dbPTM

CDK12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CDK12_HUMAN
UniProt AC	Q9NYV4
Protein Name	Cyclin-dependent kinase 12
Gene Name	CDK12
Organism	Homo sapiens (Human).
Sequence Length	1490
Subcellular Localization	Nucleus. Nucleus speckle. Colocalized with nuclear speckles throughout interphase.
Protein Description	Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors..
Protein Sequence	MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLPTTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQRTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSLSHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRVPPRGGRGRGVPY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MPNSERHGGKK ----CCCCCCCCCCC	46.89	30576142
14	Phosphorylation	HGGKKDGSGGASGTL CCCCCCCCCCCCCCC	44.16	21712546
18	Phosphorylation	KDGSGGASGTLQPSS CCCCCCCCCCCCCCC	35.27	28450419
20	Phosphorylation	GSGGASGTLQPSSGG CCCCCCCCCCCCCCC	21.52	20068231
24	Phosphorylation	ASGTLQPSSGGGSSN CCCCCCCCCCCCCCC	28.75	25159151
25	Phosphorylation	SGTLQPSSGGGSSNS CCCCCCCCCCCCCCH	48.41	25159151
29	Phosphorylation	QPSSGGGSSNSRERH CCCCCCCCCCHHHHH	29.62	23401153
30	Phosphorylation	PSSGGGSSNSRERHR CCCCCCCCCHHHHHH	41.94	25159151
32	Phosphorylation	SGGGSSNSRERHRLV CCCCCCCHHHHHHHH	37.15	25159151
57	Phosphorylation	SKDMGLVTPEAASLG CCCCCCCCHHHHHHC	22.06	28355574
62	Phosphorylation	LVTPEAASLGTVIKP CCCHHHHHHCCCCEE	34.09	17081983
65	Phosphorylation	PEAASLGTVIKPLVE HHHHHHCCCCEECCC	25.09	22199227
73	Phosphorylation	VIKPLVEYDDISSDS CCEECCCCCCCCCCC	16.07	17192257
77	Phosphorylation	LVEYDDISSDSDTFS CCCCCCCCCCCCCCC	34.78	28102081
78	Phosphorylation	VEYDDISSDSDTFSD CCCCCCCCCCCCCCC	41.28	28102081
80	Phosphorylation	YDDISSDSDTFSDDM CCCCCCCCCCCCCHH	40.26	28102081
82	Phosphorylation	DISSDSDTFSDDMAF CCCCCCCCCCCHHCH	29.05	20068231
84	Phosphorylation	SSDSDTFSDDMAFKL CCCCCCCCCHHCHHH	34.49	28102081
102	Phosphorylation	ENDERRGSDRSDRLH CCCCCCCCCHHHHHH	28.21	29449344
105	Phosphorylation	ERRGSDRSDRLHKHR CCCCCCHHHHHHHHH	31.88	29449344
133	Phosphorylation	KQTEKEKSQEVSSKS HHHHHHHHHHHHHCC	32.44	28985074
139	Acetylation	KSQEVSSKSGSMKDR HHHHHHHCCCCCHHH	51.86	25953088
148	Phosphorylation	GSMKDRISGSSKRSN CCCHHHHCCCCCCCC	33.25	-
154	Phosphorylation	ISGSSKRSNEETDDY HCCCCCCCCCCCCCH	52.94	25850435
158	Phosphorylation	SKRSNEETDDYGKAQ CCCCCCCCCCHHHHH	28.17	30576142
161	Phosphorylation	SNEETDDYGKAQVAK CCCCCCCHHHHHHHH	24.28	23312004
169	Phosphorylation	GKAQVAKSSSKESRS HHHHHHHHCCCHHHH	30.06	21712546
171	Phosphorylation	AQVAKSSSKESRSSK HHHHHHCCCHHHHHH	47.75	21712546
176	Phosphorylation	SSSKESRSSKLHKEK HCCCHHHHHHHHHHH	40.90	28152594
