dbPTM

SODC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SODC_HUMAN
UniProt AC	P00441
Protein Name	Superoxide dismutase [Cu-Zn]
Gene Name	SOD1
Organism	Homo sapiens (Human).
Sequence Length	154
Subcellular Localization	Cytoplasm . Mitochondrion . Nucleus . Predominantly cytoplasmic the pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria.
Protein Description	Destroys radicals which are normally produced within the cells and which are toxic to biological systems..
Protein Sequence	MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATKAVCVL ------CCCEEEEEE	20.15	25944712
3	Phosphorylation	-----MATKAVCVLK -----CCCEEEEEEC	20.45	19299510
4	Succinylation	----MATKAVCVLKG ----CCCEEEEEECC	29.32	-
4	Ubiquitination	----MATKAVCVLKG ----CCCEEEEEECC	29.32	-
4	Glycation	----MATKAVCVLKG ----CCCEEEEEECC	29.32	-
4	2-Hydroxyisobutyrylation	----MATKAVCVLKG ----CCCEEEEEECC	29.32	-
4	Succinylation	----MATKAVCVLKG ----CCCEEEEEECC	29.32	-
4	Acetylation	----MATKAVCVLKG ----CCCEEEEEECC	29.32	25953088
7	S-nitrosocysteine	-MATKAVCVLKGDGP -CCCEEEEEECCCCC	3.38	-
7	Glutathionylation	-MATKAVCVLKGDGP -CCCEEEEEECCCCC	3.38	22555962
7	S-nitrosylation	-MATKAVCVLKGDGP -CCCEEEEEECCCCC	3.38	19483679
7	S-palmitoylation	-MATKAVCVLKGDGP -CCCEEEEEECCCCC	3.38	23760509
10	Succinylation	TKAVCVLKGDGPVQG CEEEEEECCCCCEEE	34.26	23954790
10	Ubiquitination	TKAVCVLKGDGPVQG CEEEEEECCCCCEEE	34.26	21890473
10	2-Hydroxyisobutyrylation	TKAVCVLKGDGPVQG CEEEEEECCCCCEEE	34.26	-
10	Glycation	TKAVCVLKGDGPVQG CEEEEEECCCCCEEE	34.26	-
10	Succinylation	TKAVCVLKGDGPVQG CEEEEEECCCCCEEE	34.26	-
10	Acetylation	TKAVCVLKGDGPVQG CEEEEEECCCCCEEE	34.26	23954790
24	Ubiquitination	GIINFEQKESNGPVK EEEEEEECCCCCCEE	56.78	-
24	Acetylation	GIINFEQKESNGPVK EEEEEEECCCCCCEE	56.78	23236377
26	Phosphorylation	INFEQKESNGPVKVW EEEEECCCCCCEEEE	54.87	26437602
31	Ubiquitination	KESNGPVKVWGSIKG CCCCCCEEEEEEEEC	35.09	21890473
31	Glycation	KESNGPVKVWGSIKG CCCCCCEEEEEEEEC	35.09	-
35	Phosphorylation	GPVKVWGSIKGLTEG CCEEEEEEEECHHCC	12.86	23312004
37	Glycation	VKVWGSIKGLTEGLH EEEEEEEECHHCCCC	49.95	-
37	Ubiquitination	VKVWGSIKGLTEGLH EEEEEEEECHHCCCC	49.95	-
40	Phosphorylation	WGSIKGLTEGLHGFH EEEEECHHCCCCEEE	36.35	-
59	Phosphorylation	GDNTAGCTSAGPHFN CCCCCCCCCCCCCCC	22.24	19299510
60	Phosphorylation	DNTAGCTSAGPHFNP CCCCCCCCCCCCCCC	34.99	19299510
69	Phosphorylation	GPHFNPLSRKHGGPK CCCCCCCCHHCCCCC	40.31	24275569
71	Acetylation	HFNPLSRKHGGPKDE CCCCCCHHCCCCCCC	43.13	90007
71	Ubiquitination	HFNPLSRKHGGPKDE CCCCCCHHCCCCCCC	43.13	-
76	Succinylation	SRKHGGPKDEERHVG CHHCCCCCCCCCCCC	79.59	23954790
76	Sumoylation	SRKHGGPKDEERHVG CHHCCCCCCCCCCCC	79.59	-
76	Ubiquitination	SRKHGGPKDEERHVG CHHCCCCCCCCCCCC	79.59	-
76	Sumoylation	SRKHGGPKDEERHVG CHHCCCCCCCCCCCC	79.59	-
