| UniProt ID | FANCC_HUMAN | |
|---|---|---|
| UniProt AC | Q00597 | |
| Protein Name | Fanconi anemia group C protein | |
| Gene Name | FANCC | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 558 | |
| Subcellular Localization | Nucleus. Cytoplasm. The major form is nuclear. The minor form is cytoplasmic. | |
| Protein Description | DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.. | |
| Protein Sequence | MAQDSVDLSCDYQFWMQKLSVWDQASTLETQQDTCLHVAQFQEFLRKMYEALKEMDSNTVIERFPTIGQLLAKACWNPFILAYDESQKILIWCLCCLINKEPQNSGQSKLNSWIQGVLSHILSALRFDKEVALFTQGLGYAPIDYYPGLLKNMVLSLASELRENHLNGFNTQRRMAPERVASLSRVCVPLITLTDVDPLVEALLICHGREPQEILQPEFFEAVNEAILLKKISLPMSAVVCLWLRHLPSLEKAMLHLFEKLISSERNCLRRIECFIKDSSLPQAACHPAIFRVVDEMFRCALLETDGALEIIATIQVFTQCFVEALEKASKQLRFALKTYFPYTSPSLAMVLLQDPQDIPRGHWLQTLKHISELLREAVEDQTHGSCGGPFESWFLFIHFGGWAEMVAEQLLMSAAEPPTALLWLLAFYYGPRDGRQQRAQTMVQVKAVLGHLLAMSRSSSLSAQDLQTVAGQGTDTDLRAPAQQLIRHLLLNFLLWAPGGHTIAWDVITLMAHTAEITHEIIGFLDQTLYRWNRLGIESPRSEKLARELLKELRTQV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 57 | Phosphorylation | EALKEMDSNTVIERF HHHHHCCCCCHHHHC | 32.84 | - | |
| 182 | Phosphorylation | MAPERVASLSRVCVP CCHHHHHHHHHHHHH | 24.83 | 27174698 | |
| 184 | Phosphorylation | PERVASLSRVCVPLI HHHHHHHHHHHHHEE | 21.85 | 27174698 | |
| 230 | Ubiquitination | VNEAILLKKISLPMS HHHHHHHHHCCCCHH | 44.61 | - | |
| 277 | Ubiquitination | RRIECFIKDSSLPQA HHHHHHHCCCCCCHH | 31.16 | - | |
| 339 | Phosphorylation | QLRFALKTYFPYTSP HHHHHHHHHCCCCCC | 31.11 | 24043423 | |
| 340 | Phosphorylation | LRFALKTYFPYTSPS HHHHHHHHCCCCCCC | 10.85 | 24043423 | |
| 343 | Phosphorylation | ALKTYFPYTSPSLAM HHHHHCCCCCCCHHH | 15.22 | 24043423 | |
| 344 | Phosphorylation | LKTYFPYTSPSLAMV HHHHCCCCCCCHHHH | 34.11 | 24043423 | |
| 345 | Phosphorylation | KTYFPYTSPSLAMVL HHHCCCCCCCHHHHH | 13.47 | 24043423 | |
| 347 | Phosphorylation | YFPYTSPSLAMVLLQ HCCCCCCCHHHHHCC | 28.64 | 24043423 | |
| 372 | Phosphorylation | LQTLKHISELLREAV HHHHHHHHHHHHHHH | 23.16 | 28555341 | |
| 447 | Ubiquitination | AQTMVQVKAVLGHLL HHHHHHHHHHHHHHH | 18.71 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FANCC_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FANCC_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FANCC_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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