dbPTM

DDX21_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DDX21_HUMAN
UniProt AC	Q9NR30
Protein Name	Nucleolar RNA helicase 2 {ECO:0000305}
Gene Name	DDX21
Organism	Homo sapiens (Human).
Sequence Length	783
Subcellular Localization	Nucleus, nucleolus . Nucleus, nucleoplasm . Present both in nucleolus and nucleoplasm. Interaction with JUN promotes translocation from the nucleolus to the nucleoplasm (PubMed:11823437, PubMed:18180292). Interaction with WDR46 is required for locali
Protein Description	RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II). [PubMed: 25470060 Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs]
Protein Sequence	MPGKLRSDAGLESDTAMKKGETLRKQTEEKEKKEKPKSDKTEEIAEEEETVFPKAKQVKKKAEPSEVDMNSPKSKKAKKKEEPSQNDISPKTKSLRKKKEPIEKKVVSSKTKKVTKNEEPSEEEIDAPKPKKMKKEKEMNGETREKSPKLKNGFPHPEPDCNPSEAASEESNSEIEQEIPVEQKEGAFSNFPISEETIKLLKGRGVTFLFPIQAKTFHHVYSGKDLIAQARTGTGKTFSFAIPLIEKLHGELQDRKRGRAPQVLVLAPTRELANQVSKDFSDITKKLSVACFYGGTPYGGQFERMRNGIDILVGTPGRIKDHIQNGKLDLTKLKHVVLDEVDQMLDMGFADQVEEILSVAYKKDSEDNPQTLLFSATCPHWVFNVAKKYMKSTYEQVDLIGKKTQKTAITVEHLAIKCHWTQRAAVIGDVIRVYSGHQGRTIIFCETKKEAQELSQNSAIKQDAQSLHGDIPQKQREITLKGFRNGSFGVLVATNVAARGLDIPEVDLVIQSSPPKDVESYIHRSGRTGRAGRTGVCICFYQHKEEYQLVQVEQKAGIKFKRIGVPSATEIIKASSKDAIRLLDSVPPTAISHFKQSAEKLIEEKGAVEALAAALAHISGATSVDQRSLINSNVGFVTMILQCSIEMPNISYAWKELKEQLGEEIDSKVKGMVFLKGKLGVCFDVPTASVTEIQEKWHDSRRWQLSVATEQPELEGPREGYGGFRGQREGSRGFRGQRDGNRRFRGQREGSRGPRGQRSGGGNKSNRSQNKGQKRSFSKAFGQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1 (in isoform 2)	Acetylation	-	9.97	22814378
7	Phosphorylation	-MPGKLRSDAGLESD -CCCCCCCCCCCCCH	42.10	23927012
13	Phosphorylation	RSDAGLESDTAMKKG CCCCCCCCHHHHHHH	45.35	22167270
15	Phosphorylation	DAGLESDTAMKKGET CCCCCCHHHHHHHHH	37.62	30266825
17	Sulfoxidation	GLESDTAMKKGETLR CCCCHHHHHHHHHHH	5.10	21406390
18	2-Hydroxyisobutyrylation	LESDTAMKKGETLRK CCCHHHHHHHHHHHH	55.98	-
18	Acetylation	LESDTAMKKGETLRK CCCHHHHHHHHHHHH	55.98	28790157
18	Ubiquitination	LESDTAMKKGETLRK CCCHHHHHHHHHHHH	55.98	24816145
19	Acetylation	ESDTAMKKGETLRKQ CCHHHHHHHHHHHHH	49.23	30583679
22	Phosphorylation	TAMKKGETLRKQTEE HHHHHHHHHHHHHHH	40.30	23927012
23	Ubiquitination	AMKKGETLRKQTEEK HHHHHHHHHHHHHHH	5.84	29967540
25	Acetylation	KKGETLRKQTEEKEK HHHHHHHHHHHHHHH	65.76	30583669
30	Acetylation	LRKQTEEKEKKEKPK HHHHHHHHHHHCCCC	69.47	30583673
38	Phosphorylation	EKKEKPKSDKTEEIA HHHCCCCCCCHHHHH	53.52	25627689