80	Methylation	GGPKDEERHVGDLGN CCCCCCCCCCCCCCC	27.95	115917473
89	Phosphorylation	VGDLGNVTADKDGVA CCCCCCCCCCCCCCE	32.89	28450419
92	Ubiquitination	LGNVTADKDGVADVS CCCCCCCCCCCEEEE	54.65	-
92	Succinylation	LGNVTADKDGVADVS CCCCCCCCCCCEEEE	54.65	-
92	Succinylation	LGNVTADKDGVADVS CCCCCCCCCCCEEEE	54.65	-
99	Phosphorylation	KDGVADVSIEDSVIS CCCCEEEEEECCEEE	22.32	25159151
103	Phosphorylation	ADVSIEDSVISLSGD EEEEEECCEEEEECC	14.46	25022875
106	Phosphorylation	SIEDSVISLSGDHCI EEECCEEEEECCEEE	17.83	28192239
108	Phosphorylation	EDSVISLSGDHCIIG ECCEEEEECCEEEEC	35.07	27251789
112	S-palmitoylation	ISLSGDHCIIGRTLV EEEECCEEEECCEEE	2.63	28120938
112	Glutathionylation	ISLSGDHCIIGRTLV EEEECCEEEECCEEE	2.63	22833525
123	Glycation	RTLVVHEKADDLGKG CEEEEEECHHHCCCC	42.09	-
123	Ubiquitination	RTLVVHEKADDLGKG CEEEEEECHHHCCCC	42.09	19608861
123	Succinylation	RTLVVHEKADDLGKG CEEEEEECHHHCCCC	42.09	19608861
123	Succinylation	RTLVVHEKADDLGKG CEEEEEECHHHCCCC	42.09	-
123	Malonylation	RTLVVHEKADDLGKG CEEEEEECHHHCCCC	42.09	26320211
123	2-Hydroxyisobutyrylation	RTLVVHEKADDLGKG CEEEEEECHHHCCCC	42.09	-
123	Acetylation	RTLVVHEKADDLGKG CEEEEEECHHHCCCC	42.09	19608861
129	Glycation	EKADDLGKGGNEEST ECHHHCCCCCCCCCC	71.58	-
129	Acetylation	EKADDLGKGGNEEST ECHHHCCCCCCCCCC	71.58	26051181
129	Ubiquitination	EKADDLGKGGNEEST ECHHHCCCCCCCCCC	71.58	-
135	Phosphorylation	GKGGNEESTKTGNAG CCCCCCCCCCCCCHH	29.08	28258704
136	Phosphorylation	KGGNEESTKTGNAGS CCCCCCCCCCCCHHH	35.59	28258704
137	Acetylation	GGNEESTKTGNAGSR CCCCCCCCCCCHHHH	64.81	26051181
137	Succinylation	GGNEESTKTGNAGSR CCCCCCCCCCCHHHH	64.81	-
137	Ubiquitination	GGNEESTKTGNAGSR CCCCCCCCCCCHHHH	64.81	-
137	Succinylation	GGNEESTKTGNAGSR CCCCCCCCCCCHHHH	64.81	-
138	Phosphorylation	GNEESTKTGNAGSRL CCCCCCCCCCHHHHE	35.44	26437602
143	Phosphorylation	TKTGNAGSRLACGVI CCCCCHHHHEEEEEE	23.01	26437602
144	Methylation	KTGNAGSRLACGVIG CCCCHHHHEEEEEEE	25.95	115917469
147	Glutathionylation	NAGSRLACGVIGIAQ CHHHHEEEEEEEEEC	5.46	22555962
147	S-palmitoylation	NAGSRLACGVIGIAQ CHHHHEEEEEEEEEC	5.46	26865113

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
40	T	Phosphorylation	Kinase	MTOR	P42345	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	AMFR	Q9UKV5	PMID:19661182
-	K	Ubiquitination	E3 ubiquitin ligase	MARCHF5	Q9NX47	PMID:19741096
-	K	Ubiquitination	E3 ubiquitin ligase	RNF19A	Q9NV58	PMID:12145308
-	K	Ubiquitination	E3 ubiquitin ligase	STUB1	Q9UNE7	PMID:15198682
-	K	Ubiquitination	E3 ubiquitin ligase	MARCHF8	Q5T0T0	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
38	R	ubiquitylation	9541385
Unlike wild-type protein, the pathogenic variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 are polyubiquitinated by RNF19A leading to their proteasomal degradation.
