| UniProt ID | BIRC2_HUMAN | |
|---|---|---|
| UniProt AC | Q13490 | |
| Protein Name | Baculoviral IAP repeat-containing protein 2 | |
| Gene Name | BIRC2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 618 | |
| Subcellular Localization | Cytoplasm. Nucleus. Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in | |
| Protein Description | Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.. | |
| Protein Sequence | MHKTASQRLFPGPSYQNIKSIMEDSTILSDWTNSNKQKMKYDFSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCSFIQNLVSASLGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTNPYSYAMSTEEARFLTYHMWPLTFLSPSELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLETLRFSISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQTVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQIPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVVCQECAPSLRKCPICRGIIKGTVRTFLS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | O-linked_Glycosylation | ----MHKTASQRLFP ----CCCCHHHHCCC | 19.50 | 30379171 | |
| 15 | Phosphorylation | RLFPGPSYQNIKSIM HCCCCCCHHHHHHHH | 14.54 | 28152594 | |
| 19 | Ubiquitination | GPSYQNIKSIMEDST CCCHHHHHHHHHCCC | 41.29 | 21906983 | |
| 36 | Ubiquitination | SDWTNSNKQKMKYDF CCCCCCCCCCCCEEE | 51.63 | 23000965 | |
| 36 | Ubiquitination | SDWTNSNKQKMKYDF CCCCCCCCCCCCEEE | 51.63 | 21890473 | |
| 38 | Ubiquitination | WTNSNKQKMKYDFSC CCCCCCCCCCEEEEE | 38.68 | 23000965 | |
| 40 | Ubiquitination | NSNKQKMKYDFSCEL CCCCCCCCEEEEEEE | 49.02 | 21890473 | |
| 40 | Ubiquitination | NSNKQKMKYDFSCEL CCCCCCCCEEEEEEE | 49.02 | 23000965 | |
| 53 | Ubiquitination | ELYRMSTYSTFPAGV EEEEECCCCCCCCCC | 9.82 | 27667366 | |
| 74 | Phosphorylation | LARAGFYYTGVNDKV HHHCCCEECCCCCCE | 8.51 | 27067055 | |
| 75 | Phosphorylation | ARAGFYYTGVNDKVK HHCCCEECCCCCCEE | 24.23 | 27067055 | |
| 77 | Ubiquitination | AGFYYTGVNDKVKCF CCCEECCCCCCEEEE | 6.89 | 21890473 | |
| 80 | Ubiquitination | YYTGVNDKVKCFCCG EECCCCCCEEEEECC | 38.09 | - | |
| 94 | Ubiquitination | GLMLDNWKLGDSPIQ CCEECCCCCCCCHHH | 49.17 | - | |
| 98 | Phosphorylation | DNWKLGDSPIQKHKQ CCCCCCCCHHHHCHH | 23.31 | 22199227 | |
| 102 | Ubiquitination | LGDSPIQKHKQLYPS CCCCHHHHCHHHCCC | 54.19 | 27667366 | |
| 118 | Phosphorylation | SFIQNLVSASLGSTS HHHHHHHHHHCCCCC | 18.46 | 28450419 | |
| 120 | Phosphorylation | IQNLVSASLGSTSKN HHHHHHHHCCCCCCC | 26.25 | 28450419 | |
| 123 | Phosphorylation | LVSASLGSTSKNTSP HHHHHCCCCCCCCCC | 34.50 | 28450419 | |
| 124 | Phosphorylation | VSASLGSTSKNTSPM HHHHCCCCCCCCCCC | 41.75 | 28450419 | |
| 125 | Phosphorylation | SASLGSTSKNTSPMR HHHCCCCCCCCCCCC | 26.13 | 28450419 | |
| 126 | Ubiquitination | ASLGSTSKNTSPMRN HHCCCCCCCCCCCCH | 65.42 | 21963094 | |
| 126 | Ubiquitination | ASLGSTSKNTSPMRN HHCCCCCCCCCCCCH | 65.42 | 21890473 | |
| 134 | Phosphorylation | NTSPMRNSFAHSLSP CCCCCCHHCHHHCCC | 17.28 | 28464451 | |
| 138 | Phosphorylation | MRNSFAHSLSPTLEH CCHHCHHHCCCCCCC | 27.41 | 28464451 | |
