DAAM1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DAAM1_HUMAN
• UniProt AC: Q9Y4D1
• Protein Name: Disheveled-associated activator of morphogenesis 1
• Gene Name: DAAM1
• Organism: Homo sapiens (Human).
• Sequence Length: 1078
• Subcellular Localization: Cytoplasm . Cytoplasm, cytoskeleton, cilium basal body . Perinuclear.
• Protein Description: Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia. [PubMed: 16630611]
• Protein Sequence: MAPRKRGGRGISFIFCCFRNNDHPEITYRLRNDSNFALQTMEPALPMPPVEELDVMFSELVDELDLTDKHREAMFALPAEKKWQIYCSKKKDQEENKGATSWPEFYIDQLNSMAARKSLLALEKEEEEERSKTIESLKTALRTKPMRFVTRFIDLDGLSCILNFLKTMDYETSESRIHTSLIGCIKALMNNSQGRAHVLAHSESINVIAQSLSTENIKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQKYASERTRFQTLINDLDKSTGRYRDEVSLKTAIMSFINAVLSQGAGVESLDFRLHLRYEFLMLGIQPVIDKLREHENSTLDRHLDFFEMLRNEDELEFAKRFELVHIDTKSATQMFELTRKRLTHSEAYPHFMSILHHCLQMPYKRSGNTVQYWLLLDRIIQQIVIQNDKGQDPDSTPLENFNIKNVVRMLVNENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKMKEKLEKETTEHKQVKQQVADLTAQLHELSRRAVCASIPGGPSPGAPGGPFPSSVPGSLLPPPPPPPLPGGMLPPPPPPLPPGGPPPPPGPPPLGAIMPPPGAPMGLALKKKSIPQPTNALKSFNWSKLPENKLEGTVWTEIDDTKVFKILDLEDLERTFSAYQRQQDFFVNSNSKQKEADAIDDTLSSKLKVKELSVIDGRRAQNCNILLSRLKLSNDEIKRAILTMDEQEDLPKDMLEQLLKFVPEKSDIDLLEEHKHELDRMAKADRFLFEMSRINHYQQRLQSLYFKKKFAERVAEVKPKVEAIRSGSEEVFRSGALKQLLEVVLAFGNYMNKGQRGNAYGFKISSLNKIADTKSSIDKNITLLHYLITIVENKYPSVLNLNEELRDIPQAAKVNMTELDKEISTLRSGLKAVETELEYQKSQPPQPGDKFVSVVSQFITVASFSFSDVEDLLAEAKDLFTKAVKHFGEEAGKIQPDEFFGIFDQFLQAVSEAKQENENMRKKKEEEERRARMEAQLKEQRERERKMRKAKENSEESGEFDDLVSALRSGEVFDKDLSKLKRNRKRITNQMTDSSRERPITKLNF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Methylation	APRKRGGRGISFIFC CCCCCCCCCEEEEEE	41.94	-
12	Phosphorylation	KRGGRGISFIFCCFR CCCCCCEEEEEEEEC	18.34	-
27	Phosphorylation	NNDHPEITYRLRNDS CCCCCCEEEEECCCC	10.83	-
28	Phosphorylation	NDHPEITYRLRNDSN CCCCCEEEEECCCCC	17.20	-
34	Phosphorylation	TYRLRNDSNFALQTM EEEECCCCCCEECCC	37.08	22817900
97	Ubiquitination	KKDQEENKGATSWPE CCCCCCCCCCCCCCH	53.88	29967540
100	Phosphorylation	QEENKGATSWPEFYI CCCCCCCCCCCHHHH	39.74	26074081
101	Phosphorylation	EENKGATSWPEFYID CCCCCCCCCCHHHHH	39.85	26074081
106	Phosphorylation	ATSWPEFYIDQLNSM CCCCCHHHHHHHHHH	11.26	26074081
112	Phosphorylation	FYIDQLNSMAARKSL HHHHHHHHHHHHHHH	20.56	26074081
118	Phosphorylation	NSMAARKSLLALEKE HHHHHHHHHHHHHHH	24.06	26074081
124	Ubiquitination	KSLLALEKEEEEERS HHHHHHHHHHHHHHH	71.87	22817900
131	Phosphorylation	KEEEEERSKTIESLK HHHHHHHHHHHHHHH	37.11	23312004
132	Ubiquitination	EEEEERSKTIESLKT HHHHHHHHHHHHHHH	60.80	29967540
186	Acetylation	TSLIGCIKALMNNSQ HHHHHHHHHHHCCCC	39.27	-
247	Phosphorylation	VLQAMLHYQKYASER HHHHHHHHHHHHCHH	11.62	29978859
255	Phosphorylation	QKYASERTRFQTLIN HHHHCHHHHHHHHHH	31.61	-
259	Phosphorylation	SERTRFQTLINDLDK CHHHHHHHHHHHHHH	27.22	-
266	Ubiquitination	TLINDLDKSTGRYRD HHHHHHHHCCCCCCC	58.16	24816145
271	Phosphorylation	LDKSTGRYRDEVSLK HHHCCCCCCCHHHHH	24.62	24719451
297	Phosphorylation	SQGAGVESLDFRLHL HCCCCCCCCCEEHHH	30.72	24719451
326	Phosphorylation	KLREHENSTLDRHLD HHHHCCCCHHHHHHH	27.62	28270605
327	Phosphorylation	LREHENSTLDRHLDF HHHCCCCHHHHHHHH	44.23	28270605