40	Acetylation	KEKPKSDKTEEIAEE HCCCCCCCHHHHHHH	66.00	25953088
40	Ubiquitination	KEKPKSDKTEEIAEE HCCCCCCCHHHHHHH	66.00	29967540
48	Ubiquitination	TEEIAEEEETVFPKA HHHHHHHHHCCCHHH	50.93	33845483
50	Phosphorylation	EIAEEEETVFPKAKQ HHHHHHHCCCHHHHH	30.63	21601212
54	Acetylation	EEETVFPKAKQVKKK HHHCCCHHHHHHHHH	57.67	26051181
54	Ubiquitination	EEETVFPKAKQVKKK HHHCCCHHHHHHHHH	57.67	29967540
60	Ubiquitination	PKAKQVKKKAEPSEV HHHHHHHHHCCCCCC	59.36	-
61	Acetylation	KAKQVKKKAEPSEVD HHHHHHHHCCCCCCC	52.87	26051181
61	Ubiquitination	KAKQVKKKAEPSEVD HHHHHHHHCCCCCCC	52.87	29967540
63	Ubiquitination	KQVKKKAEPSEVDMN HHHHHHCCCCCCCCC	59.23	29967540
65	Phosphorylation	VKKKAEPSEVDMNSP HHHHCCCCCCCCCCC	41.58	23927012
69	Sulfoxidation	AEPSEVDMNSPKSKK CCCCCCCCCCCHHHH	6.90	21406390
71	Phosphorylation	PSEVDMNSPKSKKAK CCCCCCCCCHHHHCC	27.37	19664994
73	Ubiquitination	EVDMNSPKSKKAKKK CCCCCCCHHHHCCCC	74.79	29967540
74	Phosphorylation	VDMNSPKSKKAKKKE CCCCCCHHHHCCCCC	42.65	24732914
79	Ubiquitination	PKSKKAKKKEEPSQN CHHHHCCCCCCCCCC	70.99	29967540
80	Acetylation	KSKKAKKKEEPSQND HHHHCCCCCCCCCCC	67.61	26051181
80	Ubiquitination	KSKKAKKKEEPSQND HHHHCCCCCCCCCCC	67.61	29967540
84	Phosphorylation	AKKKEEPSQNDISPK CCCCCCCCCCCCCHH	44.91	23927012
89	Phosphorylation	EPSQNDISPKTKSLR CCCCCCCCHHHHHHH	24.17	19664994
91	Ubiquitination	SQNDISPKTKSLRKK CCCCCCHHHHHHHHC	62.89	29967540
92	Phosphorylation	QNDISPKTKSLRKKK CCCCCHHHHHHHHCC	29.29	24732914
104	2-Hydroxyisobutyrylation	KKKEPIEKKVVSSKT HCCCCCHHHHCCCCC	52.14	-
105	Phosphorylation	KKEPIEKKVVSSKTK CCCCCHHHHCCCCCC	34.77	33259812
112	Acetylation	KVVSSKTKKVTKNEE HHCCCCCCCCCCCCC	49.32	20167786
115	Phosphorylation	SSKTKKVTKNEEPSE CCCCCCCCCCCCCCH	36.71	23927012
116	Acetylation	SKTKKVTKNEEPSEE CCCCCCCCCCCCCHH	66.41	20167786
116	Sumoylation	SKTKKVTKNEEPSEE CCCCCCCCCCCCCHH	66.41	25114211
116	Ubiquitination	SKTKKVTKNEEPSEE CCCCCCCCCCCCCHH	66.41	33845483
121	Phosphorylation	VTKNEEPSEEEIDAP CCCCCCCCHHHCCCC	62.00	29255136
129	Acetylation	EEEIDAPKPKKMKKE HHHCCCCCCCCCCHH	71.79	26051181
129	Ubiquitination	EEEIDAPKPKKMKKE HHHCCCCCCCCCCHH	71.79	29967540
131	Ubiquitination	EIDAPKPKKMKKEKE HCCCCCCCCCCHHHH	72.18	32015554
135	Acetylation	PKPKKMKKEKEMNGE CCCCCCCHHHHCCCC	71.20	26051181
137	Acetylation	PKKMKKEKEMNGETR CCCCCHHHHCCCCCC	71.75	23749302
143	Phosphorylation	EKEMNGETREKSPKL HHHCCCCCCCCCCCC	45.59	27174698
147	Phosphorylation	NGETREKSPKLKNGF CCCCCCCCCCCCCCC	23.63	25849741
