RYR2_HUMAN - dbPTM
RYR2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RYR2_HUMAN
UniProt AC Q92736
Protein Name Ryanodine receptor 2
Gene Name RYR2
Organism Homo sapiens (Human).
Sequence Length 4967
Subcellular Localization Sarcoplasmic reticulum membrane
Multi-pass membrane protein . Membrane
Multi-pass membrane protein . Sarcoplasmic reticulum . The number of predicted transmembrane domains varies between orthologs, but both N-terminus and C-terminus seem to be cy
Protein Description Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development..
Protein Sequence MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPDLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYLSLMEDKNLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSVCYIQHVDTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGISLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKAKASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREYKQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEDKVKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCSGTGERFRIFRAEKTYAVKAGRWYFEFETVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGFKAQRWHQGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDGFIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQVPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSNTDIMFYRLSMPIECAEVFSKTVAGGLPGAGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPEFNNHKDYAQEKPSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDFLMQTSTYYYSVRIFPGQEPANVWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGRNNNGLEIGCVVDAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQCLDPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHVDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEYIVPMTEETKSITLFPDENKKHGLPGIGLSTSLRPRMQFSSPSFVSISNECYQYSPEFPLDILKSKTIQMLTEAVKEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAATPEEESDTLEKELSVDDAKLQGAGEEEAKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGNSDLTIRGRLLSLVEKVTYLKKKQAEKPVESDSKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEEAIKIAEDPSRDGPSPNSGSSKTLDTEEEEDDTIHMGNAIMTFYSALIDLLGRCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGNFNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSVDAAHGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAKEKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDGGSRGKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAFLDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGEDLILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLDKHNIYSIYNTKSSRERAALSLPTNVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILPMLCSYMSRWWEHGPENNPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAATVVSEEDHLKAEARGDMSEAELLILDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFVVQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNICAPGDQELIALAKNRFSLKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTDDTSDPEKTVERVLDIANVLFHLEQKSKRVGRRHYCLVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGAEPPEEDEGTKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERSANKEESEKERPEEQGPRMAFFSILTVRSALFALRYNILTLMRMLSLKSLKKQMKKVKKMTVKDMVTAFFSSYWSIFMTLLHFVASVFRGFFRIICSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGDGEEGERKPLEAALPSEDLTDLKELTEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMSNPVPMPEVQEKFQEQKAKEEEKEEKEETKSEPEKAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKELPTRSSSENAKVTSLDSSSHRIIAVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
74PhosphorylationFVLEQSLSVRALQEM
HHHCCCCHHHHHHHH		18.1424719451
170PhosphorylationHPASKQRSEGEKVRV
CCCCCCCCCCCCEEE		47.6724719451
196PhosphorylationERYLHLSYGNGSLHV
CCEEEEEECCCCEEC		22.44-
273PhosphorylationAVSVHARSLWRLETL
CEEEEHHHEEEEEEE		32.8224719451
305PhosphorylationRHVTTGKYLSLMEDK
EECCCCCCHHHHCCC		11.6729759185
307PhosphorylationVTTGKYLSLMEDKNL
CCCCCCHHHHCCCCE		23.6825262027
376PhosphorylationGLWLTYQSVDVKSVR
CEEEEEEEEECEECC		15.1822210691
390UbiquitinationRMGSIQRKAIMHHEG
CCCCHHHHHHHCCCC		26.37-
404PhosphorylationGHMDDGISLSRSQHE
CCCCCCCCCCHHHCH		26.3124719451
406PhosphorylationMDDGISLSRSQHEES
CCCCCCCCHHHCHHH		24.08-
767PhosphorylationDLSAPSISFRINGQP
CCCCCEEEEEECCEE		16.8924719451
823PhosphorylationPPGYAPCYEAVLPKE
CCCCCCCCHHHCCHH		13.08-
854PhosphorylationTRDLLGPTVSLTQAA
CCCCCCCCEEEEECC		22.4124043423
856PhosphorylationDLLGPTVSLTQAAFT
CCCCCCEEEEECCCC		28.3324043423
858PhosphorylationLGPTVSLTQAAFTPI
CCCCEEEEECCCCCC		14.5124043423
863PhosphorylationSLTQAAFTPIPVDTS
EEEECCCCCCCCCHH		18.6424043423
869PhosphorylationFTPIPVDTSQIVLPP
CCCCCCCHHHCCCCH		23.8224043423
870PhosphorylationTPIPVDTSQIVLPPH
CCCCCCHHHCCCCHH		17.2824043423
970PhosphorylationKMKLPKNYQLTSGYK
HCCCCCCCCCCCCCC		15.83-
984PhosphorylationKPAPMDLSFIKLTPS
CCCCCCCCEEECCCC		22.2124719451
1049PhosphorylationTKKSNKDSLREAVRT
CCCCCHHHHHHHHHH		30.8222210691
1141AcetylationAFAFDGFKAQRWHQG
CCHHCCCHHEECCCC		49.497923725
1172PhosphorylationMVDMNEHTMMFTLNG
EEECCCCEEEEEECC		12.26-
1176PhosphorylationNEHTMMFTLNGEILL
CCCEEEEEECCEEEE		11.04-
1317PhosphorylationCAEVFSKTVAGGLPG
HHHHHHHHCCCCCCC		17.87-
1341PhosphorylationLEDYDADSDFEVLMK
CCCCCCCCCHHHHHH		46.01-
1402PhosphorylationPDYSTSHSARLTEDV
CCCCCCCCCCCCHHH		18.1726329039
1427PhosphorylationLMQTSTYYYSVRIFP
HHHCCEEEEEEEECC		6.8618083107
1428PhosphorylationMQTSTYYYSVRIFPG
HHCCEEEEEEEECCC		7.1218083107
1468O-linked_GlycosylationRVRTVTVTLGDEKGK
CEEEEEEEECCCCCC		18.6928657654
1483PhosphorylationVHESIKRSNCYMVCA
CCCHHHCCCCEEEEC		26.67-
1486PhosphorylationSIKRSNCYMVCAGES
