VPS51_HUMAN - dbPTM
VPS51_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID VPS51_HUMAN
UniProt AC Q9UID3
Protein Name Vacuolar protein sorting-associated protein 51 homolog
Gene Name VPS51
Organism Homo sapiens (Human).
Sequence Length 782
Subcellular Localization Golgi apparatus, trans-Golgi network . Recycling endosome . Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex (PubMed:25799061).
Protein Description Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN. [PubMed: 20685960 Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane]
Protein Sequence MAAAAAAGPSPGSGPGDSPEGPEGEAPERRRKAHGMLKLYYGLSEGEAAGRPAGPDPLDPTDLNGAHFDPEVYLDKLRRECPLAQLMDSETDMVRQIRALDSDMQTLVYENYNKFISATDTIRKMKNDFRKMEDEMDRLATNMAVITDFSARISATLQDRHERITKLAGVHALLRKLQFLFELPSRLTKCVELGAYGQAVRYQGRAQAVLQQYQHLPSFRAIQDDCQVITARLAQQLRQRFREGGSGAPEQAECVELLLALGEPAEELCEEFLAHARGRLEKELRNLEAELGPSPPAPDVLEFTDHGGSGFVGGLCQVAAAYQELFAAQGPAGAEKLAAFARQLGSRYFALVERRLAQEQGGGDNSLLVRALDRFHRRLRAPGALLAAAGLADAATEIVERVARERLGHHLQGLRAAFLGCLTDVRQALAAPRVAGKEGPGLAELLANVASSILSHIKASLAAVHLFTAKEVSFSNKPYFRGEFCSQGVREGLIVGFVHSMCQTAQSFCDSPGEKGGATPPALLLLLSRLCLDYETATISYILTLTDEQFLVQDQFPVTPVSTLCAEARETARRLLTHYVKVQGLVISQMLRKSVETRDWLSTLEPRNVRAVMKRVVEDTTAIDVQVGLLYEEGVRKAQSSDSSKRTFSVYSSSRQQGRYAPSYTPSAPMDTNLLSNIQKLFSERIDVFSPVEFNKVSVLTGIIKISLKTLLECVRLRTFGRFGLQQVQVDCHFLQLYLWRFVADEELVHLLLDEVVASAALRCPDPVPMEPSVVEVICERG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAAAAAAGP
------CCCCHHCCC		19413330
10PhosphorylationAAAAAGPSPGSGPGD
CCHHCCCCCCCCCCC		25159151
13PhosphorylationAAGPSPGSGPGDSPE
HCCCCCCCCCCCCCC		23401153
18PhosphorylationPGSGPGDSPEGPEGE
CCCCCCCCCCCCCCC		29255136
40PhosphorylationAHGMLKLYYGLSEGE
HHHHHHHHHCCCCCC		28796482
41PhosphorylationHGMLKLYYGLSEGEA
HHHHHHHHCCCCCCC		28796482
42 (in isoform 2)Ubiquitination-21890473
44PhosphorylationLKLYYGLSEGEAAGR
HHHHHCCCCCCCCCC		26471730
76UbiquitinationDPEVYLDKLRRECPL
CHHHHHHHHHHHCCH		21906983
76 (in isoform 1)Ubiquitination-21890473
106PhosphorylationALDSDMQTLVYENYN
HHCCCHHHHHHHCHH		28796482
109PhosphorylationSDMQTLVYENYNKFI
CCHHHHHHHCHHHHH		28796482
112PhosphorylationQTLVYENYNKFISAT
HHHHHHCHHHHHHHH		28796482
114UbiquitinationLVYENYNKFISATDT
HHHHCHHHHHHHHHH		-
117PhosphorylationENYNKFISATDTIRK
HCHHHHHHHHHHHHH		-
119PhosphorylationYNKFISATDTIRKMK
HHHHHHHHHHHHHHH		19664995
121PhosphorylationKFISATDTIRKMKND
HHHHHHHHHHHHHHH		27067055
126UbiquitinationTDTIRKMKNDFRKME
HHHHHHHHHHHHHHH		24816145
131UbiquitinationKMKNDFRKMEDEMDR
HHHHHHHHHHHHHHH		-
160MethylationISATLQDRHERITKL
HHHHHHHHHHHHHHH		-
166UbiquitinationDRHERITKLAGVHAL
HHHHHHHHHHHHHHH		22817900
166 (in isoform 1)Ubiquitination-21890473
176UbiquitinationGVHALLRKLQFLFEL
HHHHHHHHHHHHHHC		-
185PhosphorylationQFLFELPSRLTKCVE
HHHHHCCHHHHHHHH		-
189 (in isoform 1)Ubiquitination-21890473
189UbiquitinationELPSRLTKCVELGAY
HCCHHHHHHHHHCCH		22053931
213PhosphorylationAQAVLQQYQHLPSFR
HHHHHHHHHCCHHHH		27642862
218PhosphorylationQQYQHLPSFRAIQDD
HHHHCCHHHHHHHHH		28857561
282UbiquitinationHARGRLEKELRNLEA
HHHHHHHHHHHHHHH		-
366PhosphorylationEQGGGDNSLLVRALD
HCCCCCCHHHHHHHH		24719451
