dbPTM

RYR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RYR1_HUMAN
UniProt AC	P21817
Protein Name	Ryanodine receptor 1
Gene Name	RYR1
Organism	Homo sapiens (Human).
Sequence Length	5038
Subcellular Localization	Sarcoplasmic reticulum membrane Multi-pass membrane protein . Sarcoplasmic reticulum . The number of predicted transmembrane domains varies between orthologs, but the 3D-structures show the presence of six transmembrane regions. Both N-terminus and
Protein Description	Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. [PubMed: 11741831]
Protein Sequence	MGDAEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPDLAICCFVLEQSLSVRALQEMLANTVEAGVESSQGGGHRTLLYGHAILLRHAHSRMYLSCLTTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDIILVSVSSERYLHLSTASGELQVDASFMQTLWNMNPICSRCEEGFVTGGHVLRLFHGHMDECLTISPADSDDQRRLVYYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRVRHVTTGQYLALTEDQGLVVVDASKAHTKATSFCFRISKEKLDVAPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYAAPDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQFIKSLDSFSGKPRGSGPPAGTALPIEGVILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQSLFQEEGMLSMVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLIRGNRSNCALFSTNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFVGRAEGTTQYSKWYFEVMVDEVTPFLTAQATHLRVGWALTEGYTPYPGAGEGWGGNGVGDDLYSYGFDGLHLWTGHVARPVTSPGQHLLAPEDVISCCLDLSVPSISFRINGCPVQGVFESFNLDGLFFPVVSFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYRREGPRGPHLVGPSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDNKRLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLPKTYMMSNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAVQDIPARRNPRLVPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVENQSRCDRVRIFRAEKSYTVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHRGQRWHLGSEPFGRPWQPGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGFLPVCSLGPGQVGHLNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKGLPQFEPVPLEHPHYEVSRVDGTVDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTAGATPLAPPGLQPPAEDEARAAEPDPDYENLRRSAGGWSEAENGKEGTAKEGAPGGTPQAGGEAQPARAENEKDATTEKNKKRGFLFKAKKVAMMTQPPATPTLPRLPHDVVPADNRDDPEIILNTTTYYYSVRVFAGQEPSCVWAGWVTPDYHQHDMSFDLSKVRVVTVTMGDEQGNVHSSLKCSNCYMVWGGDFVSPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQNVIQFELGKQKNIMPLSAAMFQSERKNPAPQCPPRLEMQMLMPVSWSRMPNHFLQVETRRAGERLGWAVQCQEPLTMMALHIPEENRCMDILELSERLDLQRFHSHTLRLYRAVCALGNNRVAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESACRSRRSMLSEYIVPLTPETRAITLFPPGRSTENGHPRHGLPGVGVTTSLRPPHHFSPPCFVAALPAAGAAEAPARLSPAIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGIFGDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESKPRSLQELVSHMVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRALPRAYTISPSSVEDTMSLLECLGQIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSGIGLGMQGSTPLDVAAASVIDNNELALALQEQDLEKVVSYLAGCGLQSCPMLVAKGYPDIGWNPCGGERYLDFLRFAVFVNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLAAIEEAIRISEDPARDGPGIRRDRRREHFGEEPPEENRVHLGHAIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVPLEDLVGIISLPLQIPTLGKDGALVQPKMSASFVPDHKASMVLFLDRVYGIENQDFLLHVLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAVLPLITKCAPLFAGTEHRAIMVDSMLHTVYRLSRGRSLTKAQRDVIEDCLMSLCRYIRPSMLQHLLRRLVFDVPILNEFAKMPLKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTRKLFWGIFDSLAHKKYDPELYRMAMPCLCAIAGALPPDYVDASYSSKAEKKATVDAEGNFDPRPVETLNVIIPEKLDSFINKFAEYTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMIAWEWTIEKAREGEEEKTEKKKTRKISQSAQTYDPREGYNPQPPDLSAVTLSRELQAMAEQLAENYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTRGLKDMELDSSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFGTDAPAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSQARTQVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGTTKNTYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNACSVYTTKSPRERAILGLPNSVEEMCPDIPVLERLMADIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEAPPSALPAGAPPPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWMKRLAVFAQPIVSRARPELLQSHFIPTIGRLRKRAGKVVSEEEQLRLEAKAEAQEGELLVRDEFSVLCRDLYALYPLLIRYVDNNRAQWLTEPNPSAEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNMSFLTADNKSKMAKAGDIQSGGSDQERTKKKRRGDRYSVQTSLIVATLKKMLPIGLNMCAPTDQDLITLAKTRYALKDTDEEVREFLHNNLHLQGKVEGSPSLRWQMALYRGVPGREEDADDPEKIVRRVQEVSAVLYYLDQTEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPTHRACNMFLESYKAAWILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDEDYLYMAYADIMAKSCHLEEGGENGEAEEEVEVSFEEKQMEKQRLLYQQARLHTRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYLKDKKEVGFFQSIQALMQTCSVLDLNAFERQNKAEGLGMVNEDGTVINRQNGEKVMADDEFTQDLFRFLQLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQDYVTDPRGLISKKDFQKAMDSQKQFSGPEIQFLLSCSEADENEMINCEEFANRFQEPARDIGFNVAVLLTNLSEHVPHDPRLHNFLELAESILEYFRPYLGRIEIMGASRRIERIYFEISETNRAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIFEMQIAAQISEPEGEPETDEDEGAGAAEAGAEGAEEGAAGLEGTAATAAAGATARVVAAAGRALRGLSYRSLRRRVRRLRRLTAREAATAVAALLWAAVTRAGAAGAGAAAGALGLLWGSLFGGGLVEGAKKVTVTELLAGMPDPTSDEVHGEQPAGPGGDADGEGASEGAGDAAEGAGDEEEAVHEAGPGGADGAVAVTDGGPFRPEGAGGLGDMGDTTPAEPPTPEGSPILKRKLGVDGVEEELPPEPEPEPEPELEPEKADAENGEKEEVPEPTPEPPKKQAPPSPPPKKEEAGGEFWGELEVQRVKFLNYLSRNFYTLRFLALFLAFAINFILLFYKVSDSPPGEDDMEGSAAGDVSGAGSGGSSGWGLGAGEEAEGDEDENMVYYFLEESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYITEQPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERIAELLGMDLATLEITAHNERKPNPPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	DEVQFLRTDDEVVLQ CCEEEEECCCCHHHH	50.37	25599653
24	Phosphorylation	DEVVLQCSATVLKEQ CCHHHHCCHHHHHHH	17.64	25599653
