dbPTM

RL37A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RL37A_HUMAN
UniProt AC	P61513
Protein Name	60S ribosomal protein L37a
Gene Name	RPL37A
Organism	Homo sapiens (Human).
Sequence Length	92
Subcellular Localization
Protein Description
Protein Sequence	MAKRTKKVGIVGKYGTRYGASLRKMVKKIEISQHAKYTCSFCGKTKMKRRAVGIWHCGSCMKTVAGGAWTYNTTSAVTVKSAIRRLKELKDQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	2-Hydroxyisobutyrylation	-MAKRTKKVGIVGKY -CCCCCCCEEEECCC	45.11	-
7	Ubiquitination	-MAKRTKKVGIVGKY -CCCCCCCEEEECCC	45.11	24816145
13	Ubiquitination	KKVGIVGKYGTRYGA CCEEEECCCHHHCHH	29.61	21906983
13	Acetylation	KKVGIVGKYGTRYGA CCEEEECCCHHHCHH	29.61	25953088
14	Phosphorylation	KVGIVGKYGTRYGAS CEEEECCCHHHCHHH	20.14	-
16	Phosphorylation	GIVGKYGTRYGASLR EEECCCHHHCHHHHH	20.02	29514088
18	Phosphorylation	VGKYGTRYGASLRKM ECCCHHHCHHHHHHH	19.51	28152594
21	Phosphorylation	YGTRYGASLRKMVKK CHHHCHHHHHHHHHH	25.09	28152594
24	Ubiquitination	RYGASLRKMVKKIEI HCHHHHHHHHHHEEC	54.03	25015289
27	Ubiquitination	ASLRKMVKKIEISQH HHHHHHHHHEECHHC	44.53	25015289
28	2-Hydroxyisobutyrylation	SLRKMVKKIEISQHA HHHHHHHHEECHHCC	33.87	-
28	Acetylation	SLRKMVKKIEISQHA HHHHHHHHEECHHCC	33.87	26051181
28	Ubiquitination	SLRKMVKKIEISQHA HHHHHHHHEECHHCC	33.87	16196087
32	Phosphorylation	MVKKIEISQHAKYTC HHHHEECHHCCCEEE	11.79	20068231
36	Acetylation	IEISQHAKYTCSFCG EECHHCCCEEECCCC	38.68	26051181
36	Ubiquitination	IEISQHAKYTCSFCG EECHHCCCEEECCCC	38.68	16196087
37	Nitration	EISQHAKYTCSFCGK ECHHCCCEEECCCCC	17.48	-
37	Phosphorylation	EISQHAKYTCSFCGK ECHHCCCEEECCCCC	17.48	27080861
38	Phosphorylation	ISQHAKYTCSFCGKT CHHCCCEEECCCCCC	10.85	27080861
40	Phosphorylation	QHAKYTCSFCGKTKM HCCCEEECCCCCCCC	18.77	28450419
44	Ubiquitination	YTCSFCGKTKMKRRA EEECCCCCCCCCCCC	46.27	33845483
44	Acetylation	YTCSFCGKTKMKRRA EEECCCCCCCCCCCC	46.27	26822725
44	2-Hydroxyisobutyrylation	YTCSFCGKTKMKRRA EEECCCCCCCCCCCC	46.27	-
44	Methylation	YTCSFCGKTKMKRRA EEECCCCCCCCCCCC	46.27	11924187
59	Phosphorylation	VGIWHCGSCMKTVAG EEEEECCCCCCEEEC	19.21	28450419
61	Sulfoxidation	IWHCGSCMKTVAGGA EEECCCCCCEEECCC	4.34	30846556
62	Ubiquitination	WHCGSCMKTVAGGAW EECCCCCCEEECCCE	44.14	16196087
62	Acetylation	WHCGSCMKTVAGGAW EECCCCCCEEECCCE	44.14	11924197
63	Phosphorylation	HCGSCMKTVAGGAWT ECCCCCCEEECCCEE	6.68	28152594
70	Phosphorylation	TVAGGAWTYNTTSAV EEECCCEEECCCCCH	13.32	28152594
71	Phosphorylation	VAGGAWTYNTTSAVT EECCCEEECCCCCHH	10.38	28152594
73	Phosphorylation	GGAWTYNTTSAVTVK CCCEEECCCCCHHHH	16.24	28152594
74	Phosphorylation	GAWTYNTTSAVTVKS CCEEECCCCCHHHHH	15.85	28152594
75	Phosphorylation	AWTYNTTSAVTVKSA CEEECCCCCHHHHHH	20.78	28152594
78	Phosphorylation	YNTTSAVTVKSAIRR ECCCCCHHHHHHHHH	23.18	28152594
