STP2_HUMAN - dbPTM
STP2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID STP2_HUMAN
UniProt AC Q05952
Protein Name Nuclear transition protein 2
Gene Name TNP2
Organism Homo sapiens (Human).
Sequence Length 138
Subcellular Localization Nucleus . Chromosome . Loaded onto the nucleosomes of condensing spermatids (By similarity). Nuclear import is ATP-dependent and nucleolar localization requires the protein to be phosphorylated (By similarity).
Protein Description Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction..
Protein Sequence MDTQTHSLPITHTQLHSNSQPQSRTCTRHCQTFSQSCRQSHRGSRSQSSSQSPASHRNPTGAHSSSGHQSQSPNTSPPPKRHKKTMNSHHSPMRPTILHCRCPKNRKNLEGKLKKKKMAKRIQQVYKTKTRSSGWKSN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
17PhosphorylationITHTQLHSNSQPQSR
CCCCCCCCCCCCCCC
46.93-
76PhosphorylationQSQSPNTSPPPKRHK
CCCCCCCCCCCCCCC
41.8924719451
85PhosphorylationPPKRHKKTMNSHHSP
CCCCCCCCCCCCCCC
26.7927174698
88PhosphorylationRHKKTMNSHHSPMRP
CCCCCCCCCCCCCCC
16.2627174698
91PhosphorylationKTMNSHHSPMRPTIL
CCCCCCCCCCCCEEE
18.2427174698
133PhosphorylationYKTKTRSSGWKSN--
HHHHCCCCCCCCC--
45.44-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of STP2_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of STP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of STP2_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PARP2_HUMANPARP2physical
19607827
KR107_HUMANKRTAP10-7physical
25416956
KR109_HUMANKRTAP10-9physical
25416956
KR108_HUMANKRTAP10-8physical
25416956
KR103_HUMANKRTAP10-3physical
25416956
NT2NL_HUMANNOTCH2NLphysical
25416956

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of STP2_HUMAN

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Related Literatures of Post-Translational Modification

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