NET1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NET1_HUMAN
• UniProt AC: O95631
• Protein Name: Netrin-1
• Gene Name: NTN1
• Organism: Homo sapiens (Human).
• Sequence Length: 604
• Subcellular Localization: Secreted, extracellular space, extracellular matrix.
• Protein Description: Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis..
• Protein Sequence: MMRAVWEALAALAAVACLVGAVRGGPGLSMFAGQAAQPDPCSDENGHPRRCIPDFVNAAFGKDVRVSSTCGRPPARYCVVSERGEERLRSCHLCNASDPKKAHPPAFLTDLNNPHNLTCWQSENYLQFPHNVTLTLSLGKKFEVTYVSLQFCSPRPESMAIYKSMDYGRTWVPFQFYSTQCRKMYNRPHRAPITKQNEQEAVCTDSHTDMRPLSGGLIAFSTLDGRPSAHDFDNSPVLQDWVTATDIRVAFSRLHTFGDENEDDSELARDSYFYAVSDLQVGGRCKCNGHAARCVRDRDDSLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGYYRDMGKPITHRKACKACDCHPVGAAGKTCNQTTGQCPCKDGVTGITCNRCAKGYQQSRSPIAPCIKIPVAPPTTAASSVEEPEDCDSYCKASKGKLKINMKKYCKKDYAVQIHILKADKAGDWWKFTVNIISVYKQGTSRIRRGDQSLWIRSRDIACKCPKIKPLKKYLLLGNAEDSPDQSGIVADKSSLVIQWRDTWARRLRKFQQREKKGKCKKA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
95	N-linked_Glycosylation	LRSCHLCNASDPKKA HHHCCCCCCCCCCCC	49.17	UniProtKB CARBOHYD
116	N-linked_Glycosylation	TDLNNPHNLTCWQSE CCCCCCCCCCCEECC	38.00	UniProtKB CARBOHYD
131	N-linked_Glycosylation	NYLQFPHNVTLTLSL CCCCCCCEEEEEEEC	28.80	UniProtKB CARBOHYD
158	Phosphorylation	FCSPRPESMAIYKSM ECCCCHHHEEEEECC	19.05	28270605
162	Phosphorylation	RPESMAIYKSMDYGR CHHHEEEEECCCCCC	6.35	28270605
164	Phosphorylation	ESMAIYKSMDYGRTW HHEEEEECCCCCCCC	10.42	28270605
167	Phosphorylation	AIYKSMDYGRTWVPF EEEECCCCCCCCCCE	10.40	28270605
271	Phosphorylation	DSELARDSYFYAVSD CCHHHHHCEEEEEEC	16.16	22468782
272	Phosphorylation	SELARDSYFYAVSDL CHHHHHCEEEEEECC	12.61	22468782
274	Phosphorylation	LARDSYFYAVSDLQV HHHHCEEEEEECCEE	9.62	22468782
357	Phosphorylation	CRFNMELYKLSGRKS CCCCEEEHHCCCCCC	9.14	26657352
387	Phosphorylation	CHYCKEGYYRDMGKP CCCCCCCCCCCCCCC	9.09	-
388	Phosphorylation	HYCKEGYYRDMGKPI CCCCCCCCCCCCCCC	15.82	-
417	N-linked_Glycosylation	GAAGKTCNQTTGQCP CCCCCCCCCCCCCCC	47.68	UniProtKB CARBOHYD
460	O-linked_Glycosylation	KIPVAPPTTAASSVE ECCCCCCCCCCCCCC	28.18	55832477
461	O-linked_Glycosylation	IPVAPPTTAASSVEE CCCCCCCCCCCCCCC	26.46	55832483
490	Phosphorylation	LKINMKKYCKKDYAV CEECHHHHCCCCEEE	12.18	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NET1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NET1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NET1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DCC_HUMAN	DCC	physical	9950216

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.