156	Ubiquitination	KLKNGFPHPEPDCNP CCCCCCCCCCCCCCH	36.77	29967540
164	Phosphorylation	PEPDCNPSEAASEES CCCCCCHHHHHCHHC	26.35	23927012
168	Phosphorylation	CNPSEAASEESNSEI CCHHHHHCHHCCCHH	49.28	23927012
168	Ubiquitination	CNPSEAASEESNSEI CCHHHHHCHHCCCHH	49.28	29967540
171	O-linked_Glycosylation	SEAASEESNSEIEQE HHHHCHHCCCHHCCC	41.42	23301498
171	Phosphorylation	SEAASEESNSEIEQE HHHHCHHCCCHHCCC	41.42	23927012
173	Phosphorylation	AASEESNSEIEQEIP HHCHHCCCHHCCCCC	49.59	25159151
184	Ubiquitination	QEIPVEQKEGAFSNF CCCCCCCCCCCCCCC	44.61	-
189	Phosphorylation	EQKEGAFSNFPISEE CCCCCCCCCCCCCHH	36.71	21082442
199	Sumoylation	PISEETIKLLKGRGV CCCHHHHHHHCCCCC	56.01	-
199	Ubiquitination	PISEETIKLLKGRGV CCCHHHHHHHCCCCC	56.01	32015554
210	Ubiquitination	GRGVTFLFPIQAKTF CCCCEEEEEEEECEE	4.35	29967540
215	Acetylation	FLFPIQAKTFHHVYS EEEEEEECEEEEEEC	35.03	25953088
216	Phosphorylation	LFPIQAKTFHHVYSG EEEEEECEEEEEECC	31.08	23312004
217	Ubiquitination	FPIQAKTFHHVYSGK EEEEECEEEEEECCH	3.55	33845483
221	Phosphorylation	AKTFHHVYSGKDLIA ECEEEEEECCHHHEE	13.83	28152594
222	Phosphorylation	KTFHHVYSGKDLIAQ CEEEEEECCHHHEEE	37.97	28152594
224	Acetylation	FHHVYSGKDLIAQAR EEEEECCHHHEEECC	43.34	26051181
224	Ubiquitination	FHHVYSGKDLIAQAR EEEEECCHHHEEECC	43.34	29967540
236	Ubiquitination	QARTGTGKTFSFAIP ECCCCCCCCCHHHHH	46.35	29967540
237	Phosphorylation	ARTGTGKTFSFAIPL CCCCCCCCCHHHHHH	26.34	23898821
239	Phosphorylation	TGTGKTFSFAIPLIE CCCCCCCHHHHHHHH	20.99	23898821
255	Methylation	LHGELQDRKRGRAPQ HHHHHHCCCCCCCCC	20.01	-
259	Ubiquitination	LQDRKRGRAPQVLVL HHCCCCCCCCCEEEE	47.31	32015554
264	Ubiquitination	RGRAPQVLVLAPTRE CCCCCCEEEECCHHH	1.89	29967540
278	2-Hydroxyisobutyrylation	ELANQVSKDFSDITK HHHHHHCCCHHHHHH	65.03	-
278	Acetylation	ELANQVSKDFSDITK HHHHHHCCCHHHHHH	65.03	26051181
278	Succinylation	ELANQVSKDFSDITK HHHHHHCCCHHHHHH	65.03	23954790
278	Ubiquitination	ELANQVSKDFSDITK HHHHHHCCCHHHHHH	65.03	29967540
285	2-Hydroxyisobutyrylation	KDFSDITKKLSVACF CCHHHHHHHHHHEEE	52.64	-
285	Acetylation	KDFSDITKKLSVACF CCHHHHHHHHHHEEE	52.64	25953088
285	Ubiquitination	KDFSDITKKLSVACF CCHHHHHHHHHHEEE	52.64	33845483
286	Acetylation	DFSDITKKLSVACFY CHHHHHHHHHHEEEC	37.03	26051181
288	Phosphorylation	SDITKKLSVACFYGG HHHHHHHHHEEECCC	19.29	29214152
293	Phosphorylation	KLSVACFYGGTPYGG HHHHEEECCCCCCCH	17.96	29214152
295	Ubiquitination	SVACFYGGTPYGGQF HHEEECCCCCCCHHH	16.49	29967540
296	Phosphorylation	VACFYGGTPYGGQFE HEEECCCCCCCHHHH	14.69	25159151
