| UniProt ID | VPS50_HUMAN | |
|---|---|---|
| UniProt AC | Q96JG6 | |
| Protein Name | Syndetin {ECO:0000303|PubMed:25799061} | |
| Gene Name | VPS50 {ECO:0000312|HGNC:HGNC:25956} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 964 | |
| Subcellular Localization | Recycling endosome . | |
| Protein Description | Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).. | |
| Protein Sequence | MQKIKSLMTRQGLKSPQESLSDLGAIESLRVPGKEEFRELREQPSDPQAEQELINSIEQVYFSVDSFDIVKYELEKLPPVLNLQELEAYRDKLKQQQAAVSKKVADLILEKQPAYVKELERVTSLQTGLQLAAVICTNGRRHLNIAKEGFTQASLGLLANQRKRQLLIGLLKSLRTIKTLQRTDVRLSEMLEEEDYPGAIQLCLECQKAASTFKHYSCISELNSKLQDTLEQIEEQLDVALSKICKNFDINHYTKVQQAYRLLGKTQTAMDQLHMHFTQAIHNTVFQVVLGYVELCAGNTDTKFQKLQYKDLCTHVTPDSYIPCLADLCKALWEVMLSYYRTMEWHEKHDNEDTASASEGSNMIGTEETNFDRGYIKKKLEHGLTRIWQDVQLKVKTYLLGTDLSIFKYDDFIFVLDIISRLMQVGEEFCGSKSEVLQESIRKQSVNYFKNYHRTRLDELRMFLENETWELCPVKSNFSILQLHEFKFMEQSRSPSVSPSKQPVSTSSKTVTLFEQYCSGGNPFEIQANHKDEETEDVLASNGYESDEQEKSAYQEYDSDSDVPEELKRDYVDEQTGDGPVKSVSRETLKSRKKSDYSLNKVNAPILTNTTLNVIRLVGKYMQMMNILKPIAFDVIHFMSQLFDYYLYAIYTFFGRNDSLESTGLGLSSSRLRTTLNRIQESLIDLEVSADPTATLTAAEERKEKVPSPHLSHLVVLTSGDTLYGLAERVVATESLVFLAEQFEFLQPHLDAVMPAVKKPFLQQFYSQTVSTASELRKPIYWIVAGKALDYEQMLLLMANVKWDVKEIMSQHNIYVDALLKEFEQFNRRLNEVSKRVRIPLPVSNILWEHCIRLANRTIVEGYANVKKCSNEGRALMQLDFQQFLMKLEKLTDIRPIPDKEFVETYIKAYYLTENDMERWIKEHREYSTKQLTNLVNVCLGSHINKKARQKLLAAIDDIDRPKR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MQKIKSLM -------CHHHHHHH | 22814378 | ||
| 3 | Ubiquitination | -----MQKIKSLMTR -----CHHHHHHHHH | 24816145 | ||
| 5 | Acetylation | ---MQKIKSLMTRQG ---CHHHHHHHHHCC | 18603813 | ||
| 6 | Phosphorylation | --MQKIKSLMTRQGL --CHHHHHHHHHCCC | 28857561 | ||
| 15 | Phosphorylation | MTRQGLKSPQESLSD HHHCCCCCCCHHHHH | 29255136 | ||
| 19 | Phosphorylation | GLKSPQESLSDLGAI CCCCCCHHHHHCCHH | 29255136 | ||
| 21 | Phosphorylation | KSPQESLSDLGAIES CCCCHHHHHCCHHHH | 29255136 | ||
| 28 | Phosphorylation | SDLGAIESLRVPGKE HHCCHHHHCCCCCHH | 23312004 | ||
| 34 | Ubiquitination | ESLRVPGKEEFRELR HHCCCCCHHHHHHHH | 29967540 | ||
| 81 | Ubiquitination | LEKLPPVLNLQELEA HHHCCCCCCHHHHHH | 29967540 | ||
| 101 | Phosphorylation | KQQQAAVSKKVADLI HHHHHHHHHHHHHHH | 24043423 | ||
| 111 | Ubiquitination | VADLILEKQPAYVKE HHHHHHHHCCHHHHH | 29967540 | ||