177	Phosphorylation	SSKESRSSKLHKEKT CCCHHHHHHHHHHHH	37.82	28152594
181	Ubiquitination	SRSSKLHKEKTRKER HHHHHHHHHHHHHHH	71.93	24816145
203	Acetylation	DRSKSHRKRETPKSY CCCHHHCCCCCCCCC	49.51	7683829
206	Phosphorylation	KSHRKRETPKSYKTV HHHCCCCCCCCCCCC	39.80	24719451
209	Phosphorylation	RKRETPKSYKTVDSP CCCCCCCCCCCCCCC	32.82	24719451
210	Phosphorylation	KRETPKSYKTVDSPK CCCCCCCCCCCCCCC	19.46	24719451
211	Acetylation	RETPKSYKTVDSPKR CCCCCCCCCCCCCCC	49.52	7683841
212	Phosphorylation	ETPKSYKTVDSPKRR CCCCCCCCCCCCCCC	22.70	28176443
215	Phosphorylation	KSYKTVDSPKRRSRS CCCCCCCCCCCCCCC	28.16	25599653
220	Phosphorylation	VDSPKRRSRSPHRKW CCCCCCCCCCCCCCC	40.94	20068231
222	Phosphorylation	SPKRRSRSPHRKWSD CCCCCCCCCCCCCCC	26.72	20068231
228	Phosphorylation	RSPHRKWSDSSKQDD CCCCCCCCCCCCCCC	30.56	23927012
230	Phosphorylation	PHRKWSDSSKQDDSP CCCCCCCCCCCCCCC	33.64	23927012
231	Phosphorylation	HRKWSDSSKQDDSPS CCCCCCCCCCCCCCC	39.05	23927012
236	Phosphorylation	DSSKQDDSPSGASYG CCCCCCCCCCCCCCC	29.29	23927012
238	Phosphorylation	SKQDDSPSGASYGQD CCCCCCCCCCCCCCC	51.44	20164059
241	Phosphorylation	DDSPSGASYGQDYDL CCCCCCCCCCCCCCC	33.06	24260401
242	Phosphorylation	DSPSGASYGQDYDLS CCCCCCCCCCCCCCC	20.48	23927012
246	Phosphorylation	GASYGQDYDLSPSRS CCCCCCCCCCCCCCC	15.76	23927012
249	Phosphorylation	YGQDYDLSPSRSHTS CCCCCCCCCCCCCCC	20.24	25159151
251	Phosphorylation	QDYDLSPSRSHTSSN CCCCCCCCCCCCCCC	42.93	23927012
253	Phosphorylation	YDLSPSRSHTSSNYD CCCCCCCCCCCCCHH	35.14	23927012
255	Phosphorylation	LSPSRSHTSSNYDSY CCCCCCCCCCCHHHC	34.79	23403867
256	Phosphorylation	SPSRSHTSSNYDSYK CCCCCCCCCCHHHCC	15.91	23927012
257	Phosphorylation	PSRSHTSSNYDSYKK CCCCCCCCCHHHCCC	40.33	23927012
259	Phosphorylation	RSHTSSNYDSYKKSP CCCCCCCHHHCCCCC	14.28	23403867
261	Phosphorylation	HTSSNYDSYKKSPGS CCCCCHHHCCCCCCC	28.61	23927012
262	Phosphorylation	TSSNYDSYKKSPGST CCCCHHHCCCCCCCC	21.38	23403867
263	Sumoylation	SSNYDSYKKSPGSTS CCCHHHCCCCCCCCC	51.21	28112733
265	Phosphorylation	NYDSYKKSPGSTSRR CHHHCCCCCCCCCCC	30.27	23927012
268	Phosphorylation	SYKKSPGSTSRRQSV HCCCCCCCCCCCCCC	26.96	23403867
269	Phosphorylation	YKKSPGSTSRRQSVS CCCCCCCCCCCCCCC	31.97	23403867
270	Phosphorylation	KKSPGSTSRRQSVSP CCCCCCCCCCCCCCC	27.45	23403867
274	Phosphorylation	GSTSRRQSVSPPYKE CCCCCCCCCCCCCCC	23.81	25159151
276	Phosphorylation	TSRRQSVSPPYKEPS CCCCCCCCCCCCCCC	25.96	25159151
279	Phosphorylation	RQSVSPPYKEPSAYQ CCCCCCCCCCCCHHC	31.22	27273156
283	Phosphorylation	SPPYKEPSAYQSSTR CCCCCCCCHHCCCCC	40.47	27273156
285	Phosphorylation	PYKEPSAYQSSTRSP CCCCCCHHCCCCCCC	17.17	27273156
287	Phosphorylation	KEPSAYQSSTRSPSP CCCCHHCCCCCCCCC	22.47	25159151
