| UniProt ID | SPTA1_HUMAN | |
|---|---|---|
| UniProt AC | P02549 | |
| Protein Name | Spectrin alpha chain, erythrocytic 1 | |
| Gene Name | SPTA1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 2419 | |
| Subcellular Localization | Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. | |
| Protein Description | Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.. | |
| Protein Sequence | MEQFPKETVVESSGPKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNLEDALILDIKYSTIGLAQQWDQLYQLGLRMQHNLEQQIQAKDIKGVSEETLKEFSTIYKHFDENLTGRLTHKEFRSCLRGLNYYLPMVEEDEHEPKFEKFLDAVDPGRKGYVSLEDYTAFLIDKESENIKSSDEIENAFQALAEGKSYITKEDMKQALTPEQVSFCATHMQQYMDPRGRSHLSGYDYVGFTNSYFGN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 8 | Phosphorylation | MEQFPKETVVESSGP CCCCCCCHHHCCCCC | 35.66 | 22468782 | |
| 13 | Phosphorylation | KETVVESSGPKVLET CCHHHCCCCCHHHHH | 45.68 | 22468782 | |
| 20 | Phosphorylation | SGPKVLETAEEIQER CCCHHHHHHHHHHHH | 34.90 | 22468782 | |
| 35 | Phosphorylation | RQEVLTRYQSFKERV HHHHHHHHHHHHHHH | 11.85 | 29449344 | |
| 37 | Phosphorylation | EVLTRYQSFKERVAE HHHHHHHHHHHHHHH | 29.38 | 28152594 | |
| 59 | Acetylation | SYHLQVFKRDADDLG HHHEEEECCCHHHHH | 50.98 | 30592629 | |
| 96 | Phosphorylation | GKYQKHQSLEAEVQT CCHHHHHCHHHHHHH | 28.09 | 27251275 | |
| 109 | Phosphorylation | QTKSRLMSELEKTRE HHHHHHHHHHHHHHH | 43.55 | 23403867 | |
| 261 | Phosphorylation | LQRQKALSNAANLQR HHHHHHHHHHHHHHH | 29.31 | 23025827 | |
| 283 | Acetylation | AIQWIKEKEPVLTSE HHHHHHHHCCCCCCC | 63.42 | 20167786 | |
| 299 | Phosphorylation | YGKDLVASEGLFHSH HCCCCHHCCCCCCCC | 25.39 | - | |
| 317 | Phosphorylation | ERNLAVMSDKVKELC HHHHHHHCHHHHHHH | 27.90 | 19664994 | |
| 361 | Phosphorylation | HIRALATSRYEKLQA HHHHHHHHHHHHHHH | 27.53 | 25627689 | |
| 370 | Phosphorylation | YEKLQATYWYHRFSS HHHHHHHHHHHHCCC | 13.64 | - | |
| 421 | Phosphorylation | QHKHEIDSYDDRFQS HCCCCCCCCHHHHHC | 35.80 | 28270605 | |
| 422 | Phosphorylation | HKHEIDSYDDRFQSA CCCCCCCCHHHHHCC | 20.36 | 28270605 | |
| 428 | Phosphorylation | SYDDRFQSADETGQD CCHHHHHCCCHHCHH | 34.67 | 28270605 | |
| 432 | Phosphorylation | RFQSADETGQDLVNA HHHCCCHHCHHHHHC | 40.46 | 28270605 | |
| 507 | Phosphorylation | ENEDLGNSLGSAEAL HCCHHHHCCCCHHHH | 32.10 | 23025827 | |
| 510 | Phosphorylation | DLGNSLGSAEALLQK HHHHCCCCHHHHHHH | 28.38 | 23025827 | |
| 548 | Phosphorylation | KLIGDDHYDSENIKA HHHCCCCCCHHHHHH | 28.32 | 20206558 | |
| 588 | Phosphorylation | SLLLQKLYEDSDDLK HHHHHHHHCCCHHHH | 25.40 | - | |
