dbPTM

FR1OP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FR1OP_HUMAN
UniProt AC	O95684
Protein Name	FGFR1 oncogene partner
Gene Name	FGFR1OP
Organism	Homo sapiens (Human).
Sequence Length	399
Subcellular Localization	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm, cytoskeleton, cilium basal body . Associated with gamma-tubulin (PubMed:16314388). Localiz
Protein Description	Required for anchoring microtubules to the centrosomes. [PubMed: 16314388]
Protein Sequence	MAATAAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQFFNLDFTLAVFQPETSTLQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPTTGEGALDLSDVHSPPKSPEGKTSAQTTPSKIPRYKGQGKKKTSGQKAGDKKANDEANQSDTSVSLSEPKSKSSLHLLSHETKIGSFLSNRTLDGKDKAGLCPDEDDMEGDSFFDDPIPKPEKTYGLRKEPRKQAGSLASLSDAPPLKSGLSSLAGAPSLKDSESKRGNTVLKDLKLISDKIGSLGLGTGEDDDYVDDFNSTSHRSEKSEISIGEEIEEDLSVEIDDINTSDKLDDLTQDLTVSQLSDVADYLEDVA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
173	Acetylation	SAQTTPSKIPRYKGQ CCCCCCCCCCCCCCC	58.91	25953088
225	Acetylation	HLLSHETKIGSFLSN HHHCCHHHHHHHHCC	41.93	25953088
315	Acetylation	KRGNTVLKDLKLISD CCCCCHHHHHHHHHC	57.59	25953088
318	Acetylation	NTVLKDLKLISDKIG CCHHHHHHHHHCCCC	54.64	25953088
323	Acetylation	DLKLISDKIGSLGLG HHHHHHCCCCCCCCC	42.02	25953088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of FR1OP_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FR1OP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FR1OP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FR1OP_HUMAN	FGFR1OP	physical	20360068
PACS1_HUMAN	PACS1	physical	20360068
CE350_HUMAN	CEP350	physical	20360068
WRIP1_HUMAN	WRNIP1	physical	17888034
ABL1_HUMAN	ABL1	physical	17888034
CEP19_HUMAN	CEP19	physical	25416956
CE350_HUMAN	CEP350	physical	26186194
POTEI_HUMAN	POTEI	physical	26186194
MS3L1_HUMAN	MSL3	physical	26186194
P2R3C_HUMAN	PPP2R3C	physical	26186194
CEP19_HUMAN	CEP19	physical	26186194
PUR8_HUMAN	ADSL	physical	26638075
AKAP1_HUMAN	AKAP1	physical	26638075
AKA11_HUMAN	AKAP11	physical	26638075
ANR17_HUMAN	ANKRD17	physical	26638075
BCL10_HUMAN	BCL10	physical	26638075
TM256_HUMAN	TMEM256	physical	26638075
C2D1A_HUMAN	CC2D1A	physical	26638075
CE350_HUMAN	CEP350	physical	26638075
CSN4_HUMAN	COPS4	physical	26638075
CRBG3_HUMAN	CRYBG3	physical	26638075
CT2NL_HUMAN	CTTNBP2NL	physical	26638075
DYN2_HUMAN	DNM2	physical	26638075
ENAH_HUMAN	ENAH	physical	26638075
EXOC4_HUMAN	EXOC4	physical	26638075
GPTC1_HUMAN	GPATCH1	physical	26638075
CSN1_HUMAN	GPS1	physical	26638075
HAUS8_HUMAN	HAUS8	physical	26638075
KLC1_HUMAN	KLC1	physical	26638075
KLC2_HUMAN	KLC2	physical	26638075
KLC4_HUMAN	KLC4	physical	26638075
CARL1_HUMAN	LRRC16A	physical	26638075
LRC47_HUMAN	LRRC47	physical	26638075
PHOCN_HUMAN	MOB4	physical	26638075
MRE11_HUMAN	MRE11A	physical	26638075
NAV1_HUMAN	NAV1	physical	26638075
NCOR1_HUMAN	NCOR1	physical	26638075
GCR_HUMAN	NR3C1	physical	26638075
PLK1_HUMAN	PLK1	physical	26638075
P2R3C_HUMAN	PPP2R3C	physical	26638075
RFIP1_HUMAN	RAB11FIP1	physical	26638075
RAB2A_HUMAN	RAB2A	physical	26638075
RAB3I_HUMAN	RAB3IP	physical	26638075
RAD50_HUMAN	RAD50	physical	26638075
RIPK2_HUMAN	RIPK2	physical	26638075
RPAP2_HUMAN	RPAP2	physical	26638075
SAV1_HUMAN	SAV1	physical	26638075
SLN11_HUMAN	SLFN11	physical	26638075
SNX30_HUMAN	SNX30	physical	26638075
SPAS2_HUMAN	SPATS2	physical	26638075
SPS2L_HUMAN	SPATS2L	physical	26638075
SRA1_HUMAN	SRA1	physical	26638075
SRSF2_HUMAN	SRSF2	physical	26638075
STK3_HUMAN	STK3	physical	26638075
STK4_HUMAN	STK4	physical	26638075
TAF12_HUMAN	TAF12	physical	26638075
TXLNA_HUMAN	TXLNA	physical	26638075
UN45A_HUMAN	UNC45A	physical	26638075
WDR83_HUMAN	WDR83	physical	26638075
BIG3_HUMAN	KIAA1244	physical	26638075
AES_HUMAN	AES	physical	26496610