| 115 | Phosphorylation | ILEKQPAYVKELERV HHHHCCHHHHHHHHH | - | ||
| 148 | Ubiquitination | RHLNIAKEGFTQASL HHHHHCHHCCCHHHH | 29967540 | ||
| 173 | Phosphorylation | LLIGLLKSLRTIKTL HHHHHHHHHHHHHHH | 23909892 | ||
| 176 | Phosphorylation | GLLKSLRTIKTLQRT HHHHHHHHHHHHHHC | 23909892 | ||
| 178 | Ubiquitination | LKSLRTIKTLQRTDV HHHHHHHHHHHHCCC | 29967540 | ||
| 194 | Ubiquitination | LSEMLEEEDYPGAIQ HHHHHCCCCCCCHHH | 24816145 | ||
| 216 | Phosphorylation | AASTFKHYSCISELN HHHHCHHHHHHHHHH | 27642862 | ||
| 225 | Ubiquitination | CISELNSKLQDTLEQ HHHHHHHHHHHHHHH | 29967540 | ||
| 255 | Ubiquitination | FDINHYTKVQQAYRL CCCCHHHHHHHHHHH | 29967540 | ||
| 260 | Phosphorylation | YTKVQQAYRLLGKTQ HHHHHHHHHHHCCHH | - | ||
| 276 | Ubiquitination | AMDQLHMHFTQAIHN HHHHHHHHHHHHHHH | 29967540 | ||
| 306 | Ubiquitination | NTDTKFQKLQYKDLC CCCCCHHHCCHHHHC | 29967540 | ||
| 349 | Ubiquitination | TMEWHEKHDNEDTAS HHHHHHHCCCCCCCC | 29967540 | ||
| 354 | Phosphorylation | EKHDNEDTASASEGS HHCCCCCCCCCCCCC | 24043423 | ||
| 356 | Phosphorylation | HDNEDTASASEGSNM CCCCCCCCCCCCCCC | 24043423 | ||
| 358 | Phosphorylation | NEDTASASEGSNMIG CCCCCCCCCCCCCCC | 24043423 | ||
| 361 | Phosphorylation | TASASEGSNMIGTEE CCCCCCCCCCCCCCC | 24043423 | ||
| 366 | Phosphorylation | EGSNMIGTEETNFDR CCCCCCCCCCCCCCH | 24043423 | ||
| 369 | Phosphorylation | NMIGTEETNFDRGYI CCCCCCCCCCCHHHH | 24043423 | ||
| 379 | Ubiquitination | DRGYIKKKLEHGLTR CHHHHHHHHHHCCHH | 29967540 | ||
| 393 | Ubiquitination | RIWQDVQLKVKTYLL HHHHHHHHHHHHHHH | 24816145 | ||
| 397 | Phosphorylation | DVQLKVKTYLLGTDL HHHHHHHHHHHCCCC | - | ||
| 398 | Phosphorylation | VQLKVKTYLLGTDLS HHHHHHHHHHCCCCH | - | ||
| 405 | Phosphorylation | YLLGTDLSIFKYDDF HHHCCCCHHHCCCHH | 24719451 | ||
| 413 | Ubiquitination | IFKYDDFIFVLDIIS HHCCCHHHHHHHHHH | 29967540 | ||
| 443 | Ubiquitination | VLQESIRKQSVNYFK HHHHHHHHHHHHHHH | 29967540 | ||
| 447 | Ubiquitination | SIRKQSVNYFKNYHR HHHHHHHHHHHHHCC | 27667366 | ||
| 464 | Phosphorylation | LDELRMFLENETWEL HHHHHHHHHCCCEEE | 32142685 | ||
| 471 | Ubiquitination | LENETWELCPVKSNF HHCCCEEECCCCCCC | 29967540 | ||
| 492 | Phosphorylation | EFKFMEQSRSPSVSP EHHHHHCCCCCCCCC | 22167270 | ||
| 494 | Phosphorylation | KFMEQSRSPSVSPSK HHHHCCCCCCCCCCC | 22167270 | ||
| 496 | Phosphorylation | MEQSRSPSVSPSKQP HHCCCCCCCCCCCCC | 22167270 | ||