47	R	ubiquitylation	12754496
Unlike wild-type protein, the pathogenic variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 are polyubiquitinated by RNF19A leading to their proteasomal degradation.
86	R	ubiquitylation	18378676
The pathogenic variants ALS1 Arg-86 and Ala-94 are ubiquitinated by MARCH5 leading to their proteasomal degradation.
86	R	ubiquitylation	18378676
Unlike wild-type protein, the pathogenic variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 are polyubiquitinated by RNF19A leading to their proteasomal degradation.
94	A	ubiquitylation	12145308
The pathogenic variants ALS1 Arg-86 and Ala-94 are ubiquitinated by MARCH5 leading to their proteasomal degradation.
94	A	ubiquitylation	12145308
Unlike wild-type protein, the pathogenic variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 are polyubiquitinated by RNF19A leading to their proteasomal degradation.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SODC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BCL2_HUMAN	BCL2	physical	15233914
HECW1_HUMAN	HECW1	physical	14684739
SSRD_HUMAN	SSR4	physical	14684739
HSP7C_HUMAN	HSPA8	physical	15358145
HSP74_HUMAN	HSPA4	physical	15358145
CHIP_HUMAN	STUB1	physical	15358145
CCS_HUMAN	CCS	physical	20154138
MARH5_HUMAN	MARCH5	physical	19741096
HSP74_HUMAN	HSPA4	physical	17992192
CHIP_MOUSE	Stub1	physical	15198682
UBC_HUMAN	UBC	physical	15198682
COMD1_HUMAN	COMMD1	physical	20595380
SODC_MOUSE	Sod1	physical	19171884
HSP7C_MOUSE	Hspa8	physical	19171884
HSP72_MOUSE	Hspa2	physical	19171884
HS74L_MOUSE	Hspa4l	physical	19171884
HS71B_MOUSE	Hspa1b	physical	19171884
HS105_MOUSE	Hsph1	physical	19171884
GRP78_MOUSE	Hspa5	physical	19171884
DNJA1_MOUSE	Dnaja1	physical	19171884
CCS_MOUSE	Ccs	physical	19171884
SODM_HUMAN	SOD2	physical	22939629
SPTB2_HUMAN	SPTBN1	physical	22939629
TIAR_HUMAN	TIAL1	physical	22939629
OPTN_HUMAN	OPTN	physical	23178947
GSH1_YEAST	GSH1	genetic	23496883
HDAC6_HUMAN	HDAC6	physical	23580651
CRYAB_HUMAN	CRYAB	physical	22993064
SODC_HUMAN	SOD1	physical	22993064
ACY1_HUMAN	ACY1	physical	26344197
ADK_HUMAN	ADK	physical	26344197
PUR8_HUMAN	ADSL	physical	26344197
KAD2_HUMAN	AK2	physical	26344197
AK1A1_HUMAN	AKR1A1	physical	26344197
ALDR_HUMAN	AKR1B1	physical	26344197
AK1BF_HUMAN	AKR1B15	physical	26344197
AK1C2_HUMAN	AKR1C2	physical	26344197
ASNS_HUMAN	ASNS	physical	26344197
ATOX1_HUMAN	ATOX1	physical	26344197
CK054_HUMAN	C11orf54	physical	26344197
CATA_HUMAN	CAT	physical	26344197
CCS_HUMAN	CCS	physical	26344197
COF1_HUMAN	CFL1	physical	26344197
COF2_HUMAN	CFL2	physical	26344197
COL10_HUMAN	COLEC10	physical	26344197
COX17_HUMAN	COX17	physical	26344197
CRIP1_HUMAN	CRIP1	physical	26344197
ACBP_HUMAN	DBI	physical	26344197
DEST_HUMAN	DSTN	physical	26344197