HHHCCCCEEEECCCC		9.24-
1493PhosphorylationYMVCAGESMSPGQGR
EEEECCCCCCCCCCC		24.5224076635
1495PhosphorylationVCAGESMSPGQGRNN
EECCCCCCCCCCCCC		34.8524076635
1788AcetylationEFPLDILKSKTIQML
CCCHHHHHHHHHHHH		50.6818526185
1790AcetylationPLDILKSKTIQMLTE
CHHHHHHHHHHHHHH		48.3218526195
1791PhosphorylationLDILKSKTIQMLTEA
HHHHHHHHHHHHHHH		24.4328796482
1796PhosphorylationSKTIQMLTEAVKEGS
HHHHHHHHHHHHHCC		19.2928796482
1856PhosphorylationSVFKEAATPEEESDT
HHHHCCCCCHHHCCH		37.9824076635
1869PhosphorylationDTLEKELSVDDAKLQ
CHHHHHCCCCHHHHC		25.29-
1887AcetylationEEEAKGGKRPKEGLL
HHHHCCCCCCCCCCC		74.357695489
1890AcetylationAKGGKRPKEGLLQMK
HCCCCCCCCCCCCCC		69.3318585971
1897AcetylationKEGLLQMKLPEPVKL
CCCCCCCCCCCCHHH		48.187695501
1903AcetylationMKLPEPVKLQMCLLL
CCCCCCHHHHHHHHH		43.6618585981
1944PhosphorylationQDNQRFRYNEVMQAL
CCCCCCCHHHHHHHH		16.98-
1954PhosphorylationVMQALNMSAALTARK
HHHHHHHHHHHHHHH		14.8722210691
1958PhosphorylationLNMSAALTARKTKEF
HHHHHHHHHHHCCCC		21.4922210691
1962PhosphorylationAALTARKTKEFRSPP
HHHHHHHCCCCCCCC		30.19-
2031PhosphorylationTIRGRLLSLVEKVTY
CHHHHHHHHHHHHHH		34.6519835603
2038PhosphorylationSLVEKVTYLKKKQAE
HHHHHHHHHHHHCCC		21.3619835603
2073PhosphorylationMVRWAQESVIEDPEL
HHHHHHHHCCCCHHH		19.13-
2136TrimethylationLLSVRMGKEEEKLMI
HHHHHCCHHHHHHHH		53.24-
2136MethylationLLSVRMGKEEEKLMI
HHHHHCCHHHHHHHH		53.2423644510
2140TrimethylationRMGKEEEKLMIRGLG
HCCHHHHHHHHCCHH		46.78-
2140MethylationRMGKEEEKLMIRGLG
HCCHHHHHHHHCCHH		46.7823644510
2170PhosphorylationRALGMHETVMEVMVN
HHHCCCHHHHHHHHH		15.5228258704
2184PhosphorylationNVLGGGESKEITFPK
HHHCCCCCCCCCHHH		38.5728258704
2191AcetylationSKEITFPKMVANCCR
CCCCCHHHHHHHHHH		41.6430585851
2202PhosphorylationNCCRFLCYFCRISRQ
HHHHHHHHHHHHHHH		14.0918083107
2211UbiquitinationCRISRQNQKAMFDHL
HHHHHHCHHHHHHHH		26.9223503661
2212UbiquitinationRISRQNQKAMFDHLS
HHHHHCHHHHHHHHH		49.7423503661
2212 (in isoform 2)Ubiquitination-49.74-
2215UbiquitinationRQNQKAMFDHLSYLL
HHCHHHHHHHHHHHH		6.8223503661
2221UbiquitinationMFDHLSYLLENSSVG
HHHHHHHHHHCCCCC		4.3123503661
2222UbiquitinationFDHLSYLLENSSVGL
HHHHHHHHHCCCCCC		4.4423503661
2276PhosphorylationLAGCGLQSCQMLVSK
HHHCCHHHHHHHHHC		16.0323898821
2282PhosphorylationQSCQMLVSKGYPDIG
HHHHHHHHCCCCCCC		19.1923898821
2363PhosphorylationDPSRDGPSPNSGSSK
CCCCCCCCCCCCCCC		42.0925307156
2369PhosphorylationPSPNSGSSKTLDTEE
CCCCCCCCCCCCCCH		32.93-
2519PhosphorylationMALALNRYLCTAVLP
HHHHHHHHHHHHHHH		12.69-
2522PhosphorylationALNRYLCTAVLPLLT
HHHHHHHHHHHHHHH		19.73-
2529PhosphorylationTAVLPLLTRCAPLFA
HHHHHHHHHHHHHCC		31.24-
2697PhosphorylationEKQSSMDSEGNFNPQ
HHCCCCCCCCCCCCC		38.47-
2736AcetylationHDKWSMDKLANGWIY
CCCCCHHHHHCCEEE		40.6419413330
2751PhosphorylationGEIYSDSSKVQPLMK
EEECCCCCCCCCCCC		41.6619413330