80	Acetylation	TTSAVTVKSAIRRLK CCCCHHHHHHHHHHH	25.46	26051181
80	Ubiquitination	TTSAVTVKSAIRRLK CCCCHHHHHHHHHHH	25.46	21963094
87	2-Hydroxyisobutyrylation	KSAIRRLKELKDQ-- HHHHHHHHHHHCC--	60.22	-
87	Ubiquitination	KSAIRRLKELKDQ-- HHHHHHHHHHHCC--	60.22	21890473
90	Ubiquitination	IRRLKELKDQ----- HHHHHHHHCC-----	55.99	24816145

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RL37A_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RL37A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RL37A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LRIF1_HUMAN	LRIF1	physical	16169070
A4_HUMAN	APP	physical	21832049
RL5_HUMAN	RPL5	physical	22939629
RL6_HUMAN	RPL6	physical	22939629
RS11_HUMAN	RPS11	physical	22939629
RS13_HUMAN	RPS13	physical	22939629
RS14_HUMAN	RPS14	physical	22939629
RS15A_HUMAN	RPS15A	physical	22939629
RS16_HUMAN	RPS16	physical	22939629
RS17_HUMAN	RPS17	physical	22939629
RS23_HUMAN	RPS23	physical	22939629
RS25_HUMAN	RPS25	physical	22939629
RS26_HUMAN	RPS26	physical	22939629
RS28_HUMAN	RPS28	physical	22939629
RS2_HUMAN	RPS2	physical	22939629
RS3A_HUMAN	RPS3A	physical	22939629
RS3_HUMAN	RPS3	physical	22939629
RS4X_HUMAN	RPS4X	physical	22939629
RS6_HUMAN	RPS6	physical	22939629
RS7_HUMAN	RPS7	physical	22939629
RS8_HUMAN	RPS8	physical	22939629
RSSA_HUMAN	RPSA	physical	22939629
RL4_HUMAN	RPL4	physical	22939629
RL7A_HUMAN	RPL7A	physical	22939629
RL7_HUMAN	RPL7	physical	22939629
RS19_HUMAN	RPS19	physical	22939629
RS5_HUMAN	RPS5	physical	22939629
RL9_HUMAN	RPL9	physical	22939629
RS24_HUMAN	RPS24	physical	22939629
RS20_HUMAN	RPS20	physical	22939629
RS12_HUMAN	RPS12	physical	22939629
RS21_HUMAN	RPS21	physical	22939629
RS27A_HUMAN	RPS27A	physical	22939629
U2AF2_HUMAN	U2AF2	physical	22939629
U2AF1_HUMAN	U2AF1	physical	22939629
RS27L_HUMAN	RPS27L	physical	22939629
TPR_HUMAN	TPR	physical	22939629
IF6_HUMAN	EIF6	physical	26344197
RL10A_HUMAN	RPL10A	physical	26344197
RL12_HUMAN	RPL12	physical	26344197
RS18_HUMAN	RPS18	physical	26344197
F199X_HUMAN	FAM199X	physical	28514442
ZCCHV_HUMAN	ZC3HAV1	physical	28514442
RL8_HUMAN	RPL8	physical	28514442
RL26L_HUMAN	RPL26L1	physical	28514442
CDK12_HUMAN	CDK12	physical	28514442
NOC3L_HUMAN	NOC3L	physical	28514442
DDX24_HUMAN	DDX24	physical	28514442
NUCL_HUMAN	NCL	physical	28514442
PUM3_HUMAN	KIAA0020	physical	28514442
DDX31_HUMAN	DDX31	physical	28514442
RL18A_HUMAN	RPL18A	physical	28514442
DDX27_HUMAN	DDX27	physical	28514442
ZC3HA_HUMAN	ZC3H10	physical	28514442
RL10A_HUMAN	RPL10A	physical	28514442
BRX1_HUMAN	BRIX1	physical	28514442
NPM_HUMAN	NPM1	physical	28514442
NOG2_HUMAN	GNL2	physical	28514442
SART3_HUMAN	SART3	physical	28514442
RL36L_HUMAN	RPL36AL	physical	28514442
