GNAZ_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GNAZ_HUMAN
• UniProt AC: P19086
• Protein Name: Guanine nucleotide-binding protein G(z) subunit alpha
• Gene Name: GNAZ
• Organism: Homo sapiens (Human).
• Sequence Length: 355
• Subcellular Localization: Membrane; Lipid-anchor.
• Protein Description: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems..
• Protein Sequence: MGCRQSSEEKEAARRSRRIDRHLRSESQRQRREIKLLLLGTSNSGKSTIVKQMKIIHSGGFNLEACKEYKPLIIYNAIDSLTRIIRALAALRIDFHNPDRAYDAVQLFALTGPAESKGEITPELLGVMRRLWADPGAQACFSRSSEYHLEDNAAYYLNDLERIAAADYIPTVEDILRSRDMTTGIVENKFTFKELTFKMVDVGGQRSERKKWIHCFEGVTAIIFCVELSGYDLKLYEDNQTSRMAESLRLFDSICNNNWFINTSLILFLNKKDLLAEKIRRIPLTICFPEYKGQNTYEEAAVYIQRQFEDLNRNKETKEIYSHFTCATDTSNIQFVFDAVTDVIIQNNLKYIGLC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	N-myristoyl glycine	------MGCRQSSEE ------CCCCCCHHH	18.47	-
2	Myristoylation	------MGCRQSSEE ------CCCCCCHHH	18.47	-
3	S-palmitoylation	-----MGCRQSSEEK -----CCCCCCHHHH	3.27	-
16	Phosphorylation	EKEAARRSRRIDRHL HHHHHHHHHHHHHHH	21.98	9166747
27	Phosphorylation	DRHLRSESQRQRREI HHHHHCHHHHHHHHH	31.73	9166747
41	Phosphorylation	IKLLLLGTSNSGKST HEEEEEECCCCCCCH	25.38	18785766
42	Phosphorylation	KLLLLGTSNSGKSTI EEEEEECCCCCCCHH	27.48	29083192
44	Phosphorylation	LLLGTSNSGKSTIVK EEEECCCCCCCHHHE	47.57	29083192
51	Ubiquitination	SGKSTIVKQMKIIHS CCCCHHHEEEEEEEC	40.60	21906983
142	Phosphorylation	PGAQACFSRSSEYHL CCHHHHCCCCCCEEC	31.01	-
179	ADP-ribosylation	VEDILRSRDMTTGIV HHHHHHCCCCCCCCC	31.14	-
179	ADP-ribosylation	VEDILRSRDMTTGIV HHHHHHCCCCCCCCC	31.14	-
182	Phosphorylation	ILRSRDMTTGIVENK HHHCCCCCCCCCCCC	26.59	25332170
183	Phosphorylation	LRSRDMTTGIVENKF HHCCCCCCCCCCCCE	20.48	25332170
189	Ubiquitination	TTGIVENKFTFKELT CCCCCCCCEEECEEE	32.07	21890473
229	Phosphorylation	IIFCVELSGYDLKLY EEEEEEECCCCEEEE	23.08	-
231	Phosphorylation	FCVELSGYDLKLYED EEEEECCCCEEEECC	18.09	-
263	Phosphorylation	NNNWFINTSLILFLN CCCCEECHHHEEHHC	21.79	-
264	Phosphorylation	NNWFINTSLILFLNK CCCEECHHHEEHHCH	14.66	-
341	Phosphorylation	QFVFDAVTDVIIQNN CEEHHHHHHHHHHCC	26.69	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
16	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
16	S	Phosphorylation	Kinase	PAK1	Q13153	PSP
16	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
16	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
27	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
27	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
27	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GNAZ_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GNAZ_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RGS20_HUMAN	RGS20	physical	12414994
RGS10_HUMAN	RGS10	physical	8774883
EYA2_HUMAN	EYA2	physical	10906137
RGS19_HUMAN	RGS19	physical	10906137
RPGP1_HUMAN	RAP1GAP	physical	10593970
A4_HUMAN	APP	physical	21832049
GNAZ_HUMAN	GNAZ	physical	25416956
DAAM1_HUMAN	DAAM1	physical	26186194
MTHR_HUMAN	MTHFR	physical	26186194
GDS1_HUMAN	RAP1GDS1	physical	26186194
GLMP_HUMAN	C1orf85	physical	26186194
VPP1_HUMAN	ATP6V0A1	physical	26186194
THOC7_HUMAN	THOC7	physical	26186194
TBB8_HUMAN	TUBB8	physical	26186194
RN123_HUMAN	RNF123	physical	26186194
EPHA4_HUMAN	EPHA4	physical	26186194
APOL2_HUMAN	APOL2	physical	26186194
DCA10_HUMAN	DCAF10	physical	26186194
F1712_HUMAN	FAM171A2	physical	26186194
MTHR_HUMAN	MTHFR	physical	28514442
EPHA4_HUMAN	EPHA4	physical	28514442
GLMP_HUMAN	C1orf85	physical	28514442
DAAM1_HUMAN	DAAM1	physical	28514442
F1712_HUMAN	FAM171A2	physical	28514442
DCA10_HUMAN	DCAF10	physical	28514442
DMWD_HUMAN	DMWD	physical	28514442
RN123_HUMAN	RNF123	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.