KAPCG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KAPCG_HUMAN
• UniProt AC: P22612
• Protein Name: cAMP-dependent protein kinase catalytic subunit gamma
• Gene Name: PRKACG
• Organism: Homo sapiens (Human).
• Sequence Length: 351
• Protein Description: Phosphorylates a large number of substrates in the cytoplasm and the nucleus..
• Protein Sequence: MGNAPAKKDTEQEESVNEFLAKARGDFLYRWGNPAQNTASSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNFDDYEEEELRISINEKCAKEFSEF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGNAPAKKD ------CCCCCCCCC	38.72	-
54	Phosphorylation	LRTLGMGSFGRVMLV HHHHCCCCCCEEEEE	18.68	17929957
110	Phosphorylation	FLVKLQFSFKDNSYL EEEEEEEEECCCEEE	20.58	24719451
118	Phosphorylation	FKDNSYLYLVMEYVP ECCCEEEEEEEEECC	6.76	22817900
123	Phosphorylation	YLYLVMEYVPGGEMF EEEEEEEECCCCHHH	8.21	22817900
132	Dimethylation	PGGEMFSRLQRVGRF CCCHHHHHHHHCCCC	24.47	-
132	Methylation	PGGEMFSRLQRVGRF CCCHHHHHHHHCCCC	24.47	24161005
190	Ubiquitination	VTDFGFAKRVKGRTW ECCCCCCEECCCCEE	56.30	23503661
193	Ubiquitination	FGFAKRVKGRTWTLC CCCCEECCCCEEEEC	46.86	23503661
196	Phosphorylation	AKRVKGRTWTLCGTP CEECCCCEEEECCCH	31.32	22322096
198	Phosphorylation	RVKGRTWTLCGTPEY ECCCCEEEECCCHHH	16.14	22322096
200	Carbamidation	KGRTWTLCGTPEYLA CCCEEEECCCHHHHC	4.45	17322306
202	Phosphorylation	RTWTLCGTPEYLAPE CEEEECCCHHHHCCH	16.38	22167270
205	Phosphorylation	TLCGTPEYLAPEIIL EECCCHHHHCCHHHH	14.90	27461979
213	Phosphorylation	LAPEIILSKGYNKAV HCCHHHHCCCCHHHH	17.39	23403867
214	Ubiquitination	APEIILSKGYNKAVD CCHHHHCCCCHHHHH	63.07	21963094
310	Ubiquitination	WIAIYEKKVEAPFIP EEEEEEECCCCCCCC	33.11	-
339	Phosphorylation	EEEELRISINEKCAK CHHHHHHHCCHHHHH	16.96	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KAPCG_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KAPCG_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KAPCG_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RYR2_HUMAN	RYR2	physical	10830164
STP1_HUMAN	TNP1	physical	9837753
STP2_HUMAN	TNP2	physical	9837753
HMGN1_HUMAN	HMGN1	physical	11438671
KAP3_HUMAN	PRKAR2B	physical	28514442
KAP0_HUMAN	PRKAR1A	physical	28514442
AKAP5_HUMAN	AKAP5	physical	28514442
MYOME_HUMAN	PDE4DIP	physical	28514442
AKAP9_HUMAN	AKAP9	physical	28514442
AKA7A_HUMAN	AKAP7	physical	28514442
AKA7G_HUMAN	AKAP7	physical	28514442
AKAP1_HUMAN	AKAP1	physical	28514442
UBB_HUMAN	UBB	physical	28514442
NUCG_HUMAN	ENDOG	physical	28514442
TTC9C_HUMAN	TTC9C	physical	28514442
HSP7C_HUMAN	HSPA8	physical	28514442
KAP1_HUMAN	PRKAR1B	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 616176: Bleeding disorder, platelet-type 19 (BDPLT19)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.