COG8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COG8_HUMAN
• UniProt AC: Q96MW5
• Protein Name: Conserved oligomeric Golgi complex subunit 8
• Gene Name: COG8
• Organism: Homo sapiens (Human).
• Sequence Length: 612
• Subcellular Localization: Golgi apparatus membrane ; Peripheral membrane protein .
• Protein Description: Required for normal Golgi function..
• Protein Sequence: MATAATIPSVATATAAALGEVEDEGLLASLFRDRFPEAQWRERPDVGRYLRELSGSGLERLRREPERLAEERAQLLQQTRDLAFANYKTFIRGAECTERIHRLFGDVEASLGRLLDRLPSFQQSCRNFVKEAEEISSNRRMNSLTLNRHTEILEILEIPQLMDTCVRNSYYEEALELAAYVRRLERKYSSIPVIQGIVNEVRQSMQLMLSQLIQQLRTNIQLPACLRVIGYLRRMDVFTEAELRVKFLQARDAWLRSILTAIPNDDPYFHITKTIEASRVHLFDIITQYRAIFSDEDPLLPPAMGEHTVNESAIFHGWVLQKVSQFLQVLETDLYRGIGGHLDSLLGQCMYFGLSFSRVGADFRGQLAPVFQRVAISTFQKAIQETVEKFQEEMNSYMLISAPAILGTSNMPAAVPATQPGTLQPPMVLLDFPPLACFLNNILVAFNDLRLCCPVALAQDVTGALEDALAKVTKIILAFHRAEEAAFSSGEQELFVQFCTVFLEDLVPYLNRCLQVLFPPAQIAQTLGIPPTQLSKYGNLGHVNIGAIQEPLAFILPKRETLFTLDDQALGPELTAPAPEPPAEEPRLEPAGPACPEGGRAETQAEPPSVGP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
54	Phosphorylation	GRYLRELSGSGLERL HHHHHHHCCCHHHHH	26.59	24114839
88	Ubiquitination	DLAFANYKTFIRGAE HHHHHCHHHHHCHHH	36.44	21906983
97	Phosphorylation	FIRGAECTERIHRLF HHCHHHHHHHHHHHH	21.58	-
115	Ubiquitination	EASLGRLLDRLPSFQ HHHHHHHHHHCHHHH	3.29	21906983
130	Ubiquitination	QSCRNFVKEAEEISS HHHHHHHHHHHHHHC	47.25	21906983
157	Ubiquitination	TEILEILEIPQLMDT HHHHHHHHHHHHHHH	59.28	21906983
169	Phosphorylation	MDTCVRNSYYEEALE HHHHHHCCHHHHHHH	20.66	26270265
239	O-linked_Glycosylation	LRRMDVFTEAELRVK HHHCCCCCHHHHHHH	33.85	31492838
246	Ubiquitination	TEAELRVKFLQARDA CHHHHHHHHHHHHHH	33.64	-
257	Phosphorylation	ARDAWLRSILTAIPN HHHHHHHHHHHHCCC	21.56	18452278
260	Phosphorylation	AWLRSILTAIPNDDP HHHHHHHHHCCCCCC	22.37	18452278
268	Phosphorylation	AIPNDDPYFHITKTI HCCCCCCCCEEECEE	18.13	22817900
273	Ubiquitination	DPYFHITKTIEASRV CCCCEEECEEEHHHH	47.07	21906983
300	Ubiquitination	FSDEDPLLPPAMGEH HCCCCCCCCCCCCCC	6.09	21906983
381	Ubiquitination	VAISTFQKAIQETVE HHHHHHHHHHHHHHH	43.18	21906983
408	Ubiquitination	SAPAILGTSNMPAAV ECCCHHCCCCCCCCC	17.30	21906983
558	Ubiquitination	PLAFILPKRETLFTL CEEECCCCCCEEEEC	60.46	2190698
585	Ubiquitination	APEPPAEEPRLEPAG CCCCCCCCCCCCCCC	37.51	21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COG8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COG8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COG8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COG1_HUMAN	COG1	physical	26344197
COG4_HUMAN	COG4	physical	26344197

Drug and Disease Associations

• Kegg Disease
• H00119: Congenital disorders of glycosylation (CDG) type II
• OMIM Disease
• 611182: Congenital disorder of glycosylation 2H (CDG2H)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.