ENOA_HUMAN	ENO1	physical	26344197
ENOG_HUMAN	ENO2	physical	26344197
ENOB_HUMAN	ENO3	physical	26344197
FABPH_HUMAN	FABP3	physical	26344197
FABP5_HUMAN	FABP5	physical	26344197
FABP7_HUMAN	FABP7	physical	26344197
FKB1A_HUMAN	FKBP1A	physical	26344197
FKB1B_HUMAN	FKBP1B	physical	26344197
FKBP7_HUMAN	FKBP7	physical	26344197
G3P_HUMAN	GAPDH	physical	26344197
GLOD4_HUMAN	GLOD4	physical	26344197
GLRX1_HUMAN	GLRX	physical	26344197
GNPI2_HUMAN	GNPDA2	physical	26344197
AATC_HUMAN	GOT1	physical	26344197
GPX4_HUMAN	GPX4	physical	26344197
MAAI_HUMAN	GSTZ1	physical	26344197
HIBCH_HUMAN	HIBCH	physical	26344197
GRP75_HUMAN	HSPA9	physical	26344197
CH10_HUMAN	HSPE1	physical	26344197
LACB2_HUMAN	LACTB2	physical	26344197
LDHA_HUMAN	LDHA	physical	26344197
LDH6A_HUMAN	LDHAL6A	physical	26344197
LDH6B_HUMAN	LDHAL6B	physical	26344197
LDHB_HUMAN	LDHB	physical	26344197
LDHC_HUMAN	LDHC	physical	26344197
LEG1_HUMAN	LGALS1	physical	26344197
LEG3_HUMAN	LGALS3	physical	26344197
MDHM_HUMAN	MDH2	physical	26344197
MPI_HUMAN	MPI	physical	26344197
NDKA_HUMAN	NME1	physical	26344197
NDKB_HUMAN	NME2	physical	26344197
NTF2_HUMAN	NUTF2	physical	26344197
OAT_HUMAN	OAT	physical	26344197
PABP3_HUMAN	PABPC3	physical	26344197
PABP4_HUMAN	PABPC4	physical	26344197
PCBP1_HUMAN	PCBP1	physical	26344197
PIMT_HUMAN	PCMT1	physical	26344197
PDC6I_HUMAN	PDCD6IP	physical	26344197
PDXK_HUMAN	PDXK	physical	26344197
PEBP1_HUMAN	PEBP1	physical	26344197
PGAM1_HUMAN	PGAM1	physical	26344197
PGM1_HUMAN	PGM1	physical	26344197
PGM5_HUMAN	PGM5	physical	26344197
PIPNB_HUMAN	PITPNB	physical	26344197
MYP2_HUMAN	PMP2	physical	26344197
PPIA_HUMAN	PPIA	physical	26344197
PPIF_HUMAN	PPIF	physical	26344197
PPIL3_HUMAN	PPIL3	physical	26344197
PRDX1_HUMAN	PRDX1	physical	26344197
PRDX2_HUMAN	PRDX2	physical	26344197
PRDX5_HUMAN	PRDX5	physical	26344197
DHPR_HUMAN	QDPR	physical	26344197
RAE1L_HUMAN	RAE1	physical	26344197
RGN_HUMAN	RGN	physical	26344197
RPE_HUMAN	RPE	physical	26344197
SCYL2_HUMAN	SCYL2	physical	26344197
SPB5_HUMAN	SERPINB5	physical	26344197
SODM_HUMAN	SOD2	physical	26344197
DHSO_HUMAN	SORD	physical	26344197
SPRE_HUMAN	SPR	physical	26344197
STIP1_HUMAN	STIP1	physical	26344197
TAGL2_HUMAN	TAGLN2	physical	26344197
TNG2_HUMAN	TANGO2	physical	26344197
TKT_HUMAN	TKT	physical	26344197
TKTL2_HUMAN	TKTL2	physical	26344197
TRAP1_HUMAN	TRAP1	physical	26344197
UB2L3_HUMAN	UBE2L3	physical	26344197
UB2V1_HUMAN	UBE2V1	physical	26344197
UFC1_HUMAN	UFC1	physical	26344197
UFM1_HUMAN	UFM1	physical	26344197
ALBU_HUMAN	ALB	physical	26496610
IF5A1_HUMAN	EIF5A	physical	26496610
HEXB_HUMAN	HEXB	physical	26496610
ZEP1_HUMAN	HIVEP1	physical	26496610
PRCC_HUMAN	PRCC	physical	26496610
LGMN_HUMAN	LGMN	physical	26496610
USP9X_HUMAN	USP9X	physical	26496610