288	Phosphorylation	EPSAYQSSTRSPSPY CCCHHCCCCCCCCCC	16.59	27273156
289	Phosphorylation	PSAYQSSTRSPSPYS CCHHCCCCCCCCCCC	40.17	27273156
291	Phosphorylation	AYQSSTRSPSPYSRR HHCCCCCCCCCCCCC	29.80	26503892
293	Phosphorylation	QSSTRSPSPYSRRQR CCCCCCCCCCCCCCC	37.40	26503892
295	Phosphorylation	STRSPSPYSRRQRSV CCCCCCCCCCCCCCC	21.10	29209046
296	Phosphorylation	TRSPSPYSRRQRSVS CCCCCCCCCCCCCCC	25.11	27273156
301	Phosphorylation	PYSRRQRSVSPYSRR CCCCCCCCCCCCCCC	20.71	27273156
303	Phosphorylation	SRRQRSVSPYSRRRS CCCCCCCCCCCCCCC	21.26	22167270
305	Phosphorylation	RQRSVSPYSRRRSSS CCCCCCCCCCCCCCC	13.80	27273156
306	Phosphorylation	QRSVSPYSRRRSSSY CCCCCCCCCCCCCCC	23.77	22167270
310	Phosphorylation	SPYSRRRSSSYERSG CCCCCCCCCCCCCCC	23.09	20363803
311	Phosphorylation	PYSRRRSSSYERSGS CCCCCCCCCCCCCCC	34.82	20363803
312	Phosphorylation	YSRRRSSSYERSGSY CCCCCCCCCCCCCCC	32.06	20363803
313	Phosphorylation	SRRRSSSYERSGSYS CCCCCCCCCCCCCCC	19.80	25884760
316	Phosphorylation	RSSSYERSGSYSGRS CCCCCCCCCCCCCCC	21.83	27273156
318	Phosphorylation	SSYERSGSYSGRSPS CCCCCCCCCCCCCCC	19.85	25159151
319	Phosphorylation	SYERSGSYSGRSPSP CCCCCCCCCCCCCCC	20.76	27273156
320	Phosphorylation	YERSGSYSGRSPSPY CCCCCCCCCCCCCCC	29.45	27273156
323	Phosphorylation	SGSYSGRSPSPYGRR CCCCCCCCCCCCCCC	33.00	25159151
325	Phosphorylation	SYSGRSPSPYGRRRS CCCCCCCCCCCCCCC	31.81	25159151
327	Phosphorylation	SGRSPSPYGRRRSSS CCCCCCCCCCCCCCC	27.83	28176443
329	Dimethylation	RSPSPYGRRRSSSPF CCCCCCCCCCCCCCC	25.62	-
330	Dimethylation	SPSPYGRRRSSSPFL CCCCCCCCCCCCCCC	38.17	-
331	Dimethylation	PSPYGRRRSSSPFLS CCCCCCCCCCCCCCC	39.26	-
332	Phosphorylation	SPYGRRRSSSPFLSK CCCCCCCCCCCCCCC	33.10	22167270
333	Phosphorylation	PYGRRRSSSPFLSKR CCCCCCCCCCCCCCC	39.97	22167270
334	Phosphorylation	YGRRRSSSPFLSKRS CCCCCCCCCCCCCCC	22.40	22167270
334 (in isoform 3)	Phosphorylation	-	22.40	25849741
338	Phosphorylation	RSSSPFLSKRSLSRS CCCCCCCCCCCCCCC	26.80	26503892
338 (in isoform 3)	Phosphorylation	-	26.80	25159151
341	Phosphorylation	SPFLSKRSLSRSPLP CCCCCCCCCCCCCCC	34.14	30266825
341 (in isoform 3)	Phosphorylation	-	34.14	25159151
343	Phosphorylation	FLSKRSLSRSPLPSR CCCCCCCCCCCCCCH	31.77	22167270
343 (in isoform 3)	Phosphorylation	-	31.77	25159151
345	Phosphorylation	SKRSLSRSPLPSRKS CCCCCCCCCCCCHHH	27.67	22167270
345 (in isoform 3)	Phosphorylation	-	27.67	25159151
349	O-linked_Glycosylation	LSRSPLPSRKSMKSR CCCCCCCCHHHHHCC	61.08	20068230
349	Phosphorylation	LSRSPLPSRKSMKSR CCCCCCCCHHHHHCC	61.08	30266825
352	Phosphorylation	SPLPSRKSMKSRSRS CCCCCHHHHHCCCCC	30.27	26074081
355	Phosphorylation	PSRKSMKSRSRSPAY CCHHHHHCCCCCCCH	27.18	20363803