| 498 | Phosphorylation | QSRSPSVSPSKQPVS CCCCCCCCCCCCCCC | 22167270 | ||
| 500 | Phosphorylation | RSPSVSPSKQPVSTS CCCCCCCCCCCCCCC | 22167270 | ||
| 501 | Ubiquitination | SPSVSPSKQPVSTSS CCCCCCCCCCCCCCC | 29967540 | ||
| 505 | Phosphorylation | SPSKQPVSTSSKTVT CCCCCCCCCCCCEEE | 23927012 | ||
| 506 | Phosphorylation | PSKQPVSTSSKTVTL CCCCCCCCCCCEEEE | 23663014 | ||
| 507 | Phosphorylation | SKQPVSTSSKTVTLF CCCCCCCCCCEEEEE | 23927012 | ||
| 508 | Phosphorylation | KQPVSTSSKTVTLFE CCCCCCCCCEEEEEH | 23927012 | ||
| 510 | Phosphorylation | PVSTSSKTVTLFEQY CCCCCCCEEEEEHHH | 27251275 | ||
| 512 | Phosphorylation | STSSKTVTLFEQYCS CCCCCEEEEEHHHHC | 27251275 | ||
| 517 | Phosphorylation | TVTLFEQYCSGGNPF EEEEEHHHHCCCCCC | 27251275 | ||
| 519 | Phosphorylation | TLFEQYCSGGNPFEI EEEHHHHCCCCCCEE | 27251275 | ||
| 529 | Phosphorylation | NPFEIQANHKDEETE CCCEEECCCCCCCCC | 32142685 | ||
| 531 | Phosphorylation | FEIQANHKDEETEDV CEEECCCCCCCCCHH | 32142685 | ||
| 535 | Phosphorylation | ANHKDEETEDVLASN CCCCCCCCCHHHHHC | 27251275 | ||
| 541 | Phosphorylation | ETEDVLASNGYESDE CCCHHHHHCCCCCHH | 30576142 | ||
| 544 | Phosphorylation | DVLASNGYESDEQEK HHHHHCCCCCHHHHH | 26657352 | ||
| 546 | Phosphorylation | LASNGYESDEQEKSA HHHCCCCCHHHHHHH | 25159151 | ||
| 552 | Phosphorylation | ESDEQEKSAYQEYDS CCHHHHHHHHHHCCC | 23927012 | ||
| 552 | Ubiquitination | ESDEQEKSAYQEYDS CCHHHHHHHHHHCCC | 24816145 | ||
| 554 | Phosphorylation | DEQEKSAYQEYDSDS HHHHHHHHHHCCCCC | 23927012 | ||
| 557 | Phosphorylation | EKSAYQEYDSDSDVP HHHHHHHCCCCCCCC | 23927012 | ||
| 559 | Phosphorylation | SAYQEYDSDSDVPEE HHHHHCCCCCCCCHH | 22167270 | ||
| 561 | Phosphorylation | YQEYDSDSDVPEELK HHHCCCCCCCCHHHH | 22167270 | ||
| 571 | Phosphorylation | PEELKRDYVDEQTGD CHHHHHHHCCCCCCC | 24927040 | ||
| 575 | Ubiquitination | KRDYVDEQTGDGPVK HHHHCCCCCCCCCCC | 24816145 | ||
| 576 | Phosphorylation | RDYVDEQTGDGPVKS HHHCCCCCCCCCCCC | 23312004 | ||
| 582 | Ubiquitination | QTGDGPVKSVSRETL CCCCCCCCCCCHHHH | 21906983 | ||
| 582 (in isoform 1) | Ubiquitination | - | 21906983 | ||
| 583 | Phosphorylation | TGDGPVKSVSRETLK CCCCCCCCCCHHHHH | 23401153 | ||
| 585 | Phosphorylation | DGPVKSVSRETLKSR CCCCCCCCHHHHHHC | 23312004 | ||
| 588 | Phosphorylation | VKSVSRETLKSRKKS CCCCCHHHHHHCCCC | 24719451 | ||
