UNC5A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UNC5A_HUMAN
• UniProt AC: Q6ZN44
• Protein Name: Netrin receptor UNC5A
• Gene Name: UNC5A
• Organism: Homo sapiens (Human).
• Sequence Length: 842
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Membrane raft . Cell projection . The interaction with PRKCABP regulates its surface expression and leads to its removal from the surface of neurons and growth cones. Detected in neurites.
• Protein Description: Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand..
• Protein Sequence: MAVRPGLWPALLGIVLAAWLRGSGAQQSATVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVCKAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKNIVARRRSASAAVIVYVDGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDLDTRNCTSDLCVHTASGPEDVALYVGLIAVAVCLVLLLLVLILVYCRKKEGLDSDVADSSILTSGFQPVSIKPSKADNPHLLTIQPDLSTTTTTYQGSLCPRQDGPSPKFQLTNGHLLSPLGGGRHTLHHSSPTSEAEEFVSRLSTQNYFRSLPRGTSNMTYGTFNFLGGRLMIPNTGISLLIPPDAIPRGKIYEIYLTLHKPEDVRLPLAGCQTLLSPIVSCGPPGVLLTRPVILAMDHCGEPSPDSWSLRLKKQSCEGSWEDVLHLGEEAPSHLYYCQLEASACYVFTEQLGRFALVGEALSVAAAKRLKLLLFAPVACTSLEYNIRVYCLHDTHDALKEVVQLEKQLGGQLIQEPRVLHFKDSYHNLRLSIHDVPSSLWKSKLLVSYQEIPFYHIWNGTQRYLHCTFTLERVSPSTSDLACKLWVWQVEGDGQSFSINFNITKDTRFAELLALESEAGVPALVGPSAFKIPFLIRQKIISSLDPPCRRGADWRTLAQKLHLDSHLSFFASKPSPTAMILNLWEARHFPNGNLSQLAAAVAGLGQPDAGLFTVSEAEC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
52 (in isoform 3)	Phosphorylation	-	49.59	25850435
57 (in isoform 3)	Phosphorylation	-	50.09	25850435
61 (in isoform 3)	Phosphorylation	-	7.43	25850435
107	N-linked_Glycosylation	PTMEVRINVSRQQVE CEEEEEEEECHHHHH	18.36	UniProtKB CARBOHYD
109	Phosphorylation	MEVRINVSRQQVEKV EEEEEEECHHHHHHH	21.63	-
130	Phosphorylation	WCQCVAWSSSGTTKS EEEEEEECCCCCCHH	12.61	30576142
131	Phosphorylation	CQCVAWSSSGTTKSQ EEEEEECCCCCCHHH	23.29	30576142
135	Phosphorylation	AWSSSGTTKSQKAYI EECCCCCCHHHHHHH	32.02	30576142
218	N-linked_Glycosylation	ARLADTANYTCVAKN HHHHHCCCCEEEEEH	34.44	UniProtKB CARBOHYD
232	Phosphorylation	NIVARRRSASAAVIV HHHHHCCCCCEEEEE	25.43	-
287	N-linked_Glycosylation	GTDLDTRNCTSDLCV CCCCCCCCCCCCEEE	35.20	UniProtKB CARBOHYD
341	Phosphorylation	LDSDVADSSILTSGF CCCCCCCCCHHCCCC	15.00	22210691
342	Phosphorylation	DSDVADSSILTSGFQ CCCCCCCCHHCCCCE	23.36	22210691
377	Phosphorylation	LSTTTTTYQGSLCPR CCCCCEEECCCCCCC	14.58	25884760
395	Phosphorylation	PSPKFQLTNGHLLSP CCCCEEEECCCEEEC	28.50	27732954
401	Phosphorylation	LTNGHLLSPLGGGRH EECCCEEECCCCCCC	25.16	24719451
413	Phosphorylation	GRHTLHHSSPTSEAE CCCCCCCCCCCHHHH	27.54	25307156
414	Phosphorylation	RHTLHHSSPTSEAEE CCCCCCCCCCHHHHH	28.04	25307156
416	Phosphorylation	TLHHSSPTSEAEEFV CCCCCCCCHHHHHHH	40.94	25307156
431	Phosphorylation	SRLSTQNYFRSLPRG HHHHHCHHHHCCCCC	7.20	25884760
459	Phosphorylation	GRLMIPNTGISLLIP CEEECCCCCEEEEEC	30.45	-
532	Phosphorylation	EPSPDSWSLRLKKQS CCCCCCCCEEECEEC	13.94	24719451
586	Phosphorylation	ALVGEALSVAAAKRL HHHHHHHHHHHHHHH	19.43	-
719	Phosphorylation	QVEGDGQSFSINFNI EEECCCEEEEEEEEE	26.87	-
721	Phosphorylation	EGDGQSFSINFNITK ECCCEEEEEEEEECC	23.13	-
730	Phosphorylation	NFNITKDTRFAELLA EEEECCCCHHHHHHH	29.28	28258704

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UNC5A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UNC5A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UNC5A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MAGD1_HUMAN	MAGED1	physical	12598531
NET1_HUMAN	NTN1	physical	12810718
FANCC_HUMAN	FANCC	physical	24676280

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.