2764PhosphorylationMKPYKLLSEKEKEIY
CCHHHCCCHHHHHHH		57.9924719451
2781PhosphorylationPIKESLKTMLAWGWR
CHHHHHHHHHHHCCE		23.7819664994
2797PhosphorylationERTREGDSMALYNRT
EECCCCCCHHEEECC		19.46-
2808PhosphorylationYNRTRRISQTSQVSV
EECCCCCCCCCCCCH		26.1217239900
2810PhosphorylationRTRRISQTSQVSVDA
CCCCCCCCCCCCHHH		17.8423312004
2811PhosphorylationTRRISQTSQVSVDAA
CCCCCCCCCCCHHHC		22.4323312004
2814PhosphorylationISQTSQVSVDAAHGY
CCCCCCCCHHHCCCC		13.4722210691
2923PhosphorylationSIEKRFAYSFLQQLI
CHHHHHHHHHHHHHH		9.39-
2947PhosphorylationILEFDGGSRGKGEHF
EEEECCCCCCCCCCC		43.31-
3228UbiquitinationLAESGIRYTQMPHVM
HHHCCCCCCCCCHHH		10.2123503661
3285PhosphorylationGNILKIIYNNLGIDE
HHHHHHHHHCCCCCC		11.06-
3296UbiquitinationGIDEGAWMKRLAVFS
CCCCCHHHHHHHHHC		1.4723503661
3297UbiquitinationIDEGAWMKRLAVFSQ
CCCCHHHHHHHHHCH		33.2923503661
3297 (in isoform 2)Ubiquitination-33.29-
3300UbiquitinationGAWMKRLAVFSQPII
CHHHHHHHHHCHHHH		12.3523503661
3303PhosphorylationMKRLAVFSQPIINKV
HHHHHHHCHHHHHHH		28.57-
3306UbiquitinationLAVFSQPIINKVKPQ
HHHHCHHHHHHHCHH		4.1523503661
3307UbiquitinationAVFSQPIINKVKPQL
HHHCHHHHHHHCHHH		5.3423503661
3367PhosphorylationTTLARDLYAFYPLLI
HHHHHHHHHHHHHHH		10.04-
3370PhosphorylationARDLYAFYPLLIRFV
HHHHHHHHHHHHHHH		5.70-
3435PhosphorylationMSFLITDTKSKMSKA
EEEEEEECCHHHHHC		28.6830377224
3437PhosphorylationFLITDTKSKMSKAAV
EEEEECCHHHHHCCC		35.37-
3438MethylationLITDTKSKMSKAAVS
EEEECCHHHHHCCCC		49.07-
3441MethylationDTKSKMSKAAVSDQE
ECCHHHHHCCCCHHH		36.55-
3459PhosphorylationMKRKGDRYSMQTSLI
HHHHCCCHHHHHHHH		17.15-
3497PhosphorylationALAKNRFSLKDTEDE
HHHHCCCCCCCCHHH		31.13-
3501PhosphorylationNRFSLKDTEDEVRDI
CCCCCCCCHHHHHHH		43.69-
3674PhosphorylationLILLFSRTALTEKCK
HHHHHCHHHCCCCCC		25.4828258704
3677PhosphorylationLFSRTALTEKCKLEE
HHCHHHCCCCCCCCH		30.8228258704
3712UbiquitinationDDGEEEVKSFEEKEM
CCCHHHHHHHHHHHH		53.35-
3713PhosphorylationDGEEEVKSFEEKEME
CCHHHHHHHHHHHHH		42.9629802988
3751PhosphorylationISASKGETGPMVAAT
HHCCCCCCCCCHHHH		56.0822210691
3758PhosphorylationTGPMVAATLKLGIAI
CCCCHHHHHEEEEEE		18.0621214269
3772PhosphorylationILNGGNSTVQQKMLD
ECCCCCHHHHHHHHH		26.7422210691
3780PhosphorylationVQQKMLDYLKEKKDV
HHHHHHHHHHHCCCC		18.7321214269
3994PhosphorylationEGNVVNGTIGKQMVD
CCCCCCCCCCHHHHH		22.7322210691
4006PhosphorylationMVDMLVESSNNVEMI
HHHHHHHCCCCHHHH		30.7724114839
4007PhosphorylationVDMLVESSNNVEMIL
HHHHHHCCCCHHHHH		20.9322210691
4040AcetylationKEYDPDGKGVISKRD
CCCCCCCCCCCCHHH		58.347431131
4050AcetylationISKRDFHKAMESHKH
CCHHHHHHHHHHCCC		49.807431143
4250PhosphorylationSALFALRYNILTLMR
HHHHHHHHHHHHHHH		13.8626074081
4254PhosphorylationALRYNILTLMRMLSL
HHHHHHHHHHHHHCH		18.0826074081
4260PhosphorylationLTLMRMLSLKSLKKQ
HHHHHHHCHHHHHHH		25.1426074081