BTF3_HUMAN	BTF3	physical	26496610
CATC_HUMAN	CTSC	physical	26496610
ERF1_HUMAN	ETF1	physical	26496610
GNS_HUMAN	GNS	physical	26496610
SP110_HUMAN	SP110	physical	26496610
I5P2_HUMAN	INPP5B	physical	26496610
KIFC3_HUMAN	KIFC3	physical	26496610
LAMB1_HUMAN	LAMB1	physical	26496610
LYN_HUMAN	LYN	physical	26496610
PCM1_HUMAN	PCM1	physical	26496610
2AAA_HUMAN	PPP2R1A	physical	26496610
KAPCB_HUMAN	PRKACB	physical	26496610
KAP2_HUMAN	PRKAR2A	physical	26496610
TTC3_HUMAN	TTC3	physical	26496610
OFD1_HUMAN	OFD1	physical	26496610
DLG5_HUMAN	DLG5	physical	26496610
MOONR_HUMAN	KIAA0753	physical	26496610
CE350_HUMAN	CEP350	physical	26496610
CE170_HUMAN	CEP170	physical	26496610
RAD50_HUMAN	RAD50	physical	26496610
AKAP9_HUMAN	AKAP9	physical	26496610
RBM5_HUMAN	RBM5	physical	26496610
PIBF1_HUMAN	PIBF1	physical	26496610
HPS5_HUMAN	HPS5	physical	26496610
COBL1_HUMAN	COBLL1	physical	26496610
CP131_HUMAN	CEP131	physical	26496610
TTLL5_HUMAN	TTLL5	physical	26496610
N4BP3_HUMAN	N4BP3	physical	26496610
SYNEM_HUMAN	SYNM	physical	26496610
GOLI4_HUMAN	GOLIM4	physical	26496610
PI3R4_HUMAN	PIK3R4	physical	26496610
ASCC1_HUMAN	ASCC1	physical	26496610
SPN90_HUMAN	NCKIPSD	physical	26496610
CCHCR_HUMAN	CCHCR1	physical	26496610
P2R3C_HUMAN	PPP2R3C	physical	26496610
ELP3_HUMAN	ELP3	physical	26496610
CEP72_HUMAN	CEP72	physical	26496610
CK5P2_HUMAN	CDK5RAP2	physical	26496610
MIB1_HUMAN	MIB1	physical	26496610
K1328_HUMAN	KIAA1328	physical	26496610
CCD14_HUMAN	CCDC14	physical	26496610
REN3A_HUMAN	UPF3A	physical	26496610
CSPP1_HUMAN	CSPP1	physical	26496610
CE290_HUMAN	CEP290	physical	26496610
CEP78_HUMAN	CEP78	physical	26496610
CCD77_HUMAN	CCDC77	physical	26496610
CE295_HUMAN	CEP295	physical	26496610
TIM29_HUMAN	C19orf52	physical	26496610
TBC31_HUMAN	TBC1D31	physical	26496610
ESCO1_HUMAN	ESCO1	physical	26496610
ADIP_HUMAN	SSX2IP	physical	26496610
FOPNL_HUMAN	FOPNL	physical	26496610
TATD3_HUMAN	TATDN3	physical	26496610
SCLT1_HUMAN	SCLT1	physical	26496610
B3GLT_HUMAN	B3GALTL	physical	26496610
SPICE_HUMAN	SPICE1	physical	26496610
CC138_HUMAN	CCDC138	physical	26496610
WDR90_HUMAN	WDR90	physical	26496610
RABL3_HUMAN	RABL3	physical	26496610
CCD18_HUMAN	CCDC18	physical	26496610
CCD61_HUMAN	CCDC61	physical	26496610
P2R3C_HUMAN	PPP2R3C	physical	28514442
CE350_HUMAN	CEP350	physical	28514442
MS3L1_HUMAN	MSL3	physical	28514442
POTEI_HUMAN	POTEI	physical	28514442
CEP19_HUMAN	CEP19	physical	28514442
AIPL1_HUMAN	AIPL1	physical	27173435
PDE5A_HUMAN	PDE5A	physical	27173435
BLM_HUMAN	BLM	physical	27173435
SPT5H_HUMAN	SUPT5H	physical	27173435
WDR24_HUMAN	WDR24	physical	27173435
PATZ1_HUMAN	PATZ1	physical	27173435
FKB15_HUMAN	FKBP15	physical	27173435

Drug and Disease Associations

Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FR1OP_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT THR-204, AND MASS SPECTROMETRY.	19413330 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-156 AND SER-160, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-156; SER-160; SER-202AND SER-254, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-209, AND MASSSPECTROMETRY.	19007248 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-156 AND SER-160, ANDMASS SPECTROMETRY.	17287340 [Abstract]
"Robust phosphoproteomic profiling of tyrosine phosphorylation sitesfrom human T cells using immobilized metal affinity chromatography andtandem mass spectrometry."; Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M.,Peters E.C.; Anal. Chem. 76:2763-2772(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-156 AND SER-160, ANDMASS SPECTROMETRY.	15144186 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT THR-204, AND MASS SPECTROMETRY.	19413330 [Abstract]