HOME2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HOME2_HUMAN
• UniProt AC: Q9NSB8
• Protein Name: Homer protein homolog 2 {ECO:0000305}
• Gene Name: HOMER2 {ECO:0000312|HGNC:HGNC:17513}
• Organism: Homo sapiens (Human).
• Sequence Length: 354
• Subcellular Localization: Cytoplasm . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Cell projection, stereocilium . Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate recep
• Protein Description: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. [PubMed: 9808459 Required for normal hearing]
• Protein Sequence: MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Phosphorylation	KKNWMPASKQAVTVS CCCCCCCCCCEEEEE	21.30	-
73	Ubiquitination	TFTKTSQKFGQWADS EEEECCHHHHCHHHH	51.75	-
117	Phosphorylation	AKIAKDKTQEKIETS HHHHHHHHHHHHHHC	52.69	-
123	Phosphorylation	KTQEKIETSSNHSQE HHHHHHHHCCCCCCC	40.71	-
138	Phosphorylation	SGRETPSSTQASSVN CCCCCCCCHHCCCCC	26.24	-
219	Ubiquitination	KRQFSICRDENDRLR HHHHHHHCCHHHHHH	53.24	24816145
232	Ubiquitination	LRNKIDELEEQCSEI HHHHHHHHHHHHHHH	8.55	24816145
242	Ubiquitination	QCSEINREKEKNTQL HHHHHHHHHHHHHHH	62.16	24816145
243	Ubiquitination	CSEINREKEKNTQLK HHHHHHHHHHHHHHH	71.41	24816145
251	Ubiquitination	EKNTQLKRRIEELEA HHHHHHHHHHHHHHH	54.09	24816145
253	Ubiquitination	NTQLKRRIEELEAEL HHHHHHHHHHHHHHH	5.83	24816145
286	Phosphorylation	QLMSECEYVSEKLEA HHHHHCHHHHHHHHH	22.42	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	SMURF1	Q9HCE7	PMID:20804422

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HOME2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HOME2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RYR1_HUMAN	RYR1	physical	12223488
UBXN1_HUMAN	UBXN1	physical	15944415
A4_HUMAN	APP	physical	21832049
IMA1_HUMAN	KPNA2	physical	21988832
RNF41_HUMAN	RNF41	physical	25416956
LZTS2_HUMAN	LZTS2	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.