4263PhosphorylationMRMLSLKSLKKQMKK
HHHHCHHHHHHHHHH		51.1926074081
4269UbiquitinationKSLKKQMKKVKKMTV
HHHHHHHHHHHCCCH		52.5030230243
4311PhosphorylationGFFRIICSLLLGGSL
HHHHHHHHHHHCCCH		16.19-
4317PhosphorylationCSLLLGGSLVEGAKK
HHHHHCCCHHHHHHH		27.69-
4391PhosphorylationLKREGGQYKLIPHNP
EEECCCCEEECCCCC		15.84-
4452AcetylationEDGEKEEKAKEDKGK
CCCHHHHHHHHHHHH		66.89129075
4454AcetylationGEKEEKAKEDKGKQK
CHHHHHHHHHHHHHH		77.007661913
4457AcetylationEEKAKEDKGKQKLRQ
HHHHHHHHHHHHHHH		69.937677855
4459AcetylationKAKEDKGKQKLRQLH
HHHHHHHHHHHHHHH		50.427677867
4500PhosphorylationNYFARNFYNMRMLAL
HHHHHCCCHHHHHHH		16.1723898821
4520PhosphorylationINFILLFYKVSTSSV
HHHHHHHHHCCCCCC		15.5023898821
4523PhosphorylationILLFYKVSTSSVVEG
HHHHHHCCCCCCCCC		20.5823898821
4524PhosphorylationLLFYKVSTSSVVEGK
HHHHHCCCCCCCCCC		28.1923898821
4525PhosphorylationLFYKVSTSSVVEGKE
HHHHCCCCCCCCCCC		17.4023898821
4526PhosphorylationFYKVSTSSVVEGKEL
HHHCCCCCCCCCCCC		30.2123898821
4550PhosphorylationKVTSLDSSSHRIIAV
EEEECCCCCCEEEEE		29.81-
4622PhosphorylationLYITEQPSEDDIKGQ
EEECCCCCCCCCCCC		54.04-
4680PhosphorylationDKAALDFSDAREKKK
CHHHCCCHHHHHHCC		29.9923322592
4695PhosphorylationPKKDSSLSAVLNSID
CCCCCCHHHHHHHHH		20.48-
4705PhosphorylationLNSIDVKYQMWKLGV
HHHHHHHHHHHEEEE		11.93-
4744UbiquitinationFFFAAHLLDIAMGFK
HHHHHHHHHHHHHHH		3.0023503661
4752PhosphorylationDIAMGFKTLRTILSS
HHHHHHHHHHHHHHH		21.15-
4755PhosphorylationMGFKTLRTILSSVTH
HHHHHHHHHHHHCCC		29.40-
4758PhosphorylationKTLRTILSSVTHNGK
HHHHHHHHHCCCCCE		20.93-
4761PhosphorylationRTILSSVTHNGKQLV
HHHHHHCCCCCEEHH		16.15-
4779PhosphorylationGLLAVVVYLYTVVAF
HHHHHHHHHHHHHHH		5.16-
4792UbiquitinationAFNFFRKFYNKSEDG
HHHHHHHHHCCCCCC		7.6723503661
4803UbiquitinationSEDGDTPDMKCDDML
CCCCCCCCCCHHHHH		51.7923503661
4805UbiquitinationDGDTPDMKCDDMLTC
CCCCCCCCHHHHHHH		41.7223503661
4811UbiquitinationMKCDDMLTCYMFHMY
CCHHHHHHHHHHHHH		8.5823503661
4813UbiquitinationCDDMLTCYMFHMYVG
HHHHHHHHHHHHHHC		9.5123503661
4813 (in isoform 2)Ubiquitination-9.51-
4815UbiquitinationDMLTCYMFHMYVGVR
HHHHHHHHHHHHCCC		0.9023503661
4816UbiquitinationMLTCYMFHMYVGVRA
HHHHHHHHHHHCCCC		7.0823503661
4818PhosphorylationTCYMFHMYVGVRAGG
HHHHHHHHHCCCCCC		5.8630576142
4822UbiquitinationFHMYVGVRAGGGIGD
HHHHHCCCCCCCCCC		22.9123503661
4823UbiquitinationHMYVGVRAGGGIGDE
HHHHCCCCCCCCCCC		20.6923503661
4944PhosphorylationESYVWKMYQERCWEF
HHHHHHHHHHHHHHH		11.96-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
2031SPhosphorylationKinasePRKACAP17612
GPS
2031SPhosphorylationKinasePKA-FAMILY-GPS
2031SPhosphorylationKinasePKA-Uniprot
2031SPhosphorylationKinasePKA_GROUP-PhosphoELM
2808SPhosphorylationKinasePRKACAP00517
GPS
2808SPhosphorylationKinasePKACAP17612
PSP
2808SPhosphorylationKinaseKCC2AQ9UQM7