298	Phosphorylation	CFYGGTPYGGQFERM EECCCCCCCHHHHHH	33.45	23186163
306	Methylation	GGQFERMRNGIDILV CHHHHHHHCCEEEEE	44.43	-
315	Phosphorylation	GIDILVGTPGRIKDH CEEEEECCCHHHHHH	18.32	23401153
319	Ubiquitination	LVGTPGRIKDHIQNG EECCCHHHHHHHHCC	8.34	29967540
320	2-Hydroxyisobutyrylation	VGTPGRIKDHIQNGK ECCCHHHHHHHHCCC	41.72	-
320	Acetylation	VGTPGRIKDHIQNGK ECCCHHHHHHHHCCC	41.72	26051181
327	2-Hydroxyisobutyrylation	KDHIQNGKLDLTKLK HHHHHCCCCCHHHCC	46.51	-
327	Acetylation	KDHIQNGKLDLTKLK HHHHHCCCCCHHHCC	46.51	25953088
327	Ubiquitination	KDHIQNGKLDLTKLK HHHHHCCCCCHHHCC	46.51	32015554
332	Acetylation	NGKLDLTKLKHVVLD CCCCCHHHCCCHHHH	63.94	26822725
332	Ubiquitination	NGKLDLTKLKHVVLD CCCCCHHHCCCHHHH	63.94	29967540
334	Ubiquitination	KLDLTKLKHVVLDEV CCCHHHCCCHHHHHH	35.59	33845483
335	Ubiquitination	LDLTKLKHVVLDEVD CCHHHCCCHHHHHHH	25.92	29967540
338	Ubiquitination	TKLKHVVLDEVDQML HHCCCHHHHHHHHHH	4.52	33845483
358	Phosphorylation	DQVEEILSVAYKKDS HHHHHHHHHHHCCCC	15.46	18452278
361	Phosphorylation	EEILSVAYKKDSEDN HHHHHHHHCCCCCCC	19.20	18452278
363	Ubiquitination	ILSVAYKKDSEDNPQ HHHHHHCCCCCCCCC	54.53	29967540
371	Phosphorylation	DSEDNPQTLLFSATC CCCCCCCEEEEEECC	27.04	-
378	Glutathionylation	TLLFSATCPHWVFNV EEEEEECCHHHHHHH	2.03	22555962
387	Acetylation	HWVFNVAKKYMKSTY HHHHHHHHHHHHHHH	39.90	25953088
387	Ubiquitination	HWVFNVAKKYMKSTY HHHHHHHHHHHHHHH	39.90	29967540
392	Phosphorylation	VAKKYMKSTYEQVDL HHHHHHHHHHHHHCC	21.49	20860994
393	Phosphorylation	AKKYMKSTYEQVDLI HHHHHHHHHHHHCCC	26.09	20860994
393	Ubiquitination	AKKYMKSTYEQVDLI HHHHHHHHHHHHCCC	26.09	29967540
394	Phosphorylation	KKYMKSTYEQVDLIG HHHHHHHHHHHCCCC	16.08	28152594
402	2-Hydroxyisobutyrylation	EQVDLIGKKTQKTAI HHHCCCCCCCCCEEE	45.73	-
402	Acetylation	EQVDLIGKKTQKTAI HHHCCCCCCCCCEEE	45.73	23236377
402	Malonylation	EQVDLIGKKTQKTAI HHHCCCCCCCCCEEE	45.73	26320211
402	Ubiquitination	EQVDLIGKKTQKTAI HHHCCCCCCCCCEEE	45.73	33845483
403	Ubiquitination	QVDLIGKKTQKTAIT HHCCCCCCCCCEEEE	51.48	29967540
406	Acetylation	LIGKKTQKTAITVEH CCCCCCCCEEEEEEH	45.19	25953088
406	Ubiquitination	LIGKKTQKTAITVEH CCCCCCCCEEEEEEH	45.19	23000965
407	Phosphorylation	IGKKTQKTAITVEHL CCCCCCCEEEEEEHH	17.30	20860994
410	Phosphorylation	KTQKTAITVEHLAIK CCCCEEEEEEHHHHH	19.85	20860994
413	Ubiquitination	KTAITVEHLAIKCHW CEEEEEEHHHHHCHH	19.07	21890473
417	Acetylation	TVEHLAIKCHWTQRA EEEHHHHHCHHHHHH	17.91	25953088
