| UniProt ID | FAP20_HUMAN | |
|---|---|---|
| UniProt AC | Q6NZ36 | |
| Protein Name | Fanconi anemia core complex-associated protein 20 {ECO:0000312|HGNC:HGNC:26428} | |
| Gene Name | FAAP20 {ECO:0000303|PubMed:22343915, ECO:0000312|HGNC:HGNC:26428} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 180 | |
| Subcellular Localization | Nucleus . Chromosome . Following DNA damage, recruited to DNA interstrand cross-links (ICLs) sites by binding to ubiquitin generated by RNF8. | |
| Protein Description | Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1.. | |
| Protein Sequence | MEAARRPRLGLSRRRPRPAGGPSGGRPWFLLGGDERERLWAELLRTVSPELILDHEVPSLPAFPGQEPRCGPEPTEVFTVGPKTFSWTPFPPDLWGPGRSYRLLHGAGGHLESPARSLPQRPAPDPCRAPRVEQQPSVEGAAALRSCPMCQKEFAPRLTQLDVDSHLAQCLAESTEDVTW | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 8 | Dimethylation | MEAARRPRLGLSRRR CCHHCCCCCCCCCCC | - | ||
| 83 | Ubiquitination | EVFTVGPKTFSWTPF EEEEECCCCCCCCCC | - | ||
| 113 | Phosphorylation | GAGGHLESPARSLPQ CCCCCCCCCCCCCCC | 30266825 | ||
| 117 | Phosphorylation | HLESPARSLPQRPAP CCCCCCCCCCCCCCC | - | ||
| 137 | Phosphorylation | PRVEQQPSVEGAAAL CCCCCCCCHHHHHHH | 28348404 | ||
| 151 | Phosphorylation | LRSCPMCQKEFAPRL HHHCCCCCHHHHCCC | - | ||
| 152 | Ubiquitination | RSCPMCQKEFAPRLT HHCCCCCHHHHCCCC | - | ||
| 186 | Ubiquitination | TW------------- CC------------- | - | ||
| 216 | Phosphorylation | ------------------------------------------- ------------------------------------------- | - | ||
| 220 | Phosphorylation | ----------------------------------------------- ----------------------------------------------- | - | ||
| 240 | Phosphorylation | ------------------------------------------------------------------- ------------------------------------------------------------------- | - | ||
| 255 | Ubiquitination | ---------------------------------------------------------------------------------- ---------------------------------------------------------------------------------- | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FAP20_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FAP20_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FAP20_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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