PhosphoELM
2808SPhosphorylationKinaseCAMK2DQ13557
Uniprot
2808SPhosphorylationKinasePKA-FAMILY-GPS
2808SPhosphorylationKinasePKA-Uniprot
2808SPhosphorylationKinasePKA_GROUP-PhosphoELM
2814SPhosphorylationKinaseCAMK2AQ9UQM7
PSP
2814SPhosphorylationKinaseCAMK2DQ13557
Uniprot
2814SPhosphorylationKinaseCAMK2-FAMILY-GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
2031SPhosphorylation

-
2808SPhosphorylation

10830164
2814SPhosphorylation

20056922
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RYR2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RYR2_HUMANRYR2physical
10830164
KAPCB_HUMANPRKACBphysical
10830164
KAPCG_HUMANPRKACGphysical
10830164
KAP2_HUMANPRKAR2Aphysical
10830164
KAP3_HUMANPRKAR2Bphysical
10830164
PP1A_HUMANPPP1CAphysical
10830164
PP1B_HUMANPPP1CBphysical
10830164
PP1G_HUMANPPP1CCphysical
10830164
AKAP6_HUMANAKAP6physical
10830164
KAPCA_HUMANPRKACAphysical
10830164
RYR3_HUMANRYR3physical
12213830
SORCN_HUMANSRIphysical
7592856
AKAP6_HUMANAKAP6physical
11352932
PSN1_HUMANPSEN1physical
24029002
RYR2_HUMANRYR2physical
21262961
RYR2_HUMANRYR2physical
25411383
Drug and Disease Associations
Kegg Disease
H00293 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
H01019 Catecholaminergic polymorphic ventricular tachycardia
OMIM Disease
600996Arrhythmogenic right ventricular dysplasia, familial, 2 (ARVD2)
604772Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy (CPVT1)
Kegg Drug
D00740 Procaine hydrochloride (JP16/USP); Novocain (TN)
D00808 Suramin hexasodium (USAN); Bayer 205 (TN)
D02274 Dantrolene sodium hydrate (JP16); Dantrolene sodium (USAN); Dantrium (TN)
D02347 Dantrolene (USAN/INN)
D08422 Procaine (INN); Solution of novocain (TN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RYR2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"CaMKII-dependent diastolic SR Ca2+ leak and elevated diastolic Ca2+levels in right atrial myocardium of patients with atrialfibrillation.";
Neef S., Dybkova N., Sossalla S., Ort K.R., Fluschnik N., Neumann K.,Seipelt R., Schondube F.A., Hasenfuss G., Maier L.S.;
Circ. Res. 106:1134-1144(2010).
Cited for: FUNCTION, AND PHOSPHORYLATION AT SER-2808 AND SER-2814.
"PKA phosphorylation dissociates FKBP12.6 from the calcium releasechannel (ryanodine receptor): defective regulation in failinghearts.";
Marx S.O., Reiken S., Hisamatsu Y., Jayaraman T., Burkhoff D.,Rosemblit N., Marks A.R.;
Cell 101:365-376(2000).
Cited for: FUNCTION, IDENTIFICATION IN A COMPLEX WITH FKBP1B; PP1; PP2A AKAP6 ANDPKA, INTERACTION WITH FKBP1B; PKA; PP1 AND PP2A, SUBCELLULAR LOCATION,TISSUE SPECIFICITY, MUTAGENESIS OF SER-2808, AND PHOSPHORYLATION ATSER-2808.

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