432	Methylation	AVIGDVIRVYSGHQG HHHHHEEEEEECCCC	22.59	-
434	Nitration	IGDVIRVYSGHQGRT HHHEEEEEECCCCCE	10.09	-
445	S-palmitoylation	QGRTIIFCETKKEAQ CCCEEEEECCHHHHH	4.59	29575903
447	Phosphorylation	RTIIFCETKKEAQEL CEEEEECCHHHHHHH	48.90	20068231
448	2-Hydroxyisobutyrylation	TIIFCETKKEAQELS EEEEECCHHHHHHHH	26.73	-
448	Acetylation	TIIFCETKKEAQELS EEEEECCHHHHHHHH	26.73	25953088
449	2-Hydroxyisobutyrylation	IIFCETKKEAQELSQ EEEECCHHHHHHHHH	66.75	-
449	Acetylation	IIFCETKKEAQELSQ EEEECCHHHHHHHHH	66.75	26051181
451	Ubiquitination	FCETKKEAQELSQNS EECCHHHHHHHHHCH	19.61	24816145
455	Phosphorylation	KKEAQELSQNSAIKQ HHHHHHHHHCHHHHH	26.94	21406692
458	Phosphorylation	AQELSQNSAIKQDAQ HHHHHHCHHHHHHHH	24.59	25159151
461	Acetylation	LSQNSAIKQDAQSLH HHHCHHHHHHHHHHC	41.67	26051181
461	Ubiquitination	LSQNSAIKQDAQSLH HHHCHHHHHHHHHHC	41.67	29967540
466	Phosphorylation	AIKQDAQSLHGDIPQ HHHHHHHHHCCCCCH	24.85	20068231
474	Acetylation	LHGDIPQKQREITLK HCCCCCHHHHEEEEE	46.07	25953088
474	Ubiquitination	LHGDIPQKQREITLK HCCCCCHHHHEEEEE	46.07	23000965
481	2-Hydroxyisobutyrylation	KQREITLKGFRNGSF HHHEEEEECCCCCCC	47.56	-
481	Acetylation	KQREITLKGFRNGSF HHHEEEEECCCCCCC	47.56	26051181
481	Malonylation	KQREITLKGFRNGSF HHHEEEEECCCCCCC	47.56	30639696
481	Methylation	KQREITLKGFRNGSF HHHEEEEECCCCCCC	47.56	-
481	Ubiquitination	KQREITLKGFRNGSF HHHEEEEECCCCCCC	47.56	22817900
487	Ubiquitination	LKGFRNGSFGVLVAT EECCCCCCCEEEEEE	23.52	29967540
494	Phosphorylation	SFGVLVATNVAARGL CCEEEEEECHHHCCC	23.81	24114839
505	Ubiquitination	ARGLDIPEVDLVIQS HCCCCCCCCCEEEEC	49.34	33845483
512	Phosphorylation	EVDLVIQSSPPKDVE CCCEEEECCCCCCHH	33.42	20873877
513	Phosphorylation	VDLVIQSSPPKDVES CCEEEECCCCCCHHH	28.92	29496963
516	Acetylation	VIQSSPPKDVESYIH EEECCCCCCHHHHHH	77.21	26051181
519	Ubiquitination	SSPPKDVESYIHRSG CCCCCCHHHHHHHCC	48.21	24816145
520	Phosphorylation	SPPKDVESYIHRSGR CCCCCHHHHHHHCCC	29.27	28122231
521	Phosphorylation	PPKDVESYIHRSGRT CCCCHHHHHHHCCCC	6.29	28122231
527	Ubiquitination	SYIHRSGRTGRAGRT HHHHHCCCCCCCCCE	34.94	29967540
537	Ubiquitination	RAGRTGVCICFYQHK CCCCEEEEEEEEECH	2.07	33845483
541	Phosphorylation	TGVCICFYQHKEEYQ EEEEEEEEECHHHEE	12.80	25159151
544	Acetylation	CICFYQHKEEYQLVQ EEEEEECHHHEEEEE	36.39	26051181
547	Phosphorylation	FYQHKEEYQLVQVEQ EEECHHHEEEEEEEH	14.29	-
555	Acetylation	QLVQVEQKAGIKFKR EEEEEEHHHCCCEEE	34.77	26051181
555	Ubiquitination	QLVQVEQKAGIKFKR EEEEEEHHHCCCEEE	34.77	29967540
