| UniProt ID | NUCG_HUMAN | |
|---|---|---|
| UniProt AC | Q14249 | |
| Protein Name | Endonuclease G, mitochondrial | |
| Gene Name | ENDOG | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 297 | |
| Subcellular Localization | Mitochondrion. | |
| Protein Description | Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA (By similarity).. | |
| Protein Sequence | MRALRAGLTLASGAGLGAVVEGWRRRREDARAAPGLLGRLPVLPVAAAAELPPVPGGPRGPGELAKYGLPGLAQLKSRESYVLCYDPRTRGALWVVEQLRPERLRGDGDRRECDFREDDSVHAYHRATNADYRGSGFDRGHLAAAANHRWSQKAMDDTFYLSNVAPQVPHLNQNAWNNLEKYSRSLTRSYQNVYVCTGPLFLPRTEADGKSYVKYQVIGKNHVAVPTHFFKVLILEAAGGQIELRTYVMPNAPVDEAIPLERFLVPIESIERASGLLFVPNILARAGSLKAITAGSK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | Phosphorylation | RALRAGLTLASGAGL CHHHHCCEECCCCCH | 21.25 | - | |
| 12 | Phosphorylation | RAGLTLASGAGLGAV HHCCEECCCCCHHHH | 32.08 | - | |
| 66 | Ubiquitination | RGPGELAKYGLPGLA CCHHHHHHHCCCCCE | 53.10 | 21906983 | |
| 67 | Phosphorylation | GPGELAKYGLPGLAQ CHHHHHHHCCCCCEE | 20.49 | 29496907 | |
| 76 | Ubiquitination | LPGLAQLKSRESYVL CCCCEECCCCCEEEE | 35.07 | 21906983 | |
| 153 | Ubiquitination | ANHRWSQKAMDDTFY HHCCHHHHHCCCCEE | 39.91 | 21906983 | |
| 181 | Ubiquitination | NAWNNLEKYSRSLTR HHHHHHHHHHHHHHH | 52.25 | 21906983 | |
| 210 | Ubiquitination | PRTEADGKSYVKYQV CCCCCCCCEEEEEEE | 38.88 | 21906983 | |
| 211 | Phosphorylation | RTEADGKSYVKYQVI CCCCCCCEEEEEEEE | 40.46 | 29496907 | |
| 214 | Ubiquitination | ADGKSYVKYQVIGKN CCCCEEEEEEEECCC | 23.02 | 21906983 | |
| 220 | Ubiquitination | VKYQVIGKNHVAVPT EEEEEECCCCEECCC | 32.53 | - | |
| 274 | Phosphorylation | IESIERASGLLFVPN HHHHHHHHCCCHHHH | 35.87 | 20068231 | |
| 288 | Phosphorylation | NILARAGSLKAITAG HHHHHHCCCEEHHCC | 26.22 | 20068231 | |
| 290 | Ubiquitination | LARAGSLKAITAGSK HHHHCCCEEHHCCCC | 39.17 | 21906983 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NUCG_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NUCG_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NUCG_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| AIFM1_HUMAN | AIFM1 | physical | 16133872 | |
| HSP74_HUMAN | HSPA4 | physical | 16133872 | |
| FEN1_HUMAN | FEN1 | physical | 16133872 | |
| HSP74_HUMAN | HSPA4 | physical | 23764847 | |
| CHIP_HUMAN | STUB1 | physical | 23764847 | |
| BIRC2_HUMAN | BIRC2 | physical | 25139236 | |
| DKC1_HUMAN | DKC1 | physical | 26344197 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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