359	Phosphorylation	LVHIDTKSATQMFEL EEEEECCCHHHHHHH	38.34	29759185
361	Phosphorylation	HIDTKSATQMFELTR EEECCCHHHHHHHHH	27.88	29759185
367	Phosphorylation	ATQMFELTRKRLTHS HHHHHHHHHHHCCCC	27.26	29759185
395	Phosphorylation	LQMPYKRSGNTVQYW HCCCCCCCCCHHHHH	32.04	30108239
398	Phosphorylation	PYKRSGNTVQYWLLL CCCCCCCHHHHHHHH	16.71	30108239
401	Phosphorylation	RSGNTVQYWLLLDRI CCCCHHHHHHHHHHH	8.16	30108239
425	Phosphorylation	KGQDPDSTPLENFNI CCCCCCCCCCCCCCH	38.99	21815630
433	Ubiquitination	PLENFNIKNVVRMLV CCCCCCHHHHHHHHH	44.81	29967540
476	Acetylation	KERECDAKTQEKEEM HHHHHHHHHHHHHHH	37.17	7681457
489	Acetylation	EMMQTLNKMKEKLEK HHHHHHHHHHHHHHH	55.23	7681467
491	Acetylation	MQTLNKMKEKLEKET HHHHHHHHHHHHHHH	53.99	19666683
499	Phosphorylation	EKLEKETTEHKQVKQ HHHHHHHHHHHHHHH	36.86	-
638	Ubiquitination	IDDTKVFKILDLEDL ECCCEEEEEEEHHHH	45.40	29967540
652	Phosphorylation	LERTFSAYQRQQDFF HHHHHHHHHHHHHHC	11.75	-
657	Ubiquitination	SAYQRQQDFFVNSNS HHHHHHHHHCCCCCC	30.52	29967540
665 (in isoform 2)	Phosphorylation	-	70.42	25849741
669	Ubiquitination	SNSKQKEADAIDDTL CCCCHHHHHHCCHHH	20.69	29967540
675	Phosphorylation	EADAIDDTLSSKLKV HHHHCCHHHHHHCCE	25.45	30576142
677	Phosphorylation	DAIDDTLSSKLKVKE HHCCHHHHHHCCEEE	27.76	29514088
678	Phosphorylation	AIDDTLSSKLKVKEL HCCHHHHHHCCEEEE	45.15	29514088
679	Ubiquitination	IDDTLSSKLKVKELS CCHHHHHHCCEEEEE	49.29	-
686	Phosphorylation	KLKVKELSVIDGRRA HCCEEEEEEECCCHH	20.37	23403867
738	Ubiquitination	LLKFVPEKSDIDLLE HHHHCCCCCCCCHHH	47.56	29967540
748	Ubiquitination	IDLLEEHKHELDRMA CCHHHHCHHHHHHHH	41.89	29967540
776	Phosphorylation	HYQQRLQSLYFKKKF HHHHHHHHHHHHHHH	29.63	27251275
799	Phosphorylation	PKVEAIRSGSEEVFR CCHHHHHCCCHHHHH	40.32	-
801	Phosphorylation	VEAIRSGSEEVFRSG HHHHHCCCHHHHHCC	31.65	-
832	Ubiquitination	NKGQRGNAYGFKISS CCCCCCCCCCCCHHH	14.51	29967540
833	Phosphorylation	KGQRGNAYGFKISSL CCCCCCCCCCCHHHH	27.39	-
839	Phosphorylation	AYGFKISSLNKIADT CCCCCHHHHHHHHCC	39.16	23403867
842	Ubiquitination	FKISSLNKIADTKSS CCHHHHHHHHCCCCC	44.56	29967540
846	Phosphorylation	SLNKIADTKSSIDKN HHHHHHCCCCCCCCH	24.65	23403867
897	Phosphorylation	TELDKEISTLRSGLK HHHHHHHHHHHHHHH	23.60	24719451
898	Phosphorylation	ELDKEISTLRSGLKA HHHHHHHHHHHHHHH	31.67	22210691
912	Phosphorylation	AVETELEYQKSQPPQ HHHHHHHHHCCCCCC	33.59	25884760
1027	Phosphorylation	MRKAKENSEESGEFD HHHHHHCHHHCCCHH	43.78	24972180
1030	Phosphorylation	AKENSEESGEFDDLV HHHCHHHCCCHHHHH	39.30	29116813
1051	Phosphorylation	EVFDKDLSKLKRNRK CCCCHHHHHHHHHHH	46.18	27535140
1061	Phosphorylation	KRNRKRITNQMTDSS HHHHHHHHHCCCCCC	24.35	25278378
1065	Phosphorylation	KRITNQMTDSSRERP HHHHHCCCCCCCCCC	23.98	25278378
1067	Phosphorylation	ITNQMTDSSRERPIT HHHCCCCCCCCCCCC	23.33	27535140
1068	Phosphorylation	TNQMTDSSRERPITK HHCCCCCCCCCCCCC	40.76	25278378
1074	Phosphorylation	SSRERPITKLNF--- CCCCCCCCCCCC---	31.96	25278378

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
652	Y	Phosphorylation	Kinase	SRC	P12931	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DAAM1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DAAM1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of DAAM1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.