559	Acetylation	VEQKAGIKFKRIGVP EEHHHCCCEEECCCC	43.87	26051181
567	Phosphorylation	FKRIGVPSATEIIKA EEECCCCCHHHHHHH	45.47	30266825
569	Phosphorylation	RIGVPSATEIIKASS ECCCCCHHHHHHHCC	31.86	30266825
573	2-Hydroxyisobutyrylation	PSATEIIKASSKDAI CCHHHHHHHCCHHHH	48.12	-
573	Acetylation	PSATEIIKASSKDAI CCHHHHHHHCCHHHH	48.12	26051181
573	Ubiquitination	PSATEIIKASSKDAI CCHHHHHHHCCHHHH	48.12	33845483
575	Phosphorylation	ATEIIKASSKDAIRL HHHHHHHCCHHHHHH	32.68	23403867
576	Phosphorylation	TEIIKASSKDAIRLL HHHHHHCCHHHHHHH	39.14	23403867
577	Acetylation	EIIKASSKDAIRLLD HHHHHCCHHHHHHHH	49.00	7683501
577	Succinylation	EIIKASSKDAIRLLD HHHHHCCHHHHHHHH	49.00	23954790
577	Ubiquitination	EIIKASSKDAIRLLD HHHHHCCHHHHHHHH	49.00	-
585	Phosphorylation	DAIRLLDSVPPTAIS HHHHHHHCCCHHHHH	36.17	21406692
589	Phosphorylation	LLDSVPPTAISHFKQ HHHCCCHHHHHHHHH	30.47	21406692
592	Phosphorylation	SVPPTAISHFKQSAE CCCHHHHHHHHHHHH	22.02	21406692
595	2-Hydroxyisobutyrylation	PTAISHFKQSAEKLI HHHHHHHHHHHHHHH	37.61	-
595	Acetylation	PTAISHFKQSAEKLI HHHHHHHHHHHHHHH	37.61	27452117
595	Ubiquitination	PTAISHFKQSAEKLI HHHHHHHHHHHHHHH	37.61	29967540
597	Phosphorylation	AISHFKQSAEKLIEE HHHHHHHHHHHHHHH	38.70	25159151
600	Acetylation	HFKQSAEKLIEEKGA HHHHHHHHHHHHHHH	55.25	25953088
600	Ubiquitination	HFKQSAEKLIEEKGA HHHHHHHHHHHHHHH	55.25	29967540
602	Ubiquitination	KQSAEKLIEEKGAVE HHHHHHHHHHHHHHH	10.73	29967540
605	Acetylation	AEKLIEEKGAVEALA HHHHHHHHHHHHHHH	39.10	26051181
605	Ubiquitination	AEKLIEEKGAVEALA HHHHHHHHHHHHHHH	39.10	33845483
610	Ubiquitination	EEKGAVEALAAALAH HHHHHHHHHHHHHHH	8.90	29967540
628	Phosphorylation	ATSVDQRSLINSNVG CCCCCHHHHHCCCCC	28.15	26270265
632	Phosphorylation	DQRSLINSNVGFVTM CHHHHHCCCCCHHHE	26.37	26270265
638	Phosphorylation	NSNVGFVTMILQCSI CCCCCHHHEEEHHHC	9.02	26270265
644	Phosphorylation	VTMILQCSIEMPNIS HHEEEHHHCCCCCHH	14.50	22617229
651	Phosphorylation	SIEMPNISYAWKELK HCCCCCHHHHHHHHH	18.55	26270265
652	Phosphorylation	IEMPNISYAWKELKE CCCCCHHHHHHHHHH	16.82	22617229
657	Ubiquitination	ISYAWKELKEQLGEE HHHHHHHHHHHHCHH	7.03	24816145
658	2-Hydroxyisobutyrylation	SYAWKELKEQLGEEI HHHHHHHHHHHCHHH	44.50	-
658	Acetylation	SYAWKELKEQLGEEI HHHHHHHHHHHCHHH	44.50	26822725
667	Phosphorylation	QLGEEIDSKVKGMVF HHCHHHHHHHCEEEE	45.04	20860994
668	2-Hydroxyisobutyrylation	LGEEIDSKVKGMVFL HCHHHHHHHCEEEEE	44.19	-
668	Acetylation	LGEEIDSKVKGMVFL HCHHHHHHHCEEEEE	44.19	26051181
668	Sumoylation	LGEEIDSKVKGMVFL HCHHHHHHHCEEEEE	44.19	-