26	Phosphorylation	VVLQCSATVLKEQLK HHHHCCHHHHHHHHH	15.29	25599653
35	S-nitrosocysteine	LKEQLKLCLAAEGFG HHHHHHHHHHHCCCC	2.02	-
35	S-nitrosylation	LKEQLKLCLAAEGFG HHHHHHHHHHHCCCC	2.02	17071618
73	Phosphorylation	FVLEQSLSVRALQEM HHHCCCCHHHHHHHH	18.14	24719451
84	Phosphorylation	LQEMLANTVEAGVES HHHHHHHHHHHCHHC	17.70	26552605
91	Phosphorylation	TVEAGVESSQGGGHR HHHHCHHCCCCCCCH	26.09	26552605
92	Phosphorylation	VEAGVESSQGGGHRT HHHCHHCCCCCCCHH	21.24	26552605
113	Phosphorylation	ILLRHAHSRMYLSCL HHHHHHCHHHHHHHH	21.37	27251275
116	Phosphorylation	RHAHSRMYLSCLTTS HHHCHHHHHHHHHCC	8.37	25599653
118	Phosphorylation	AHSRMYLSCLTTSRS HCHHHHHHHHHCCCC	6.92	27251275
121	Phosphorylation	RMYLSCLTTSRSMTD HHHHHHHHCCCCHHC	27.36	25599653
122	Phosphorylation	MYLSCLTTSRSMTDK HHHHHHHCCCCHHCC	14.81	25599653
123	Phosphorylation	YLSCLTTSRSMTDKL HHHHHHCCCCHHCCC	19.68	27251275
157	Phosphorylation	HPASKQRSEGEKVRV CCCCCCCCCCCCEEC	47.67	20068231
175	Phosphorylation	IILVSVSSERYLHLS EEEEEECCCCEEEEE	24.76	20068231
197	Phosphorylation	VDASFMQTLWNMNPI CCHHHHHHHHCCCCC	23.19	22210691
245	Phosphorylation	DDQRRLVYYEGGAVC CCCCCEEEECCCEEE	10.61	26437602
252	S-nitrosocysteine	YYEGGAVCTHARSLW EECCCEEECCCHHHE	1.98	-
252	S-nitrosylation	YYEGGAVCTHARSLW EECCCEEECCCHHHE	1.98	17071618
257	Phosphorylation	AVCTHARSLWRLEPL EEECCCHHHEEEECE	32.82	24719451
267	Phosphorylation	RLEPLRISWSGSHLR EEECEEEEECCCCCC	14.57	26437602
269	Phosphorylation	EPLRISWSGSHLRWG ECEEEEECCCCCCCC	24.51	28634298
271	Phosphorylation	LRISWSGSHLRWGQP EEEEECCCCCCCCCC	17.52	28634298
314	S-nitrosocysteine	HTKATSFCFRISKEK CCCCCCCCEECCHHH	1.93	-
314	S-nitrosylation	HTKATSFCFRISKEK CCCCCCCCEECCHHH	1.93	17071618
388	Phosphorylation	GHMDDALSLTRCQQE CCHHHHHHHHHHHHH	29.43	24719451
421	Phosphorylation	IKSLDSFSGKPRGSG HHHHHHCCCCCCCCC	50.27	-
675	Phosphorylation	DEVTPFLTAQATHLR HCCCHHCEEECCEEE	19.66	-
679	Phosphorylation	PFLTAQATHLRVGWA HHCEEECCEEECEEE	14.90	-
755	Phosphorylation	DLSVPSISFRINGCP CCCCCEEEEEECCCC	16.89	24719451
781	Phosphorylation	GLFFPVVSFSAGVKV CCEEEEEEECCCCEE	17.45	22817900
810	S-nitrosocysteine	PPPGYAPCHEAVLPR CCCCCCCCCCCCCCH	3.26	-
810	S-nitrosylation	PPPGYAPCHEAVLPR CCCCCCCCCCCCCCH	3.26	17071618
842	Phosphorylation	GPHLVGPSRCLSHTD CCCCCCCCCCCCCCC	29.69	26437602
905	S-nitrosocysteine	DNKRLHPCLVDFHSL CCCEEECEEEEHHHC	3.94	-
905	S-nitrosylation	DNKRLHPCLVDFHSL CCCEEECEEEEHHHC	3.94	17071618
930	Phosphorylation	MSGETLKTLLALGCH CCHHHHHHHHHHCCC	30.07	28857561
982	Phosphorylation	RLTPAQTTLVDRLAE CCCCCCCHHHHHHHH	16.83	26437602
1006	Phosphorylation	RVGQGWSYSAVQDIP CCCCCCCCCCCCCCC	8.30	22210691
1007	Phosphorylation	VGQGWSYSAVQDIPA CCCCCCCCCCCCCCC	19.22	22210691
1023	Phosphorylation	RNPRLVPYRLLDEAT CCCCCCCHHHHHHHH	13.35	-
1039	S-nitrosocysteine	RSNRDSLCQAVRTLL HCCHHHHHHHHHHHH	2.56	-