NFS1_HUMAN	NFS1	physical	26496610
CCS_HUMAN	CCS	physical	26496610
SYNE2_HUMAN	SYNE2	physical	26496610
ASCC1_HUMAN	ASCC1	physical	26496610
PF21A_HUMAN	PHF21A	physical	26496610
CEP55_HUMAN	CEP55	physical	26496610
PRR12_HUMAN	PRR12	physical	26496610
KLC2_HUMAN	KLC2	physical	26496610
FAP20_HUMAN	C1orf86	physical	26496610
COMD1_HUMAN	COMMD1	physical	24691167
SODC_HUMAN	SOD1	physical	24691167
MAVS_HUMAN	MAVS	physical	28514442
CCS_HUMAN	CCS	physical	28514442
STXB2_HUMAN	STXBP2	physical	28514442
CENPV_HUMAN	CENPV	physical	28514442
KPB1_HUMAN	PHKA1	physical	28514442
CCS1_YEAST	CCS1	physical	28533431
BASP1_HUMAN	BASP1	physical	29128334
LDHB_HUMAN	LDHB	physical	29128334
H10_HUMAN	H1F0	physical	29128334
PRDX2_HUMAN	PRDX2	physical	29128334
TPIS_HUMAN	TPI1	physical	29128334
PPIA_HUMAN	PPIA	physical	29128334
GSTP1_HUMAN	GSTP1	physical	29128334
EF2_HUMAN	EEF2	physical	29128334
MRP_HUMAN	MARCKSL1	physical	29128334
CH10_HUMAN	HSPE1	physical	29128334
TBCA_HUMAN	TBCA	physical	29128334
PRDX6_HUMAN	PRDX6	physical	29128334
RL30_HUMAN	RPL30	physical	29128334
MIF_HUMAN	MIF	physical	29128334
TCPB_HUMAN	CCT2	physical	29128334
PGK1_HUMAN	PGK1	physical	29128334
APT_HUMAN	APRT	physical	29128334
TCPQ_HUMAN	CCT8	physical	29128334
1433Z_HUMAN	YWHAZ	physical	29128334
1433B_HUMAN	YWHAB	physical	29128334
NOP10_HUMAN	NOP10	physical	29128334
UCHL1_HUMAN	UCHL1	physical	29128334
PIMT_HUMAN	PCMT1	physical	29128334
PPM1A_HUMAN	PPM1A	physical	29128334
TKT_HUMAN	TKT	physical	29128334
PPM1B_HUMAN	PPM1B	physical	29128334
PAL4A_HUMAN	PPIAL4B	physical	29128334
UBA1_HUMAN	UBA1	physical	29128334
BAF_HUMAN	BANF1	physical	29128334
TCPH_HUMAN	CCT7	physical	29128334
ALDOA_HUMAN	ALDOA	physical	29128334
FETUA_HUMAN	AHSG	physical	29128334
LGUL_HUMAN	GLO1	physical	29128334
RUVB2_HUMAN	RUVBL2	physical	29128334
PARK7_HUMAN	PARK7	physical	29128334
TIM13_HUMAN	TIMM13	physical	29128334
SUMO2_HUMAN	SUMO2	physical	29128334
TAGL2_HUMAN	TAGLN2	physical	29128334
PDIA3_HUMAN	PDIA3	physical	29128334
PTMS_HUMAN	PTMS	physical	29128334
PSDE_HUMAN	PSMD14	physical	29128334
TIF1B_HUMAN	TRIM28	physical	29128334
S10AB_HUMAN	S100A11	physical	29128334
H1X_HUMAN	H1FX	physical	29128334
NACAM_HUMAN	NACA	physical	29128334
NACA_HUMAN	NACA	physical	29128334
LDHA_HUMAN	LDHA	physical	29128334
GDIA_HUMAN	GDI1	physical	29128334
MDHM_HUMAN	MDH2	physical	29128334
TERA_HUMAN	VCP	physical	29128334
MTPN_HUMAN	MTPN	physical	29128334
PSB6_HUMAN	PSMB6	physical	29128334
RFA3_HUMAN	RPA3	physical	29128334
1433T_HUMAN	YWHAQ	physical	29128334
HINT1_HUMAN	HINT1	physical	29128334
BACH_HUMAN	ACOT7	physical	29128334
KCRB_HUMAN	CKB	physical	29128334
ETFB_HUMAN	ETFB	physical	29128334
ILF2_HUMAN	ILF2	physical	29128334
SPIN1_HUMAN	SPIN1	physical	29128334
