRIGQVGKFKNGTLI
CCCCCCCCCCCCEEE		23.07-
271AcetylationRIGQVGKFKNGTLIL
CCCCCCCCCCCEEEE		55.0725953088
271MethylationRIGQVGKFKNGTLIL
CCCCCCCCCCCEEEE		55.07-
276PhosphorylationGKFKNGTLILSPVDI
CCCCCCEEEECCCCH		21.7324732914
279PhosphorylationKNGTLILSPVDIKKI
CCCEEEECCCCHHHC		5.4919664995
280PhosphorylationNGTLILSPVDIKKIN
CCEEEECCCCHHHCC		18.8430266825
285AcetylationLSPVDIKKINSSRVA
ECCCCHHHCCHHHCC		43.0425953088
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CA131_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CA131_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CA131_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
CA131_HUMANC1orf131physical
26472760
SYRC_HUMANRARSphysical
26472760
IF2P_HUMANEIF5Bphysical
26472760
SYIC_HUMANIARSphysical
26472760
SYK_HUMANKARSphysical
26472760
MBB1A_HUMANMYBBP1Aphysical
26472760
2AAA_HUMANPPP2R1Aphysical
26472760
LRC59_HUMANLRRC59physical
26472760
RL23A_HUMANRPL23Aphysical
26472760
SYQ_HUMANQARSphysical
26472760
RS15_HUMANRPS15physical
26472760
DDX21_HUMANDDX21physical
26472760
NAT10_HUMANNAT10physical
26472760
AIMP2_HUMANAIMP2physical
26472760
PR40A_HUMANPRPF40Aphysical
26472760
U520_HUMANSNRNP200physical
26472760
RL17_HUMANRPL17physical
26472760
SMRC1_HUMANSMARCC1physical
26472760
DDX18_HUMANDDX18physical
26472760
2ABA_HUMANPPP2R2Aphysical
26472760
SYEP_HUMANEPRSphysical
26472760
IF2G_HUMANEIF2S3physical
26472760
IQGA1_HUMANIQGAP1physical
26472760
PRP8_HUMANPRPF8physical
26472760
EIF3L_HUMANEIF3Lphysical
26472760
SNF5_HUMANSMARCB1physical
26472760
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CA131_HUMAN

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-185, AND MASS SPECTROMETRY.
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-280, AND MASSSPECTROMETRY.
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86; SER-207 AND SER-280,AND MASS SPECTROMETRY.
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-163, AND MASSSPECTROMETRY.

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