423PhosphorylationAAFLGCLTDVRQALA
HHHHHHHHHHHHHHH		24670416
477UbiquitinationKEVSFSNKPYFRGEF
CEEECCCCCCCCCCC		27667366
579PhosphorylationARRLLTHYVKVQGLV
HHHHHHHHHHHHHHH		22817900
588PhosphorylationKVQGLVISQMLRKSV
HHHHHHHHHHHHHCC		27135362
620PhosphorylationMKRVVEDTTAIDVQV
HHHHHCCCCCHHHHH		-
631PhosphorylationDVQVGLLYEEGVRKA
HHHHHHHHHHCCCCC		-
637UbiquitinationLYEEGVRKAQSSDSS
HHHHCCCCCCCCCCC		-
640PhosphorylationEGVRKAQSSDSSKRT
HCCCCCCCCCCCCCE		22617229
641PhosphorylationGVRKAQSSDSSKRTF
CCCCCCCCCCCCCEE		23090842
643PhosphorylationRKAQSSDSSKRTFSV
CCCCCCCCCCCEEEE		33259812
644PhosphorylationKAQSSDSSKRTFSVY
CCCCCCCCCCEEEEE		22617229
647PhosphorylationSSDSSKRTFSVYSSS
CCCCCCCEEEEEECC		23403867
649PhosphorylationDSSKRTFSVYSSSRQ
CCCCCEEEEEECCCC		27499020
651PhosphorylationSKRTFSVYSSSRQQG
CCCEEEEEECCCCCC		28122231
652PhosphorylationKRTFSVYSSSRQQGR
CCEEEEEECCCCCCC		22617229
653PhosphorylationRTFSVYSSSRQQGRY
CEEEEEECCCCCCCC		27794612
654PhosphorylationTFSVYSSSRQQGRYA
EEEEEECCCCCCCCC		27499020
660PhosphorylationSSRQQGRYAPSYTPS
CCCCCCCCCCCCCCC		21945579
663PhosphorylationQQGRYAPSYTPSAPM
CCCCCCCCCCCCCCC		21945579
664PhosphorylationQGRYAPSYTPSAPMD
CCCCCCCCCCCCCCC		21945579
665PhosphorylationGRYAPSYTPSAPMDT
CCCCCCCCCCCCCCC		21945579
667PhosphorylationYAPSYTPSAPMDTNL
CCCCCCCCCCCCCCH		21945579
672PhosphorylationTPSAPMDTNLLSNIQ
CCCCCCCCCHHHHHH		21945579
676PhosphorylationPMDTNLLSNIQKLFS
CCCCCHHHHHHHHHH		21945579
680UbiquitinationNLLSNIQKLFSERID
CHHHHHHHHHHCCCC		-
690PhosphorylationSERIDVFSPVEFNKV
HCCCCCCCCCCCCHH		24076635
705UbiquitinationSVLTGIIKISLKTLL
HHHHHHHHHHHHHHH		33845483
709UbiquitinationGIIKISLKTLLECVR
HHHHHHHHHHHHHHH		33845483
710PhosphorylationIIKISLKTLLECVRL
HHHHHHHHHHHHHHH		27794612
773PhosphorylationDPVPMEPSVVEVICE
CCCCCCCHHEEEEEE		29507054
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of VPS51_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of VPS51_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of VPS51_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VPS52_HUMANVPS52physical
20685960
VPS53_HUMANVPS53physical
20685960
VPS54_HUMANVPS54physical
20685960
COG8_HUMANCOG8physical
20685960
CDN1A_HUMANCDKN1Aphysical
21988832
YTDC1_HUMANYTHDC1physical
21988832
EXOC4_HUMANEXOC4physical
27173435
PKN3_HUMANPKN3physical
27173435
NCK5L_HUMANNCKAP5Lphysical
27173435
TFPT_HUMANTFPTphysical
27173435
YETS4_HUMANYEATS4physical
27173435
GOGA5_HUMANGOLGA5physical
27173435
CLOCK_HUMANCLOCKphysical
27173435
PSMD9_HUMANPSMD9physical
27173435
DZIP3_HUMANDZIP3physical
27173435
GRAP1_HUMANGRIPAP1physical
27173435
RCOR1_HUMANRCOR1physical
27173435
VPS50_HUMANCCDC132physical
27173435
CCD93_HUMANCCDC93physical
27173435
PF21A_HUMANPHF21Aphysical
27173435
CAVN1_HUMANPTRFphysical
27173435
HAUS6_HUMANHAUS6physical
27173435
RPR1A_HUMANRPRD1Aphysical
27173435
BMAL1_HUMANARNTLphysical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of VPS51_HUMAN

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Related Literatures of Post-Translational Modification

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