IFT57_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IFT57_HUMAN
• UniProt AC: Q9NWB7
• Protein Name: Intraflagellar transport protein 57 homolog
• Gene Name: IFT57
• Organism: Homo sapiens (Human).
• Sequence Length: 429
• Subcellular Localization: Cytoplasm, cytoskeleton, cilium basal body. Concentrates within the inner segment of cilia..
• Protein Description: Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear..
• Protein Sequence: MTAALAVVTTSGLEDGVPRSRGEGTGEVVLERGPGAAYHMFVVMEDLVEKLKLLRYEEEFLRKSNLKAPSRHYFALPTNPGEQFYMFCTLAAWLINKAGRPFEQPQEYDDPNATISNILSELRSFGRTADFPPSKLKSGYGEHVCYVLDCFAEEALKYIGFTWKRPIYPVEELEEESVAEDDAELTLNKVDEEFVEEETDNEENFIDLNVLKAQTYHLDMNETAKQEDILESTTDAAEWSLEVERVLPQLKVTIRTDNKDWRIHVDQMHQHRSGIESALKETKGFLDKLHNEITRTLEKISSREKYINNQLENLVQEYRAAQAQLSEAKERYQQGNGGVTERTRLLSEVMEELEKVKQEMEEKGSSMTDGAPLVKIKQSLTKLKQETVEMDIRIGIVEHTLLQSKLKEKSNMTRNMHATVIPEPATGFY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
168	Phosphorylation	FTWKRPIYPVEELEE CEECCCEEEHHHHCC	12.15	26471730
177	Phosphorylation	VEELEEESVAEDDAE HHHHCCCCCCCCCHH	29.88	26471730
199	Phosphorylation	EEFVEEETDNEENFI HHHHHHHCCCCCCEE	47.61	22496350
232	Phosphorylation	KQEDILESTTDAAEW CHHHHHHHCCCHHHH	32.91	-
233	Phosphorylation	QEDILESTTDAAEWS HHHHHHHCCCHHHHH	21.22	-
234	Phosphorylation	EDILESTTDAAEWSL HHHHHHCCCHHHHHH	32.68	-
253	Phosphorylation	VLPQLKVTIRTDNKD HHCCCEEEEECCCCC	11.80	24719451
299	Ubiquitination	EITRTLEKISSREKY HHHHHHHHHHHHHHH	51.50	29967540
305	Ubiquitination	EKISSREKYINNQLE HHHHHHHHHHHHHHH	50.77	21906983
329	Ubiquitination	QAQLSEAKERYQQGN HHHHHHHHHHHHHCC	38.38	21906983
343	Phosphorylation	NGGVTERTRLLSEVM CCCHHHHHHHHHHHH	21.31	28102081
347	Phosphorylation	TERTRLLSEVMEELE HHHHHHHHHHHHHHH	32.51	25106551
365	Phosphorylation	QEMEEKGSSMTDGAP HHHHHHCCCCCCCCC	28.18	-
366	Phosphorylation	EMEEKGSSMTDGAPL HHHHHCCCCCCCCCH	34.08	-
368	Phosphorylation	EEKGSSMTDGAPLVK HHHCCCCCCCCCHHH	32.98	-
379	Phosphorylation	PLVKIKQSLTKLKQE CHHHHHHHHHHHHHH	32.76	29083192
381	Phosphorylation	VKIKQSLTKLKQETV HHHHHHHHHHHHHHH	39.31	29083192
384	Ubiquitination	KQSLTKLKQETVEMD HHHHHHHHHHHHHHH	47.87	-
387	Phosphorylation	LTKLKQETVEMDIRI HHHHHHHHHHHHHHH	21.19	29083192

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IFT57_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IFT57_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IFT57_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HIP1_HUMAN	HIP1	physical	11788820
CASP8_HUMAN	CASP8	physical	11788820
BFAR_HUMAN	BFAR	physical	14502241
IF172_HUMAN	IFT172	physical	26186194
IFT56_HUMAN	TTC26	physical	26186194
IFT81_HUMAN	IFT81	physical	26186194
MIPT3_HUMAN	TRAF3IP1	physical	26186194
EHBP1_HUMAN	EHBP1	physical	26186194
SYNE1_HUMAN	SYNE1	physical	26186194