356 (in isoform 3)	Phosphorylation	-	30.48	25849741
357	Phosphorylation	RKSMKSRSRSPAYSR HHHHHCCCCCCCHHH	44.17	26846344
358 (in isoform 3)	Phosphorylation	-	45.62	25849741
359	Phosphorylation	SMKSRSRSPAYSRHS HHHCCCCCCCHHHCC	18.35	26846344
362	Phosphorylation	SRSRSPAYSRHSSSH CCCCCCCHHHCCCCC	15.04	20363803
363	Phosphorylation	RSRSPAYSRHSSSHS CCCCCCHHHCCCCCC	26.14	20363803
366	Phosphorylation	SPAYSRHSSSHSKKK CCCHHHCCCCCCCCC	32.21	26074081
367	Phosphorylation	PAYSRHSSSHSKKKR CCHHHCCCCCCCCCC	26.41	26074081
368	Phosphorylation	AYSRHSSSHSKKKRS CHHHCCCCCCCCCCC	34.49	26074081
370	Phosphorylation	SRHSSSHSKKKRSSS HHCCCCCCCCCCCCC	48.39	26074081
375	Phosphorylation	SHSKKKRSSSRSRHS CCCCCCCCCCCCCCC	41.36	28509920
376	Phosphorylation	HSKKKRSSSRSRHSS CCCCCCCCCCCCCCC	33.53	28509920
379	Phosphorylation	KKRSSSRSRHSSISP CCCCCCCCCCCCCCC	35.97	23927012
382	Phosphorylation	SSSRSRHSSISPVRL CCCCCCCCCCCCCCC	28.40	22167270
383	Phosphorylation	SSRSRHSSISPVRLP CCCCCCCCCCCCCCC	22.44	22167270
385	Phosphorylation	RSRHSSISPVRLPLN CCCCCCCCCCCCCCC	21.20	29255136
393	Phosphorylation	PVRLPLNSSLGAELS CCCCCCCCCHHHHHH	34.32	30266825
394	Phosphorylation	VRLPLNSSLGAELSR CCCCCCCCHHHHHHH	29.74	30266825
400	Phosphorylation	SSLGAELSRKKKERA CCHHHHHHHHHHHHH	33.29	29255136
414	Acetylation	AAAAAAAKMDGKESK HHHHHHHHHCCCCCC	32.56	25953088
420	Phosphorylation	AKMDGKESKGSPVFL HHHCCCCCCCCCCCC	45.89	29255136
421	Ubiquitination	KMDGKESKGSPVFLP HHCCCCCCCCCCCCC	65.58	29967540
423	Phosphorylation	DGKESKGSPVFLPRK CCCCCCCCCCCCCCC	22.94	29255136
433	Phosphorylation	FLPRKENSSVEAKDS CCCCCCCCCCCCCCC	36.53	26074081
434	Phosphorylation	LPRKENSSVEAKDSG CCCCCCCCCCCCCCC	35.24	26074081
437	Ubiquitination	KENSSVEAKDSGLES CCCCCCCCCCCCCCC	20.85	24816145
438	Ubiquitination	ENSSVEAKDSGLESK CCCCCCCCCCCCCCC	38.63	24816145
440	Phosphorylation	SSVEAKDSGLESKKL CCCCCCCCCCCCCCC	44.57	25159151
449	Dimethylation	LESKKLPRSVKLEKS CCCCCCCCCEECHHC	65.60	-
456	Phosphorylation	RSVKLEKSAPDTELV CCEECHHCCCCCEEE	35.34	28102081
460	Phosphorylation	LEKSAPDTELVNVTH CHHCCCCCEEEEEEE	30.11	28102081
466	Phosphorylation	DTELVNVTHLNTEVK CCEEEEEEECCCEEC	18.55	28555341
489	Acetylation	KLDENSEKHLVKDLK ECCCCCHHHHHHHHH	41.90	25953088
493	Acetylation	NSEKHLVKDLKAQGT CCHHHHHHHHHHCCC	64.80	26051181
503	Phosphorylation	KAQGTRDSKPIALKE HHCCCCCCCCEEEEE	36.72	28387310
504	Acetylation	AQGTRDSKPIALKEE HCCCCCCCCEEEEEE	44.74	19608861
509	Acetylation	DSKPIALKEEIVTPK CCCCEEEEEEECCCC	44.25	25953088
509	Sumoylation	DSKPIALKEEIVTPK CCCCEEEEEEECCCC	44.25	28112733
514	Phosphorylation	ALKEEIVTPKETETS EEEEEECCCCCCCCC	34.01	29255136