| 635 | Phosphorylation | KELAVNKTQLENIQK HHHCCCHHHHHHHHH | 32.93 | 19664994 | |
| 762 | Ubiquitination | EIGHPDSKDIRARQE HHCCCCHHHHHHHHH | 65.63 | 30230243 | |
| 812 | Phosphorylation | EEAWIQETEPSATST HHHHHHCCCCCCCHH | 36.50 | - | |
| 818 | Phosphorylation | ETEPSATSTYLGKDL CCCCCCCHHCCCHHH | 18.12 | - | |
| 844 | O-linked_Glycosylation | VILENIASHEPRIQE HHHHHHHHCCHHHHH | 25.29 | 30379171 | |
| 876 | Phosphorylation | DVASRVKSLNQNMES HHHHHHHHHHHHHHH | 29.69 | 23898821 | |
| 986 | Phosphorylation | EQRVMALYDFQARSP HHHHHHHHEECCCCC | 12.74 | 23917254 | |
| 992 | Phosphorylation | LYDFQARSPREVTMK HHEECCCCCCEECCC | 31.18 | 23025827 | |
| 1064 | Phosphorylation | QEQIENQYRSLLDRA HHHHHHHHHHHHHHH | 17.47 | - | |
| 1151 | Phosphorylation | LLFEGLLTPEGAQIR HHHCCCCCCCHHHHH | 25.08 | 23025827 | |
| 1167 | Phosphorylation | ELNSRWGSLQRLADE HHHHCHHHHHHHHHH | 17.86 | 23025827 | |
| 1250 | O-linked_Glycosylation | GETAERLSESHPDAT HHHHHHHHHHCCCHH | 43.18 | 30379171 | |
| 1250 | Phosphorylation | GETAERLSESHPDAT HHHHHHHHHHCCCHH | 43.18 | - | |
| 1257 | Phosphorylation | SESHPDATEDLQRQK HHHCCCHHHHHHHHH | 37.09 | - | |
| 1278 | Phosphorylation | WEDLQGRTKDRKESL HHHHCCCCCCHHHHH | 44.09 | 22199227 | |
| 1284 | Phosphorylation | RTKDRKESLNEAQKF CCCCHHHHHHHHHHH | 39.26 | 23025827 | |
| 1296 | Phosphorylation | QKFYLFLSKARDLQN HHHHHHHHHHHHHHH | 19.55 | 23025827 | |
| 1344 | Phosphorylation | DMEAEAPTFQALEDF CCCCCCCHHHHHHHH | 35.11 | 28270605 | |
| 1352 | Phosphorylation | FQALEDFSAELIDSG HHHHHHHHHHHHHCC | 32.91 | 28270605 | |
| 1358 | Phosphorylation | FSAELIDSGHHASPE HHHHHHHCCCCCCHH | 32.79 | 28270605 | |
| 1363 | Phosphorylation | IDSGHHASPEIEKKL HHCCCCCCHHHHHHH | 20.78 | 28270605 | |
| 1424 | Phosphorylation | SLRSDDKSSLDSLEA CCCCCCCCHHHHHHH | 43.03 | - | |
| 1425 | Phosphorylation | LRSDDKSSLDSLEAL CCCCCCCHHHHHHHH | 41.77 | - | |
| 1428 | Phosphorylation | DDKSSLDSLEALMKK CCCCHHHHHHHHHHC | 33.14 | 23186163 | |
| 1486 | Ubiquitination | LDRWKALKAQLIDER HHHHHHHHHHHHCHH | 38.66 | 29967540 | |
| 1499 | Phosphorylation | ERTKLGDYANLKQFY HHHHHCCHHCHHHHH | 8.80 | 20206558 | |
| 1538 | Phosphorylation | ATNIQRKYLKHQTFA CHHHHHHHHHHCCCE | 24.15 | 18083107 | |
| 1579 | Acetylation | DGNEEAMKEQLEQLK CCCHHHHHHHHHHHH | 49.73 | 11922443 | |
| 1586 | Acetylation | KEQLEQLKEHWDHLL HHHHHHHHHHHHHHH | 47.42 | 11922455 | |
| 1710 | Ubiquitination | AAHHEKLKEAYALFQ HHCHHHHHHHHHHHH | 51.90 | 11165260 | |