| 140 | Phosphorylation | NSFAHSLSPTLEHSS HHCHHHCCCCCCCCC | 20.89 | 26055452 | |
| 142 | Phosphorylation | FAHSLSPTLEHSSLF CHHHCCCCCCCCCCC | 41.21 | 28464451 | |
| 146 | Phosphorylation | LSPTLEHSSLFSGSY CCCCCCCCCCCCCCC | 21.25 | 28450419 | |
| 147 | Phosphorylation | SPTLEHSSLFSGSYS CCCCCCCCCCCCCCC | 35.03 | 28450419 | |
| 150 | Phosphorylation | LEHSSLFSGSYSSLS CCCCCCCCCCCCCCC | 31.93 | 28450419 | |
| 152 | Phosphorylation | HSSLFSGSYSSLSPN CCCCCCCCCCCCCCC | 22.20 | 28450419 | |
| 153 | Phosphorylation | SSLFSGSYSSLSPNP CCCCCCCCCCCCCCC | 13.05 | 28450419 | |
| 154 | Phosphorylation | SLFSGSYSSLSPNPL CCCCCCCCCCCCCCC | 26.88 | 28450419 | |
| 155 | Phosphorylation | LFSGSYSSLSPNPLN CCCCCCCCCCCCCCC | 25.32 | 28450419 | |
| 157 | Phosphorylation | SGSYSSLSPNPLNSR CCCCCCCCCCCCCCC | 25.28 | 28450419 | |
| 163 | Phosphorylation | LSPNPLNSRAVEDIS CCCCCCCCCHHCHHH | 29.33 | 23090842 | |
| 170 | Phosphorylation | SRAVEDISSSRTNPY CCHHCHHHCCCCCCC | 34.28 | 24905233 | |
| 171 | Phosphorylation | RAVEDISSSRTNPYS CHHCHHHCCCCCCCC | 24.95 | 27251275 | |
| 172 | Phosphorylation | AVEDISSSRTNPYSY HHCHHHCCCCCCCCC | 36.01 | 24905233 | |
| 177 | Ubiquitination | SSSRTNPYSYAMSTE HCCCCCCCCCCCCHH | 19.18 | 21890473 | |
| 177 | Phosphorylation | SSSRTNPYSYAMSTE HCCCCCCCCCCCCHH | 19.18 | 27642862 | |
| 178 | O-linked_Glycosylation | SSRTNPYSYAMSTEE CCCCCCCCCCCCHHH | 13.99 | 30379171 | |
| 184 | Ubiquitination | YSYAMSTEEARFLTY CCCCCCHHHHHHHHE | 42.21 | 33845483 | |
| 210 | Phosphorylation | ELARAGFYYIGPGDR HHHHCCCEEECCCCC | 8.02 | 28152594 | |
| 211 | Phosphorylation | LARAGFYYIGPGDRV HHHCCCEEECCCCCE | 9.35 | 28152594 | |
| 226 | Ubiquitination | ACFACGGKLSNWEPK EEEECCCCCCCCCCC | 33.74 | 21890473 | |
| 226 | Ubiquitination | ACFACGGKLSNWEPK EEEECCCCCCCCCCC | 33.74 | 2266 | |
| 233 | Ubiquitination | KLSNWEPKDDAMSEH CCCCCCCCCCHHHHH | 57.64 | 21906983 | |
| 233 | Ubiquitination | KLSNWEPKDDAMSEH CCCCCCCCCCHHHHH | 57.64 | 21890473 | |
| 253 | Phosphorylation | NCPFLENSLETLRFS CCHHHHCHHHHHHHH | 20.43 | 28188228 | |
| 256 | Phosphorylation | FLENSLETLRFSISN HHHCHHHHHHHHHHH | 28.64 | 28450419 | |
| 256 | Ubiquitination | FLENSLETLRFSISN HHHCHHHHHHHHHHH | 28.64 | 33845483 | |
| 260 | Phosphorylation | SLETLRFSISNLSMQ HHHHHHHHHHHHHHH | 20.76 | 27080861 | |
| 262 | Phosphorylation | ETLRFSISNLSMQTH HHHHHHHHHHHHHHC | 30.44 | 27080861 | |
| 265 | Phosphorylation | RFSISNLSMQTHAAR HHHHHHHHHHHCHHH | 17.07 | 27080861 | |
| 291 | Ubiquitination | PVQPEQLASAGFYYV CCCHHHHHHCCEEEE | 9.31 | 22817900 | |
| 305 | Ubiquitination | VGRNDDVKCFCCDGG ECCCCCCCEEEECCC | 28.70 | 33845483 | |
| 340 | Ubiquitination | CEFLIRMKGQEFVDE CCEEEEECCHHHHHH | 47.82 | 21906983 | |
| 361 | Ubiquitination | HLLEQLLSTSDTTGE HHHHHHHCCCCCCCC | 34.16 | 22817900 | |
| 367 | Ubiquitination | LSTSDTTGEENADPP HCCCCCCCCCCCCCC | 42.17 | 21890473 | |
| 376 | Ubiquitination | ENADPPIIHFGPGES CCCCCCEEECCCCCC | 2.44 | 21890473 | |
| 392 | Ubiquitination | SEDAVMMNTPVVKSA HHCCHHHCCHHHHHH | 24.12 | 21963094 | |
