VPS54_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VPS54_HUMAN
• UniProt AC: Q9P1Q0
• Protein Name: Vacuolar protein sorting-associated protein 54
• Gene Name: VPS54
• Organism: Homo sapiens (Human).
• Sequence Length: 977
• Subcellular Localization: Golgi apparatus, trans-Golgi network .
• Protein Description: Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. [PubMed: 18367545 Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling]
• Protein Sequence: MASSHSSSPVPQGSSSDVFFKIEVDPSKHIRPVPSLPDVCPKEPTGDSHSLYVAPSLVTDQHRWTVYHSKVNLPAALNDPRLAKRESDFFTKTWGLDFVDTEVIPSFYLPQISKEHFTVYQQEISQREKIHERCKNICPPKDTFERTLLHTHDKSRTDLEQVPKIFMKPDFALDDSLTFNSVLPWSHFNTAGGKGNRDAASSKLLQEKLSHYLDIVEVNIAHQISLRSEAFFHAMTSQHELQDYLRKTSQAVKMLRDKIAQIDKVMCEGSLHILRLALTRNNCVKVYNKLKLMATVHQTQPTVQVLLSTSEFVGALDLIATTQEVLQQELQGIHSFRHLGSQLCELEKLIDKMMIAEFSTYSHSDLNRPLEDDCQVLEEERLISLVFGLLKQRKLNFLEIYGEKMVITAKNIIKQCVINKVSQTEEIDTDVVVKLADQMRMLNFPQWFDLLKDIFSKFTIFLQRVKATLNIIHSVVLSVLDKNQRTRELEEISQQKNAAKDNSLDTEVAYLIHEGMFISDAFGEGELTPIAVDTTSQRNASPNSEPCSSDSVSEPECTTDSSSSKEHTSSSAIPGGVDIMVSEDMKLTDSELGKLANNIQELLYSASDICHDRAVKFLMSRAKDGFLEKLNSMEFITLSRLMETFILDTEQICGRKSTSLLGALQSQAIKFVNRFHEERKTKLSLLLDNERWKQADVPAEFQDLVDSLSDGKIALPEKKSGATEERKPAEVLIVEGQQYAVVGTVLLLIRIILEYCQCVDNIPSVTTDMLTRLSDLLKYFNSRSCQLVLGAGALQVVGLKTITTKNLALSSRCLQLIVHYIPVIRAHFEARLPPKQYSMLRHFDHITKDYHDHIAEISAKLVAIMDSLFDKLLSKYEVKAPVPSACFRNICKQMTKMHEAIFDLLPEEQTQMLFLRINASYKLHLKKQLSHLNVINDGGPQNGLVTADVAFYTGNLQALKGLKDLDLNMAEIWEQKR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASSHSSSPV -----CCCCCCCCCC	27.56	22199227
4	Phosphorylation	----MASSHSSSPVP ----CCCCCCCCCCC	20.18	22199227
6	Phosphorylation	--MASSHSSSPVPQG --CCCCCCCCCCCCC	34.16	25159151
7	Phosphorylation	-MASSHSSSPVPQGS -CCCCCCCCCCCCCC	32.98	25159151
8	Phosphorylation	MASSHSSSPVPQGSS CCCCCCCCCCCCCCC	32.69	25159151
14	Phosphorylation	SSPVPQGSSSDVFFK CCCCCCCCCCCEEEE	22.78	22199227
15	Phosphorylation	SPVPQGSSSDVFFKI CCCCCCCCCCEEEEE	37.06	22199227
16	Phosphorylation	PVPQGSSSDVFFKIE CCCCCCCCCEEEEEE	39.22	22199227
27	Phosphorylation	FKIEVDPSKHIRPVP EEEEECCCCCCCCCC	32.19	28355574
35 (in isoform 4)	Phosphorylation	-	53.41	24719451
35	Phosphorylation	KHIRPVPSLPDVCPK CCCCCCCCCCCCCCC	53.41	29496963
45	Phosphorylation	DVCPKEPTGDSHSLY CCCCCCCCCCCCEEE	55.50	28796482
48	Phosphorylation	PKEPTGDSHSLYVAP CCCCCCCCCEEEECH	19.13	28796482
50	Phosphorylation	EPTGDSHSLYVAPSL CCCCCCCEEEECHHH	25.91	28796482
52	Phosphorylation	TGDSHSLYVAPSLVT CCCCCEEEECHHHCC	9.51	28796482
69	Phosphorylation	HRWTVYHSKVNLPAA CCEEEEECCCCCCHH	22.17	24114839
87	Phosphorylation	PRLAKRESDFFTKTW HHHHHHHCCCCCCCC	43.69	29396449
143	Phosphorylation	NICPPKDTFERTLLH CCCCCCCHHHHHHCC	33.26	-
151	Phosphorylation	FERTLLHTHDKSRTD HHHHHCCCCCCCCCC	31.57	29457462
157	Phosphorylation	HTHDKSRTDLEQVPK CCCCCCCCCHHHCCC	52.61	22817900
225	Phosphorylation	VNIAHQISLRSEAFF CCCHHHHHHCHHHHH	15.91	24719451
237	Phosphorylation	AFFHAMTSQHELQDY HHHHHHCCHHHHHHH	19.22	19413330
249	Phosphorylation	QDYLRKTSQAVKMLR HHHHHHHHHHHHHHH	21.12	19413330
414	Malonylation	ITAKNIIKQCVINKV EEHHHHHHHHHHCCC	33.57	26320211
456	Phosphorylation	DLLKDIFSKFTIFLQ HHHHHHHHHHHHHHH	27.48	24719451
493	Phosphorylation	TRELEEISQQKNAAK HHHHHHHHHHHHHHH	29.82	21815630
541	Phosphorylation	TTSQRNASPNSEPCS CCCCCCCCCCCCCCC	28.32	28188228
544	Phosphorylation	QRNASPNSEPCSSDS CCCCCCCCCCCCCCC	46.42	28450419
548	Phosphorylation	SPNSEPCSSDSVSEP CCCCCCCCCCCCCCC	48.14	28450419
549	Phosphorylation	PNSEPCSSDSVSEPE CCCCCCCCCCCCCCC	40.39	28450419
551	Phosphorylation	SEPCSSDSVSEPECT CCCCCCCCCCCCCCC	29.50	28450419
568	Phosphorylation	SSSSKEHTSSSAIPG CCCCCCCCCCCCCCC	31.25	-
616	Malonylation	ICHDRAVKFLMSRAK HHHHHHHHHHHHHCC	31.62	26320211
623	Malonylation	KFLMSRAKDGFLEKL HHHHHHCCCCHHHHH	58.22	26320211
644	Phosphorylation	TLSRLMETFILDTEQ HHHHHHHHHCCCHHH	11.30	24043423
649	Phosphorylation	METFILDTEQICGRK HHHHCCCHHHHCCCC	26.75	24043423
700	Ubiquitination	KQADVPAEFQDLVDS HHCCCCHHHHHHHHH	37.46	29967540
712	Ubiquitination	VDSLSDGKIALPEKK HHHHCCCCCCCCCCC	29.78	29967540
764	Phosphorylation	QCVDNIPSVTTDMLT CHHCCCCCCCHHHHH	28.44	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VPS54_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VPS54_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VPS54_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VPS53_HUMAN	VPS53	physical	20685960

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.