1039	S-nitrosylation	RSNRDSLCQAVRTLL HCCHHHHHHHHHHHH	2.56	17071618
1079	Phosphorylation	RIFRAEKSYTVQSGR EEEEEEEEEEEECCC	19.96	26437602
1081	Phosphorylation	FRAEKSYTVQSGRWY EEEEEEEEEECCCEE	21.11	24719451
1084	Phosphorylation	EKSYTVQSGRWYFEF EEEEEEECCCEEEEE	26.45	30576142
1208	Phosphorylation	LNLGQDVSSLRFFAI CCCCCCHHHHHHHHH	31.76	24719451
1209	Phosphorylation	NLGQDVSSLRFFAIC CCCCCHHHHHHHHHC	24.34	24719451
1275	Phosphorylation	CLRLTHRTWGSQNSL CEEEEECCCCCCCHH	26.94	23312004
1278	Phosphorylation	LTHRTWGSQNSLVEM EEECCCCCCCHHHHH	20.11	23312004
1281	Phosphorylation	RTWGSQNSLVEMLFL CCCCCCCHHHHHHHH	26.59	23312004
1302	S-nitrosocysteine	QFHQHFRCTAGATPL EECCCCCCCCCCCCC	2.75	-
1302	S-nitrosylation	QFHQHFRCTAGATPL EECCCCCCCCCCCCC	2.75	17071618
1337	Phosphorylation	DYENLRRSAGGWSEA CHHHHHHHCCCCCCH	25.49	26437602
1342	Phosphorylation	RRSAGGWSEAENGKE HHHCCCCCCHHCCCC	30.15	26437602
1360	Phosphorylation	KEGAPGGTPQAGGEA CCCCCCCCCCCCCCC	20.38	26437602
1399	Phosphorylation	AKKVAMMTQPPATPT EEEEEECCCCCCCCC	25.49	-
1404	Phosphorylation	MMTQPPATPTLPRLP ECCCCCCCCCCCCCC	23.68	26437602
1590	S-nitrosocysteine	RKNPAPQCPPRLEMQ CCCCCCCCCCCEEEE	4.95	-
1590	S-nitrosylation	RKNPAPQCPPRLEMQ CCCCCCCCCCCEEEE	4.95	17071618
1725	Phosphorylation	HLESACRSRRSMLSE HHHHHHHHCHHHHHH	31.74	26552605
1728	Phosphorylation	SACRSRRSMLSEYIV HHHHHCHHHHHHCEE	23.98	26552605
1731	Phosphorylation	RSRRSMLSEYIVPLT HHCHHHHHHCEECCC	21.51	26552605
1733	Phosphorylation	RRSMLSEYIVPLTPE CHHHHHHCEECCCCC	12.11	26552605
1738	Phosphorylation	SEYIVPLTPETRAIT HHCEECCCCCCCEEE	17.01	25954137
1741	Phosphorylation	IVPLTPETRAITLFP EECCCCCCCEEEECC	26.97	24719451
1860	Acetylation	IFGDEDVKQILKMIE HHCCHHHHHHHHHHC	43.90	18584373
1965	Phosphorylation	LAAFAERYVDKLQAN HHHHHHHHHHHHHHC	12.42	19664994
2065	Phosphorylation	TLGSRLMSLLEKVRL CHHHHHHHHHHHHHH	34.10	24719451
2069	Ubiquitination	RLMSLLEKVRLVKKK HHHHHHHHHHHHHCC	32.40	21139048
2085	Phosphorylation	EKPEEERSAEESKPR CCCHHHHCHHHHCCC	43.22	-
2118	Methylation	VQSPELVRAMFSLLH CCCHHHHHHHHHHHH	32.72	115384831
2206	Phosphorylation	RALGMHETVMEVMVN HHHCCCHHHHHHHHH	15.52	28258704
2220	Phosphorylation	NVLGGGESKEIRFPK HHHCCCCCCCCCCHH	38.57	28258704
2326	S-nitrosocysteine	PDIGWNPCGGERYLD CCCCCCCCCCHHHHH	11.19	-
2326	S-nitrosylation	PDIGWNPCGGERYLD CCCCCCCCCCHHHHH	11.19	17071618
2345	Phosphorylation	AVFVNGESVEENANV EEEECCCCHHHCHHH	35.91	-
2363	S-nitrosocysteine	LLIRKPECFGPALRG EEECCHHHHCHHHCC	6.92	-
2363	S-nitrosylation	LLIRKPECFGPALRG EEECCHHHHCHHHCC	6.92	17071618
2426	Phosphorylation	GHAIMSFYAALIDLL HHHHHHHHHHHHHHH	5.44	22817900
2459	Phosphorylation	RIRAILRSLVPLEDL HHHHHHHHCCCHHHH	30.21	-
2491	Phosphorylation	ALVQPKMSASFVPDH CCCCCCCCCCCCCCC	27.21	26437602
2543	Phosphorylation	LDTATFSTTEMALAL CCCCCCCHHHHHHHH	23.68	-