METK2_HUMAN	MAT2A	physical	29128334
PROF1_HUMAN	PFN1	physical	29128334
EF1D_HUMAN	EEF1D	physical	29128334
THIL_HUMAN	ACAT1	physical	29128334
DX39B_HUMAN	DDX39B	physical	29128334
SRP19_HUMAN	SRP19	physical	29128334
IF1AX_HUMAN	EIF1AX	physical	29128334
PRS7_HUMAN	PSMC2	physical	29128334
EF1G_HUMAN	EEF1G	physical	29128334
STMN1_HUMAN	STMN1	physical	29128334
CHCH2_HUMAN	CHCHD2	physical	29128334
UBE2N_HUMAN	UBE2N	physical	29128334
PFD2_HUMAN	PFDN2	physical	29128334
QOR_HUMAN	CRYZ	physical	29128334
DEST_HUMAN	DSTN	physical	29128334
ROAA_HUMAN	HNRNPAB	physical	29128334
LDH6A_HUMAN	LDHAL6A	physical	29128334
TAB1_HUMAN	TAB1	physical	29128334
PDIA1_HUMAN	P4HB	physical	29128334
GBB1_HUMAN	GNB1	physical	29128334
MCM4_HUMAN	MCM4	physical	29128334
ANXA1_HUMAN	ANXA1	physical	29128334
SAE1_HUMAN	SAE1	physical	29128334
RBM8A_HUMAN	RBM8A	physical	29128334
CUTA_HUMAN	CUTA	physical	29128334
AL7A1_HUMAN	ALDH7A1	physical	29128334
IDH3A_HUMAN	IDH3A	physical	29128334
UBC12_HUMAN	UBE2M	physical	29128334
DNM1L_HUMAN	DNM1L	physical	29128334
RAP1A_HUMAN	RAP1A	physical	29128334
HEXB_HUMAN	HEXB	physical	29128334
NP1L4_HUMAN	NAP1L4	physical	29128334
CDC42_HUMAN	CDC42	physical	29128334
RHOA_HUMAN	RHOA	physical	29128334
PRS10_HUMAN	PSMC6	physical	29128334
LMNB1_HUMAN	LMNB1	physical	29128334
2AAA_HUMAN	PPP2R1A	physical	29128334
VAT1_HUMAN	VAT1	physical	29128334
RM12_HUMAN	MRPL12	physical	29128334
HMGB3_HUMAN	HMGB3	physical	29128334
ENPL_HUMAN	HSP90B1	physical	29128334
RAB9A_HUMAN	RAB9A	physical	29128334
IF4A3_HUMAN	EIF4A3	physical	29128334
SERPH_HUMAN	SERPINH1	physical	29128334
RPAB1_HUMAN	POLR2E	physical	29128334
PRDX5_HUMAN	PRDX5	physical	29128334
HMGB1_HUMAN	HMGB1	physical	29128334
MOB1B_HUMAN	MOB1B	physical	29128334
ENOB_HUMAN	ENO3	physical	29128334
PDIA6_HUMAN	PDIA6	physical	29128334
CLD17_HUMAN	CLDN17	physical	29128334
EPDR1_HUMAN	EPDR1	physical	29128334
TPD52_HUMAN	TPD52	physical	29128334
RAB21_HUMAN	RAB21	physical	29128334
EF1B_HUMAN	EEF1B2	physical	29128334
GSTK1_HUMAN	GSTK1	physical	29128334
PSA2_HUMAN	PSMA2	physical	29128334
KAD2_HUMAN	AK2	physical	29128334
PSME2_HUMAN	PSME2	physical	29128334
SYAC_HUMAN	AARS	physical	29128334
CN166_HUMAN	C14orf166	physical	29128334
PSA6_HUMAN	PSMA6	physical	29128334
1433G_HUMAN	YWHAG	physical	29128334
VATB1_HUMAN	ATP6V1B1	physical	29128334
SYSC_HUMAN	SARS	physical	29128334
SAP_HUMAN	PSAP	physical	29128334
GLU2B_HUMAN	PRKCSH	physical	29128334
MCM3_HUMAN	MCM3	physical	29128334
PRDX4_HUMAN	PRDX4	physical	29128334
PIPNB_HUMAN	PITPNB	physical	29128334
EXOS6_HUMAN	EXOSC6	physical	29128334
IPYR_HUMAN	PPA1	physical	29128334
IMB1_HUMAN	KPNB1	physical	29128334
LMNB2_HUMAN	LMNB2	physical	29128334
PSMD2_HUMAN	PSMD2	physical	29128334
XRCC6_HUMAN	XRCC6	physical	29128334