| 397 | Ubiquitination | MMNTPVVKSALEMGF HHCCHHHHHHHHCCC | 30.19 | 22817900 | |
| 399 | Ubiquitination | NTPVVKSALEMGFNR CCHHHHHHHHCCCCH | 11.21 | 29901268 | |
| 410 | Ubiquitination | GFNRDLVKQTVQSKI CCCHHHHHHHHHHHH | 47.77 | 21906983 | |
| 416 | Ubiquitination | VKQTVQSKILTTGEN HHHHHHHHHCCCCCC | 25.33 | 21890473 | |
| 416 | Ubiquitination | VKQTVQSKILTTGEN HHHHHHHHHCCCCCC | 25.33 | 21890473 | |
| 425 | Ubiquitination | LTTGENYKTVNDIVS CCCCCCCCCHHHHHH | 58.54 | 22817900 | |
| 425 | Ubiquitination | LTTGENYKTVNDIVS CCCCCCCCCHHHHHH | 58.54 | 21890473 | |
| 441 | Ubiquitination | LLNAEDEKREEEKEK HHCCHHHHHHHHHHH | 76.93 | 21963094 | |
| 446 | Ubiquitination | DEKREEEKEKQAEEM HHHHHHHHHHHHHHH | 73.77 | 21906983 | |
| 448 | Ubiquitination | KREEEKEKQAEEMAS HHHHHHHHHHHHHHH | 66.91 | 21906983 | |
| 450 | Ubiquitination | EEEKEKQAEEMASDD HHHHHHHHHHHHHHH | 26.28 | 23503661 | |
| 459 | Phosphorylation | EMASDDLSLIRKNRM HHHHHHHHHHHHHHH | 28.84 | 24719451 | |
| 480 | Ubiquitination | TCVLPILDNLLKANV HHHHHHHHHHHHHCC | 44.44 | 29967540 | |
| 488 | Ubiquitination | NLLKANVINKQEHDI HHHHHCCCCHHHHHH | 5.52 | 21890473 | |
| 490 | Ubiquitination | LKANVINKQEHDIIK HHHCCCCHHHHHHHH | 46.03 | 33845483 | |
| 494 | Ubiquitination | VINKQEHDIIKQKTQ CCCHHHHHHHHHCCC | 43.48 | 23503661 | |
| 497 | Ubiquitination | KQEHDIIKQKTQIPL HHHHHHHHHCCCCCH | 46.18 | 23503661 | |
| 499 | Ubiquitination | EHDIIKQKTQIPLQA HHHHHHHCCCCCHHH | 37.08 | 23503661 | |
| 516 | Ubiquitination | LIDTILVKGNAAANI HHHHHHHCCHHHHHH | 42.90 | - | |
| 529 | Ubiquitination | NIFKNCLKEIDSTLY HHHHHHHHHCHHHHH | 55.62 | 29967540 | |
| 537 | Ubiquitination | EIDSTLYKNLFVDKN HCHHHHHHHHCCCCC | 50.73 | 21890473 | |
| 537 | Ubiquitination | EIDSTLYKNLFVDKN HCHHHHHHHHCCCCC | 50.73 | 21906983 | |
| 543 | Ubiquitination | YKNLFVDKNMKYIPT HHHHCCCCCCCCCCC | 54.35 | 23503661 | |
| 546 | Ubiquitination | LFVDKNMKYIPTEDV HCCCCCCCCCCCCCC | 49.80 | 23503661 | |
| 550 | Phosphorylation | KNMKYIPTEDVSGLS CCCCCCCCCCCCCCC | 34.95 | 28122231 | |
| 554 | Phosphorylation | YIPTEDVSGLSLEEQ CCCCCCCCCCCHHHH | 46.46 | 30087585 | |
| 557 | Phosphorylation | TEDVSGLSLEEQLRR CCCCCCCCHHHHHHH | 36.94 | 28102081 | |
| 580 | Phosphorylation | VCMDKEVSVVFIPCG HHCCCCEEEEEEECC | 17.41 | 27251275 | |
| 610 | Ubiquitination | PICRGIIKGTVRTFL CCCCHHCCHHHHHHC | 46.76 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| - | K | Ubiquitination | E3 ubiquitin ligase | FBXO7 | Q9Y3I1 | PMID:16510124 |
| - | K | Ubiquitination | E3 ubiquitin ligase | BIRC2 | Q13490 | PMID:18939944 |
| - | K | Ubiquitination | E3 ubiquitin ligase | FBXW7 | Q969H0 | PMID:16510124 |
| - | K | Ubiquitination | E3 ubiquitin ligase | ITCH | Q96J02 | PMID:23109427 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BIRC2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BIRC2_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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