RLA2_HUMAN	RPLP2	physical	28514442
RRP8_HUMAN	RRP8	physical	28514442
SPB1_HUMAN	FTSJ3	physical	28514442
RS3A_HUMAN	RPS3A	physical	28514442
NOP2_HUMAN	NOP2	physical	28514442
BUD13_HUMAN	BUD13	physical	28514442
RL15_HUMAN	RPL15	physical	28514442
EBP2_HUMAN	EBNA1BP2	physical	28514442
RS8_HUMAN	RPS8	physical	28514442
CENPN_HUMAN	CENPN	physical	28514442
NSA2_HUMAN	NSA2	physical	28514442
SREK1_HUMAN	SREK1	physical	28514442
RL30_HUMAN	RPL30	physical	28514442
GLYR1_HUMAN	GLYR1	physical	28514442
RBM34_HUMAN	RBM34	physical	28514442
RL4_HUMAN	RPL4	physical	28514442
RL6_HUMAN	RPL6	physical	28514442
PAPD5_HUMAN	PAPD5	physical	28514442
RPF2_HUMAN	RPF2	physical	28514442
STAU1_HUMAN	STAU1	physical	28514442
REXO4_HUMAN	REXO4	physical	28514442
RL7A_HUMAN	RPL7A	physical	28514442
NOP53_HUMAN	GLTSCR2	physical	28514442
RL36_HUMAN	RPL36	physical	28514442
ZFP62_HUMAN	ZFP62	physical	28514442
NSD2_HUMAN	WHSC1	physical	28514442
RBM28_HUMAN	RBM28	physical	28514442
TAF1C_HUMAN	TAF1C	physical	28514442
MYEF2_HUMAN	MYEF2	physical	28514442
RL18_HUMAN	RPL18	physical	28514442
MPP10_HUMAN	MPHOSPH10	physical	28514442
DDX21_HUMAN	DDX21	physical	28514442
RL3_HUMAN	RPL3	physical	28514442
ZN512_HUMAN	ZNF512	physical	28514442
TAF1A_HUMAN	TAF1A	physical	28514442
DKC1_HUMAN	DKC1	physical	28514442
IMP4_HUMAN	IMP4	physical	28514442
CC137_HUMAN	CCDC137	physical	28514442
DHX30_HUMAN	DHX30	physical	28514442
KNOP1_HUMAN	KNOP1	physical	28514442
NIP7_HUMAN	NIP7	physical	28514442
RL7L_HUMAN	RPL7L1	physical	28514442
GAR1_HUMAN	GAR1	physical	28514442
LYAR_HUMAN	LYAR	physical	28514442
RS24_HUMAN	RPS24	physical	28514442
NOG1_HUMAN	GTPBP4	physical	28514442
RL27_HUMAN	RPL27	physical	28514442
RL5_HUMAN	RPL5	physical	28514442
RPF1_HUMAN	RPF1	physical	28514442
STAU2_HUMAN	STAU2	physical	28514442
RLA0_HUMAN	RPLP0	physical	28514442
NOP56_HUMAN	NOP56	physical	28514442
UIF_HUMAN	FYTTD1	physical	28514442
UTP23_HUMAN	UTP23	physical	28514442
CEBPZ_HUMAN	CEBPZ	physical	28514442
RL23A_HUMAN	RPL23A	physical	28514442
RL29_HUMAN	RPL29	physical	28514442
TTF1_HUMAN	TTF1	physical	28514442
RL32_HUMAN	RPL32	physical	28514442
SAS10_HUMAN	UTP3	physical	28514442
RL26_HUMAN	RPL26	physical	28514442
ZNF22_HUMAN	ZNF22	physical	28514442
DDX10_HUMAN	DDX10	physical	28514442
SURF6_HUMAN	SURF6	physical	28514442
RLP24_HUMAN	RSL24D1	physical	28514442
DDX56_HUMAN	DDX56	physical	28514442
H2A2B_HUMAN	HIST2H2AB	physical	28514442
RBBP5_HUMAN	RBBP5	physical	28514442
PK1IP_HUMAN	PAK1IP1	physical	28514442
RL13_HUMAN	RPL13	physical	28514442
MDM2_HUMAN	MDM2	physical	28514442
MBB1A_HUMAN	MYBBP1A	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RL37A_HUMAN

Related Literatures of Post-Translational Modification