518	Phosphorylation	EIVTPKETETSEKET EECCCCCCCCCCCCC	51.17	23186163
520	Phosphorylation	VTPKETETSEKETPP CCCCCCCCCCCCCCC	49.99	24247654
521	Phosphorylation	TPKETETSEKETPPP CCCCCCCCCCCCCCC	40.20	28961369
592	O-linked_Glycosylation	PPSTHSKTSAVSSQA CCCCCCCCCCCCCCC	25.57	30059200
592	O-linked_Glycosylation	PPSTHSKTSAVSSQA CCCCCCCCCCCCCCC	25.57	20068230
593	O-linked_Glycosylation	PSTHSKTSAVSSQAN CCCCCCCCCCCCCCC	30.34	20068230
596	O-linked_Glycosylation	HSKTSAVSSQANSQP CCCCCCCCCCCCCCC	19.22	20068230
597	O-linked_Glycosylation	SKTSAVSSQANSQPP CCCCCCCCCCCCCCC	27.06	30059200
597	O-linked_Glycosylation	SKTSAVSSQANSQPP CCCCCCCCCCCCCCC	27.06	20068230
601	O-linked_Glycosylation	AVSSQANSQPPVQVS CCCCCCCCCCCEEEE	47.26	20068230
608	O-linked_Glycosylation	SQPPVQVSVKTQVSV CCCCEEEEEEEEEEE	10.78	20068230
611	Phosphorylation	PVQVSVKTQVSVTAA CEEEEEEEEEEEEEE	31.86	28450419
614	Phosphorylation	VSVKTQVSVTAAIPH EEEEEEEEEEEECCC	12.16	28450419
616	Phosphorylation	VKTQVSVTAAIPHLK EEEEEEEEEECCCCC	11.67	23186163
624	Phosphorylation	AAIPHLKTSTLPPLP EECCCCCCCCCCCCC	33.05	26074081
625	Phosphorylation	AIPHLKTSTLPPLPL ECCCCCCCCCCCCCC	26.76	26074081
626	Phosphorylation	IPHLKTSTLPPLPLP CCCCCCCCCCCCCCC	48.82	26074081
644	Phosphorylation	PGDDDMDSPKETLPS CCCCCCCCCHHCCCC	31.10	25159151
646	Acetylation	DDDMDSPKETLPSKP CCCCCCCHHCCCCCC	68.25	26051181
648	Phosphorylation	DMDSPKETLPSKPVK CCCCCHHCCCCCCCC	50.52	29116813
651	Phosphorylation	SPKETLPSKPVKKEK CCHHCCCCCCCCCHH	53.34	29978859
655	Sumoylation	TLPSKPVKKEKEQRT CCCCCCCCCHHHHHH	64.84	28112733
667	Phosphorylation	QRTRHLLTDLPLPPE HHHHHHHHCCCCCCC	41.68	23403867
681	Phosphorylation	ELPGGDLSPPDSPEP CCCCCCCCCCCCCCC	38.84	29255136
685	Phosphorylation	GDLSPPDSPEPKAIT CCCCCCCCCCCCCCC	36.62	29255136
692	Phosphorylation	SPEPKAITPPQQPYK CCCCCCCCCCCCCCC	33.50	19664994
698	Phosphorylation	ITPPQQPYKKRPKIC CCCCCCCCCCCCCCC	25.46	23403867
747	Ubiquitination	QVYKAKDKDTGELVA EEEEEECCCCCEEEE	57.38	29967540
756	Ubiquitination	TGELVALKKVRLDNE CCEEEEEEEEECCCC	39.21	29967540
763	Ubiquitination	KKVRLDNEKEGFPIT EEEECCCCCCCCCCH	52.75	24816145
764	Ubiquitination	KVRLDNEKEGFPITA EEECCCCCCCCCCHH	70.19	24816145
770	Phosphorylation	EKEGFPITAIREIKI CCCCCCCHHHHHHHH	19.10	20068231
790	2-Hydroxyisobutyrylation	HRSVVNMKEIVTDKQ HHHHCCHHHHCCCCH	38.80	-
796	2-Hydroxyisobutyrylation	MKEIVTDKQDALDFK HHHHCCCCHHHHHHC	40.49	-
796	Acetylation	MKEIVTDKQDALDFK HHHHCCCCHHHHHHC	40.49	23954790
796	Ubiquitination	MKEIVTDKQDALDFK HHHHCCCCHHHHHHC	40.49	29967540
803	Ubiquitination	KQDALDFKKDKGAFY CHHHHHHCCCCCCEE	60.78	29967540
838	Phosphorylation	FSEDHIKSFMKQLME CCHHHHHHHHHHHHH	29.94	24719451