2594	Phosphorylation	YRLSRGRSLTKAQRD HHHHHCCCCCHHHHH	43.12	-
2596	Phosphorylation	LSRGRSLTKAQRDVI HHHCCCCCHHHHHHH	26.11	-
2654	Phosphorylation	HYERCWKYYCLPTGW HHHHHHHEEECCCCC	3.79	22210691
2655	Phosphorylation	YERCWKYYCLPTGWA HHHHHHEEECCCCCC	5.47	22210691
2659	Phosphorylation	WKYYCLPTGWANFGV HHEEECCCCCCCCCC	32.19	22210691
2691	Phosphorylation	DSLAHKKYDPELYRM HHHHHHCCCHHHHHH	41.35	22210691
2696	Phosphorylation	KKYDPELYRMAMPCL HCCCHHHHHHHHHHH	9.18	22817900
2719	Phosphorylation	PDYVDASYSSKAEKK HHHCCCCCCCCCCCC	20.77	22817900
2761	Phosphorylation	FINKFAEYTHEKWAF HHHHHHHHHHHHHHH	15.23	-
2762	Phosphorylation	INKFAEYTHEKWAFD HHHHHHHHHHHHHHH	18.31	-
2822	Phosphorylation	AMIAWEWTIEKAREG HHHHHHHHHHHHHCC	14.03	23663014
2839	Phosphorylation	EKTEKKKTRKISQSA HHCHHHHHHHHHHHC	46.18	26437602
2843	Phosphorylation	KKKTRKISQSAQTYD HHHHHHHHHHCCCCC	22.55	8380342
2845	Phosphorylation	KTRKISQSAQTYDPR HHHHHHHHCCCCCCC	18.63	22673903
2848	Phosphorylation	KISQSAQTYDPREGY HHHHHCCCCCCCCCC	29.61	-
2849	Phosphorylation	ISQSAQTYDPREGYN HHHHCCCCCCCCCCC	16.33	26437602
2863	Phosphorylation	NPQPPDLSAVTLSRE CCCCCCCHHHHHHHH	28.24	-
2868	Phosphorylation	DLSAVTLSRELQAMA CCHHHHHHHHHHHHH	17.84	-
2935	Phosphorylation	KFLQMNGYAVTRGLK HHHHHHCHHHHCCCC	7.90	-
2950	Phosphorylation	DMELDSSSIEKRFAF CCCCCCCHHHHHHHH	38.42	26437602
2953	Acetylation	LDSSSIEKRFAFGFL CCCCHHHHHHHHHHH	51.66	30592093
3027	Phosphorylation	TPAKVLGSGGHASNK CCHHHHCCCCCCCHH	37.12	-
3032	Phosphorylation	LGSGGHASNKEKEMI HCCCCCCCHHHHHHH	42.64	-
3079	Phosphorylation	ARSLDARTVMKSGPE HHCCCHHHHHHHCHH	27.03	17322306
3094	Phosphorylation	IVKAGLRSFFESASE HHHHHHHHHHHHCHH	39.05	22468782
3100	Phosphorylation	RSFFESASEDIEKMV HHHHHHCHHHHHHHH	45.11	22468782
3131	Phosphorylation	GVGQNLTYTTVALLP CCCCCCHHHHHHHHH	11.99	-
3132	Phosphorylation	VGQNLTYTTVALLPV CCCCCHHHHHHHHHH	15.01	-
3133	Phosphorylation	GQNLTYTTVALLPVL CCCCHHHHHHHHHHH	8.05	-
3177	Phosphorylation	CSIYSLGTTKNTYVE HHHHHCCCCCCHHHH	39.63	-
3178	Phosphorylation	SIYSLGTTKNTYVEK HHHHCCCCCCHHHHH	22.09	-
3193	S-nitrosocysteine	LRPALGECLARLAAA HHHHHHHHHHHHHHH	3.23	-
3193	S-nitrosylation	LRPALGECLARLAAA HHHHHHHHHHHHHHH	3.23	17071618
3489	Phosphorylation	GDIQSGGSDQERTKK CCCCCCCCHHHHHHH	39.38	-
3532	Neddylation	CAPTDQDLITLAKTR CCCCCHHHHHHHHHH	2.40	32015554
3537	Neddylation	QDLITLAKTRYALKD HHHHHHHHHHHHCCC	36.33	32015554
3566	Phosphorylation	LQGKVEGSPSLRWQM CCCCCCCCCCHHHHH	9.60	26437602
3568	Phosphorylation	GKVEGSPSLRWQMAL CCCCCCCCHHHHHHH	32.06	22673903
3605	Phosphorylation	EVSAVLYYLDQTEHP HHHHHHHHHHCCCCC	10.31	30576142
3609	Phosphorylation	VLYYLDQTEHPYKSK HHHHHHCCCCCCCCH	35.61	30576142
3635	S-nitrosocysteine	RRRAVVACFRMTPLY HHHHHHHHHCCCCCC	1.18	-
3635	S-nitrosylation	RRRAVVACFRMTPLY HHHHHHHHHCCCCCC	1.18	17071618
3639	Phosphorylation	VVACFRMTPLYNLPT HHHHHCCCCCCCCCH	13.09	22210691