GLO2_HUMAN	HAGH	physical	29128334
VATA_HUMAN	ATP6V1A	physical	29128334
ADPPT_HUMAN	AASDHPPT	physical	29128334
GANAB_HUMAN	GANAB	physical	29128334
IF2A_HUMAN	EIF2S1	physical	29128334
KINH_HUMAN	KIF5B	physical	29128334
FUBP1_HUMAN	FUBP1	physical	29128334
EIF3I_HUMAN	EIF3I	physical	29128334
ELAV1_HUMAN	ELAVL1	physical	29128334
EIF3H_HUMAN	EIF3H	physical	29128334
XRCC5_HUMAN	XRCC5	physical	29128334
FEN1_HUMAN	FEN1	physical	29128334
ACON_HUMAN	ACO2	physical	29128334
PRS8_HUMAN	PSMC5	physical	29128334
ADRM1_HUMAN	ADRM1	physical	29128334
LA_HUMAN	SSB	physical	29128334
M4K1_HUMAN	MAP4K1	physical	29128334
HSP74_HUMAN	HSPA4	physical	29128334
PSD11_HUMAN	PSMD11	physical	29128334
PRS4_HUMAN	PSMC1	physical	29128334
EIF3E_HUMAN	EIF3E	physical	29128334
ACTN4_HUMAN	ACTN4	physical	29128334
RUVB1_HUMAN	RUVBL1	physical	29128334
C1TC_HUMAN	MTHFD1	physical	29128334
PERI_HUMAN	PRPH	physical	29128334
DESM_HUMAN	DES	physical	29128334
CPSF7_HUMAN	CPSF7	physical	29128334
SYDC_HUMAN	DARS	physical	29128334
IMDH2_HUMAN	IMPDH2	physical	29128334
API5_HUMAN	API5	physical	29128334
EIF3D_HUMAN	EIF3D	physical	29128334
TPR_HUMAN	TPR	physical	29128334
PABP4_HUMAN	PABPC4	physical	29128334
PDIA4_HUMAN	PDIA4	physical	29128334
LMNA_HUMAN	LMNA	physical	29128334
EIF3A_HUMAN	EIF3A	physical	29128334
TRAP1_HUMAN	TRAP1	physical	29128334
MCM5_HUMAN	MCM5	physical	29128334
SYEP_HUMAN	EPRS	physical	29128334
NSUN2_HUMAN	NSUN2	physical	29128334
NUP93_HUMAN	NUP93	physical	29128334
MCM6_HUMAN	MCM6	physical	29128334
PDC6I_HUMAN	PDCD6IP	physical	29128334
COPG1_HUMAN	COPG1	physical	29128334
MCM2_HUMAN	MCM2	physical	29128334
SND1_HUMAN	SND1	physical	29128334
CCAR2_HUMAN	CCAR2	physical	29128334
AT1A1_HUMAN	ATP1A1	physical	29128334
AP3D1_HUMAN	AP3D1	physical	29128334
SYLC_HUMAN	LARS	physical	29128334
COPA_HUMAN	COPA	physical	29128334
MBB1A_HUMAN	MYBBP1A	physical	29128334
IQGA1_HUMAN	IQGAP1	physical	29128334
MYH11_HUMAN	MYH11	physical	29128334
HUWE1_HUMAN	HUWE1	physical	29128334
HORN_HUMAN	HRNR	physical	29128334
H2A1B_HUMAN	HIST1H2AE	physical	29128334

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
105400	Amyotrophic lateral sclerosis 1 (ALS1)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SODC_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Atomic structures of wild-type and thermostable mutant recombinanthuman Cu,Zn superoxide dismutase."; Parge H.E., Hallewell R.A., Tainer J.A.; Proc. Natl. Acad. Sci. U.S.A. 89:6109-6113(1992). Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).	1463506 [Abstract]
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-123, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99, AND MASSSPECTROMETRY.	18669648 [Abstract]

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