849	Phosphorylation	QLMEGLEYCHKKNFL HHHHHHHHHHHCCCC	12.61	24719451
861	Ubiquitination	NFLHRDIKCSNILLN CCCCCCCCHHHEEEC	35.58	29967540
884	Phosphorylation	DFGLARLYNSEESRP HHHHHHCCCCCCCCC	15.87	23403867
886	Phosphorylation	GLARLYNSEESRPYT HHHHCCCCCCCCCCC	29.23	23927012
889	Phosphorylation	RLYNSEESRPYTNKV HCCCCCCCCCCCCCE	34.21	30266825
892	Phosphorylation	NSEESRPYTNKVITL CCCCCCCCCCCEEEE	23.10	23927012
893	Phosphorylation	SEESRPYTNKVITLW CCCCCCCCCCEEEEE	31.11	22167270
939	Ubiquitination	KKPIFQANLELAQLE CCCHHHCCHHHHHHH	24.22	22817900
949	Phosphorylation	LAQLELISRLCGSPC HHHHHHHHHHHCCCC	31.65	24719451
954	Phosphorylation	LISRLCGSPCPAVWP HHHHHHCCCCCCCCC	23.49	27251275
964	Ubiquitination	PAVWPDVIKLPYFNT CCCCCCCCCCCCCCC	5.03	22817900
965	Ubiquitination	AVWPDVIKLPYFNTM CCCCCCCCCCCCCCC	43.17	22817900
973	Acetylation	LPYFNTMKPKKQYRR CCCCCCCCCHHHHHH	52.20	-
995	Ubiquitination	FIPSAALDLLDHMLT CCCHHHHHHHHHHHC	40.22	21963094
1001	Ubiquitination	LDLLDHMLTLDPSKR HHHHHHHHCCCHHHC	3.74	21963094
1002	Phosphorylation	DLLDHMLTLDPSKRC HHHHHHHCCCHHHCC	22.88	-
1006	Phosphorylation	HMLTLDPSKRCTAEQ HHHCCCHHHCCCHHH	32.19	-
1020	Ubiquitination	QTLQSDFLKDVELSK HHHCHHHHHHHHHHH	5.78	21963094
1021	Ubiquitination	TLQSDFLKDVELSKM HHCHHHHHHHHHHHC	60.77	21963094
1026	Ubiquitination	FLKDVELSKMAPPDL HHHHHHHHHCCCCCC	13.59	21963094
1027	Ubiquitination	LKDVELSKMAPPDLP HHHHHHHHCCCCCCC	52.27	21963094
1038	Ubiquitination	PDLPHWQDCHELWSK CCCCCHHHHHHHHHH	30.46	24816145
1045	Ubiquitination	DCHELWSKKRRRQRQ HHHHHHHHHHHHHHC	38.42	29967540
1053	Phosphorylation	KRRRQRQSGVVVEEP HHHHHHCCCCEECCC	35.43	21082442
1063	Phosphorylation	VVEEPPPSKTSRKET EECCCCCCCCCCCCC	55.10	-
1063	Ubiquitination	VVEEPPPSKTSRKET EECCCCCCCCCCCCC	55.10	24816145
1064	Acetylation	VEEPPPSKTSRKETT ECCCCCCCCCCCCCC	57.18	25953088
1064	Ubiquitination	VEEPPPSKTSRKETT ECCCCCCCCCCCCCC	57.18	24816145
1066	Phosphorylation	EPPPSKTSRKETTSG CCCCCCCCCCCCCCC	45.12	-
1070	Phosphorylation	SKTSRKETTSGTSTE CCCCCCCCCCCCCCC	29.33	30278072
1071	Phosphorylation	KTSRKETTSGTSTEP CCCCCCCCCCCCCCC	26.67	23927012
1072	Phosphorylation	TSRKETTSGTSTEPV CCCCCCCCCCCCCCC	47.71	23927012
1074	Phosphorylation	RKETTSGTSTEPVKN CCCCCCCCCCCCCCC	32.04	29255136
1075	Phosphorylation	KETTSGTSTEPVKNS CCCCCCCCCCCCCCC	34.01	30266825
1076	Phosphorylation	ETTSGTSTEPVKNSS CCCCCCCCCCCCCCC	44.11	30266825
1082	Phosphorylation	STEPVKNSSPAPPQP CCCCCCCCCCCCCCC	31.79	29255136
1083	Phosphorylation	TEPVKNSSPAPPQPA CCCCCCCCCCCCCCC	34.18	19664994
1191	Phosphorylation	SAPVILPSAEQTTLE CCCEECCCCCHHCCC	40.78	27732954
1195	Phosphorylation	ILPSAEQTTLEASST ECCCCCHHCCCCCCC	25.50	27732954
1196	Phosphorylation	LPSAEQTTLEASSTP CCCCCHHCCCCCCCH	23.46	27732954