| 1738 | O-linked_Glycosylation | EKLIRVSSQDYGRDL HHHHHHHCCHHCCCH | 24.98 | 30379171 | |
| 1803 (in isoform 1) | Ubiquitination | - | 60.72 | 21890473 | |
| 1803 | Ubiquitination | QFVEHWEKLKELAKA HHHHHHHHHHHHHHH | 60.72 | 22817900 | |
| 1803 (in isoform 2) | Ubiquitination | - | 60.72 | 21890473 | |
| 1803 | Acetylation | QFVEHWEKLKELAKA HHHHHHHHHHHHHHH | 60.72 | 25953088 | |
| 1805 | Ubiquitination | VEHWEKLKELAKARG HHHHHHHHHHHHHCC | 62.85 | 22817900 | |
| 1901 | Phosphorylation | SQNKEISSKIEALNE HCCHHHHHHHHHHHC | 43.23 | - | |
| 1909 | Acetylation | KIEALNEKTPSLAKA HHHHHHCCCHHHHHH | 65.74 | 19413330 | |
| 1910 | Phosphorylation | IEALNEKTPSLAKAI HHHHHCCCHHHHHHH | 16.36 | - | |
| 1912 | Phosphorylation | ALNEKTPSLAKAIAA HHHCCCHHHHHHHHH | 46.31 | - | |
| 1976 | Phosphorylation | KQDTLDASLQSFQQE HCCCHHHHHHHHHHH | 26.97 | 8018926 | |
| 2051 | Acetylation | LFVEFAHKASALNNW HHHHHHHHHHHHHHH | 40.38 | 30592617 | |
| 2184 | Phosphorylation | RAYFLDGSLLKETGT HHHHCCCCHHHHCCC | 30.14 | 24719451 | |
| 2200 | Acetylation | ESQLEANKRKQKEIQ HHHHHHHHHHHHHHH | 68.94 | 30592623 | |
| 2269 | Phosphorylation | AKDIKGVSEETLKEF HHCCCCCCHHHHHHH | 38.08 | 23025827 | |
| 2272 | Phosphorylation | IKGVSEETLKEFSTI CCCCCHHHHHHHHHH | 38.79 | 23025827 | |
| 2277 | Phosphorylation | EETLKEFSTIYKHFD HHHHHHHHHHHHHCC | 18.26 | 23403867 | |
| 2278 | Phosphorylation | ETLKEFSTIYKHFDE HHHHHHHHHHHHCCC | 33.38 | 23403867 | |
| 2280 | Phosphorylation | LKEFSTIYKHFDENL HHHHHHHHHHCCCCC | 9.86 | 23403867 | |
| 2288 | Phosphorylation | KHFDENLTGRLTHKE HHCCCCCCCCCCHHH | 31.66 | 23312004 | |
| 2333 | Phosphorylation | VDPGRKGYVSLEDYT CCCCCCCEECHHHHH | 7.01 | 19060867 | |
| 2335 | Phosphorylation | PGRKGYVSLEDYTAF CCCCCEECHHHHHEE | 19.98 | 27251275 | |
| 2381 | Phosphorylation | EDMKQALTPEQVSFC HHHHHCCCHHHHHHH | 28.00 | 28450419 | |
| 2386 | Phosphorylation | ALTPEQVSFCATHMQ CCCHHHHHHHHHHHH | 17.82 | 28450419 | |
| 2390 | Phosphorylation | EQVSFCATHMQQYMD HHHHHHHHHHHHHCC | 21.04 | 28450419 | |
| 2395 | Phosphorylation | CATHMQQYMDPRGRS HHHHHHHHCCCCCCC | 6.13 | 28450419 | |
| 2405 | Phosphorylation | PRGRSHLSGYDYVGF CCCCCCCCCCCCCCC | 29.86 | - | |
| 2407 | Phosphorylation | GRSHLSGYDYVGFTN CCCCCCCCCCCCCCC | 10.75 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SPTA1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SPTA1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SPTA1_HUMAN !! | ||||||
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