| UniProt ID | SCLT1_HUMAN | |
|---|---|---|
| UniProt AC | Q96NL6 | |
| Protein Name | Sodium channel and clathrin linker 1 | |
| Gene Name | SCLT1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 688 | |
| Subcellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Localizes to the distal appendage region of the centriole, which anchors the mother centriole to the plasma membrane. | |
| Protein Description | Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization (By similarity).. | |
| Protein Sequence | MAAEIDFLREQNRRLNEDFRRYQMESFSKYSSVQKAVCQGEGDDTFENLVFDQSFLAPLVTEYDKHLGELNGQLKYYQKQVGEMKLQLENVIKENERLHSELKDAVEKKLEAFPLGTEVGTDIYADDETVRNLQEQLQLANQEKTQAVELWQTVSQELDRLHKLYQEHMTEAQIHVFESQKQKDQLFDFQQLTKQLHVTNENMEVTNQQFLKTVTEQSVIIEQLRKKLRQAKLELRVAVAKVEELTNVTEDLQGQMKKKEKDVVSAHGREEASDRRLQQLQSSIKQLEIRLCVTIQEANQLRTENTHLEKQTRELQAKCNELENERYEAIVRARNSMQLLEEANLQKSQALLEEKQKEEDIEKMKETVSRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQMECAEKQGQIERVIKEKKAVEEELEKIYREGRGNESDYRKLEEMHQRFLVSERSKDDLQLRLTRAENRIKQLETDSSEEISRYQEMIQKLQNVLESERENCGLVSEQRLKLQQENKQLRKETESLRKIALEAQKKAKVKISTMEHEFSIKERGFEVQLREMEDSNRNSIVELRHLLATQQKAANRWKEETKKLTESAEIRINNLKSELSRQKLHTQELLSQLEMANEKVAENEKLILEHQEKANRLQRRLSQAEERAASASQQLSVITVQRRKAASLMNLENI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MAAEIDFLR ------CHHHHHHHH | 17.50 | 22814378 | |
| 22 | Phosphorylation | LNEDFRRYQMESFSK HCHHHHHHHHHHHHC | 14.14 | 29759185 | |
| 26 | Phosphorylation | FRRYQMESFSKYSSV HHHHHHHHHHCCCHH | 29.49 | 24719451 | |
| 28 | Phosphorylation | RYQMESFSKYSSVQK HHHHHHHHCCCHHHH | 39.71 | 23532336 | |
| 29 | Ubiquitination | YQMESFSKYSSVQKA HHHHHHHCCCHHHHH | 47.33 | - | |
| 75 | Ubiquitination | GELNGQLKYYQKQVG HHHHHHHHHHHHHHC | 33.74 | - | |
| 79 | Ubiquitination | GQLKYYQKQVGEMKL HHHHHHHHHHCCHHH | 30.72 | - | |
| 93 | Ubiquitination | LQLENVIKENERLHS HHHHHHHHHHHHHHH | 50.64 | - | |
| 109 | Ubiquitination | LKDAVEKKLEAFPLG HHHHHHHHHHHCCCC | 37.75 | - | |
| 183 | Ubiquitination | VFESQKQKDQLFDFQ HHHCHHHHHHCCCHH | 55.25 | - | |
| 261 | Acetylation | GQMKKKEKDVVSAHG HHHHHHHHCHHHHCC | 65.78 | 7711431 | |
| 265 | Phosphorylation | KKEKDVVSAHGREEA HHHHCHHHHCCCHHH | 17.88 | - | |
| 294 | Phosphorylation | LEIRLCVTIQEANQL HHHHHHHHHHHHHHH | 18.88 | 27174698 | |
| 303 | Phosphorylation | QEANQLRTENTHLEK HHHHHHHCCCHHHHH | 42.03 | 27174698 | |
| 306 | Phosphorylation | NQLRTENTHLEKQTR HHHHCCCHHHHHHHH | 22.93 | 27174698 | |
| 312 | Phosphorylation | NTHLEKQTRELQAKC CHHHHHHHHHHHHHH | 36.86 | 27174698 | |
| 336 | Phosphorylation | AIVRARNSMQLLEEA HHHHHHHHHHHHHHH | 11.44 | 28555341 | |
| 347 | Ubiquitination | LEEANLQKSQALLEE HHHHCHHHHHHHHHH | 47.93 | - | |
| 367 | Phosphorylation | DIEKMKETVSRFVQD HHHHHHHHHHHHHHH | 20.47 | 26074081 | |
| 369 | Phosphorylation | EKMKETVSRFVQDAT HHHHHHHHHHHHHCH | 27.67 | 26074081 | |
| 376 | Phosphorylation | SRFVQDATIRTKKEV HHHHHHCHHHHHHHH | 21.20 | 26074081 | |
| 379 | Phosphorylation | VQDATIRTKKEVANT HHHCHHHHHHHHHCC | 42.49 | 26074081 | |
| 386 | Phosphorylation | TKKEVANTKKQCNIQ HHHHHHCCHHHHCCH | 29.85 | - | |
| 398 | Phosphorylation | NIQISRLTEELSALQ CCHHHHHHHHHHHHH | 26.72 | - | |
| 422 | Acetylation | IERVIKEKKAVEEEL HHHHHHHHHHHHHHH | 40.82 | 7707155 | |
| 423 | Acetylation | ERVIKEKKAVEEELE HHHHHHHHHHHHHHH | 59.77 | 7707163 | |
| 431 | Acetylation | AVEEELEKIYREGRG HHHHHHHHHHHCCCC | 58.63 | 7707171 | |
| 431 | Ubiquitination | AVEEELEKIYREGRG HHHHHHHHHHHCCCC | 58.63 | - | |
| 445 | Trimethylation | GNESDYRKLEEMHQR CCHHHHHHHHHHHHH | 54.76 | - | |
| 445 | Ubiquitination | GNESDYRKLEEMHQR CCHHHHHHHHHHHHH | 54.76 | - | |
| 445 | Methylation | GNESDYRKLEEMHQR CCHHHHHHHHHHHHH | 54.76 | 23644510 | |
| 475 | Ubiquitination | TRAENRIKQLETDSS HHHHHHHHHHCCCCH | 45.66 | - | |
| 494 | Ubiquitination | RYQEMIQKLQNVLES HHHHHHHHHHHHHHH | 40.91 | - | |
| 521 | Ubiquitination | LKLQQENKQLRKETE HHHHHHHHHHHHHHH | 50.38 | - | |
| 553 | Phosphorylation | STMEHEFSIKERGFE EECCCEEEHHHCCEE | 29.75 | 24719451 | |
| 569 | Phosphorylation | QLREMEDSNRNSIVE EHHCCCCCCCCCHHH | 25.12 | - | |
| 573 | Phosphorylation | MEDSNRNSIVELRHL CCCCCCCCHHHHHHH | 25.44 | - | |
| 586 | Ubiquitination | HLLATQQKAANRWKE HHHHHHHHHHHHHHH | 39.38 | - | |
| 597 | Acetylation | RWKEETKKLTESAEI HHHHHHHHHHHHHHH | 68.97 | 24848985 | |
| 639 | Ubiquitination | EKVAENEKLILEHQE HHHHHHHHHHHHHHH | 53.03 | - | |
| 656 | Phosphorylation | NRLQRRLSQAEERAA HHHHHHHHHHHHHHH | 26.07 | 29255136 | |
| 681 | Phosphorylation | VQRRKAASLMNLENI HHHHHHHHHHCCCCC | 32.77 | 23401153 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SCLT1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SCLT1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SCLT1_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-681, AND MASSSPECTROMETRY. | |