| 595 | Phosphorylation | TLKSRKKSDYSLNKV HHHHCCCCCCCCCCC | 28348404 | ||
| 597 | Phosphorylation | KSRKKSDYSLNKVNA HHCCCCCCCCCCCCC | 26552605 | ||
| 598 | Phosphorylation | SRKKSDYSLNKVNAP HCCCCCCCCCCCCCC | 26552605 | ||
| 608 | Phosphorylation | KVNAPILTNTTLNVI CCCCCCCCCHHHHHH | - | ||
| 621 | Phosphorylation | VIRLVGKYMQMMNIL HHHHHHHHHHHHHHH | 19664994 | ||
| 646 | Ubiquitination | MSQLFDYYLYAIYTF HHHHHHHHHHHHHHH | 27667366 | ||
| 670 | Phosphorylation | TGLGLSSSRLRTTLN CCCCCCHHHHHHHHH | - | ||
| 674 | Phosphorylation | LSSSRLRTTLNRIQE CCHHHHHHHHHHHHH | - | ||
| 675 | Phosphorylation | SSSRLRTTLNRIQES CHHHHHHHHHHHHHH | - | ||
| 682 | Phosphorylation | TLNRIQESLIDLEVS HHHHHHHHHHCCCCC | - | ||
| 766 | Phosphorylation | KPFLQQFYSQTVSTA HHHHHHHHHCCCCCH | 29083192 | ||
| 767 | Phosphorylation | PFLQQFYSQTVSTAS HHHHHHHHCCCCCHH | 29083192 | ||
| 769 | Phosphorylation | LQQFYSQTVSTASEL HHHHHHCCCCCHHHH | 29083192 | ||
| 771 | Phosphorylation | QFYSQTVSTASELRK HHHHCCCCCHHHHHC | 29083192 | ||
| 772 | Phosphorylation | FYSQTVSTASELRKP HHHCCCCCHHHHHCC | 29083192 | ||
| 774 | Ubiquitination | SQTVSTASELRKPIY HCCCCCHHHHHCCEE | 24816145 | ||
| 774 | Phosphorylation | SQTVSTASELRKPIY HCCCCCHHHHHCCEE | 29083192 | ||
| 781 | Phosphorylation | SELRKPIYWIVAGKA HHHHCCEEEEECCCC | 29083192 | ||
| 805 | Ubiquitination | MANVKWDVKEIMSQH HHHCCCCHHHHHHHC | 27667366 | ||
| 810 | Phosphorylation | WDVKEIMSQHNIYVD CCHHHHHHHCCHHHH | - | ||
| 815 | Phosphorylation | IMSQHNIYVDALLKE HHHHCCHHHHHHHHH | - | ||
| 834 | Phosphorylation | NRRLNEVSKRVRIPL HHHHHHHHHHCCCCC | - | ||
| 835 | Ubiquitination | RRLNEVSKRVRIPLP HHHHHHHHHCCCCCC | 27667366 | ||
| 892 | Phosphorylation | LMKLEKLTDIRPIPD HHHHHHHCCCCCCCC | - | ||
| 933 | Ubiquitination | EYSTKQLTNLVNVCL HCCHHHHHHHHHHHH | 24816145 | ||
| 963 | Sumoylation | IDDIDRPKR------ HHCCCCCCC------ | - | ||
| 963 | Sumoylation | IDDIDRPKR------ HHCCCCCCC------ | 25114211 | ||
| 963 | Ubiquitination | IDDIDRPKR------ HHCCCCCCC------ | 24816145 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of VPS50_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of VPS50_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of VPS50_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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