| UniProt ID | P2R3C_HUMAN | |
|---|---|---|
| UniProt AC | Q969Q6 | |
| Protein Name | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma | |
| Gene Name | PPP2R3C | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 453 | |
| Subcellular Localization | Nucleus . Cytoplasm . Excluded from the nucleoli. Localization is cell cycle-dependent. Localizes to the cytoplasm during cytokinesis. | |
| Protein Description | May regulate MCM3AP phosphorylation through phosphatase recruitment. May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex. May play a role in the activation-induced cell death of B-cells.. | |
| Protein Sequence | MDWKEVLRRRLATPNTCPNKKKSEQELKDEEMDLFTKYYSEWKGGRKNTNEFYKTIPRFYYRLPAEDEVLLQKLREESRAVFLQRKSRELLDNEELQNLWFLLDKHQTPPMIGEEAMINYENFLKVGEKAGAKCKQFFTAKVFAKLLHTDSYGRISIMQFFNYVMRKVWLHQTRIGLSLYDVAGQGYLRESDLENYILELIPTLPQLDGLEKSFYSFYVCTAVRKFFFFLDPLRTGKIKIQDILACSFLDDLLELRDEELSKESQETNWFSAPSALRVYGQYLNLDKDHNGMLSKEELSRYGTATMTNVFLDRVFQECLTYDGEMDYKTYLDFVLALENRKEPAALQYIFKLLDIENKGYLNVFSLNYFFRAIQELMKIHGQDPVSFQDVKDEIFDMVKPKDPLKISLQDLINSNQGDTVTTILIDLNGFWTYENREALVANDSENSADLDDT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 13 | Phosphorylation | VLRRRLATPNTCPNK HHHHHCCCCCCCCCC | 22.97 | 24719451 | |
| 21 | Ubiquitination | PNTCPNKKKSEQELK CCCCCCCCCCHHHHC | 69.08 | 22817900 | |
| 23 | Phosphorylation | TCPNKKKSEQELKDE CCCCCCCCHHHHCHH | 54.08 | 24719451 | |
| 54 | Ubiquitination | KNTNEFYKTIPRFYY CCHHHHHHHCCCHHH | 45.35 | 29967540 | |
| 55 | Phosphorylation | NTNEFYKTIPRFYYR CHHHHHHHCCCHHHC | 25.49 | - | |
| 60 | Phosphorylation | YKTIPRFYYRLPAED HHHCCCHHHCCCCCC | 6.75 | - | |
| 73 | Ubiquitination | EDEVLLQKLREESRA CCHHHHHHHHHHHHH | 49.86 | 21906983 | |
| 73 (in isoform 1) | Ubiquitination | - | 49.86 | 21890473 | |
| 178 | Phosphorylation | HQTRIGLSLYDVAGQ HHCCCEEEHHHCCCC | 21.48 | - | |
| 180 | Phosphorylation | TRIGLSLYDVAGQGY CCCEEEHHHCCCCCC | 12.66 | - | |
| 185 (in isoform 2) | Ubiquitination | - | 27.85 | 21890473 | |
| 185 | Ubiquitination | SLYDVAGQGYLRESD EHHHCCCCCCCCHHH | 27.85 | 22817900 | |
| 231 (in isoform 2) | Ubiquitination | - | 34.72 | 21890473 | |
| 231 | Ubiquitination | RKFFFFLDPLRTGKI HHHHHHHCCCCCCCC | 34.72 | 21890473 | |
| 243 | Ubiquitination | GKIKIQDILACSFLD CCCCHHHHHHHHHHH | 1.18 | 22817900 | |
| 289 | Ubiquitination | YLNLDKDHNGMLSKE HCCCCCCCCCCCCHH | 38.18 | 21890473 | |
| 295 (in isoform 1) | Ubiquitination | - | 51.77 | 21890473 | |
| 295 | Ubiquitination | DHNGMLSKEELSRYG CCCCCCCHHHHHHHC | 51.77 | 22817900 | |
| 341 (in isoform 1) | Ubiquitination | - | 78.58 | 21890473 | |
| 341 | Ubiquitination | VLALENRKEPAALQY HHHHCCCCCHHHHHH | 78.58 | 23000965 | |
| 360 | Phosphorylation | LDIENKGYLNVFSLN HCCCCCCCEEEHHHH | 9.19 | 25072903 | |
| 365 | Phosphorylation | KGYLNVFSLNYFFRA CCCEEEHHHHHHHHH | 16.06 | 25072903 | |
| 368 | Phosphorylation | LNVFSLNYFFRAIQE EEEHHHHHHHHHHHH | 14.91 | 25072903 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of P2R3C_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of P2R3C_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of P2R3C_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| IKKB_HUMAN | IKBKB | physical | 20925653 | |
| CCD33_HUMAN | CCDC33 | physical | 25416956 | |
| CKLF5_HUMAN | CMTM5 | physical | 25416956 | |
| CCD33_HUMAN | CCDC33 | physical | 21516116 | |
| DYHC1_HUMAN | DYNC1H1 | physical | 26496610 | |
| ITB4_HUMAN | ITGB4 | physical | 26496610 | |
| MYBB_HUMAN | MYBL2 | physical | 26496610 | |
| PCM1_HUMAN | PCM1 | physical | 26496610 | |
| LGMN_HUMAN | LGMN | physical | 26496610 | |
| OFD1_HUMAN | OFD1 | physical | 26496610 | |
| MOONR_HUMAN | KIAA0753 | physical | 26496610 | |
| CE350_HUMAN | CEP350 | physical | 26496610 | |
| FR1OP_HUMAN | FGFR1OP | physical | 26496610 | |
| CP131_HUMAN | CEP131 | physical | 26496610 | |
| CEP72_HUMAN | CEP72 | physical | 26496610 | |
| DYHC2_HUMAN | DYNC2H1 | physical | 26496610 | |
| CCD77_HUMAN | CCDC77 | physical | 26496610 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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