3642	Phosphorylation	CFRMTPLYNLPTHRA HHCCCCCCCCCHHHH	18.82	22210691
3646	Phosphorylation	TPLYNLPTHRACNMF CCCCCCCHHHHHHHH	27.45	22210691
3656	Phosphorylation	ACNMFLESYKAAWIL HHHHHHHHHHHHEEE	33.80	22210691
3668	Phosphorylation	WILTEDHSFEDRMID EEECCCCCCHHHHHH	42.53	21815630
3751	Phosphorylation	AEEEVEVSFEEKQME HHHEEEECHHHHHHH	17.27	24719451
3771	Phosphorylation	YQQARLHTRGAAEMV HHHHHHHHHHHHHHH	35.08	24719451
3783	Phosphorylation	EMVLQMISACKGETG HHHHHHHHHCCCCCC	23.44	22210691
3789	Phosphorylation	ISACKGETGAMVSST HHHCCCCCCCCCHHH	38.62	22210691
3795	Phosphorylation	ETGAMVSSTLKLGIS CCCCCCHHHHHHEEE	26.75	22210691
3796	Phosphorylation	TGAMVSSTLKLGISI CCCCCHHHHHHEEEE	22.02	22210691
3918	Phosphorylation	TINIIICTVDYLLRL EEEEEEEEHHHHHHH	13.15	-
3921	Phosphorylation	IIICTVDYLLRLQES EEEEEHHHHHHHHHH	11.87	-
4052	Phosphorylation	DMLVESSSNVEMILK HHHHHCCCCHHHHHH	54.92	22210691
4079	Phosphorylation	GSEAFQDYVTDPRGL CCHHHHHHCCCCCCC	8.41	24275569
4081	Phosphorylation	EAFQDYVTDPRGLIS HHHHHHCCCCCCCCC	33.77	24275569
4088	Phosphorylation	TDPRGLISKKDFQKA CCCCCCCCHHHHHHH	38.40	24719451
4098	Phosphorylation	DFQKAMDSQKQFSGP HHHHHHHHCCCCCCH	26.62	29083192
4212	Phosphorylation	EMPQVKESKRQFIFD CCCCHHHHHHHEEEE	27.67	22617229
4229	Methylation	NEGGEAEKMELFVSF CCCCHHHCHHHHHHH	44.73	-
4285	Phosphorylation	GAAGLEGTAATAAAG CCCCCCHHHHHHHHH	12.07	23879269
4288	Phosphorylation	GLEGTAATAAAGATA CCCHHHHHHHHHHHH	17.86	23879269
4324	Phosphorylation	VRRLRRLTAREAATA HHHHHHHHHHHHHHH	23.12	-
4330	Phosphorylation	LTAREAATAVAALLW HHHHHHHHHHHHHHH	28.81	-
4341	Phosphorylation	ALLWAAVTRAGAAGA HHHHHHHHHHHHHHH	15.29	-
4375	Phosphorylation	VEGAKKVTVTELLAG HHCCCEEEHHHHHCC	30.50	26074081
4377	Phosphorylation	GAKKVTVTELLAGMP CCCEEEHHHHHCCCC	16.14	26074081
4387	Phosphorylation	LAGMPDPTSDEVHGE HCCCCCCCCCCCCCC	57.07	26074081
4388	Phosphorylation	AGMPDPTSDEVHGEQ CCCCCCCCCCCCCCC	36.84	26074081
4460	Phosphorylation	GLGDMGDTTPAEPPT CCCCCCCCCCCCCCC	29.02	22210691
4467	Phosphorylation	TTPAEPPTPEGSPIL CCCCCCCCCCCCCCH	44.69	-
4471	Phosphorylation	EPPTPEGSPILKRKL CCCCCCCCCCHHHHH	13.70	24719451
4518	Phosphorylation	KEEVPEPTPEPPKKQ CCCCCCCCCCCCCCC	38.33	26437602
4529	Phosphorylation	PKKQAPPSPPPKKEE CCCCCCCCCCCCCHH	49.32	24719451
4540	Ubiquitination	KKEEAGGEFWGELEV CCHHCCCCCCEEEHH	36.99	23000965
4545	Ubiquitination	GGEFWGELEVQRVKF CCCCCEEEHHHHHHH	7.42	23000965
4546	Ubiquitination	GEFWGELEVQRVKFL CCCCEEEHHHHHHHH	32.10	23000965
4551	Ubiquitination	ELEVQRVKFLNYLSR EEHHHHHHHHHHHCC	46.45	23000965
4562	Phosphorylation	YLSRNFYTLRFLALF HHCCCHHHHHHHHHH	13.81	24719451
4699	Ubiquitination	QPEDDDVKGQWDRLV CCCCCCCCCCCEEEE	52.99	27667366
4717	Ubiquitination	PSFPSNYWDKFVKRK CCCCHHHHHHHHHHH	13.43	27667366
4722	Ubiquitination	NYWDKFVKRKVLDKH HHHHHHHHHHHHHHC	50.03	27667366