668	Ubiquitination	LGEEIDSKVKGMVFL HCHHHHHHHCEEEEE	44.19	29967540
670	2-Hydroxyisobutyrylation	EEIDSKVKGMVFLKG HHHHHHHCEEEEECC	45.05	-
670	Ubiquitination	EEIDSKVKGMVFLKG HHHHHHHCEEEEECC	45.05	29967540
676	Acetylation	VKGMVFLKGKLGVCF HCEEEEECCCEEEEE	42.40	25953088
678	2-Hydroxyisobutyrylation	GMVFLKGKLGVCFDV EEEEECCCEEEEEEC	40.24	-
678	Acetylation	GMVFLKGKLGVCFDV EEEEECCCEEEEEEC	40.24	25953088
678	Ubiquitination	GMVFLKGKLGVCFDV EEEEECCCEEEEEEC	40.24	29967540
682	Glutathionylation	LKGKLGVCFDVPTAS ECCCEEEEEECCCCC	1.98	22555962
696	Acetylation	SVTEIQEKWHDSRRW CCHHHHHHHHHCCCE	33.19	26051181
711	Acetylation	QLSVATEQPELEGPR EEEEEECCCCCCCCC	32.20	19608861
711	Ubiquitination	QLSVATEQPELEGPR EEEEEECCCCCCCCC	32.20	33845483
721	Phosphorylation	LEGPREGYGGFRGQR CCCCCCCCCCCCCCC	14.88	20860994
725	Methylation	REGYGGFRGQREGSR CCCCCCCCCCCCCCC	43.54	-
725	Ubiquitination	REGYGGFRGQREGSR CCCCCCCCCCCCCCC	43.54	24816145
728	Methylation	YGGFRGQREGSRGFR CCCCCCCCCCCCCCC	53.74	-
731	Phosphorylation	FRGQREGSRGFRGQR CCCCCCCCCCCCCCC	25.20	21406692
751	Phosphorylation	FRGQREGSRGPRGQR CCCCCCCCCCCCCCC	29.34	28176443
759	O-linked_Glycosylation	RGPRGQRSGGGNKSN CCCCCCCCCCCCCCC	33.62	23301498
759	Phosphorylation	RGPRGQRSGGGNKSN CCCCCCCCCCCCCCC	33.62	-
776	Phosphorylation	QNKGQKRSFSKAFGQ CCCCCCCCHHHHHCC	40.69	27422710
778	Phosphorylation	KGQKRSFSKAFGQ-- CCCCCCHHHHHCC--	25.07	27422710
779	Acetylation	GQKRSFSKAFGQ--- CCCCCHHHHHCC---	45.80	19608861
779	Ubiquitination	GQKRSFSKAFGQ--- CCCCCHHHHHCC---	45.80	33845483

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DDX21_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DDX21_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DDX21_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RL6_HUMAN	RPL6	physical	22939629
NPM_HUMAN	NPM1	physical	22939629
RL7_HUMAN	RPL7	physical	22939629
RL31_HUMAN	RPL31	physical	22939629
RL37A_HUMAN	RPL37A	physical	22939629
RS11_HUMAN	RPS11	physical	22939629
RS24_HUMAN	RPS24	physical	22939629
RL5_HUMAN	RPL5	physical	22939629
RL1D1_HUMAN	RSL1D1	physical	22939629
RL19_HUMAN	RPL19	physical	22939629
RS23_HUMAN	RPS23	physical	22939629
RED_HUMAN	IK	physical	22939629
RNPS1_HUMAN	RNPS1	physical	22939629
SAP18_HUMAN	SAP18	physical	22939629
SRSF5_HUMAN	SRSF5	physical	22939629
SRSF7_HUMAN	SRSF7	physical	22939629
HNRPR_HUMAN	HNRNPR	physical	22939629
SFPQ_HUMAN	SFPQ	physical	22939629