1200	Phosphorylation	EQTTLEASSTPADMQ CHHCCCCCCCHHHHH	25.93	27732954
1201	Phosphorylation	QTTLEASSTPADMQN HHCCCCCCCHHHHHH	45.52	27732954
1202	Phosphorylation	TTLEASSTPADMQNI HCCCCCCCHHHHHHH	21.72	27732954
1215	Phosphorylation	NILAVLLSQLMKTQE HHHHHHHHHHHCCCC	19.67	27732954
1226	Phosphorylation	KTQEPAGSLEENNSD CCCCCCCCCCCCCCC	34.41	28348404
1232	Phosphorylation	GSLEENNSDKNSGPQ CCCCCCCCCCCCCCC	62.64	25159151
1236	Phosphorylation	ENNSDKNSGPQGPRR CCCCCCCCCCCCCCC	58.55	25159151
1236 (in isoform 2)	Phosphorylation	-	58.55	21955146
1244	Phosphorylation	GPQGPRRTPTMPQEE CCCCCCCCCCCCHHH	25.13	22322096
1244 (in isoform 2)	Phosphorylation	-	25.13	20201521
1246	Phosphorylation	QGPRRTPTMPQEEAA CCCCCCCCCCHHHHH	40.65	30266825
1246 (in isoform 2)	Phosphorylation	-	40.65	30266825
1358	Phosphorylation	IDTDERNSGPALTES CCCCCCCCCCCHHHH	52.99	20068231
1363	Phosphorylation	RNSGPALTESLVQTL CCCCCCHHHHHHHHH	26.15	20068231
1363	Ubiquitination	RNSGPALTESLVQTL CCCCCCHHHHHHHHH	26.15	32015554
1365	Phosphorylation	SGPALTESLVQTLVK CCCCHHHHHHHHHHH	28.71	28555341
1369	Phosphorylation	LTESLVQTLVKNRTF HHHHHHHHHHHCCCC	26.49	20068231
1372	Ubiquitination	SLVQTLVKNRTFSGS HHHHHHHHCCCCCCC	43.77	32015554
1375	Phosphorylation	QTLVKNRTFSGSLSH HHHHHCCCCCCCCCC	31.39	27422710
1377	Phosphorylation	LVKNRTFSGSLSHLG HHHCCCCCCCCCCCC	27.19	27080861
1379	Phosphorylation	KNRTFSGSLSHLGES HCCCCCCCCCCCCCC	26.04	24247654
1381	Phosphorylation	RTFSGSLSHLGESSS CCCCCCCCCCCCCCC	20.54	27080861
1386	Phosphorylation	SLSHLGESSSYQGTG CCCCCCCCCCCCCCC	23.84	27080861
1387	Phosphorylation	LSHLGESSSYQGTGS CCCCCCCCCCCCCCC	28.85	27251275
1388	Phosphorylation	SHLGESSSYQGTGSV CCCCCCCCCCCCCCC	30.65	27251275
1389	Phosphorylation	HLGESSSYQGTGSVQ CCCCCCCCCCCCCCC	16.95	27080861
1392	Phosphorylation	ESSSYQGTGSVQFPG CCCCCCCCCCCCCCC	15.68	27080861
1394	Phosphorylation	SSYQGTGSVQFPGDQ CCCCCCCCCCCCCCC	16.75	27080861
1404	Methylation	FPGDQDLRFARVPLA CCCCCCCEEEECCEE	31.31	-
1440	Phosphorylation	AETKLQNYGELGPGT EEEECCCCCCCCCCC	10.06	27642862
1448	O-linked_Glycosylation	GELGPGTTGASSSGA CCCCCCCCCCCCCCC	36.34	20068230
1470	Acetylation	TQSSAYGKLYRGPTR CCCCCCCCCCCCCCC	29.66	25953088
1472	Phosphorylation	SSAYGKLYRGPTRVP CCCCCCCCCCCCCCC	19.60	20068231
1473	Methylation	SAYGKLYRGPTRVPP CCCCCCCCCCCCCCC	55.86	-
1476	Phosphorylation	GKLYRGPTRVPPRGG CCCCCCCCCCCCCCC	47.31	23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
893	T	Phosphorylation	Kinase	CDK7	P50613	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
893	T	Phosphorylation		20068231