4723	Ubiquitination	YWDKFVKRKVLDKHG HHHHHHHHHHHHHCC	29.07	27667366
4728	Ubiquitination	VKRKVLDKHGDIYGR HHHHHHHHCCCCCCH	45.38	27667366
4823	Phosphorylation	DIAMGVKTLRTILSS HHHHHHHHHHHHHHH	21.04	-
4826	Phosphorylation	MGVKTLRTILSSVTH HHHHHHHHHHHHCCC	29.40	22210691
4829	Phosphorylation	KTLRTILSSVTHNGK HHHHHHHHHCCCCCC	20.93	-
4832	Phosphorylation	RTILSSVTHNGKQLV HHHHHHCCCCCCHHH	16.15	-
4841	Phosphorylation	NGKQLVMTVGLLAVV CCCHHHHHHHHHHHH	12.16	22210691
4850	Phosphorylation	GLLAVVVYLYTVVAF HHHHHHHHHHHHHHH	5.16	-
4864	Phosphorylation	FNFFRKFYNKSEDED HHHHHHHHCCCCCCC	25.39	18318008
4867	Phosphorylation	FRKFYNKSEDEDEPD HHHHHCCCCCCCCCC	46.79	27586648

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
2843	S	Phosphorylation	Kinase	PKA	-	Uniprot
2843	S	Phosphorylation	Kinase	PKG	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
2843	S	Phosphorylation	18268335
Phosphorylation at Ser-2843 may increase channel activity.
2843	S	Phosphorylation	18268335
Repeated very high-level exercise increases phosphorylation at Ser-2843.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RYR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRDN_HUMAN	TRDN	physical	14638677
FKB1A_HUMAN	FKBP1A	physical	12704193
RYR2_HUMAN	RYR2	physical	12213830
FKB1A_HUMAN	FKBP1A	physical	11171121
FKB1A_HUMAN	FKBP1A	physical	11279144
TRDN_HUMAN	TRDN	physical	10212196
ANK1_HUMAN	ANK1	physical	7629097

Drug and Disease Associations

Kegg Disease
H00699	Central core disease
H01310	Multi-minicore disease (MmD); Multicore myopathy with external ophthalmoplegia
OMIM Disease
145600	Malignant hyperthermia 1 (MHS1)
117000	Central core disease of muscle (CCD)
255320	Multiminicore disease with external ophthalmoplegia (MMDO)
255310	Myopathy, congenital, with fiber-type disproportion (CFTD)
Kegg Drug
D00740	Procaine hydrochloride (JP16/USP); Novocain (TN)
D00808	Suramin hexasodium (USAN); Bayer 205 (TN)
D02274	Dantrolene sodium hydrate (JP16); Dantrolene sodium (USAN); Dantrium (TN)
D02347	Dantrolene (USAN/INN)
D08422	Procaine (INN); Solution of novocain (TN)
DrugBank
DB00201	Caffeine
DB01219	Dantrolene
DB04786	Suramin

Regulatory Network of RYR1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography."; Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.; Proteomics 8:1346-1361(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-4864 AND SER-4867, ANDMASS SPECTROMETRY.	18318008 [Abstract]
S-nitrosylation
Reference	PubMed
"Cysteine-3635 is responsible for skeletal muscle ryanodine receptormodulation by NO."; Sun J., Xin C., Eu J.P., Stamler J.S., Meissner G.; Proc. Natl. Acad. Sci. U.S.A. 98:11158-11162(2001). Cited for: S-NITROSYLATION AT CYS-3635.	11562475 [Abstract]

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