U5S1_HUMAN	EFTUD2	physical	22939629
RBM39_HUMAN	RBM39	physical	22939629
PARP1_HUMAN	PARP1	physical	22939629
RRP7A_HUMAN	RRP7A	physical	22939629
RRS1_HUMAN	RRS1	physical	22939629
TR150_HUMAN	THRAP3	physical	22939629
SON_HUMAN	SON	physical	22939629
MYO1C_HUMAN	MYO1C	physical	22939629
SSRG_HUMAN	SSR3	physical	22939629
SPB1_HUMAN	FTSJ3	physical	22939629
NFIA_HUMAN	NFIA	physical	22939629
NOP2_HUMAN	NOP2	physical	22939629
SMCA1_HUMAN	SMARCA1	physical	22939629
PCDA2_HUMAN	PCDHA2	physical	22939629
SP16H_HUMAN	SUPT16H	physical	22939629
PDS5A_HUMAN	PDS5A	physical	22939629
LAMP2_HUMAN	LAMP2	physical	22939629
LMNB1_HUMAN	LMNB1	physical	22939629
S10A9_HUMAN	S100A9	physical	22939629
IL7RA_HUMAN	IL7R	physical	23151878

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DDX21_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-779, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13; SER-71; SER-121 ANDTHR-315, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-89 AND SER-121, AND MASSSPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13; SER-71; SER-89;SER-121; SER-168; SER-171 AND SER-173, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13; SER-71; SER-89;SER-121; SER-164; SER-168; SER-171; SER-173 AND THR-315, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-171, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71; SER-89 AND SER-121,AND MASS SPECTROMETRY.	19007248 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71; SER-89 AND SER-121,AND MASS SPECTROMETRY.	17287340 [Abstract]
"Toward a global characterization of the phosphoproteome in prostatecancer cells: identification of phosphoproteins in the LNCaP cellline."; Giorgianni F., Zhao Y., Desiderio D.M., Beranova-Giorgianni S.; Electrophoresis 28:2027-2034(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-121, AND MASSSPECTROMETRY.	17487921 [Abstract]
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71; SER-89 AND SER-121,AND MASS SPECTROMETRY.	16565220 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71; SER-89 AND SER-121,AND MASS SPECTROMETRY.	17081983 [Abstract]
"Global phosphoproteome of HT-29 human colon adenocarcinoma cells."; Kim J.-E., Tannenbaum S.R., White F.M.; J. Proteome Res. 4:1339-1346(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-89, AND MASSSPECTROMETRY.	16083285 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-171, AND MASSSPECTROMETRY.	15302935 [Abstract]