Phosphorylation at Thr-893 increases kinase activity.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CDK12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRP4_HUMAN	PRPF4	physical	22939629
TIF1A_HUMAN	TRIM24	physical	22939629
IPPK_HUMAN	IPPK	physical	22939629
VPS51_HUMAN	VPS51	physical	22939629
ZN606_HUMAN	ZNF606	physical	22939629
ELOA1_HUMAN	TCEB3	physical	22939629
EWS_HUMAN	EWSR1	physical	21988832

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CDK12_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-504, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-236; SER-383; SER-385;SER-681; SER-685 AND THR-1244, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14; SER-24; SER-29;THR-57; SER-62; THR-82; SER-84; SER-228; SER-236; SER-249; SER-274;SER-276; SER-291; SER-293; SER-301; SER-303; SER-323; SER-325;SER-332; SER-333; SER-334; SER-382; SER-383; SER-385; SER-393;SER-420; SER-423; SER-434; THR-514; SER-681; SER-685; THR-692;TYR-892; THR-893; SER-1053; THR-1070; THR-1074; THR-1076; SER-1082;SER-1083 AND THR-1244, AND MASS SPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-681; SER-685; THR-692;THR-1076; SER-1082 AND SER-1083, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-249; SER-301; SER-303;SER-318; SER-320; SER-323; SER-325; SER-332; SER-333; SER-334;SER-343; SER-345; SER-382; SER-383; SER-385; SER-400; SER-423;SER-681; SER-685 AND THR-692, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24; SER-25; SER-32;THR-57; TYR-73; SER-77; SER-78; SER-80; SER-84; SER-236; SER-238;SER-249; SER-274; SER-276; SER-291; SER-293; SER-301; SER-303;SER-341; SER-343; SER-383; SER-385; SER-400; SER-423; THR-514;SER-681; SER-685; THR-692; THR-893; SER-1083 AND THR-1244, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1083, AND MASSSPECTROMETRY.	19007248 [Abstract]
"Proteomics analysis of protein kinases by target class-selectiveprefractionation and tandem mass spectrometry."; Wissing J., Jaensch L., Nimtz M., Dieterich G., Hornberger R.,Keri G., Wehland J., Daub H.; Mol. Cell. Proteomics 6:537-547(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-274; SER-276; SER-383;SER-385; SER-423; SER-681; SER-685 AND THR-893, AND MASS SPECTROMETRY.	17192257 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-423 AND THR-692, ANDMASS SPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77; SER-78; SER-80;SER-84; SER-274; SER-276; SER-423; SER-681 AND SER-685, AND MASSSPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-215; SER-249; SER-265;SER-293; SER-303; SER-423; THR-692 AND SER-1083, AND MASSSPECTROMETRY.	15302935 [Abstract]

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