APOL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: APOL2_HUMAN
• UniProt AC: Q9BQE5
• Protein Name: Apolipoprotein L2
• Gene Name: APOL2
• Organism: Homo sapiens (Human).
• Sequence Length: 337
• Subcellular Localization: Cytoplasm .
• Protein Description: May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles..
• Protein Sequence: MNPESSIFIEDYLKYFQDQVSRENLLQLLTDDEAWNGFVAAAELPRDEADELRKALNKLASHMVMKDKNRHDKDQQHRQWFLKEFPRLKRELEDHIRKLRALAEEVEQVHRGTTIANVVSNSVGTTSGILTLLGLGLAPFTEGISFVLLDTGMGLGAAAAVAGITCSVVELVNKLRARAQARNLDQSGTNVAKVMKEFVGGNTPNVLTLVDNWYQVTQGIGRNIRAIRRARANPQLGAYAPPPHIIGRISAEGGEQVERVVEGPAQAMSRGTMIVGAATGGILLLLDVVSLAYESKHLLEGAKSESAEELKKRAQELEGKLNFLTKIHEMLQPGQDQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MNPESSIF -------CCHHHHHC	19.94	-
58	Ubiquitination	ELRKALNKLASHMVM HHHHHHHHHHHHHHH	46.40	-
66	Ubiquitination	LASHMVMKDKNRHDK HHHHHHHCCCCCCCH	54.89	-
73	Methylation	KDKNRHDKDQQHRQW CCCCCCCHHHHHHHH	51.84	-
83	Ubiquitination	QHRQWFLKEFPRLKR HHHHHHHHHCHHHHH	48.08	21890473
187	Phosphorylation	QARNLDQSGTNVAKV HHCCCCCCCCHHHHH	47.45	28857561
193	Ubiquitination	QSGTNVAKVMKEFVG CCCCHHHHHHHHHHC	38.28	21890473
196	Ubiquitination	TNVAKVMKEFVGGNT CHHHHHHHHHHCCCC	51.49	-
203	Phosphorylation	KEFVGGNTPNVLTLV HHHHCCCCCCCEEHH	21.37	27251275
239	Phosphorylation	ANPQLGAYAPPPHII CCCCCCCCCCCCCEE	20.17	-
250	Phosphorylation	PHIIGRISAEGGEQV CCEEEEEECCCCCCE	20.93	25159151
268	Sulfoxidation	VEGPAQAMSRGTMIV HCCHHHHHHCCCEEE	1.54	21406390
269	Phosphorylation	EGPAQAMSRGTMIVG CCHHHHHHCCCEEEE	30.49	20071362
272	Phosphorylation	AQAMSRGTMIVGAAT HHHHHCCCEEEEECH	11.56	22210691
279	Phosphorylation	TMIVGAATGGILLLL CEEEEECHHHHHHHH	35.09	22210691
303	Ubiquitination	KHLLEGAKSESAEEL HHHHCCCCCCCHHHH	66.66	-
303	Acetylation	KHLLEGAKSESAEEL HHHHCCCCCCCHHHH	66.66	23236377
304	Phosphorylation	HLLEGAKSESAEELK HHHCCCCCCCHHHHH	35.93	22210691
306	Phosphorylation	LEGAKSESAEELKKR HCCCCCCCHHHHHHH	48.33	22210691
320	2-Hydroxyisobutyrylation	RAQELEGKLNFLTKI HHHHHHHHHHHHHHH	30.77	-
320	Ubiquitination	RAQELEGKLNFLTKI HHHHHHHHHHHHHHH	30.77	21890473
326	Ubiquitination	GKLNFLTKIHEMLQP HHHHHHHHHHHHHCC	44.18	21890473
330	Sulfoxidation	FLTKIHEMLQPGQDQ HHHHHHHHHCCCCCC	2.32	21406390

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of APOL2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of APOL2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of APOL2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBB_HUMAN	UBB	physical	26186194
BASI_HUMAN	BSG	physical	26496610
UBL4A_HUMAN	UBL4A	physical	26496610
RTL8C_HUMAN	FAM127A	physical	26496610
MAST3_HUMAN	MAST3	physical	26496610
RT09_HUMAN	MRPS9	physical	26496610
BPNT1_HUMAN	BPNT1	physical	28514442
UBB_HUMAN	UBB	physical	28514442
SODC_HUMAN	SOD1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-250, AND MASSSPECTROMETRY.
PubMed: 18669648

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-250, AND MASSSPECTROMETRY.
PubMed: 18691976

"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-250, AND MASSSPECTROMETRY.
PubMed: 19007248