CLUA1_HUMAN	CLUAP1	physical	26186194
IFT46_HUMAN	IFT46	physical	26186194
HOME1_HUMAN	HOMER1	physical	26186194
HOME2_HUMAN	HOMER2	physical	26186194
HOME3_HUMAN	HOMER3	physical	26186194
IFT88_HUMAN	IFT88	physical	26186194
STX18_HUMAN	STX18	physical	26186194
COG6_HUMAN	COG6	physical	26186194
RABE2_HUMAN	RABEP2	physical	26186194
IFT74_HUMAN	IFT74	physical	26186194
EXOC7_HUMAN	EXOC7	physical	26186194
TT30B_HUMAN	TTC30B	physical	26186194
TT30A_HUMAN	TTC30A	physical	26186194
SPAG5_HUMAN	SPAG5	physical	26186194
IFT20_HUMAN	IFT20	physical	26186194
TRAF7_HUMAN	TRAF7	physical	26186194
IFT52_HUMAN	IFT52	physical	26186194
IFT80_HUMAN	IFT80	physical	26186194
CENPH_HUMAN	CENPH	physical	26186194
CDR2_HUMAN	CDR2	physical	26186194
HOOK3_HUMAN	HOOK3	physical	26186194
HSBP1_HUMAN	HSBP1	physical	26186194
CCD22_HUMAN	CCDC22	physical	26186194
SKAP_HUMAN	KNSTRN	physical	26186194
IFT22_HUMAN	IFT22	physical	26186194
COR1A_HUMAN	CORO1A	physical	26186194
SEC20_HUMAN	BNIP1	physical	26186194
POC1A_HUMAN	POC1A	physical	26186194
COR1B_HUMAN	CORO1B	physical	26186194
NEDD1_HUMAN	NEDD1	physical	26186194
ATP9A_HUMAN	ATP9A	physical	26186194
TRPM4_HUMAN	TRPM4	physical	26186194
UBX10_HUMAN	UBXN10	physical	26389662
TT30A_HUMAN	TTC30A	physical	28514442
COR1A_HUMAN	CORO1A	physical	28514442
TT30B_HUMAN	TTC30B	physical	28514442
IFT80_HUMAN	IFT80	physical	28514442
MIPT3_HUMAN	TRAF3IP1	physical	28514442
IFT88_HUMAN	IFT88	physical	28514442
SYNE1_HUMAN	SYNE1	physical	28514442
IFT20_HUMAN	IFT20	physical	28514442
COG6_HUMAN	COG6	physical	28514442
IF172_HUMAN	IFT172	physical	28514442
HOME1_HUMAN	HOMER1	physical	28514442
IFT81_HUMAN	IFT81	physical	28514442
IFT46_HUMAN	IFT46	physical	28514442
IFT22_HUMAN	IFT22	physical	28514442
SPAG5_HUMAN	SPAG5	physical	28514442
IFT52_HUMAN	IFT52	physical	28514442
IFT74_HUMAN	IFT74	physical	28514442
HOME2_HUMAN	HOMER2	physical	28514442
HSBP1_HUMAN	HSBP1	physical	28514442
RABE2_HUMAN	RABEP2	physical	28514442
CLUA1_HUMAN	CLUAP1	physical	28514442
TRPM4_HUMAN	TRPM4	physical	28514442
EHBP1_HUMAN	EHBP1	physical	28514442
POC1A_HUMAN	POC1A	physical	28514442
TRAF7_HUMAN	TRAF7	physical	28514442
SKAP_HUMAN	KNSTRN	physical	28514442
CENPH_HUMAN	CENPH	physical	28514442
HOME3_HUMAN	HOMER3	physical	28514442
NEDD1_HUMAN	NEDD1	physical	28514442
ATP9A_HUMAN	ATP9A	physical	28514442
CDR2_HUMAN	CDR2	physical	28514442
HOOK3_HUMAN	HOOK3	physical	28514442
STX18_HUMAN	STX18	physical	28514442
EXOC7_HUMAN	EXOC7	physical	28514442
SGF29_HUMAN	CCDC101	physical	28514442
SEC20_HUMAN	BNIP1	physical	28514442
IFT56_HUMAN	TTC26	physical	28514442
IF172_HUMAN	IFT172	physical	27173435
IFT74_HUMAN	IFT74	physical	27173435
IFT46_HUMAN	IFT46	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.